UniProtKB - Q8CJ91 (C209B_MOUSE)
Protein
CD209 antigen-like protein B
Gene
Cd209b
Organism
Mus musculus (Mouse)
Status
Functioni
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Miscellaneous
In vitro, is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested.
Caution
In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 285 | CalciumBy similarity | 1 | |
Metal bindingi | 287 | CalciumBy similarity | 1 | |
Metal bindingi | 289 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 292 | CalciumBy similarity | 1 | |
Metal bindingi | 303 | CalciumBy similarity | 1 | |
Metal bindingi | 304 | CalciumBy similarity | 1 |
GO - Molecular functioni
- (1->3)-beta-D-glucan binding Source: MGI
- mannose binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- polysaccharide binding Source: MGI
GO - Biological processi
- detection of bacterium Source: MGI
- detection of yeast Source: MGI
- endocytosis Source: MGI
- phagocytosis, recognition Source: MGI
- positive regulation of phagocytosis Source: MGI
- positive regulation of tumor necrosis factor production Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Ligand | Calcium, Lectin, Mannose-binding, Metal-binding |
Protein family/group databases
UniLectini | Q8CJ91 |
Names & Taxonomyi
Protein namesi | Recommended name: CD209 antigen-like protein BAlternative name(s): DC-SIGN-related protein 1 Short name: DC-SIGNR1 OtB7 CD_antigen: CD209 |
Gene namesi | Name:Cd209b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916415, Cd209b |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 52 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 53 – 73 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 325 | ExtracellularSequence analysisAdd BLAST | 252 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046605 | 1 – 325 | CD209 antigen-like protein BAdd BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 195 ↔ 206 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 315 | PROSITE-ProRule annotation | ||
Disulfide bondi | 294 ↔ 307 | PROSITE-ProRule annotation | ||
Glycosylationi | 303 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8CJ91 |
PRIDEi | Q8CJ91 |
PTM databases
GlyGeni | Q8CJ91, 3 sites |
PhosphoSitePlusi | Q8CJ91 |
Expressioni
Tissue specificityi
Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000065987, Expressed in mesenteric lymph node and 65 other tissues |
ExpressionAtlasi | Q8CJ91, baseline and differential |
Genevisiblei | Q8CJ91, MM |
Interactioni
Protein-protein interaction databases
DIPi | DIP-61328N |
STRINGi | 10090.ENSMUSP00000081104 |
Miscellaneous databases
RNActi | Q8CJ91, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8CJ91 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 201 – 316 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 116 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155012 |
HOGENOMi | CLU_049894_7_3_1 |
InParanoidi | Q8CJ91 |
OMAi | EDCAAMY |
PhylomeDBi | Q8CJ91 |
TreeFami | TF333341 |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CJ91-1) [UniParc]FASTAAdd to basket
Also known as: alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDSTEAKMQ PLSSMDDDEL MVSGSRYSIK SSRLRPNSGI KCLAGCSGHS
60 70 80 90 100
QVPLVLQLLS FLFLAGLLLI ILFQVSKTPN TERQKEQEKI LQELTQLTDE
110 120 130 140 150
LTSRIPISQG KNESMQAKIT EQLMQLKTEL LSRIPIFQGQ NESIQEKISE
160 170 180 190 200
QLMQLKAELL SKISSFPVKD DSKQEKIYQQ LVQMKTELFR LCRLCPWDWT
210 220 230 240 250
FLLGNCYFFS KSQRNWNDAV TACKEVKAQL VIINSDEEQT FLQQTSKAKG
260 270 280 290 300
PTWMGLSDLK KEATWLWVDG STLSSRFQKY WNRGEPNNIG EEDCVEFAGD
310 320
GWNDSKCELK KFWICKKSAT PCTEG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8CJ85 | Q8CJ85_MOUSE | CD209 antigen-like protein B | Cd209b | 195 | Annotation score: |
Sequence cautioni
The sequence BAB25166 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | I → V in AAN75588 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 87 | Q → P in AAN75589 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 112 | N → D in AAN75586 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 124 | M → T in AAN75585 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 138 | Q → R in AAN75588 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 163 | I → V in AAN75586 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 226 | V → A in AAN75588 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 229 | Q → R in AAN75589 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 232 | I → T in AAN75587 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 235 | S → G in AAN75587 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 267 | W → R in AAN75589 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 308 | E → G in AAN75585 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 312 | F → L in AAN75597 (PubMed:12137941).Curated | 1 | |
Sequence conflicti | 321 – 325 | PCTEG → HA in AAN75590 (PubMed:12137941).Curated | 5 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75585 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75586 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75587 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75588 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75589 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75591 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75592 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75593 (PubMed:12137941).Curated | 3 | |
Sequence conflicti | 323 – 325 | TEG → P in AAN75594 (PubMed:12137941).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010068 | 1 – 183 | Missing in isoform 4. 1 PublicationAdd BLAST | 183 | |
Alternative sequenceiVSP_010069 | 45 – 74 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 30 | |
Alternative sequenceiVSP_010070 | 275 | S → SSRPRHAPISRGRPIYNMHS GR in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF373409 mRNA Translation: AAL13235.1 AF374471 mRNA Translation: AAL27540.1 AF424790 mRNA Translation: AAN75585.1 AF424791 mRNA Translation: AAN75586.1 AF424792 mRNA Translation: AAN75587.1 AF424793 mRNA Translation: AAN75588.1 AF424794 mRNA Translation: AAN75589.1 AF424795 mRNA Translation: AAN75590.1 AF424797 mRNA Translation: AAN75592.1 AF424798 mRNA Translation: AAN75593.1 AF424796 mRNA Translation: AAN75591.1 AF424799 mRNA Translation: AAN75594.1 AF424800 mRNA Translation: AAN75595.1 AF424801 mRNA Translation: AAN75596.1 AF424802 mRNA Translation: AAN75597.1 AF422108 mRNA Translation: AAN31450.1 AK007656 mRNA Translation: BAB25166.1 Different initiation. |
CCDSi | CCDS22076.1 [Q8CJ91-2] CCDS22077.1 [Q8CJ91-1] CCDS72089.1 [Q8CJ91-3] |
RefSeqi | NP_001032889.3, NM_001037800.3 [Q8CJ91-2] NP_001274140.1, NM_001287211.1 [Q8CJ91-3] NP_081248.4, NM_026972.5 [Q8CJ91-1] |
Genome annotation databases
Ensembli | ENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987 [Q8CJ91-1] ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987 [Q8CJ91-2] ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987 [Q8CJ91-3] |
GeneIDi | 69165 |
KEGGi | mmu:69165 |
UCSCi | uc009ksu.2, mouse [Q8CJ91-1] uc009ksv.2, mouse [Q8CJ91-2] uc012fyw.2, mouse [Q8CJ91-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding SIGNR1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF373409 mRNA Translation: AAL13235.1 AF374471 mRNA Translation: AAL27540.1 AF424790 mRNA Translation: AAN75585.1 AF424791 mRNA Translation: AAN75586.1 AF424792 mRNA Translation: AAN75587.1 AF424793 mRNA Translation: AAN75588.1 AF424794 mRNA Translation: AAN75589.1 AF424795 mRNA Translation: AAN75590.1 AF424797 mRNA Translation: AAN75592.1 AF424798 mRNA Translation: AAN75593.1 AF424796 mRNA Translation: AAN75591.1 AF424799 mRNA Translation: AAN75594.1 AF424800 mRNA Translation: AAN75595.1 AF424801 mRNA Translation: AAN75596.1 AF424802 mRNA Translation: AAN75597.1 AF422108 mRNA Translation: AAN31450.1 AK007656 mRNA Translation: BAB25166.1 Different initiation. |
CCDSi | CCDS22076.1 [Q8CJ91-2] CCDS22077.1 [Q8CJ91-1] CCDS72089.1 [Q8CJ91-3] |
RefSeqi | NP_001032889.3, NM_001037800.3 [Q8CJ91-2] NP_001274140.1, NM_001287211.1 [Q8CJ91-3] NP_081248.4, NM_026972.5 [Q8CJ91-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ZHG | X-ray | 1.87 | A/B/C | 191-325 | [»] | |
D | 190-325 | [»] | ||||
4C9F | X-ray | 2.60 | A/B/C/D | 191-323 | [»] | |
4CAJ | X-ray | 2.19 | A/B/C/D | 191-325 | [»] | |
SMRi | Q8CJ91 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-61328N |
STRINGi | 10090.ENSMUSP00000081104 |
Protein family/group databases
UniLectini | Q8CJ91 |
PTM databases
GlyGeni | Q8CJ91, 3 sites |
PhosphoSitePlusi | Q8CJ91 |
Proteomic databases
PaxDbi | Q8CJ91 |
PRIDEi | Q8CJ91 |
Protocols and materials databases
ABCDi | Q8CJ91, 6 sequenced antibodies |
DNASUi | 69165 |
Genome annotation databases
Ensembli | ENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987 [Q8CJ91-1] ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987 [Q8CJ91-2] ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987 [Q8CJ91-3] |
GeneIDi | 69165 |
KEGGi | mmu:69165 |
UCSCi | uc009ksu.2, mouse [Q8CJ91-1] uc009ksv.2, mouse [Q8CJ91-2] uc012fyw.2, mouse [Q8CJ91-3] |
Organism-specific databases
CTDi | 69165 |
MGIi | MGI:1916415, Cd209b |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155012 |
HOGENOMi | CLU_049894_7_3_1 |
InParanoidi | Q8CJ91 |
OMAi | EDCAAMY |
PhylomeDBi | Q8CJ91 |
TreeFami | TF333341 |
Miscellaneous databases
BioGRID-ORCSi | 69165, 2 hits in 19 CRISPR screens |
PROi | PR:Q8CJ91 |
RNActi | Q8CJ91, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000065987, Expressed in mesenteric lymph node and 65 other tissues |
ExpressionAtlasi | Q8CJ91, baseline and differential |
Genevisiblei | Q8CJ91, MM |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C209B_MOUSE | |
Accessioni | Q8CJ91Primary (citable) accession number: Q8CJ91 Secondary accession number(s): Q8BGZ0 Q9D8V4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references