UniProtKB - Q8CJ69 (BMPER_MOUSE)
Protein
BMP-binding endothelial regulator protein
Gene
Bmper
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.By similarity
GO - Biological processi
- blood vessel development Source: GO_Central
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: MGI
- endothelial cell activation Source: MGI
- inner ear development Source: MGI
- negative regulation of BMP signaling pathway Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: MGI
- positive regulation of sprouting angiogenesis Source: MGI
- regulation of angiogenesis Source: GO_Central
- regulation of endothelial cell migration Source: MGI
- regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- ureteric bud development Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: BMP-binding endothelial regulator proteinAlternative name(s): Bone morphogenetic protein-binding endothelial cell precursor-derived regulator Protein crossveinless-2 Short name: mCV2 |
Gene namesi | Name:Bmper Synonyms:Cv2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920480, Bmper |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: BHF-UCL
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 39 | Sequence analysisAdd BLAST | 39 | |
ChainiPRO_0000020821 | 40 – 685 | BMP-binding endothelial regulator proteinAdd BLAST | 646 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 441 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q8CJ69 |
PaxDbi | Q8CJ69 |
PRIDEi | Q8CJ69 |
ProteomicsDBi | 265313 |
PTM databases
GlyGeni | Q8CJ69, 5 sites |
PhosphoSitePlusi | Q8CJ69 |
Expressioni
Developmental stagei
At 9.0 dpc, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at 10.5 dpc, also expressed in mesonephric ridge.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031963, Expressed in semi-lunar valve and 248 other tissues |
ExpressionAtlasi | Q8CJ69, baseline and differential |
Genevisiblei | Q8CJ69, MM |
Interactioni
Subunit structurei
Interacts with BMP4.
1 PublicationProtein-protein interaction databases
BioGRIDi | 215850, 1 interactor |
STRINGi | 10090.ENSMUSP00000071872 |
Miscellaneous databases
RNActi | Q8CJ69, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 105 | VWFC 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 108 – 163 | VWFC 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 164 – 225 | VWFC 3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 238 – 289 | VWFC 4PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 299 – 358 | VWFC 5PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 363 – 574 | VWFDPROSITE-ProRule annotationAdd BLAST | 212 | |
Domaini | 629 – 682 | TILAdd BLAST | 54 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT00940000156485 |
HOGENOMi | CLU_018024_2_0_1 |
InParanoidi | Q8CJ69 |
OMAi | AGTCTVF |
OrthoDBi | 1104860at2759 |
PhylomeDBi | Q8CJ69 |
TreeFami | TF343473 |
Family and domain databases
InterProi | View protein in InterPro IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D |
Pfami | View protein in Pfam PF08742, C8, 1 hit PF01826, TIL, 1 hit PF00093, VWC, 2 hits PF00094, VWD, 1 hit |
SMARTi | View protein in SMART SM00832, C8, 1 hit SM00214, VWC, 5 hits SM00216, VWD, 1 hit |
SUPFAMi | SSF57567, SSF57567, 1 hit |
PROSITEi | View protein in PROSITE PS01208, VWFC_1, 3 hits PS50184, VWFC_2, 2 hits PS51233, VWFD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8CJ69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLWFFSVRAL AERPCRRSPG ITCCVLLLLN CSGVPMSLAS SFLTGSVAKC
60 70 80 90 100
ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA
110 120 130 140 150
CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK
160 170 180 190 200
NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR
210 220 230 240 250
EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS
260 270 280 290 300
FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV
310 320 330 340 350
CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR
360 370 380 390 400
KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP
410 420 430 440 450
FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH
460 470 480 490 500
TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY
510 520 530 540 550
NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV
560 570 580 590 600
KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE
610 620 630 640 650
SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN
660 670 680
EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SS01 | A0A1L1SS01_MOUSE | BMP-binding endothelial regulator p... | Bmper | 213 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 151 | N → K in AAH66153 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 224 – 235 | CLGQR…FDLPF → MFGSEKSIRPSL in BAB29213 (PubMed:16141072).CuratedAdd BLAST | 12 | |
Sequence conflicti | 350 | R → G in AAP88382 (PubMed:12897139).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF454954 mRNA Translation: AAN45857.1 AY263358 mRNA Translation: AAP88382.1 BC042718 mRNA Translation: AAH42718.1 BC066153 mRNA Translation: AAH66153.1 AK014221 mRNA Translation: BAB29213.1 |
CCDSi | CCDS22929.1 |
RefSeqi | NP_082748.1, NM_028472.2 |
Genome annotation databases
Ensembli | ENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963 |
GeneIDi | 73230 |
KEGGi | mmu:73230 |
UCSCi | uc009oow.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF454954 mRNA Translation: AAN45857.1 AY263358 mRNA Translation: AAP88382.1 BC042718 mRNA Translation: AAH42718.1 BC066153 mRNA Translation: AAH66153.1 AK014221 mRNA Translation: BAB29213.1 |
CCDSi | CCDS22929.1 |
RefSeqi | NP_082748.1, NM_028472.2 |
3D structure databases
SMRi | Q8CJ69 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215850, 1 interactor |
STRINGi | 10090.ENSMUSP00000071872 |
PTM databases
GlyGeni | Q8CJ69, 5 sites |
PhosphoSitePlusi | Q8CJ69 |
Proteomic databases
MaxQBi | Q8CJ69 |
PaxDbi | Q8CJ69 |
PRIDEi | Q8CJ69 |
ProteomicsDBi | 265313 |
Protocols and materials databases
Antibodypediai | 12854, 171 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963 |
GeneIDi | 73230 |
KEGGi | mmu:73230 |
UCSCi | uc009oow.2, mouse |
Organism-specific databases
CTDi | 168667 |
MGIi | MGI:1920480, Bmper |
Phylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT00940000156485 |
HOGENOMi | CLU_018024_2_0_1 |
InParanoidi | Q8CJ69 |
OMAi | AGTCTVF |
OrthoDBi | 1104860at2759 |
PhylomeDBi | Q8CJ69 |
TreeFami | TF343473 |
Miscellaneous databases
BioGRID-ORCSi | 73230, 1 hit in 52 CRISPR screens |
ChiTaRSi | Bmper, mouse |
PROi | PR:Q8CJ69 |
RNActi | Q8CJ69, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031963, Expressed in semi-lunar valve and 248 other tissues |
ExpressionAtlasi | Q8CJ69, baseline and differential |
Genevisiblei | Q8CJ69, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D |
Pfami | View protein in Pfam PF08742, C8, 1 hit PF01826, TIL, 1 hit PF00093, VWC, 2 hits PF00094, VWD, 1 hit |
SMARTi | View protein in SMART SM00832, C8, 1 hit SM00214, VWC, 5 hits SM00216, VWD, 1 hit |
SUPFAMi | SSF57567, SSF57567, 1 hit |
PROSITEi | View protein in PROSITE PS01208, VWFC_1, 3 hits PS50184, VWFC_2, 2 hits PS51233, VWFD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMPER_MOUSE | |
Accessioni | Q8CJ69Primary (citable) accession number: Q8CJ69 Secondary accession number(s): Q7TN57, Q80UZ1, Q9CXM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot