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Protein

Abnormal spindle-like microcephaly-associated protein homolog

Gene

Aspm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calmodulin binding Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Abnormal spindle-like microcephaly-associated protein homolog
Alternative name(s):
Calmodulin-binding protein Sha1
Short name:
Calmodulin-binding protein 1
Spindle and hydroxyurea checkpoint abnormal protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aspm
Synonyms:Calmbp1, Sha1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1334448 Aspm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi302F → A: Disrupts interaction with KATNA1:KATNB1; when associated with A-377. 1 Publication1
Mutagenesisi352F → A: Disrupts interaction with KATNA1:KATNB1. 1 Publication1
Mutagenesisi377F → A: Disrupts interaction with KATNA1:KATNB1; when associated with A-302. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913361 – 3122Abnormal spindle-like microcephaly-associated protein homologAdd BLAST3122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei348PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1
Modified residuei1071PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CJ27

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8CJ27

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8CJ27

PeptideAtlas

More...
PeptideAtlasi
Q8CJ27

PRoteomics IDEntifications database

More...
PRIDEi
Q8CJ27

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8CJ27

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CJ27

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain, peripheral nervous system, liver and spleen. In the adult, expressed exclusively in testis, ovary and spleen.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during cerebral cortical neurogenesis, specifically in the cerebral cortical ventricular zone at E14.5 and E16.5. Expression is greatly reduced by the day of birth (P0), when neurogenesis in the cortical ventricular zone is completed and gliogenesis is increased. Expression is limited to rare scattered cells in the neocortex by postnatal day 9 (P9).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000033952 Expressed in 198 organ(s), highest expression level in primary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8CJ27 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KATNA1 and KATNB1; katanin complex formation KATNA1:KATNB1 is required for the association.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8CJ27, 3 interactors

Molecular INTeraction database

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MINTi
Q8CJ27

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000059159

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8CJ27

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CJ27

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini888 – 1024Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST137
Domaini1078 – 1229Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST152
Domaini1234 – 1263IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1315 – 1346IQ 2PROSITE-ProRule annotationAdd BLAST32
Domaini1410 – 1439IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini1504 – 1535IQ 4PROSITE-ProRule annotationAdd BLAST32
Domaini1550 – 1579IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1600 – 1629IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1623 – 1652IQ 7PROSITE-ProRule annotationAdd BLAST30
Domaini1696 – 1725IQ 8PROSITE-ProRule annotationAdd BLAST30
Domaini1719 – 1750IQ 9PROSITE-ProRule annotationAdd BLAST32
Domaini1769 – 1798IQ 10PROSITE-ProRule annotationAdd BLAST30
Domaini1792 – 1821IQ 11PROSITE-ProRule annotationAdd BLAST30
Domaini1842 – 1871IQ 12PROSITE-ProRule annotationAdd BLAST30
Domaini1865 – 1896IQ 13PROSITE-ProRule annotationAdd BLAST32
Domaini1915 – 1946IQ 14PROSITE-ProRule annotationAdd BLAST32
Domaini1938 – 1967IQ 15PROSITE-ProRule annotationAdd BLAST30
Domaini1988 – 2017IQ 16PROSITE-ProRule annotationAdd BLAST30
Domaini2011 – 2042IQ 17PROSITE-ProRule annotationAdd BLAST32
Domaini2061 – 2092IQ 18PROSITE-ProRule annotationAdd BLAST32
Domaini2134 – 2165IQ 19PROSITE-ProRule annotationAdd BLAST32
Domaini2157 – 2188IQ 20PROSITE-ProRule annotationAdd BLAST32
Domaini2207 – 2238IQ 21PROSITE-ProRule annotationAdd BLAST32
Domaini2230 – 2261IQ 22PROSITE-ProRule annotationAdd BLAST32
Domaini2279 – 2310IQ 23PROSITE-ProRule annotationAdd BLAST32
Domaini2302 – 2333IQ 24PROSITE-ProRule annotationAdd BLAST32
Domaini2343 – 2374IQ 25PROSITE-ProRule annotationAdd BLAST32
Domaini2366 – 2397IQ 26PROSITE-ProRule annotationAdd BLAST32
Domaini2416 – 2447IQ 27PROSITE-ProRule annotationAdd BLAST32
Domaini2491 – 2522IQ 28PROSITE-ProRule annotationAdd BLAST32
Domaini2602 – 2633IQ 29PROSITE-ProRule annotationAdd BLAST32
Domaini2674 – 2705IQ 30PROSITE-ProRule annotationAdd BLAST32
Domaini2724 – 2755IQ 31PROSITE-ProRule annotationAdd BLAST32
Domaini2849 – 2880IQ 32PROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 388Sufficient for interaction with KATNA1:KATNB11 PublicationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1025 – 1045Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0165 Eukaryota
ENOG410XSAR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00560000077332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034105

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050595

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CJ27

KEGG Orthology (KO)

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KOi
K16743

Identification of Orthologs from Complete Genome Data

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OMAi
IQVRYRA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0332

TreeFam database of animal gene trees

More...
TreeFami
TF351180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR44613 PTHR44613, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15780 ASH, 1 hit
PF00307 CH, 1 hit
PF00612 IQ, 30 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00015 IQ, 55 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 2 hits
PS50096 IQ, 33 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CJ27-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MATMQAASCP EERGRRARPD PEAGDPSPPV LLLSHFCGVP FLCFGDVRVG
60 70 80 90 100
TSRTRSLVLH NPHEEPLQVE LSLLRAAGQG FSVAPNRCEL KPKEKLTISV
110 120 130 140 150
TWTPLREGGV REIVTFLVND FLKHQAILLG NAEEPKKKKR SLWNTSKKIP
160 170 180 190 200
ASSKHTKRTS KNQHFNESFT ISQKDRIRSP LQPCENLAMS ECSSPTENKV
210 220 230 240 250
PTPSISPIRE CQSETCLPLF LRESTAYSSL HESENTQNLK VQDASISQTF
260 270 280 290 300
DFNEEVANET FINPISVCHQ SEGDRKLTLA PNCSSPLNST QTQIHFLSPD
310 320 330 340 350
SFVNNRYTSD NDLKSMKNVL SDTFRKDPAE SVCLESQTVH EVCQTILSPD
360 370 380 390 400
SFLNDNYGLK KGLNFKSVNP VLSPTQFVKD SMGHVGQQTG KSNEASQDWR
410 420 430 440 450
INEGLAYTPE CQHAQTPSSR SEKQNPVEVK PHTYDFTKQK PKISEFQDAF
460 470 480 490 500
CHQSKQPHKR RPILSATVTK RKPTNAREKL PEINKPDAKR CLEGLVGERG
510 520 530 540 550
KEVGSLREKG FHSSLPVVEP GVSKALSYRD EVTPATVVVA RKRKSHGTVG
560 570 580 590 600
DANGKVAAEE WMDMCEVKRI HFSPLESTPS TVARTTKKEG HTSKRISSLE
610 620 630 640 650
RSGLKKKMDS SILKTPLSKT KKKRRSIVAV AQSHLTFIKP LKAAIPRHPM
660 670 680 690 700
PFAAKNMFYD ERWKEKQEQG FTWWLNYILT PDDFTVKTNV SKVNAASLVL
710 720 730 740 750
GAESQHKISV PKAPTKEEVS LRAYTASCRL NRLRRTACSL FTSEKMVKAI
760 770 780 790 800
KKVEIEIEVG RLLVRKDRHL WKDIGQRQKV LNWLLSYNPL WLRIGLETVF
810 820 830 840 850
GELIPLADNS DVTGLAMFIL NRLLWNPDIA AEYRHPTVPL LFRDGHEAAL
860 870 880 890 900
SKFTLKKLLL LICFLDHAKI SRLIDHDPCL FCKDAEFKAS KELLLAFSRD
910 920 930 940 950
FLSGEGDLSR HLSFLGLPVS HVQTPLDEFD FAVTNLAVDL QCGVRLVRTV
960 970 980 990 1000
ELLTQNWNLS DKLRIPAISR VQKMHNVDLV LQVLKSRGVP LTDEHGSAIS
1010 1020 1030 1040 1050
SKDVVDRHRE KTLGLLWKIA LAFQVDISLN LDQLKEEIDF LKHTHSIKRA
1060 1070 1080 1090 1100
MSALTCPSQA ITNKQRDKRI SGNFERYGDS VQLLMDWVNA VCAFYNKKVE
1110 1120 1130 1140 1150
NFTVSFSDGR ILCYLIHHYH PCYVPFDAIC QRTSQSVACA QTGSVVLNSS
1160 1170 1180 1190 1200
SESEGGCLDL SLEALDHEST PEMYKELLEN EKKNFHLVRS AARDLGGIPA
1210 1220 1230 1240 1250
MIHHSDMSNT IPDEKVVITY LSFLCARLLD LRKEIRAARL IQTTWRKYKL
1260 1270 1280 1290 1300
KRDLKHHQER DKAARVIQSV VLNFLSRRRL QKNVSAALVI QKCWRRVSAQ
1310 1320 1330 1340 1350
RKLRMLKNEK LAKLQNKSAV LIQAYWRRYS TRKRFLRLKH YSVILQSRIR
1360 1370 1380 1390 1400
MKIALTSYKR YLWATVTIQR HWRAYLSRKR DQQIFRKLKS SSLVIQFMFR
1410 1420 1430 1440 1450
RWKRRKLQLQ TKAAVTLQRA FREWHLRKQI RERSAVVIQS WYRMHRELQK
1460 1470 1480 1490 1500
YIYIRSCVIV IQRRVRCFQA QKLYKRRKDA ILTLQKHYRA RQKGKLAHAD
1510 1520 1530 1540 1550
YLQKRAATIR LQAAFRGMKA RHSYRLQIGA ACVLQSYWRM RQERVRFLNL
1560 1570 1580 1590 1600
KKMVIKLQAH IRKYQQLQKY KKIKKAAITI QTHFRASISA RRVLASYQKT
1610 1620 1630 1640 1650
RSSVIVLQSA CRGMQARKAF RHALASVIKI QSYYRAYICR KTFQNFKNAT
1660 1670 1680 1690 1700
IKLQSIVKMK QSRKQYLQIR AAALFIQRWY RSQKLASQKR KEYIQVRESC
1710 1720 1730 1740 1750
IKLQSHFRGC LVRKQLRLQC KAAISLQSYF RMRTARQRYL KMCKAALVIQ
1760 1770 1780 1790 1800
SFYCAYRAQI SQRKNFLQVK RAAICLQAAY RGCKVRRQIK QQSTAAVTIQ
1810 1820 1830 1840 1850
RVFRGHSQRM KYQTMLQSAV KIQRWYRAQK VAYDMRIQFL KTREAVVCLQ
1860 1870 1880 1890 1900
SAYRGWQVRQ QLRRQHEAAV KIQSTFRMAV AQQQYKLLRA AAAVIQQHVR
1910 1920 1930 1940 1950
ARAAGKRQHL AYIQLRHAAL VFQAAWKGKM LRRQIARQHQ CAALIQSYYR
1960 1970 1980 1990 2000
MHIQRRKWSI MKTAALQIQL CYRAYKVGKE QRHLYLKTKA AVVTLQSAYR
2010 2020 2030 2040 2050
GMKVRKRVAE CHKAAVTIQS KFRAYRTQKK YTTYRTSAIV IQRWYRNIKI
2060 2070 2080 2090 2100
TTQQHQEYLN LRRAAVQVQA AYRGIRVRRR IQHMHMAATL IEAMFKMRQS
2110 2120 2130 2140 2150
RVRYLKMRTA ALIIQVRYRA YYLGKIQHEK YLRTLKAIKT LQAGVRGARV
2160 2170 2180 2190 2200
RRTVRKMHFA ATLIQSHFRG HRQQTYFHRL RKAATMVQQR YRAVKEGSAE
2210 2220 2230 2240 2250
FQRYSRLRRS VLLIQAAFRG LRTRRHLKAM HLAATLIQRR FRTFAMRRKF
2260 2270 2280 2290 2300
LSLRKTAIWI QRQYRARLYA KYSRQQLLLE KAVIKIQSSY RGWVVRKRVQ
2310 2320 2330 2340 2350
KMHRAATVIQ ATFRMHGAYM RYQHLKRASV VIQVHTAAEL QRQKHAAVIL
2360 2370 2380 2390 2400
QAAVRGMKTR SHLKTMHSSA TLIQSQFRAF IVRRRFIALR KAAIFVQRKF
2410 2420 2430 2440 2450
RATLYAKHKL HQFLQLRKAA ITIQSSYRRL MVQKKLQEMH RAAALIQATF
2460 2470 2480 2490 2500
RMHRTYVAFH IWKCASIRIQ QCYRTYRTIK LQKEKLIREE QHSAAVLIQS
2510 2520 2530 2540 2550
TYRMYRQRCF YQQRRWAAKV IQKTYRANKR RQDLLYVCKE ETPLLQMHFQ
2560 2570 2580 2590 2600
GLNTAKQGRQ QHGAAMITQK HFRAFKARRL MEAERGFQAG CRKYKAKKYL
2610 2620 2630 2640 2650
SKVEAACRIQ AWYRRWRAHK KYLTLLKAVN IIEGYLSAQL ARRRFLKMRA
2660 2670 2680 2690 2700
AAIIIQRKWR ATLSVRGARE NLKRHRAACV IQAHFRGYQA RQSFLQQRSA
2710 2720 2730 2740 2750
VLIIQRHVRA MVAAKQERIK YIKLKKSTVV VQALVRGWLV RKRVSEQKAK
2760 2770 2780 2790 2800
TRLFHFTAAA YCHMCALKIQ RAYRLHVTLR NAKKHMDSVI FIQRWFRKRL
2810 2820 2830 2840 2850
QRKRFIEQYH KILSTRREAH ACWLQQDRAA SVIQKAVRRF LLCRRQEKIT
2860 2870 2880 2890 2900
SCATRIQALW RGYSWRKKND HTEIKAIRRS LRAVSTTVEE ENKLYRRTER
2910 2920 2930 2940 2950
ALHHLLTYKH LSAILDALKH LEVVTRLSPL CCENMAESGA VSTIFVVIRS
2960 2970 2980 2990 3000
CNRSVPCMEV VGYAVQVLLN VAKYDKTIAA VYEAENCVDT LLELLQVYRE
3010 3020 3030 3040 3050
KPGDRVAEKS ASIFTRTCCL LAVLLKTEQC AFDAQSRSKV TDRIYRLYKF
3060 3070 3080 3090 3100
TVPKHKVNTQ GLFDKQKQNS CVGFPCIPER TMKTRLVSRL KPQWVLRRDN
3110 3120
VEEITNSLQA IQLVMDTLGI SY
Length:3,122
Mass (Da):364,218
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB559BA254EE8270
GO
Isoform 2 (identifier: Q8CJ27-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1323-2587: Missing.

Show »
Length:1,857
Mass (Da):212,056
Checksum:iF3B2F3FE8E8C4DA2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC79683 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433T → K in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti433T → K in AAY46816 (PubMed:15972725).Curated1
Sequence conflicti443 – 444IS → TC in AAN46088 (PubMed:12355089).Curated2
Sequence conflicti443 – 444IS → TC in AAY46816 (PubMed:15972725).Curated2
Sequence conflicti498E → Q in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti498E → Q in AAY46816 (PubMed:15972725).Curated1
Sequence conflicti513S → P in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti513S → P in AAY46816 (PubMed:15972725).Curated1
Sequence conflicti591H → L in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti591H → L in AAY46816 (PubMed:15972725).Curated1
Sequence conflicti1111I → V in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti1111I → V in AAY46816 (PubMed:15972725).Curated1
Sequence conflicti1378R → G in AAN46088 (PubMed:12355089).Curated1
Sequence conflicti2836 – 2866AVRRF…GYSWR → RYAAFSSAEDRKRSLAAPLE FRHYGEAILE in AAC79683 (PubMed:9819352).CuratedAdd BLAST31
Sequence conflicti2938S → R in AAC79683 (PubMed:9819352).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0590141323 – 2587Missing in isoform 2. Add BLAST1265

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF533752 mRNA Translation: AAN46088.1
AY971958 mRNA Translation: AAY46816.1
AL606536, AC158946 Genomic DNA Translation: CAM27347.1
AK050785 mRNA Translation: BAC34410.2
AK083710 mRNA Translation: BAC39000.1
AF062378 mRNA Translation: AAC79683.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35729.1 [Q8CJ27-1]

NCBI Reference Sequences

More...
RefSeqi
NP_033921.3, NM_009791.4 [Q8CJ27-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.168523

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000053364; ENSMUSP00000059159; ENSMUSG00000033952 [Q8CJ27-1]
ENSMUST00000200083; ENSMUSP00000142880; ENSMUSG00000033952 [Q8CJ27-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12316

UCSC genome browser

More...
UCSCi
uc007cwh.1 mouse [Q8CJ27-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533752 mRNA Translation: AAN46088.1
AY971958 mRNA Translation: AAY46816.1
AL606536, AC158946 Genomic DNA Translation: CAM27347.1
AK050785 mRNA Translation: BAC34410.2
AK083710 mRNA Translation: BAC39000.1
AF062378 mRNA Translation: AAC79683.1 Different initiation.
CCDSiCCDS35729.1 [Q8CJ27-1]
RefSeqiNP_033921.3, NM_009791.4 [Q8CJ27-1]
UniGeneiMm.168523

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LB7X-ray1.50C347-355[»]
ProteinModelPortaliQ8CJ27
SMRiQ8CJ27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CJ27, 3 interactors
MINTiQ8CJ27
STRINGi10090.ENSMUSP00000059159

PTM databases

iPTMnetiQ8CJ27
PhosphoSitePlusiQ8CJ27

Proteomic databases

EPDiQ8CJ27
MaxQBiQ8CJ27
PaxDbiQ8CJ27
PeptideAtlasiQ8CJ27
PRIDEiQ8CJ27

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053364; ENSMUSP00000059159; ENSMUSG00000033952 [Q8CJ27-1]
ENSMUST00000200083; ENSMUSP00000142880; ENSMUSG00000033952 [Q8CJ27-2]
GeneIDi12316
KEGGimmu:12316
UCSCiuc007cwh.1 mouse [Q8CJ27-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
259266
MGIiMGI:1334448 Aspm

Phylogenomic databases

eggNOGiKOG0165 Eukaryota
ENOG410XSAR LUCA
GeneTreeiENSGT00560000077332
HOGENOMiHOG000034105
HOVERGENiHBG050595
InParanoidiQ8CJ27
KOiK16743
OMAiIQVRYRA
OrthoDBiEOG091G0332
TreeFamiTF351180

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8CJ27

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033952 Expressed in 198 organ(s), highest expression level in primary oocyte
GenevisibleiQ8CJ27 MM

Family and domain databases

Gene3Di1.10.418.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR44613 PTHR44613, 4 hits
PfamiView protein in Pfam
PF15780 ASH, 1 hit
PF00307 CH, 1 hit
PF00612 IQ, 30 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00015 IQ, 55 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 16 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
PS50096 IQ, 33 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASPM_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJ27
Secondary accession number(s): A0A0G2JES1
, B1ARM7, O88482, Q4G1G9, Q8BJI8, Q8BKT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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