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Protein

Plexin-B1

Gene

Plxnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1799Important for interaction with RAC1 and RND1By similarity1

GO - Molecular functioni

  • GTPase activating protein binding Source: BHF-UCL
  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-416482 G alpha (12/13) signalling events
R-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Gene namesi
Name:Plxnb1
Synonyms:Kiaa0407
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2154238 Plxnb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1474ExtracellularSequence analysisAdd BLAST1455
Transmembranei1475 – 1495HelicalSequence analysisAdd BLAST21
Topological domaini1496 – 2119CytoplasmicSequence analysisAdd BLAST624

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002467220 – 2119Plexin-B1Add BLAST2100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1251N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1314N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.By similarity
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CJH3
PaxDbiQ8CJH3
PRIDEiQ8CJH3

PTM databases

iPTMnetiQ8CJH3
PhosphoSitePlusiQ8CJH3

Expressioni

Tissue specificityi

Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta.1 Publication

Gene expression databases

BgeeiENSMUSG00000053646 Expressed in 270 organ(s), highest expression level in ear vesicle
CleanExiMM_PLXNB1
ExpressionAtlasiQ8CJH3 baseline and differential
GenevisibleiQ8CJH3 MM

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Interacts with RRAS, ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, RHOD, NRP1 and NRP2 (By similarity). Binds PLXNA1.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ8CJH3
IntActiQ8CJH3, 4 interactors
MINTiQ8CJH3
STRINGi10090.ENSMUSP00000071966

Structurei

3D structure databases

ProteinModelPortaliQ8CJH3
SMRiQ8CJH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 479SemaPROSITE-ProRule annotationAdd BLAST460
Domaini1068 – 1158IPT/TIG 1Add BLAST91
Domaini1160 – 1247IPT/TIG 2Add BLAST88
Domaini1250 – 1359IPT/TIG 3Add BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1492 – 1523Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 835Pro-richAdd BLAST158

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiQ8CJH3
KOiK06821
OMAiVQTSDNM
OrthoDBiEOG091G00EK
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CJH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLGPVLLQ VFWAGCVVTL RSPLPAAFTA NGTHLQHLAR DPTTGTLYVG
60 70 80 90 100
ATNFLFQLSP GLQLEAVVST GPVNDSRDCL PPVIPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPEALVV CGSVHQGICE LRSLGQIRQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL VGEPLLFVGR GYTSRGVGGG IPPITTRALR PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFVRGASAYF LFLRRDLKAP SRAFRAYVSR
260 270 280 290 300
VCLQDQHYYS YVELPLACQG GRYGLIQAAA VATSKEVARG DVLFAAFSSV
310 320 330 340 350
APPTVDWPLS ASTGASGTSV LCAFPLDEVD QLANYTRDAC YTREGRAENG
360 370 380 390 400
TKVADIAYDV LSDCAQLPVD TPDAFPCGSD HTPSPMVSCV PLEATPILEL
410 420 430 440 450
PGVQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGRSAA PYSKQSIQPG
460 470 480 490 500
SPVNRDLTFD GTFEHLYVAT QTTLVKVPVA PCAQHLDCDS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRDQGP EQWLWSFQPE LGCLRVVAVS PANISREERR
560 570 580 590 600
EVFLSVPGLP SLWPGESYFC YFGDQQSPAL LTSSGVMCPS PDPSEAPVLQ
610 620 630 640 650
RGADHISVNV ELRFGAVVIA STSLSFYDCV AVTASSPSAP CRACVSSRWG
660 670 680 690 700
CNWCVWQQLC THKASCDAGP MVASQQSPLL PLIPPARDEL TPFPPTVPQT
710 720 730 740 750
TVTPTPNSFP IEPRAPSTAS DVLPGAKPSR LSLWGPWAGP GPILSPTSTE
760 770 780 790 800
SPLHEKPLPP DPPTIPGTTV PAPTGLGPST TPEDLLASYP FPSDAAAVSP
810 820 830 840 850
AEPGPEALPS MVALDQPPGT VPDTTFPGAP GSMKPVLDWL TKGGGELPEA
860 870 880 890 900
DEWMGGDTPA FSTSTLLSGD GDSAEHEGPP APLILLSSLD YQYDTPGLWE
910 920 930 940 950
LGEVNQRVSS CPCVETVQGS LLIPVHVERE VQLRGRNLWL FQDGPRSSEC
960 970 980 990 1000
VLELGSREVA VEAQVECAPP PDVWCHIKCQ QHQFSYEALK PELQVGLFLR
1010 1020 1030 1040 1050
WAGGLRVDSA DGLHVVLYDC SVGHGDCSRC QTAMPQYDCV WCEGERPRCV
1060 1070 1080 1090 1100
AREACNEAET VATQCPAPLI HSVDPLTGPI DGGTRVTIRG SNLGQHVQDV
1110 1120 1130 1140 1150
LDMVRVAGVP CAVDAGEYDV SSSLVCITGA SGEEVTGTVA VEVPGRGHGV
1160 1170 1180 1190 1200
SEFSFAYQDP KVHSIFPARG PRAGGTRLTL HGSKLLTGRL EDIRVVVGDQ
1210 1220 1230 1240 1250
PCHLLLEQQS EQLHCETGPY PVPAELPVTV LFGATERRLQ HGQFKYTSDP
1260 1270 1280 1290 1300
NVTSVGPSKS FFSGGREIWV RGQDLDVVQR PRIRVTVVPR QHGQGLAQKQ
1310 1320 1330 1340 1350
HVVPEKFEEP CLVNSSHLLM CRTPALPGPP WDSGVQVEFI LDNMVFDFAA
1360 1370 1380 1390 1400
LSPTPFSYEA DPTLRSLNPE DPSTPFRHKP GSVFSVEGEN LDLAMSKEEV
1410 1420 1430 1440 1450
VAMIGDGPCV VKTLTRNHLY CEPPVEQPLP HPHALREAPD ALPEFTVQMG
1460 1470 1480 1490 1500
NLRFSLGHVQ YDGESPVAFP VAAQVGLGVG TSLLALGVII IVLIYRRKSK
1510 1520 1530 1540 1550
QALRDYKKVQ IQLENLESSV RDRCKKEFTD LMTEMTDLTS DLLGSGIPFL
1560 1570 1580 1590 1600
DYKVYAERVF FPGYRESPLH RDLGVPDSRR PTVEQGLGQL SNLLNSKLFL
1610 1620 1630 1640 1650
TKFIHTLESQ RTFSARDRAY VASLLTVALH GKLEYFTDIL RTLLSDLVAQ
1660 1670 1680 1690 1700
YVAKNPKLML RRTETVVEKL LTNWMSICLY TFVRDSVGEP LYMLFRGIKH
1710 1720 1730 1740 1750
QVDKGPVDSV TGKAKYTLND NRLLREDVEY RPLTLNALLA VGPGAGEAQC
1760 1770 1780 1790 1800
VPVKVLDCDT ISQAKEKMLD QLYKGVPLAQ RPDSCTLDVE WRSGVAGHLI
1810 1820 1830 1840 1850
LSDEDVTSEL QGLWRRLNTL QHYKVPDGAT VALVPCLTKH ILRENQDYVP
1860 1870 1880 1890 1900
GERTPMLEDV DEGGIRPWHL VKPSDEPEPP RPRRGSLRGG ERERAKAIPE
1910 1920 1930 1940 1950
IYLTRLLSMK GTLQKFVDDL FQVILSTSRP VPLAVKYFFD LLDEQAQQHG
1960 1970 1980 1990 2000
ISDQDTIHIW KTNSLPLRFW INIIKNPQFV FDVQTSDNMD AVLLVIAQTF
2010 2020 2030 2040 2050
MDACTLADHK LGRDSPINKL LYARDIPRYK QMVERYYADI RQTVPASDQE
2060 2070 2080 2090 2100
MNSVLAELSR NCSADLGARV ALHELYKYIN KYYDQIITAL EEDGTAQKMQ
2110
LGYRLQQIAA AVENKVTDL
Length:2,119
Mass (Da):231,376
Last modified:July 27, 2011 - v2
Checksum:i08FB5ECD2E6DE342
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUD0D3YUD0_MOUSE
Plexin-B1
Plxnb1
140Annotation score:
A0A0G2JDM9A0A0G2JDM9_MOUSE
Plexin-B1
Plxnb1
266Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Q → L in BAC22660 (PubMed:12559962).Curated1
Sequence conflicti1777P → L in BAC97943 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072381 mRNA Translation: BAC22660.1
AC140383 Genomic DNA No translation available.
AC174646 Genomic DNA No translation available.
AK129133 mRNA Translation: BAC97943.1
BC043322 mRNA Translation: AAH43322.1
CCDSiCCDS23546.1
RefSeqiNP_766363.2, NM_172775.2
XP_006512138.1, XM_006512075.3
XP_006512139.1, XM_006512076.3
XP_006512140.1, XM_006512077.3
XP_006512141.1, XM_006512078.2
XP_006512142.1, XM_006512079.3
XP_006512143.1, XM_006512080.2
UniGeneiMm.53862

Genome annotation databases

EnsembliENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646
GeneIDi235611
KEGGimmu:235611
UCSCiuc009rrz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072381 mRNA Translation: BAC22660.1
AC140383 Genomic DNA No translation available.
AC174646 Genomic DNA No translation available.
AK129133 mRNA Translation: BAC97943.1
BC043322 mRNA Translation: AAH43322.1
CCDSiCCDS23546.1
RefSeqiNP_766363.2, NM_172775.2
XP_006512138.1, XM_006512075.3
XP_006512139.1, XM_006512076.3
XP_006512140.1, XM_006512077.3
XP_006512141.1, XM_006512078.2
XP_006512142.1, XM_006512079.3
XP_006512143.1, XM_006512080.2
UniGeneiMm.53862

3D structure databases

ProteinModelPortaliQ8CJH3
SMRiQ8CJH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ8CJH3
IntActiQ8CJH3, 4 interactors
MINTiQ8CJH3
STRINGi10090.ENSMUSP00000071966

PTM databases

iPTMnetiQ8CJH3
PhosphoSitePlusiQ8CJH3

Proteomic databases

MaxQBiQ8CJH3
PaxDbiQ8CJH3
PRIDEiQ8CJH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646
GeneIDi235611
KEGGimmu:235611
UCSCiuc009rrz.2 mouse

Organism-specific databases

CTDi5364
MGIiMGI:2154238 Plxnb1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiQ8CJH3
KOiK06821
OMAiVQTSDNM
OrthoDBiEOG091G00EK
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-MMU-416482 G alpha (12/13) signalling events
R-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

ChiTaRSiPlxnb1 mouse
PROiPR:Q8CJH3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053646 Expressed in 270 organ(s), highest expression level in ear vesicle
CleanExiMM_PLXNB1
ExpressionAtlasiQ8CJH3 baseline and differential
GenevisibleiQ8CJH3 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXB1_MOUSE
AccessioniPrimary (citable) accession number: Q8CJH3
Secondary accession number(s): E9QKS4, Q6ZQC3, Q80ZZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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