UniProtKB - Q8CJ12 (AGRG2_MOUSE)
Adhesion G-protein coupled receptor G2
Adgrg2
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Protein family/group databases
MEROPSi | P02.007 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor G2Alternative name(s): G-protein coupled receptor 64 Mouse epididymis-specific protein 6 Short name: Me6 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2446854, Adgrg2 |
Subcellular locationi
Plasma membrane
- Apical cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Cytosol
- cytosol Source: MGI
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 38 – 619 | ExtracellularCuratedAdd BLAST | 582 | |
Transmembranei | 620 – 640 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 641 – 659 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 660 – 680 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 681 – 683 | ExtracellularCurated | 3 | |
Transmembranei | 684 – 704 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 705 – 729 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 730 – 750 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 751 – 781 | ExtracellularCuratedAdd BLAST | 31 | |
Transmembranei | 782 – 802 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 803 – 826 | CytoplasmicCuratedAdd BLAST | 24 | |
Transmembranei | 827 – 847 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 848 – 849 | ExtracellularCurated | 2 | |
Transmembranei | 850 – 870 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 871 – 1009 | CytoplasmicCuratedAdd BLAST | 139 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | Sequence analysisAdd BLAST | 37 | |
ChainiPRO_0000012887 | 38 – 1009 | Adhesion G-protein coupled receptor G2Add BLAST | 972 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 427 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 448 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 453 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 520 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 534 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 539 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 543 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 589 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 849 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1002 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8CJ12 |
PRIDEi | Q8CJ12 |
PTM databases
GlyGeni | Q8CJ12, 20 sites |
iPTMneti | Q8CJ12 |
PhosphoSitePlusi | Q8CJ12 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000031298, Expressed in white adipose tissue and 156 other tissues |
ExpressionAtlasi | Q8CJ12, baseline and differential |
Genevisiblei | Q8CJ12, MM |
Interactioni
Subunit structurei
Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
CuratedProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108019 |
Miscellaneous databases
RNActi | Q8CJ12, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 559 – 610 | GPSPROSITE-ProRule annotationAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 248 – 251 | Poly-Ser | 4 | |
Compositional biasi | 664 – 669 | Poly-Leu | 6 | |
Compositional biasi | 808 – 811 | Poly-Lys | 4 | |
Compositional biasi | 917 – 922 | Poly-Ser | 6 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000156341 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q8CJ12 |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q8CJ12 |
TreeFami | TF321769 |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLFSGGQYSP VGRPEEVLLI YKIFLVIICF HVILVTSLKE NGNSSLLSPS
60 70 80 90 100
AESSLVSLIP YSNGTPDAAS EVLSTLNKTE KSKITIVKTF NASGVKSQRN
110 120 130 140 150
ICNLSSLCND SVFFRGEIVF QHDEDHNVTQ NQDTANGTFA GVLSLSELKR
160 170 180 190 200
SELNKTLQTL SETYFIVCAT AEAQSTVNCT FTVKLNETMN VCAMMVTFQT
210 220 230 240 250
VQIRPMEQCC CSPRTPCPSS PEELEKLQCE LQDPIVCLAD QPHGPPLSSS
260 270 280 290 300
SKPVVPQATI ISHVASDFSL AEPLDHALMT PSTPSLTQES NLPSPQPTIP
310 320 330 340 350
LASSPATDLP VQSVVVSSLP QTDLSHTLSP VQSSIPSPTT PAPSVPTELV
360 370 380 390 400
TISTPPGETV VNTSTVSDLE AQVSQMEKAL SLGSLEPNLA GEMVNRVSKL
410 420 430 440 450
LHSPPALLAP LAQRLLKVVD AIGLQLNFSS TTISLTSPSL ALAVIRVNAS
460 470 480 490 500
NFNTTTFAAQ DPTNLQVSLE TPPPENSIGA ITLPSSLMNN LPANDVELAS
510 520 530 540 550
RIQFNFFETP ALFQDPSLEN LTLISYVISS SVTNMTIKNL TRNVTVALKH
560 570 580 590 600
INPSPDDLTV KCVFWDLGRN GGKGGWSSDG CSVKDKRMNE TICTCSHLTS
610 620 630 640 650
FGILLDLSRT SLPPSQMMAL TFITYIGCGL SSIFLSVTLV TYIAFEKIRR
660 670 680 690 700
DYPSKILIQL CAALLLLNLI FLLDSWIALY NTRGFCIAVA VFLHYFLLVS
710 720 730 740 750
FTWMGLEAFH MYLALVKVFN TYIRKYILKF CIVGWGIPAV VVSIVLTISP
760 770 780 790 800
DNYGIGSYGK FPNGTPDDFC WINSNVVFYI TVVGYFCVIF LLNVSMFIVV
810 820 830 840 850
LVQLCRIKKK KQLGAQRKTS IQDLRSIAGL TFLLGITWGF AFFAWGPVNV
860 870 880 890 900
TFMYLFAIFN TLQGFFIFIF YCAAKENVRK QWRRYLCCGK LRLAENSDWS
910 920 930 940 950
KTATNGLKKQ TVNQGVSSSS NSLQSSCNST NSTTLLVNSD CSVHASGNGN
960 970 980 990 1000
ASTERNGVSF SVQNGDVCLH DLTGKQHMFS DKEDSCNGKS RIALRRTSKR
GSLHFIEQM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14BH6 | Q14BH6_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg2 Gpr64 | 992 | Annotation score: | ||
A2AHQ2 | A2AHQ2_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg2 | 955 | Annotation score: | ||
A2AHP7 | A2AHP7_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg2 | 105 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 781 | T → K in BAC32902 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009806 | 40 – 66 | Missing in isoform 5. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_009807 | 51 – 66 | Missing in isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_009808 | 64 – 66 | Missing in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_009809 | 80 – 93 | Missing in isoform 3. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF538952 mRNA Translation: AAN33054.1 AF538955 mRNA Translation: AAN33057.1 AF538956 mRNA Translation: AAN33058.1 AF538957 mRNA Translation: AAN33059.1 AK046871 mRNA Translation: BAC32902.1 AL731801 Genomic DNA No translation available. |
CCDSi | CCDS41196.1 [Q8CJ12-1] CCDS41197.1 [Q8CJ12-3] CCDS41199.1 [Q8CJ12-5] CCDS72459.1 [Q8CJ12-2] CCDS81192.1 [Q8CJ12-4] |
RefSeqi | NP_001073317.1, NM_001079848.2 [Q8CJ12-5] NP_001073326.1, NM_001079857.2 [Q8CJ12-3] NP_001277374.1, NM_001290445.1 [Q8CJ12-4] NP_001277375.1, NM_001290446.1 [Q8CJ12-2] NP_848827.1, NM_178712.4 [Q8CJ12-1] |
Genome annotation databases
Ensembli | ENSMUST00000112400; ENSMUSP00000108019; ENSMUSG00000031298 [Q8CJ12-1] ENSMUST00000112402; ENSMUSP00000108021; ENSMUSG00000031298 [Q8CJ12-3] ENSMUST00000112404; ENSMUSP00000108023; ENSMUSG00000031298 [Q8CJ12-5] ENSMUST00000112405; ENSMUSP00000108024; ENSMUSG00000031298 [Q8CJ12-4] ENSMUST00000112408; ENSMUSP00000108027; ENSMUSG00000031298 [Q8CJ12-2] |
GeneIDi | 237175 |
KEGGi | mmu:237175 |
UCSCi | uc009utd.2, mouse [Q8CJ12-1] uc009ute.2, mouse [Q8CJ12-3] uc009utg.2, mouse [Q8CJ12-5] uc009uth.2, mouse [Q8CJ12-2] uc009uti.2, mouse [Q8CJ12-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF538952 mRNA Translation: AAN33054.1 AF538955 mRNA Translation: AAN33057.1 AF538956 mRNA Translation: AAN33058.1 AF538957 mRNA Translation: AAN33059.1 AK046871 mRNA Translation: BAC32902.1 AL731801 Genomic DNA No translation available. |
CCDSi | CCDS41196.1 [Q8CJ12-1] CCDS41197.1 [Q8CJ12-3] CCDS41199.1 [Q8CJ12-5] CCDS72459.1 [Q8CJ12-2] CCDS81192.1 [Q8CJ12-4] |
RefSeqi | NP_001073317.1, NM_001079848.2 [Q8CJ12-5] NP_001073326.1, NM_001079857.2 [Q8CJ12-3] NP_001277374.1, NM_001290445.1 [Q8CJ12-4] NP_001277375.1, NM_001290446.1 [Q8CJ12-2] NP_848827.1, NM_178712.4 [Q8CJ12-1] |
3D structure databases
SMRi | Q8CJ12 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108019 |
Protein family/group databases
MEROPSi | P02.007 |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8CJ12, 20 sites |
iPTMneti | Q8CJ12 |
PhosphoSitePlusi | Q8CJ12 |
Proteomic databases
PaxDbi | Q8CJ12 |
PRIDEi | Q8CJ12 |
Protocols and materials databases
Antibodypediai | 473, 125 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000112400; ENSMUSP00000108019; ENSMUSG00000031298 [Q8CJ12-1] ENSMUST00000112402; ENSMUSP00000108021; ENSMUSG00000031298 [Q8CJ12-3] ENSMUST00000112404; ENSMUSP00000108023; ENSMUSG00000031298 [Q8CJ12-5] ENSMUST00000112405; ENSMUSP00000108024; ENSMUSG00000031298 [Q8CJ12-4] ENSMUST00000112408; ENSMUSP00000108027; ENSMUSG00000031298 [Q8CJ12-2] |
GeneIDi | 237175 |
KEGGi | mmu:237175 |
UCSCi | uc009utd.2, mouse [Q8CJ12-1] uc009ute.2, mouse [Q8CJ12-3] uc009utg.2, mouse [Q8CJ12-5] uc009uth.2, mouse [Q8CJ12-2] uc009uti.2, mouse [Q8CJ12-4] |
Organism-specific databases
CTDi | 10149 |
MGIi | MGI:2446854, Adgrg2 |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000156341 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q8CJ12 |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q8CJ12 |
TreeFami | TF321769 |
Miscellaneous databases
BioGRID-ORCSi | 237175, 1 hit in 17 CRISPR screens |
ChiTaRSi | Adgrg2, mouse |
PROi | PR:Q8CJ12 |
RNActi | Q8CJ12, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031298, Expressed in white adipose tissue and 156 other tissues |
ExpressionAtlasi | Q8CJ12, baseline and differential |
Genevisiblei | Q8CJ12, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRG2_MOUSE | |
Accessioni | Q8CJ12Primary (citable) accession number: Q8CJ12 Secondary accession number(s): A2AHP8 Q8CJ10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families