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Protein

Malate dehydrogenase

Gene

mdh

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei101NADUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Active sitei181Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADUniRule annotation6
Nucleotide bindingi124 – 126NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-463-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:SE_0461
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134721 – 315Malate dehydrogenaseAdd BLAST315

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0461

Structurei

3D structure databases

ProteinModelPortaliQ8CQ25
SMRiQ8CQ25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiRQPGQTR

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CQ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMVNRRKIS IIGAGHTGGT LAFILAQKEL GDIVLIERQQ SEGMAKGKAL
60 70 80 90 100
DILESGPIWG FDTSVHGSVN IEDIKDSDIV VMTAGIPRKS GMTREELVQT
110 120 130 140 150
NEQIVRETAL QIATYAPHSI IIVLTNPVDV MTYTAFKASG FPKERIIGQS
160 170 180 190 200
GILDAARYRT FIAQELNVSV KDVNGFVLGG HGDTMLPLIN NTHINGIPVK
210 220 230 240 250
HLISEEKIDQ IVERTRKGGA EIVALLGQGS AYYAPATAIY ETIDAIFNDR
260 270 280 290 300
KRLLPSIAYL EGEYGCSDIC FGVPTIIGYQ GIEKIIEVDM NNDEYQQLQH
310
SAQAVSEVKN SLKFK
Length:315
Mass (Da):34,476
Last modified:March 1, 2003 - v1
Checksum:i85AC28A6477330B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04058.1
RefSeqiNP_764016.1, NC_004461.1
WP_011082618.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04058; AAO04058; SE_0461
GeneIDi1056153
KEGGisep:SE0461
PATRICifig|176280.10.peg.434

Similar proteinsi

Entry informationi

Entry nameiMDH_STAES
AccessioniPrimary (citable) accession number: Q8CQ25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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