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Entry version 155 (29 Sep 2021)
Sequence version 2 (13 Jul 2010)
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Protein

[F-actin]-monooxygenase MICAL3

Gene

Mical3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H2O2. Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei97FADBy similarity1
Binding sitei183FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei298FADBy similarity1
Binding sitei398FADBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi764Zinc 1By similarity1
Metal bindingi767Zinc 1By similarity1
Metal bindingi785Zinc 1; via pros nitrogenBy similarity1
Metal bindingi788Zinc 1By similarity1
Metal bindingi791Zinc 2By similarity1
Metal bindingi794Zinc 2By similarity1
Metal bindingi814Zinc 2By similarity1
Metal bindingi817Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi116 – 118FADBy similarity3
Nucleotide bindingi123 – 125FADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
Biological processCell cycle, Cell division, Exocytosis
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[F-actin]-monooxygenase MICAL3 (EC:1.14.13.225By similarity)
Alternative name(s):
Molecule interacting with CasL protein 3
Short name:
MICAL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mical3
Synonyms:Kiaa0819, Kiaa1364
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442733, Mical3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000051586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758471 – 1993[F-actin]-monooxygenase MICAL3Add BLAST1993

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei649PhosphoserineBy similarity1
Modified residuei685PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei887PhosphothreonineBy similarity1
Modified residuei977PhosphoserineCombined sources1
Modified residuei1131PhosphoserineBy similarity1
Modified residuei1187PhosphoserineCombined sources1
Modified residuei1272PhosphoserineBy similarity1
Modified residuei1274PhosphothreonineBy similarity1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1335PhosphoserineBy similarity1
Modified residuei1339PhosphothreonineBy similarity1
Modified residuei1369PhosphoserineCombined sources1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1431PhosphoserineBy similarity1
Modified residuei1452PhosphothreonineCombined sources1
Modified residuei1640PhosphoserineBy similarity1
Modified residuei1692PhosphoserineBy similarity1
Modified residuei1695PhosphoserineBy similarity1
Modified residuei1903PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CJ19

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CJ19

PeptideAtlas

More...
PeptideAtlasi
Q8CJ19

PRoteomics IDEntifications database

More...
PRIDEi
Q8CJ19

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
292319 [Q8CJ19-1]
292320 [Q8CJ19-2]
292321 [Q8CJ19-3]
292322 [Q8CJ19-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CJ19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CJ19

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CJ19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000051586, Expressed in cumulus cell and 256 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CJ19, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A can bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively.

Interacts with ERC1 and RAB8A; may bridge ERC1 with RAB8A.

Interacts with KIF23 and ERC1; enhances the interaction between KIF23 and ERC1.

Interacts with NINL.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228787, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8CJ19, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CJ19, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CJ19

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini518 – 624Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST107
Domaini762 – 824LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63
Domaini1832 – 1981bMERBPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 494Monooxygenase domainBy similarityAdd BLAST493
Regioni658 – 704DisorderedSequence analysisAdd BLAST47
Regioni854 – 886DisorderedSequence analysisAdd BLAST33
Regioni905 – 1023DisorderedSequence analysisAdd BLAST119
Regioni1039 – 1309DisorderedSequence analysisAdd BLAST271
Regioni1332 – 1546DisorderedSequence analysisAdd BLAST215
Regioni1559 – 1837DisorderedSequence analysisAdd BLAST279

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1817 – 1983Sequence analysisAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 697Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi856 – 874Polar residuesSequence analysisAdd BLAST19
Compositional biasi934 – 953Acidic residuesSequence analysisAdd BLAST20
Compositional biasi969 – 983Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi984 – 1013Acidic residuesSequence analysisAdd BLAST30
Compositional biasi1065 – 1093Acidic residuesSequence analysisAdd BLAST29
Compositional biasi1094 – 1144Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi1145 – 1161Polar residuesSequence analysisAdd BLAST17
Compositional biasi1226 – 1240Polar residuesSequence analysisAdd BLAST15
Compositional biasi1241 – 1259Pro residuesSequence analysisAdd BLAST19
Compositional biasi1260 – 1295Polar residuesSequence analysisAdd BLAST36
Compositional biasi1349 – 1367Polar residuesSequence analysisAdd BLAST19
Compositional biasi1419 – 1451Polar residuesSequence analysisAdd BLAST33
Compositional biasi1452 – 1467Pro residuesSequence analysisAdd BLAST16
Compositional biasi1501 – 1518Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1585 – 1604Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1617 – 1648Polar residuesSequence analysisAdd BLAST32
Compositional biasi1663 – 1690Polar residuesSequence analysisAdd BLAST28
Compositional biasi1735 – 1750Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1791 – 1837Basic and acidic residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155580

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000329_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CJ19

Identification of Orthologs from Complete Genome Data

More...
OMAi
CREIRIE

Database of Orthologous Groups

More...
OrthoDBi
430978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CJ19

TreeFam database of animal gene trees

More...
TreeFami
TF324129

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029941, MICAL3
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24206:SF66, PTHR24206:SF66, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CJ19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEERKQETTN QAHVLFDRFV QATTCKGTLR AFQELCDHLE LKPKDYRSFY
60 70 80 90 100
HKLKSKLNYW KAKALWAKLD KRGSHKDYKK GKACTNTKCL IIGAGPCGLR
110 120 130 140 150
TAIDLSLLGA KVVVIEKRDA FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC
160 170 180 190 200
AGAIDHISIR QLQLILLKVA LILGIEIHVN VEFQGLVQPP EDQENERIGW
210 220 230 240 250
RALVHPKTHP VSEYEFEVII GGDGRRNTLE GFRRKEFRGK LAIAITANFI
260 270 280 290 300
NRNTTAEAKV EEISGVAFIF NQKFFQELRE ATGIDLENIV YYKDDTHYFV
310 320 330 340 350
MTAKKQSLLD KGVILHDYTD TELLLSRENV DQEALLNYAR EAADFSTQQQ
360 370 380 390 400
LPSLDFAINH YGQPDVAMFD FTCMYASENA ALVREQNGHQ LLVALVGDSL
410 420 430 440 450
LEPFWPMGTG IARGFLAAMD SAWMVRSWSL GTSPLEVLAE RESIYRLLPQ
460 470 480 490 500
TTPENVSKNF SQYSIDPVTR YPNININFLR PSQVRHLYDS GETKDIHLEM
510 520 530 540 550
ENMVNPRTTP KLTRNESVAR SSKLLGWCQR QTEGYSGVNV TDLTMSWKSG
560 570 580 590 600
LALCAIIHRY RPDLIDFDSL DEQNVEKNNQ LAFDIAEKEL GISPIMTGKE
610 620 630 640 650
MASVGEPDKL SMVMYLTQFY EMFKDSLSSS DTLDLNAEEK AVLIASTKSP
660 670 680 690 700
ISFLSKLGQT ISRKRSPKDK KEKDSDGAGK RRKTSQSEEE EPPRSYKGER
710 720 730 740 750
PTLVSTLTDR RMDAAVGNQN KVKYMATQLL AKFEENAPAQ STGVRRQGSI
760 770 780 790 800
KKEFPQNLGG SDTCYFCQKR VYVMERLSAE GKFFHRSCFK CEYCATTLRL
810 820 830 840 850
SAYAYDIEDG KFYCKPHYCY RLSGYAQRKR PAVAPLSGKE VKGALQDGPT
860 870 880 890 900
ADANGLASVA ASSAERSPGT SMNGLEEPSI AKRLRGTPER IELENYRRSV
910 920 930 940 950
RQVEELEEVP EETQAEHNLS SVLDKGTEED VASSSSESEM EEEEEEDDED
960 970 980 990 1000
DHLPTSDLGG VPWKEAVRIH ALLKGRSEEE LEASKNFEPE EEEEEEEYEE
1010 1020 1030 1040 1050
EDEEYEEEEE EESSEAGNKR LQQIITAADP LAIQADVHWT HIREREAEER
1060 1070 1080 1090 1100
MLPTSESSTS RAPLDEDDLE EDADSEPAET EGEAAEDGDP GDTGAELDDQ
1110 1120 1130 1140 1150
HWSDDIPSDA EAEHRLQSQA KVKAELELRV SENEEEKPSD APKQEERGTS
1160 1170 1180 1190 1200
QVSSPSQPPE KQVGVFSPAR SPGTEEAKSP LATKVKSPEE PLFPTPLLLR
1210 1220 1230 1240 1250
EKPKAEVPEE QKAVLSPIRS QPVALPEARS PTSPTSLQPE SLLAPPTPPT
1260 1270 1280 1290 1300
PPPTQLPICS QPQPSSDASI PSPTKSPIRF QPVPAKTSTP LTPLPVKSQG
1310 1320 1330 1340 1350
DPKDRLSGPL AVEEVLKRSD LVEEFWMKSA EIRRSLGLTP VDRSKGSEPS
1360 1370 1380 1390 1400
LPSPASKPIS LKSYSVDKSP QDEGLCLLKP PSVPKRLGLP KSAGDQPPLL
1410 1420 1430 1440 1450
TPKSPSDKEL RSSQEERRDL SSSSGLGLHD SSSNMKTLGS QSFNTSDSTM
1460 1470 1480 1490 1500
LTPPSSPPPP PPPNEEPATL RRKPHQTFER REASIIPPPT PASFMRPPRE
1510 1520 1530 1540 1550
PAQPPREEVR KSFVESVDEI PFADDVEDTY DDKTEDSSLQ EKFFTPPSCW
1560 1570 1580 1590 1600
SRSEKLQAKE NGRLPPLEQD VPPQKRGLPL VSAEAKELAE ERMRAREKSV
1610 1620 1630 1640 1650
KSQALRDAMA KQLSRMQAME MVSSRSHTAQ SQGKELGSES TRHPSLRGTQ
1660 1670 1680 1690 1700
EPTLKHEATS EEILSPPSDS GGPDGSVTSS EGSSGKSKKR SSLFSPRRNK
1710 1720 1730 1740 1750
KEKKTKGEAR PPEKPSPGLP EDVVAKPKSL WKSVFSGYKK DKKKKSDEKS
1760 1770 1780 1790 1800
CSSTPSSGAT VDSGQRRASP MVRAELQLRR QLSFSEDSDL SSDDILERSS
1810 1820 1830 1840 1850
QKSKREPRTY TEEELSAKLT RRVQKAARRQ AKQEELKRLH RAQIIQRQLE
1860 1870 1880 1890 1900
QVEEKQRQLE ERGVAVEKAL RGEAGMGKKD DPKLMQEWFK LVQEKNAMVR
1910 1920 1930 1940 1950
YESELMIFAR ELELEDRQSR LQQELRERMA VEDHLKTEGE LSEEKKILNE
1960 1970 1980 1990
MLEVVEQRDS LVALLEEQRL REKEEDKDLE AAMLCKGFSL DWS
Length:1,993
Mass (Da):223,721
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5059DCB5EF4DB091
GO
Isoform 2 (identifier: Q8CJ19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     748-774: GSIKKEFPQNLGGSDTCYFCQKRVYVM → VSPKLSSRMTTWYRKEGLHAAISQALV
     775-1993: Missing.

Show »
Length:774
Mass (Da):87,756
Checksum:i4462E3F5D243F398
GO
Isoform 3 (identifier: Q8CJ19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-864: GKFYCKPHYC...GLASVAASSA → EFSPNFWTSA...SPVLFNDTNS
     865-1993: Missing.

Show »
Length:864
Mass (Da):97,929
Checksum:iAE85BDBE5F521770
GO
Isoform 4 (identifier: Q8CJ19-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-871: Missing.
     1016-1061: Missing.

Show »
Length:1,076
Mass (Da):120,185
Checksum:iB78F41F27B4F00CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8MPU7A0A5F8MPU7_MOUSE
F-actin monooxygenase
Mical3
2,044Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPF3A0A5F8MPF3_MOUSE
F-actin monooxygenase
Mical3
1,968Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPN4A0A5F8MPN4_MOUSE
F-actin monooxygenase
Mical3
2,014Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWA5A0A0N4SWA5_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
695Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVV2A0A0N4SVV2_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
661Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM34A0A1D5RM34_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
1,139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUZ1A0A0N4SUZ1_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RME9A0A1D5RME9_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SV64A0A0N4SV64_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LID8A0A140LID8_MOUSE
[F-actin]-monooxygenase MICAL3
Mical3
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65779 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281A → T in AAN06715 (Ref. 1) Curated1
Sequence conflicti1249P → H in BAE28149 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0394901 – 871Missing in isoform 4. 1 PublicationAdd BLAST871
Alternative sequenceiVSP_039491748 – 774GSIKK…RVYVM → VSPKLSSRMTTWYRKEGLHA AISQALV in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_039492775 – 1993Missing in isoform 2. 1 PublicationAdd BLAST1219
Alternative sequenceiVSP_039493810 – 864GKFYC…AASSA → EFSPNFWTSASYHVPVALPA TVMPMCLLYHPSQVLVCLEG GPAFMSPVLFNDTNS in isoform 3. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_039494865 – 1993Missing in isoform 3. 2 PublicationsAdd BLAST1129
Alternative sequenceiVSP_0394951016 – 1061Missing in isoform 4. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF536756 mRNA Translation: AAN06715.1
AK173033 mRNA Translation: BAD32311.1
AK122497 mRNA Translation: BAC65779.1 Different initiation.
AC079443 Genomic DNA No translation available.
AC083894 Genomic DNA No translation available.
BC138257 mRNA Translation: AAI38258.1
AK132669 mRNA Translation: BAE21292.1
AK147803 mRNA Translation: BAE28149.1
AK048201 mRNA Translation: BAC33271.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20487.1 [Q8CJ19-3]
CCDS85152.1 [Q8CJ19-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001257404.1, NM_001270475.1 [Q8CJ19-1]
NP_700445.2, NM_153396.3 [Q8CJ19-3]
XP_006505863.1, XM_006505800.2 [Q8CJ19-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000077159; ENSMUSP00000076402; ENSMUSG00000051586 [Q8CJ19-3]
ENSMUST00000207889; ENSMUSP00000146544; ENSMUSG00000051586 [Q8CJ19-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
194401

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:194401

UCSC genome browser

More...
UCSCi
uc009dnw.2, mouse [Q8CJ19-1]
uc009dnx.1, mouse [Q8CJ19-4]
uc009dnz.3, mouse [Q8CJ19-3]
uc009doa.1, mouse [Q8CJ19-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536756 mRNA Translation: AAN06715.1
AK173033 mRNA Translation: BAD32311.1
AK122497 mRNA Translation: BAC65779.1 Different initiation.
AC079443 Genomic DNA No translation available.
AC083894 Genomic DNA No translation available.
BC138257 mRNA Translation: AAI38258.1
AK132669 mRNA Translation: BAE21292.1
AK147803 mRNA Translation: BAE28149.1
AK048201 mRNA Translation: BAC33271.1
CCDSiCCDS20487.1 [Q8CJ19-3]
CCDS85152.1 [Q8CJ19-1]
RefSeqiNP_001257404.1, NM_001270475.1 [Q8CJ19-1]
NP_700445.2, NM_153396.3 [Q8CJ19-3]
XP_006505863.1, XM_006505800.2 [Q8CJ19-1]

3D structure databases

SMRiQ8CJ19
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228787, 15 interactors
IntActiQ8CJ19, 5 interactors
STRINGi10090.ENSMUSP00000096056

PTM databases

iPTMnetiQ8CJ19
PhosphoSitePlusiQ8CJ19
SwissPalmiQ8CJ19

Proteomic databases

EPDiQ8CJ19
PaxDbiQ8CJ19
PeptideAtlasiQ8CJ19
PRIDEiQ8CJ19
ProteomicsDBi292319 [Q8CJ19-1]
292320 [Q8CJ19-2]
292321 [Q8CJ19-3]
292322 [Q8CJ19-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34804, 27 antibodies

The DNASU plasmid repository

More...
DNASUi
194401

Genome annotation databases

EnsembliENSMUST00000077159; ENSMUSP00000076402; ENSMUSG00000051586 [Q8CJ19-3]
ENSMUST00000207889; ENSMUSP00000146544; ENSMUSG00000051586 [Q8CJ19-1]
GeneIDi194401
KEGGimmu:194401
UCSCiuc009dnw.2, mouse [Q8CJ19-1]
uc009dnx.1, mouse [Q8CJ19-4]
uc009dnz.3, mouse [Q8CJ19-3]
uc009doa.1, mouse [Q8CJ19-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57553
MGIiMGI:2442733, Mical3
VEuPathDBiHostDB:ENSMUSG00000051586

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...
Search...

Phylogenomic databases

eggNOGiKOG1700, Eukaryota
GeneTreeiENSGT00940000155580
HOGENOMiCLU_000329_0_1_1
InParanoidiQ8CJ19
OMAiCREIRIE
OrthoDBi430978at2759
PhylomeDBiQ8CJ19
TreeFamiTF324129

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
194401, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mical3, mouse

Protein Ontology

More...
PROi
PR:Q8CJ19
RNActiQ8CJ19, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000051586, Expressed in cumulus cell and 256 other tissues
ExpressionAtlasiQ8CJ19, baseline and differential

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029941, MICAL3
IPR001781, Znf_LIM
PANTHERiPTHR24206:SF66, PTHR24206:SF66, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMICA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJ19
Secondary accession number(s): B2RR77
, Q3UGQ8, Q3V160, Q69ZY5, Q80TE8, Q8BXB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 13, 2010
Last modified: September 29, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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