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Entry version 112 (31 Jul 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Rootletin

Gene

Crocc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (PubMed:12427867). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity). Contributes to centrosome cohesion before mitosis (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rootletin
Alternative name(s):
Ciliary rootlet coiled-coil protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CroccImported
Synonyms:Kiaa0445Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3529431 Crocc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice have no ciliary rootlets in ciliated cells.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002399441 – 2009RootletinAdd BLAST2009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1453PhosphoserineBy similarity1
Modified residuei1463PhosphoserineCombined sources1
Modified residuei1469PhosphoserineCombined sources1
Modified residuei1475PhosphotyrosineCombined sources1
Modified residuei1476PhosphoserineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1483PhosphoserineCombined sources1
Modified residuei1489PhosphoserineCombined sources1
Modified residuei1568PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK2 which may regulate its association with centrosomes.

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CJ40

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CJ40

PeptideAtlas

More...
PeptideAtlasi
Q8CJ40

PRoteomics IDEntifications database

More...
PRIDEi
Q8CJ40

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CJ40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CJ40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression detected in photoreceptor cells of retina. Expressed at lower levels in brain, trachea and kidney. Detected in all major ciliated epithelia. During embryonic development, enriched along the apical domains of neuroepithelium in brain ventricular zone, in primordia of retinal pigment epithelia and in neural retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040860 Expressed in 197 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8CJ40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CJ40 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopolymer.

Interacts with KLC3, NEK2 and the N-terminus of CEP250.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231046, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8CJ40, 6 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000099549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CJ40

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 265Sequence analysisAdd BLAST192
Coiled coili346 – 438Sequence analysisAdd BLAST93
Coiled coili550 – 1058Sequence analysisAdd BLAST509
Coiled coili1091 – 1439Sequence analysisAdd BLAST349
Coiled coili1498 – 1697Sequence analysisAdd BLAST200
Coiled coili1744 – 1998Sequence analysisAdd BLAST255

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rootletin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAN Eukaryota
ENOG410XPG3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155758

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231187

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CJ40

KEGG Orthology (KO)

More...
KOi
K16469

Identification of Orthologs from Complete Genome Data

More...
OMAi
HENNAQA

Database of Orthologous Groups

More...
OrthoDBi
76868at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026733 Rootletin

The PANTHER Classification System

More...
PANTHERi
PTHR23159:SF34 PTHR23159:SF34, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8CJ40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLGLAGSLQ AQLALEIVIQ SLENCVLGPN QEKSLSVQNR VQDFQGASLL
60 70 80 90 100
VCAREVIASN LSRPETPAPL QVPEMASLLS LQEENQLLQQ ELSRVEDLLA
110 120 130 140 150
QSRAERDELA IKYNAVNERL EQAVRLETGE LEAQEPRGLV RQSVELRRQL
160 170 180 190 200
QEEQSSYRRK LQAYQEGQQR QAQLVQRLQA KILQYKKQCS ELEKQLMDRS
210 220 230 240 250
TELEQQRLRD TEHSQDLDSA LLRLEEEQQR SASLAQVNAM LREQLDQANL
260 270 280 290 300
ANQALSEDIR KVTSDWTRSC KELEQREAVW RREEESFNTY FSSEHSRLLR
310 320 330 340 350
LWRQVMGLRR QASEVKMGTE RDLLQLGGEL VRTSRAVQEL GLGLSASLHR
360 370 380 390 400
AESKAEAALE KQKLLQAQLE EQLQAKLLRE KDLAQLQVQS DLDKADLSAR
410 420 430 440 450
VTELALSVEH LQNQNSEKDQ VNRTLSDKLE ALESLRLQEQ TTLDTEDGEG
460 470 480 490 500
LQQTLRDLAQ AALSDTESGV QLSSSERTAD TSDGSLRGFS GQRTPTPPRH
510 520 530 540 550
SPGRGRSPRR GLSPACSDSS TLTLIHSALH KRQLQVQDMR GRYEASQELL
560 570 580 590 600
GSVRKQLSDS EGERRGLEEQ LQRLRDQTAA SAQAQEDAQR EAQRLRSANE
610 620 630 640 650
LLSREKGNLT HSLQVTQQQA KELRQELEKL QAAQEELKRQ HNQLEDAQED
660 670 680 690 700
SVQEGARARR ELERSHRQLE QLEVKRSGLT KELVEVREAL SCAILQRDVL
710 720 730 740 750
QTEKAEVAEA LTKAEAGRAQ LELSLTKLRA EEASLRDSLS KMSALNESLA
760 770 780 790 800
QDKLELNRLI AQLEEEKVAL LGRQQQAEHA TTMAVEKQEL LEQLRLEQEV
810 820 830 840 850
ERQGLQGSLC VAEQAREALE QQILVLRSER SHLQEQLAQL SRQLSGRDQE
860 870 880 890 900
LEQALRESQR QVEALERAAR EKEAMAKERA GLAVKLAAAE REGRTLSEEA
910 920 930 940 950
IRLRLEKEAL ESSLFDVQRQ LAQLEARREQ LEADSQALLL AKETLTGELA
960 970 980 990 1000
GLRQQVTSTE EKAALDKELM TQKLVQAERE AQASLREQRA AHEEDLQRLQ
1010 1020 1030 1040 1050
HEKEAAWREL QAERAQLQGQ LQQEREELLA RMEAEKEELS KEIAALQQER
1060 1070 1080 1090 1100
DEGLLLAESE KQQALSLKES EKTALSEKLM GTRHSLAAIS LEMERQKRDA
1110 1120 1130 1140 1150
QSRQEQDRNT LNALTSELRD LRAQLEEATA AHAQTVKELE ERTGNLGRQR
1160 1170 1180 1190 1200
EACMREAEEL RTQLRVLEDT RDGLRRELLE AQRKGRDSQD SSEAHRQEAS
1210 1220 1230 1240 1250
ELRRSLSEGA KEREALRRSN EELRSAVKKA ESERISLKLA NEDKEQKLAL
1260 1270 1280 1290 1300
LEEARVSVAK EAGELRASLQ EVERSRLEAR RELQELRRQM KTLDSDNGRL
1310 1320 1330 1340 1350
GRELADLQGR LALGERTEKE SRREALGLRQ RLLKGESSLE ALKQELQGSQ
1360 1370 1380 1390 1400
RKLQEQEAEF RARERGLLGS LEEARGAEKR LLDSARSLEL RLEAVRAETS
1410 1420 1430 1440 1450
ELGLRLSAAE GRAQGLEVEL ARVEAQRRVA EAQLGGLRSA LRRGLGLGRV
1460 1470 1480 1490 1500
SSSPAREAPA GGSGDGLSSP SPLEYSPRSQ PPSPGLIASP APPDLDPEAV
1510 1520 1530 1540 1550
RDALRDFLQE LRSAQRERDE LKVQTSTLSQ QLVEMEAERD HAASRAKQLQ
1560 1570 1580 1590 1600
KAVAESEEAW RSADRRLSGA QAELALQEES VRRSKRECRA TLDQMAVLER
1610 1620 1630 1640 1650
SLQATESELR ASQEKVSKMK ATEAKLESDK RRLKEVLDAS ESRSIKLELQ
1660 1670 1680 1690 1700
RRALEGELQR SRLGLGDREA HAQALQDRVD SLQRQVADSE VKAGTLQLTV
1710 1720 1730 1740 1750
ERLSGALAKV EESEGNLRSK VQSLTDALTQ SSASLSSTQD KNLHLQKALS
1760 1770 1780 1790 1800
TCEHDRQVLQ ERLDAARQAL SEARRQSSSL GEQVQTLRGE LASLELQRGD
1810 1820 1830 1840 1850
AEGQLQQLQQ ALRQRQEGEA MALRSVQKLQ EERRLLQERL GSLQRALAQL
1860 1870 1880 1890 1900
EAEKRDLERS ALQFDKDRVA LRKTLDKVER EKLRSHEDTL RLNAERGRLD
1910 1920 1930 1940 1950
RTLTGAELDL AEAQQQIQHL EAQVDVALEG NHNPVQPEAG EQQLELQQEV
1960 1970 1980 1990 2000
ERLRSAQVQT ERTLEARERA HRQRVSGLEE QVSTLKAQLH QELRRSSASV

SLPPGTPEK
Length:2,009
Mass (Da):226,945
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62D942401C1085DA
GO
Isoform 21 Publication (identifier: Q8CJ40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     120-209: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,845
Mass (Da):208,269
Checksum:i12C8A15759C8B64D
GO
Isoform 31 Publication (identifier: Q8CJ40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1136-1156: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,988
Mass (Da):224,458
Checksum:i0F53D354E8559A2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC90B7ZC90_MOUSE
Rootletin
Crocc
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH27090 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289T → A in AAN73044 (PubMed:12427867).Curated1
Sequence conflicti289T → A in AAH54054 (PubMed:15489334).Curated1
Sequence conflicti360E → G in AAH54054 (PubMed:15489334).Curated1
Sequence conflicti811V → M in AAH54054 (PubMed:15489334).Curated1
Sequence conflicti1041K → E in AAH54054 (PubMed:15489334).Curated1
Sequence conflicti1346L → V in BAC65567 (PubMed:15489334).Curated1
Sequence conflicti1864F → L in AAH54054 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520661 – 74Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_052067120 – 209Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0520681136 – 1156Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF527975 mRNA Translation: AAN73044.1
AL645625 Genomic DNA No translation available.
BC027090 mRNA Translation: AAH27090.1 Different initiation.
BC054054 mRNA Translation: AAH54054.1
AK122285 Transcribed RNA Translation: BAC65567.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18861.1 [Q8CJ40-1]
CCDS51346.1 [Q8CJ40-2]

NCBI Reference Sequences

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RefSeqi
NP_001139430.1, NM_001145958.1 [Q8CJ40-2]
NP_742120.2, NM_172122.2 [Q8CJ40-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040222; ENSMUSP00000037679; ENSMUSG00000040860 [Q8CJ40-2]
ENSMUST00000097816; ENSMUSP00000095425; ENSMUSG00000040860 [Q8CJ40-2]
ENSMUST00000102491; ENSMUSP00000099549; ENSMUSG00000040860 [Q8CJ40-1]
ENSMUST00000168157; ENSMUSP00000126543; ENSMUSG00000040860 [Q8CJ40-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
230872

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:230872

UCSC genome browser

More...
UCSCi
uc008vns.2 mouse [Q8CJ40-1]
uc012dnz.1 mouse [Q8CJ40-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527975 mRNA Translation: AAN73044.1
AL645625 Genomic DNA No translation available.
BC027090 mRNA Translation: AAH27090.1 Different initiation.
BC054054 mRNA Translation: AAH54054.1
AK122285 Transcribed RNA Translation: BAC65567.3
CCDSiCCDS18861.1 [Q8CJ40-1]
CCDS51346.1 [Q8CJ40-2]
RefSeqiNP_001139430.1, NM_001145958.1 [Q8CJ40-2]
NP_742120.2, NM_172122.2 [Q8CJ40-1]

3D structure databases

SMRiQ8CJ40
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231046, 9 interactors
IntActiQ8CJ40, 6 interactors
STRINGi10090.ENSMUSP00000099549

PTM databases

iPTMnetiQ8CJ40
PhosphoSitePlusiQ8CJ40

Proteomic databases

jPOSTiQ8CJ40
PaxDbiQ8CJ40
PeptideAtlasiQ8CJ40
PRIDEiQ8CJ40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040222; ENSMUSP00000037679; ENSMUSG00000040860 [Q8CJ40-2]
ENSMUST00000097816; ENSMUSP00000095425; ENSMUSG00000040860 [Q8CJ40-2]
ENSMUST00000102491; ENSMUSP00000099549; ENSMUSG00000040860 [Q8CJ40-1]
ENSMUST00000168157; ENSMUSP00000126543; ENSMUSG00000040860 [Q8CJ40-2]
GeneIDi230872
KEGGimmu:230872
UCSCiuc008vns.2 mouse [Q8CJ40-1]
uc012dnz.1 mouse [Q8CJ40-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9696
MGIiMGI:3529431 Crocc

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IFAN Eukaryota
ENOG410XPG3 LUCA
GeneTreeiENSGT00940000155758
HOGENOMiHOG000231187
InParanoidiQ8CJ40
KOiK16469
OMAiHENNAQA
OrthoDBi76868at2759
TreeFamiTF101138

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Crocc mouse

Protein Ontology

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PROi
PR:Q8CJ40

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040860 Expressed in 197 organ(s), highest expression level in retina
ExpressionAtlasiQ8CJ40 baseline and differential
GenevisibleiQ8CJ40 MM

Family and domain databases

InterProiView protein in InterPro
IPR026733 Rootletin
PANTHERiPTHR23159:SF34 PTHR23159:SF34, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCROCC_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJ40
Secondary accession number(s): A2AA81
, Q7TQL2, Q80U01, Q8R0B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 27, 2011
Last modified: July 31, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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