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Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity
7,8-dihydroneopterin = 7,8-dihydromonapterin.By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22SubstrateBy similarity1
Binding sitei54SubstrateBy similarity1
Active sitei100Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase
Biological processFolate biosynthesis

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-2337-MONOMER
UniPathwayi
UPA00077;UER00154

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25By similarity)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin 2'-epimerase
7,8-dihydroneopterin aldolase
7,8-dihydroneopterin epimerase (EC:5.1.99.8By similarity)
Dihydroneopterin epimerase
Gene namesi
Name:folB
Ordered Locus Names:SE_2268
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682841 – 121Dihydroneopterin aldolaseAdd BLAST121

Interactioni

Subunit structurei

Homooctamer. Four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 a diameter (By similarity).By similarity

Protein-protein interaction databases

STRINGi176280.SE2268

Structurei

3D structure databases

ProteinModelPortaliQ8CMT8
SMRiQ8CMT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

eggNOGiENOG4105KRF Bacteria
COG1539 LUCA
KOiK01633
OMAiFYAYHGV

Family and domain databases

CDDicd00534 DHNA_DHNTPE, 1 hit
InterProiView protein in InterPro
IPR006156 Dihydroneopterin_aldolase
IPR006157 FolB_dom
PfamiView protein in Pfam
PF02152 FolB, 1 hit
SMARTiView protein in SMART
SM00905 FolB, 1 hit
TIGRFAMsiTIGR00525 folB, 1 hit
TIGR00526 folB_dom, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CMT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDIIFLNGM RFYGYHGVLA AENDIGQIFV VDITLKVDLS YAGQSDDVKD
60 70 80 90 100
TVNYGEVYKD VKSIVEGPRS CLIEHLAERI AKHINSHYNR VMETKVRITK
110 120
ENPPIPGHYD GVGIEIVREN D
Length:121
Mass (Da):13,694
Last modified:March 1, 2003 - v1
Checksum:iE9963A5D126D5EB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO05910.1
RefSeqiNP_765823.1, NC_004461.1
WP_001832204.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO05910; AAO05910; SE_2268
GeneIDi1057979
KEGGisep:SE2268
PATRICifig|176280.10.peg.2211

Similar proteinsi

Entry informationi

Entry nameiFOLB_STAES
AccessioniPrimary (citable) accession number: Q8CMT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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