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Entry version 137 (18 Sep 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Plexin-B1

Gene

Plxnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for SEMA4D (PubMed:19788569). Plays a role in GABAergic synapse development (PubMed:23699507, PubMed:29981480). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (PubMed:23699507, PubMed:29981480). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity). Plays a role in axon guidance, invasive growth and cell migration (By similarity).By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1799Important for interaction with RAC1 and RND1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plxnb1
Synonyms:Kiaa0407
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2154238 Plxnb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1474ExtracellularSequence analysisAdd BLAST1455
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1475 – 1495HelicalSequence analysisAdd BLAST21
Topological domaini1496 – 2119CytoplasmicSequence analysisAdd BLAST624

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002467220 – 2119Plexin-B1Add BLAST2100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1251N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1314N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.By similarity
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CJH3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CJH3

PRoteomics IDEntifications database

More...
PRIDEi
Q8CJH3

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2593

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CJH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CJH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta (PubMed:12559962). Expressed in neurons and glia in the developing hippocampus (PubMed:29981480).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053646 Expressed in 270 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CJH3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CJH3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing (By similarity). Binds RAC1 that has been activated by GTP binding (By similarity). Interaction with SEMA4D promotes binding of cytoplasmic ligands (By similarity).

Interacts with RRAS, ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, RHOD, NRP1 and NRP2 (By similarity).

Interacts with PLXNA1 (PubMed:12559962).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231692, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8CJH3

Protein interaction database and analysis system

More...
IntActi
Q8CJH3, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8CJH3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071966

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CJH3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 479SemaPROSITE-ProRule annotationAdd BLAST460
Domaini1068 – 1158IPT/TIG 1Add BLAST91
Domaini1160 – 1247IPT/TIG 2Add BLAST88
Domaini1250 – 1359IPT/TIG 3Add BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1492 – 1523Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi678 – 835Pro-richAdd BLAST158

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410XR88 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231376

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CJH3

KEGG Orthology (KO)

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KOi
K06821

Identification of Orthologs from Complete Genome Data

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OMAi
FQDSPGD

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CJH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLGPVLLQ VFWAGCVVTL RSPLPAAFTA NGTHLQHLAR DPTTGTLYVG
60 70 80 90 100
ATNFLFQLSP GLQLEAVVST GPVNDSRDCL PPVIPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPEALVV CGSVHQGICE LRSLGQIRQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL VGEPLLFVGR GYTSRGVGGG IPPITTRALR PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFVRGASAYF LFLRRDLKAP SRAFRAYVSR
260 270 280 290 300
VCLQDQHYYS YVELPLACQG GRYGLIQAAA VATSKEVARG DVLFAAFSSV
310 320 330 340 350
APPTVDWPLS ASTGASGTSV LCAFPLDEVD QLANYTRDAC YTREGRAENG
360 370 380 390 400
TKVADIAYDV LSDCAQLPVD TPDAFPCGSD HTPSPMVSCV PLEATPILEL
410 420 430 440 450
PGVQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGRSAA PYSKQSIQPG
460 470 480 490 500
SPVNRDLTFD GTFEHLYVAT QTTLVKVPVA PCAQHLDCDS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRDQGP EQWLWSFQPE LGCLRVVAVS PANISREERR
560 570 580 590 600
EVFLSVPGLP SLWPGESYFC YFGDQQSPAL LTSSGVMCPS PDPSEAPVLQ
610 620 630 640 650
RGADHISVNV ELRFGAVVIA STSLSFYDCV AVTASSPSAP CRACVSSRWG
660 670 680 690 700
CNWCVWQQLC THKASCDAGP MVASQQSPLL PLIPPARDEL TPFPPTVPQT
710 720 730 740 750
TVTPTPNSFP IEPRAPSTAS DVLPGAKPSR LSLWGPWAGP GPILSPTSTE
760 770 780 790 800
SPLHEKPLPP DPPTIPGTTV PAPTGLGPST TPEDLLASYP FPSDAAAVSP
810 820 830 840 850
AEPGPEALPS MVALDQPPGT VPDTTFPGAP GSMKPVLDWL TKGGGELPEA
860 870 880 890 900
DEWMGGDTPA FSTSTLLSGD GDSAEHEGPP APLILLSSLD YQYDTPGLWE
910 920 930 940 950
LGEVNQRVSS CPCVETVQGS LLIPVHVERE VQLRGRNLWL FQDGPRSSEC
960 970 980 990 1000
VLELGSREVA VEAQVECAPP PDVWCHIKCQ QHQFSYEALK PELQVGLFLR
1010 1020 1030 1040 1050
WAGGLRVDSA DGLHVVLYDC SVGHGDCSRC QTAMPQYDCV WCEGERPRCV
1060 1070 1080 1090 1100
AREACNEAET VATQCPAPLI HSVDPLTGPI DGGTRVTIRG SNLGQHVQDV
1110 1120 1130 1140 1150
LDMVRVAGVP CAVDAGEYDV SSSLVCITGA SGEEVTGTVA VEVPGRGHGV
1160 1170 1180 1190 1200
SEFSFAYQDP KVHSIFPARG PRAGGTRLTL HGSKLLTGRL EDIRVVVGDQ
1210 1220 1230 1240 1250
PCHLLLEQQS EQLHCETGPY PVPAELPVTV LFGATERRLQ HGQFKYTSDP
1260 1270 1280 1290 1300
NVTSVGPSKS FFSGGREIWV RGQDLDVVQR PRIRVTVVPR QHGQGLAQKQ
1310 1320 1330 1340 1350
HVVPEKFEEP CLVNSSHLLM CRTPALPGPP WDSGVQVEFI LDNMVFDFAA
1360 1370 1380 1390 1400
LSPTPFSYEA DPTLRSLNPE DPSTPFRHKP GSVFSVEGEN LDLAMSKEEV
1410 1420 1430 1440 1450
VAMIGDGPCV VKTLTRNHLY CEPPVEQPLP HPHALREAPD ALPEFTVQMG
1460 1470 1480 1490 1500
NLRFSLGHVQ YDGESPVAFP VAAQVGLGVG TSLLALGVII IVLIYRRKSK
1510 1520 1530 1540 1550
QALRDYKKVQ IQLENLESSV RDRCKKEFTD LMTEMTDLTS DLLGSGIPFL
1560 1570 1580 1590 1600
DYKVYAERVF FPGYRESPLH RDLGVPDSRR PTVEQGLGQL SNLLNSKLFL
1610 1620 1630 1640 1650
TKFIHTLESQ RTFSARDRAY VASLLTVALH GKLEYFTDIL RTLLSDLVAQ
1660 1670 1680 1690 1700
YVAKNPKLML RRTETVVEKL LTNWMSICLY TFVRDSVGEP LYMLFRGIKH
1710 1720 1730 1740 1750
QVDKGPVDSV TGKAKYTLND NRLLREDVEY RPLTLNALLA VGPGAGEAQC
1760 1770 1780 1790 1800
VPVKVLDCDT ISQAKEKMLD QLYKGVPLAQ RPDSCTLDVE WRSGVAGHLI
1810 1820 1830 1840 1850
LSDEDVTSEL QGLWRRLNTL QHYKVPDGAT VALVPCLTKH ILRENQDYVP
1860 1870 1880 1890 1900
GERTPMLEDV DEGGIRPWHL VKPSDEPEPP RPRRGSLRGG ERERAKAIPE
1910 1920 1930 1940 1950
IYLTRLLSMK GTLQKFVDDL FQVILSTSRP VPLAVKYFFD LLDEQAQQHG
1960 1970 1980 1990 2000
ISDQDTIHIW KTNSLPLRFW INIIKNPQFV FDVQTSDNMD AVLLVIAQTF
2010 2020 2030 2040 2050
MDACTLADHK LGRDSPINKL LYARDIPRYK QMVERYYADI RQTVPASDQE
2060 2070 2080 2090 2100
MNSVLAELSR NCSADLGARV ALHELYKYIN KYYDQIITAL EEDGTAQKMQ
2110
LGYRLQQIAA AVENKVTDL
Length:2,119
Mass (Da):231,376
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08FB5ECD2E6DE342
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUD0D3YUD0_MOUSE
Plexin-B1
Plxnb1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDM9A0A0G2JDM9_MOUSE
Plexin-B1
Plxnb1
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36Q → L in BAC22660 (PubMed:12559962).Curated1
Sequence conflicti1777P → L in BAC97943 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB072381 mRNA Translation: BAC22660.1
AC140383 Genomic DNA No translation available.
AC174646 Genomic DNA No translation available.
AK129133 mRNA Translation: BAC97943.1
BC043322 mRNA Translation: AAH43322.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23546.1

NCBI Reference Sequences

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RefSeqi
NP_766363.2, NM_172775.2
XP_006512138.1, XM_006512075.3
XP_006512139.1, XM_006512076.3
XP_006512140.1, XM_006512077.3
XP_006512141.1, XM_006512078.2
XP_006512142.1, XM_006512079.3
XP_006512143.1, XM_006512080.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646

Database of genes from NCBI RefSeq genomes

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GeneIDi
235611

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:235611

UCSC genome browser

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UCSCi
uc009rrz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072381 mRNA Translation: BAC22660.1
AC140383 Genomic DNA No translation available.
AC174646 Genomic DNA No translation available.
AK129133 mRNA Translation: BAC97943.1
BC043322 mRNA Translation: AAH43322.1
CCDSiCCDS23546.1
RefSeqiNP_766363.2, NM_172775.2
XP_006512138.1, XM_006512075.3
XP_006512139.1, XM_006512076.3
XP_006512140.1, XM_006512077.3
XP_006512141.1, XM_006512078.2
XP_006512142.1, XM_006512079.3
XP_006512143.1, XM_006512080.2

3D structure databases

SMRiQ8CJH3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231692, 6 interactors
CORUMiQ8CJH3
IntActiQ8CJH3, 4 interactors
MINTiQ8CJH3
STRINGi10090.ENSMUSP00000071966

PTM databases

GlyConnecti2593
iPTMnetiQ8CJH3
PhosphoSitePlusiQ8CJH3

Proteomic databases

MaxQBiQ8CJH3
PaxDbiQ8CJH3
PRIDEiQ8CJH3

Genome annotation databases

EnsembliENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646
GeneIDi235611
KEGGimmu:235611
UCSCiuc009rrz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5364
MGIiMGI:2154238 Plxnb1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00970000193384
HOGENOMiHOG000231376
InParanoidiQ8CJH3
KOiK06821
OMAiFQDSPGD
OrthoDBi90434at2759
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-MMU-416482 G alpha (12/13) signalling events
R-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plxnb1 mouse

Protein Ontology

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PROi
PR:Q8CJH3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053646 Expressed in 270 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ8CJH3 baseline and differential
GenevisibleiQ8CJH3 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXB1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJH3
Secondary accession number(s): E9QKS4, Q6ZQC3, Q80ZZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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