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UniProtKB - Q8CJF7 (ELYS_MOUSE)

Entry version 142 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Protein ELYS

Gene

Ahctf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1955 – 1967A.T hookBy similarityAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processCell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Transcription, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-5663220, RHO GTPases Activate Formins
R-MMU-68877, Mitotic Prometaphase
R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation
R-MMU-9648025, EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ELYS
Alternative name(s):
Embryonic large molecule derived from yolk sac
Protein MEL-28
Putative AT-hook-containing transcription factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ahctf1
Synonyms:Elys
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915033, Ahctf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality before 7.5 dpc. Impaired proliferation of the inner cells of the blastocyst due at least in part to increased apoptosis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi272 – 280FQEPENDPR → GSGSGSGSG: Abolishes nuclear pore localization; when associated with S-284. 1 Publication9
Mutagenesisi284Y → S: Abolishes nuclear pore localization; when associated with 272-GSGSGSGSG-280. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002463201 – 2243Protein ELYSAdd BLAST2243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei528PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1138PhosphoserineCombined sources1
Modified residuei1142PhosphoserineBy similarity1
Modified residuei1150PhosphoserineBy similarity1
Modified residuei1155PhosphoserineBy similarity1
Modified residuei1175PhosphothreonineBy similarity1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1222PhosphoserineBy similarity1
Modified residuei1235PhosphoserineBy similarity1
Modified residuei1381PhosphoserineCombined sources1
Modified residuei1517PhosphothreonineBy similarity1
Modified residuei1533PhosphoserineBy similarity1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1725PhosphoserineBy similarity1
Modified residuei1864PhosphoserineBy similarity1
Modified residuei1870PhosphoserineBy similarity1
Modified residuei1884PhosphoserineBy similarity1
Modified residuei1928PhosphoserineCombined sources1
Modified residuei1930PhosphoserineBy similarity1
Modified residuei1980PhosphoserineBy similarity1
Modified residuei2021PhosphoserineBy similarity1
Modified residuei2099PhosphoserineBy similarity1
Modified residuei2132PhosphoserineBy similarity1
Modified residuei2188PhosphoserineCombined sources1
Modified residuei2198PhosphoserineCombined sources1
Modified residuei2202PhosphoserineBy similarity1
Modified residuei2221N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CJF7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CJF7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8CJF7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CJF7

PeptideAtlas

More...PeptideAtlasi		Q8CJF7

PRoteomics IDEntifications database

More...PRIDEi		Q8CJF7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CJF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CJF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in testis, lung and kidney. Expressed in T-cells, B-cells and granulocytes in bone marrow.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout the embryo at 3.5 dpc and 6.5 dpc. Higher expression is detected at 10.5 dpc nad then progressively decreases. Highly expressed in fetal hematopoietic tissues including liver, spleen and thymus. Expressed in the endothelium lining the dorsal aorta of 11.5 dpc embryos (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026491, Expressed in forelimb bud and 306 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CJF7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the Nup107-160 subcomplex of the NPC.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		230549, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4474, Nuclear pore complex

Protein interaction database and analysis system

More...IntActi		Q8CJF7, 2 interactors

Molecular INTeraction database

More...MINTi		Q8CJF7

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000027768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CJF7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CJF7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 981Necessary for cytoplasmic localization1 PublicationAdd BLAST981
Regioni1 – 494Seven-bladed beta propeller repeats1 PublicationAdd BLAST494
Regioni591 – 1092Important for nuclear localizationBy similarityAdd BLAST502
Regioni1019 – 2243Disordered1 PublicationAdd BLAST1225
Regioni1149 – 2243Necessary for nuclear localization1 PublicationAdd BLAST1095
Regioni1447 – 1694Mediates transcriptional activity1 PublicationAdd BLAST248
Regioni1828 – 2243Important for nuclear localization and chromatin bindingBy similarityAdd BLAST416

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (PubMed:23499022).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELYS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QU0D, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001145_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CJF7

Identification of Orthologs from Complete Genome Data

More...OMAi		TSPHYIL

Database of Orthologous Groups

More...OrthoDBi		1040332at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CJF7

TreeFam database of animal gene trees

More...TreeFami		TF350425

Family and domain databases

Database of protein disorder

More...DisProti		DP01548

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032040, ELYS-bb
IPR025151, ELYS_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13934, ELYS, 1 hit
PF16687, ELYS-bb, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CJF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDLTAQVTS DLLHFPEVTI EALGEDEITL ESVLRGKFAA GKNGLACLAC 
        60         70         80         90        100
GPQLEVVNSL TGERLSAYRF SGVNEQPPVV LAVKEFSWHK RTGLLIGLEE 
       110        120        130        140        150
ADGSVLCLYD LGISRVVKAV VLPGRVTAIE PIINHGGASA STQHLHPSLR 
       160        170        180        190        200
WLFGVAAVVT DVGQILLIDL CLDDLSCSQN EVEASDLEVI TGIPAEVPHI 
       210        220        230        240        250
RERVMREGRH LCFQLVSPLG VAISTLSYIN RTNQLAVGFS DGYLALWNMK 
       260        270        280        290        300
SMKREYYTQL EGGRVPVHAV AFQEPENDPR NCCYLWAVQS TQDSEGDVLS 
       310        320        330        340        350
LHLLQLAFGD RKCLASGQIL YEGLEYCEER YTLDLAGGTF PLRGQTSNTK 
       360        370        380        390        400
LLGCQSIERF PSHGDREESM REALSPDTSV SVFTWQVNIY GQGKPSVYLG 
       410        420        430        440        450
LFDINRWYHA QMPDSLRSGE SLHNCSYFAL WSLDSVVSRT SPHHILDILV 
       460        470        480        490        500
HERSLNRGVP PSYPPPEQFF NPSTFNFDAT CLLDSGVIHV TCAGFQKETL 
       510        520        530        540        550
TFLKKSGPTL NEVIPDSYNR CLVAGLLSPR LIDIQPSSLS QEEQLEAILS 
       560        570        580        590        600
AAIQTSSLGL LTGYIRTWII EEQPNSAANL RFVLEWTWNK VVLTKEEFDR 
       610        620        630        640        650
LCVPLFDGSC RFIDPQTIQS IQQCHLLLSN LSTVLSCFAM EAQGITERGL 
       660        670        680        690        700
VDLSNKHMVT QLLCQYAHMV LWFCHSGLLP EGLDDALQLS RLRYNYPVIQ 
       710        720        730        740        750
NYYTSRRQKS ERSPRGKWNH DCLMIDGLVS QLGDEVEKLW KRDEGGTGRY 
       760        770        780        790        800
PPASIHALLD IYLLDNITEA SKHAITIYLL LDIMYSFPNK TDTPIESFPT 
       810        820        830        840        850
AFAISWGQVK LVQGFWLLDH NDYENGLDLL FHPVTAKPAS WQHSKIIEAF 
       860        870        880        890        900
MSQGEHKQAL RYLQTMKPTV SSSNEVILHL TVLLFNRCMV EAWNLLRQNS 
       910        920        930        940        950
NRVNIEELLK HAYEVCQEMG LMEDLLKLPF TNTEQECLVK FLQSSTSVEN 
       960        970        980        990       1000
HEFLLVHHLQ RANYISALKL NQILKNNLMS DRDPRLRERS VTRNSILDQY 
      1010       1020       1030       1040       1050
GKILPRVQRK LAVERAKPYH LSTSSVFHEV SRPKPLSAFP KKAITGTVLT 
      1060       1070       1080       1090       1100
RSTFISNVLS KIGEVWASHE PRNGVSLFNS PKTEQPSPVV HSFPHPELPE 
      1110       1120       1130       1140       1150
AFVGTPISNT SQRISRLLDL VVHPVPQPSQ CLEFIQQSPT RSPLCLLSSS 
      1160       1170       1180       1190       1200
LPLSSQFKRP HQNTSRPSEL LLLETPLIVK KAKSLALSAT SSGFAEFTPP 
      1210       1220       1230       1240       1250
SILRSGFRTT PLASPSLSPG RSLTPPFRVK ETRISFMEEG MNTHWTDRAT 
      1260       1270       1280       1290       1300
DDRNTKAFVS TSFHKCGLPA ETEWMKTSDK NTYFPLDVPA KGPQKVVAES 
      1310       1320       1330       1340       1350
LATHSGRLEK LDVSKEDSTA STRSDQTSLE YHDAPSPEDL EGAVFVSPKP 
      1360       1370       1380       1390       1400
ASSSTELTTN STLQTERDND KDAFKSEGAP SPVKKQIGTG DAAVEAFSEL 
      1410       1420       1430       1440       1450
SRLDPVERAE ASFAVSSVCE GETSTSNSKT SVLDGIVPIE SRTSILTADH 
      1460       1470       1480       1490       1500
KESVANTVAD VESSGSTSSK CPVTSERSLG QKLTLNLKED EIEAHVPKEN 
      1510       1520       1530       1540       1550
VGLPEESPRI SAAPSDTHEI HLIGCENLEV QNSEEEAKNL SFDELYPLGA 
      1560       1570       1580       1590       1600
EKLEYNLSTI EQQFCDLPDD KDSAECDAAE VDGELFVAQS NFTLILEGEE 
      1610       1620       1630       1640       1650
GEAEASDSAA PNMLPKATKE KPVCHREPHN QERVTDLPSA VTADQESHKV 
      1660       1670       1680       1690       1700
ETLPYVPEPV KVAIAENLLD VIKDTRSKEA TPVAAGEAGD EDGAVIVSKA 
      1710       1720       1730       1740       1750
AHSSRLTNST PKTVKEPHAE TVNTSQNDDM VSSRTLTRRQ HALSLNVTSE 
      1760       1770       1780       1790       1800
QEPSAVATPK KRTRKIKETP ESSERTCSDL KVAPENQLTA QSPPAPRRGK 
      1810       1820       1830       1840       1850
KKDVSQGTLP SSGAVEPEPE PQGTPGRLRL RTQPPEPAAE ETPSRTKVRL 
      1860       1870       1880       1890       1900
SSVRKGTPRR LKKSVENGQS TEILDDLKGS EAASHDGTVT ELRNANLEDT 
      1910       1920       1930       1940       1950
QNMEYKQDEH SDQQLPLKRK RVREREVSVS SVTEEPKLDS SQLPLQTGLD 
      1960       1970       1980       1990       2000
VPATPRKRGR PRKVVPLEAD GGTTGKEQTS PQKKDVPVVR RSTRNTPARN 
      2010       2020       2030       2040       2050
VSTLEKSVLV PNKEAALVVT SKRRPTKKSA EESSKDPSAA VSDLAGGAAH 
      2060       2070       2080       2090       2100
TESADRRDGL LAAAALTPSA QGTRTRSRRT MLLTDISEPK TEPLFPPPSV 
      2110       2120       2130       2140       2150
KVPKKKSKAE NMEAAAQLKE LVSDLSSQFV VSPPALRTRQ KSISNTSKLL 
      2160       2170       2180       2190       2200
GELESDPKPL EIIEQKPKRS RTVKTRASRN TGKGSSWSPP PVEIKLVSPL 
      2210       2220       2230       2240 
ASPVDEIKTG KPRKTAEIAG KTLGRGRKKP SSFPKQILRR KML
Length:2,243
Mass (Da):247,646
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEEA09B70F2B5691
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QTR3F6QTR3_MOUSE
Protein ELYS
Ahctf1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SJR1F6SJR1_MOUSE
Protein ELYS
Ahctf1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S6E4F6S6E4_MOUSE
Protein ELYS
Ahctf1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XUM6F6XUM6_MOUSE
Protein ELYS
Ahctf1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1207F → L in BAB78517 (PubMed:11952839).Curated1
Sequence conflicti1379A → T in BAB78517 (PubMed:11952839).Curated1
Sequence conflicti1414A → G in BAB78517 (PubMed:11952839).Curated1
Sequence conflicti1718H → R in BAB78517 (PubMed:11952839).Curated1
Sequence conflicti2084T → A in BAC37101 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB059278 mRNA Translation: BAB78517.1
AB081498 Genomic DNA Translation: BAC22610.1
BC138343 mRNA Translation: AAI38344.1
BC138344 mRNA Translation: AAI38345.1
AK078022 mRNA Translation: BAC37101.2 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS15564.1

NCBI Reference Sequences

More...RefSeqi		NP_080651.2, NM_026375.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000027768; ENSMUSP00000027768; ENSMUSG00000026491

Database of genes from NCBI RefSeq genomes

More...GeneIDi		226747

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:226747

UCSC genome browser

More...UCSCi		uc011wxn.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059278 mRNA Translation: BAB78517.1
AB081498 Genomic DNA Translation: BAC22610.1
BC138343 mRNA Translation: AAI38344.1
BC138344 mRNA Translation: AAI38345.1
AK078022 mRNA Translation: BAC37101.2 Sequence problems.
CCDSiCCDS15564.1
RefSeqiNP_080651.2, NM_026375.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0OX-ray1.90A1-494[»]
SMRiQ8CJF7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi230549, 4 interactors
ComplexPortaliCPX-4474, Nuclear pore complex
IntActiQ8CJF7, 2 interactors
MINTiQ8CJF7
STRINGi10090.ENSMUSP00000027768

PTM databases

iPTMnetiQ8CJF7
PhosphoSitePlusiQ8CJF7

Proteomic databases

EPDiQ8CJF7
jPOSTiQ8CJF7
MaxQBiQ8CJF7
PaxDbiQ8CJF7
PeptideAtlasiQ8CJF7
PRIDEiQ8CJF7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20836, 110 antibodies

Genome annotation databases

EnsembliENSMUST00000027768; ENSMUSP00000027768; ENSMUSG00000026491
GeneIDi226747
KEGGimmu:226747
UCSCiuc011wxn.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25909
MGIiMGI:1915033, Ahctf1

Phylogenomic databases

eggNOGiENOG502QU0D, Eukaryota
GeneTreeiENSGT00390000018900
HOGENOMiCLU_001145_0_0_1
InParanoidiQ8CJF7
OMAiTSPHYIL
OrthoDBi1040332at2759
PhylomeDBiQ8CJF7
TreeFamiTF350425

Enzyme and pathway databases

ReactomeiR-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-5663220, RHO GTPases Activate Formins
R-MMU-68877, Mitotic Prometaphase
R-MMU-9615933, Postmitotic nuclear pore complex (NPC) reformation
R-MMU-9648025, EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		226747, 7 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ahctf1, mouse

Protein Ontology

More...PROi		PR:Q8CJF7
RNActiQ8CJF7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026491, Expressed in forelimb bud and 306 other tissues
GenevisibleiQ8CJF7, MM

Family and domain databases

DisProtiDP01548
InterProiView protein in InterPro
IPR032040, ELYS-bb
IPR025151, ELYS_dom
PfamiView protein in Pfam
PF13934, ELYS, 1 hit
PF16687, ELYS-bb, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELYS_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJF7
Secondary accession number(s): B2RRC8, Q8BVJ5, Q8VD55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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