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Protein

Formimidoylglutamase

Gene

hutG

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Manganese 1UniRule annotation1
Metal bindingi155Manganese 1UniRule annotation1
Metal bindingi155Manganese 2UniRule annotation1
Metal bindingi157Manganese 2UniRule annotation1
Metal bindingi159Manganese 1UniRule annotation1
Metal bindingi242Manganese 1UniRule annotation1
Metal bindingi242Manganese 2UniRule annotation1
Metal bindingi244Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-1966-MONOMER
UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:SE_1907
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737721 – 311FormimidoylglutamaseAdd BLAST311

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1907

Structurei

3D structure databases

ProteinModelPortaliQ8CNA3
SMRiQ8CNA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41088SP Bacteria
COG0010 LUCA
KOiK01479
OMAiNFDAHLD

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01227 hutG, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CNA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQLAQSNLW TGRLDSETDP TQFRHFQTVK FGDLSQLDFS DEHKGVGLLG
60 70 80 90 100
YAIDKGVELN KGRVGAKEGP NAIKRAFAGL PDLNQCEEII DYGNVEHNHE
110 120 130 140 150
LLIDTQREFA DLAAKSIKRH KQTFLLGGGH DIAYAQYLAT RKVYPESSIG
160 170 180 190 200
VINIDAHFDT RDEGYSTSGT SFRQILEEDD NADYLVLGIS QGGNTQALFN
210 220 230 240 250
YAKEKDIQFV YADELLHQVS PPIKDMIERF IHNHDTVMFT ICMDVVDSAF
260 270 280 290 300
APGVSAPAVL GIYPHTVFEL AKRVIPSEKV KSISIAEMNP TYDSDQRTAK
310
LVANLVHHCL I
Length:311
Mass (Da):34,720
Last modified:March 1, 2003 - v1
Checksum:iACBB614D587EA6A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO05548.1
RefSeqiNP_765462.1, NC_004461.1
WP_001831441.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO05548; AAO05548; SE_1907
GeneIDi1057940
KEGGisep:SE1907
PATRICifig|176280.10.peg.1866

Similar proteinsi

Entry informationi

Entry nameiHUTG_STAES
AccessioniPrimary (citable) accession number: Q8CNA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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