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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-796-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:SE_0791
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622111 – 370Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST370

Proteomic databases

PRIDEiQ8CPN3

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi176280.SE0791

Structurei

3D structure databases

ProteinModelPortaliQ8CPN3
SMRiQ8CPN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4107RUY Bacteria
COG1071 LUCA
KOiK00161
OMAiNTMDKIL

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017596 PdhA/BkdA
IPR029061 THDP-binding
PANTHERiPTHR11516:SF41 PTHR11516:SF41, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03181 PDH_E1_alph_x, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CPN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKLQAQFD AVKVLNETQS KFEMVQILDE DGNVVNEDLV PDLTDEQLVE
60 70 80 90 100
LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALESEDFI
110 120 130 140 150
LPGYRDVPQI IWHGLPLTDA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY
160 170 180 190 200
IQTAGVAFGL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA SAYKAPAIFV
210 220 230 240 250
IQNNNYAIST PRSKQTAAET LAQKAISVGI PGIQVDGMDA LAVYQATLEA
260 270 280 290 300
RERAVAGEGP TVIETLTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR
310 320 330 340 350
FRKYLEAKGL WNEDKENEVV ERAKSEIKAA IKEADNTEKQ TVTSLMDIMY
360 370
EEMPQNLAEQ YEIYKEKESK
Length:370
Mass (Da):41,330
Last modified:March 1, 2003 - v1
Checksum:iF691D1D8C2E3EEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04388.1
RefSeqiNP_764346.1, NC_004461.1
WP_001831653.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04388; AAO04388; SE_0791
GeneIDi1057335
KEGGisep:SE0791
PATRICifig|176280.10.peg.764

Similar proteinsi

Entry informationi

Entry nameiODPA_STAES
AccessioniPrimary (citable) accession number: Q8CPN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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