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UniProtKB - Q8CJ12 (AGRG2_MOUSE)

Entry version 138 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Adhesion G-protein coupled receptor G2

Gene

Adgrg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G2
Alternative name(s):
G-protein coupled receptor 64
Mouse epididymis-specific protein 6
Short name:
Me6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrg2Imported
Synonyms:Gpr64, Me6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2446854, Adgrg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini38 – 619ExtracellularCuratedAdd BLAST582
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei620 – 640Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini641 – 659CytoplasmicCuratedAdd BLAST19
Transmembranei660 – 680Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini681 – 683ExtracellularCurated3
Transmembranei684 – 704Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini705 – 729CytoplasmicCuratedAdd BLAST25
Transmembranei730 – 750Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini751 – 781ExtracellularCuratedAdd BLAST31
Transmembranei782 – 802Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini803 – 826CytoplasmicCuratedAdd BLAST24
Transmembranei827 – 847Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini848 – 849ExtracellularCurated2
Transmembranei850 – 870Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini871 – 1009CytoplasmicCuratedAdd BLAST139

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant male are infertile. Targeted disruption leads to sperm stasis and duct obstruction, resulting from dysregulation of fluid reabsorption.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001288738 – 1009Adhesion G-protein coupled receptor G2Add BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi849N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1002PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated
Highly glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CJ12

PRoteomics IDEntifications database

More...PRIDEi		Q8CJ12

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8CJ12, 20 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CJ12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CJ12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Epididymis-specific expression (at protein level). Associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031298, Expressed in white adipose tissue and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8CJ12, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CJ12, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

Curated

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000108019

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CJ12, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CJ12

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini559 – 610GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi248 – 251Poly-Ser4
Compositional biasi664 – 669Poly-Leu6
Compositional biasi808 – 811Poly-Lys4
Compositional biasi917 – 922Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4193, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CJ12

Database of Orthologous Groups

More...OrthoDBi		148879at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CJ12

TreeFam database of animal gene trees

More...TreeFami		TF321769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00303, GPS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CJ12-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLFSGGQYSP VGRPEEVLLI YKIFLVIICF HVILVTSLKE NGNSSLLSPS 
        60         70         80         90        100
AESSLVSLIP YSNGTPDAAS EVLSTLNKTE KSKITIVKTF NASGVKSQRN 
       110        120        130        140        150
ICNLSSLCND SVFFRGEIVF QHDEDHNVTQ NQDTANGTFA GVLSLSELKR 
       160        170        180        190        200
SELNKTLQTL SETYFIVCAT AEAQSTVNCT FTVKLNETMN VCAMMVTFQT 
       210        220        230        240        250
VQIRPMEQCC CSPRTPCPSS PEELEKLQCE LQDPIVCLAD QPHGPPLSSS 
       260        270        280        290        300
SKPVVPQATI ISHVASDFSL AEPLDHALMT PSTPSLTQES NLPSPQPTIP 
       310        320        330        340        350
LASSPATDLP VQSVVVSSLP QTDLSHTLSP VQSSIPSPTT PAPSVPTELV 
       360        370        380        390        400
TISTPPGETV VNTSTVSDLE AQVSQMEKAL SLGSLEPNLA GEMVNRVSKL 
       410        420        430        440        450
LHSPPALLAP LAQRLLKVVD AIGLQLNFSS TTISLTSPSL ALAVIRVNAS 
       460        470        480        490        500
NFNTTTFAAQ DPTNLQVSLE TPPPENSIGA ITLPSSLMNN LPANDVELAS 
       510        520        530        540        550
RIQFNFFETP ALFQDPSLEN LTLISYVISS SVTNMTIKNL TRNVTVALKH 
       560        570        580        590        600
INPSPDDLTV KCVFWDLGRN GGKGGWSSDG CSVKDKRMNE TICTCSHLTS 
       610        620        630        640        650
FGILLDLSRT SLPPSQMMAL TFITYIGCGL SSIFLSVTLV TYIAFEKIRR 
       660        670        680        690        700
DYPSKILIQL CAALLLLNLI FLLDSWIALY NTRGFCIAVA VFLHYFLLVS 
       710        720        730        740        750
FTWMGLEAFH MYLALVKVFN TYIRKYILKF CIVGWGIPAV VVSIVLTISP 
       760        770        780        790        800
DNYGIGSYGK FPNGTPDDFC WINSNVVFYI TVVGYFCVIF LLNVSMFIVV 
       810        820        830        840        850
LVQLCRIKKK KQLGAQRKTS IQDLRSIAGL TFLLGITWGF AFFAWGPVNV 
       860        870        880        890        900
TFMYLFAIFN TLQGFFIFIF YCAAKENVRK QWRRYLCCGK LRLAENSDWS 
       910        920        930        940        950
KTATNGLKKQ TVNQGVSSSS NSLQSSCNST NSTTLLVNSD CSVHASGNGN 
       960        970        980        990       1000
ASTERNGVSF SVQNGDVCLH DLTGKQHMFS DKEDSCNGKS RIALRRTSKR 

GSLHFIEQM
Length:1,009
Mass (Da):110,200
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA53C67C5527A5B6C
GO
Isoform 2 (identifier: Q8CJ12-2) [UniParc]FASTAAdd to basket
Also known as: d2

The sequence of this isoform differs from the canonical sequence as follows:
     64-66: Missing.

Show »
Length:1,006
Mass (Da):109,945
Checksum:i84EB92A305DAAF64
GO
Isoform 3 (identifier: Q8CJ12-3) [UniParc]FASTAAdd to basket
Also known as: d1

The sequence of this isoform differs from the canonical sequence as follows:
     80-93: Missing.

Show »
Length:995
Mass (Da):108,652
Checksum:i0B11972D6B6DD226
GO
Isoform 4 (identifier: Q8CJ12-4) [UniParc]FASTAAdd to basket
Also known as: d3

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.

Show »
Length:993
Mass (Da):108,583
Checksum:i4E63FEF1D355E6EF
GO
Isoform 5 (identifier: Q8CJ12-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-66: Missing.

Show »
Length:982
Mass (Da):107,497
Checksum:iA73D80E41A0E08B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14BH6Q14BH6_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg2 Gpr64
992Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AHQ2A2AHQ2_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg2
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AHP7A2AHP7_MOUSE
Adhesion G-protein-coupled receptor...
Adgrg2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti781T → K in BAC32902 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00980640 – 66Missing in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_00980751 – 66Missing in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_00980864 – 66Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_00980980 – 93Missing in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF538952 mRNA Translation: AAN33054.1
AF538955 mRNA Translation: AAN33057.1
AF538956 mRNA Translation: AAN33058.1
AF538957 mRNA Translation: AAN33059.1
AK046871 mRNA Translation: BAC32902.1
AL731801 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41196.1 [Q8CJ12-1]
CCDS41197.1 [Q8CJ12-3]
CCDS41199.1 [Q8CJ12-5]
CCDS72459.1 [Q8CJ12-2]
CCDS81192.1 [Q8CJ12-4]

NCBI Reference Sequences

More...RefSeqi		NP_001073317.1, NM_001079848.2 [Q8CJ12-5]
NP_001073326.1, NM_001079857.2 [Q8CJ12-3]
NP_001277374.1, NM_001290445.1 [Q8CJ12-4]
NP_001277375.1, NM_001290446.1 [Q8CJ12-2]
NP_848827.1, NM_178712.4 [Q8CJ12-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000112400; ENSMUSP00000108019; ENSMUSG00000031298 [Q8CJ12-1]
ENSMUST00000112402; ENSMUSP00000108021; ENSMUSG00000031298 [Q8CJ12-3]
ENSMUST00000112404; ENSMUSP00000108023; ENSMUSG00000031298 [Q8CJ12-5]
ENSMUST00000112405; ENSMUSP00000108024; ENSMUSG00000031298 [Q8CJ12-4]
ENSMUST00000112408; ENSMUSP00000108027; ENSMUSG00000031298 [Q8CJ12-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		237175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:237175

UCSC genome browser

More...UCSCi		uc009utd.2, mouse [Q8CJ12-1]
uc009ute.2, mouse [Q8CJ12-3]
uc009utg.2, mouse [Q8CJ12-5]
uc009uth.2, mouse [Q8CJ12-2]
uc009uti.2, mouse [Q8CJ12-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538952 mRNA Translation: AAN33054.1
AF538955 mRNA Translation: AAN33057.1
AF538956 mRNA Translation: AAN33058.1
AF538957 mRNA Translation: AAN33059.1
AK046871 mRNA Translation: BAC32902.1
AL731801 Genomic DNA No translation available.
CCDSiCCDS41196.1 [Q8CJ12-1]
CCDS41197.1 [Q8CJ12-3]
CCDS41199.1 [Q8CJ12-5]
CCDS72459.1 [Q8CJ12-2]
CCDS81192.1 [Q8CJ12-4]
RefSeqiNP_001073317.1, NM_001079848.2 [Q8CJ12-5]
NP_001073326.1, NM_001079857.2 [Q8CJ12-3]
NP_001277374.1, NM_001290445.1 [Q8CJ12-4]
NP_001277375.1, NM_001290446.1 [Q8CJ12-2]
NP_848827.1, NM_178712.4 [Q8CJ12-1]

3D structure databases

SMRiQ8CJ12
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108019

Protein family/group databases

MEROPSiP02.007

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ8CJ12, 20 sites
iPTMnetiQ8CJ12
PhosphoSitePlusiQ8CJ12

Proteomic databases

PaxDbiQ8CJ12
PRIDEiQ8CJ12

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		473, 125 antibodies

Genome annotation databases

EnsembliENSMUST00000112400; ENSMUSP00000108019; ENSMUSG00000031298 [Q8CJ12-1]
ENSMUST00000112402; ENSMUSP00000108021; ENSMUSG00000031298 [Q8CJ12-3]
ENSMUST00000112404; ENSMUSP00000108023; ENSMUSG00000031298 [Q8CJ12-5]
ENSMUST00000112405; ENSMUSP00000108024; ENSMUSG00000031298 [Q8CJ12-4]
ENSMUST00000112408; ENSMUSP00000108027; ENSMUSG00000031298 [Q8CJ12-2]
GeneIDi237175
KEGGimmu:237175
UCSCiuc009utd.2, mouse [Q8CJ12-1]
uc009ute.2, mouse [Q8CJ12-3]
uc009utg.2, mouse [Q8CJ12-5]
uc009uth.2, mouse [Q8CJ12-2]
uc009uti.2, mouse [Q8CJ12-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10149
MGIiMGI:2446854, Adgrg2

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000156341
HOGENOMiCLU_002753_3_3_1
InParanoidiQ8CJ12
OrthoDBi148879at2759
PhylomeDBiQ8CJ12
TreeFamiTF321769

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		237175, 1 hit in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Adgrg2, mouse

Protein Ontology

More...PROi		PR:Q8CJ12
RNActiQ8CJ12, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031298, Expressed in white adipose tissue and 156 other tissues
ExpressionAtlasiQ8CJ12, baseline and differential
GenevisibleiQ8CJ12, MM

Family and domain databases

InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
PROSITEiView protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CJ12
Secondary accession number(s): A2AHP8
, A2AHP9, A2AHQ0, A2AHQ3, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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