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Entry version 141 (13 Feb 2019)
Sequence version 2 (01 Oct 2003)
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Protein

von Willebrand factor

Gene

Vwf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Cleaved into the following chain:
Alternative name(s):
von Willebrand antigen II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VwfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98941 Vwf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Platelet deposition and thrombus formation is significantly delayed, but despite this small thrombi do eventually form. At later stages, thrombus growth frequently arrests leaving open channels within arterioles. In double knockouts of FGA and VWF, in addition to delayed platelet deposition, thrombi are fragile and frequently embolize.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1205R → H: Accelerated clearance of VWF from blood plasma. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002268423 – 763von Willebrand antigen 2Add BLAST741
ChainiPRO_0000022685764 – 2813von Willebrand factorAdd BLAST2050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 2811By similarity
Disulfide bondi? ↔ 996By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi767 ↔ 808By similarity
Disulfide bondi776 ↔ 804By similarity
Disulfide bondi810 ↔ 821By similarity
Glycosylationi857N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi889 ↔ 1031By similarity
Disulfide bondi898 ↔ 993By similarity
Disulfide bondi914 ↔ 921By similarity
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1060 ↔ 1084By similarity
Disulfide bondi1071 ↔ 1111By similarity
Disulfide bondi1089 ↔ 1091By similarity
Disulfide bondi1126 ↔ 1130By similarity
Glycosylationi1147N-linked (GlcNAc...) asparagine; atypicalBy similarity1
Disulfide bondi1149 ↔ 1169By similarity
Disulfide bondi1153 ↔ 1165By similarity
Disulfide bondi1196 ↔ 1199By similarity
Glycosylationi1231N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi1234 ↔ 1237By similarity
Glycosylationi1248O-linked (GalNAc...) threonineBy similarityCurated1
Glycosylationi1255O-linked (GalNAc...) threonineBy similarityCurated1
Glycosylationi1256O-linked (GalNAc...) threonineBy similarityCurated1
Disulfide bondi1272 ↔ 14581 Publication
Glycosylationi1468O-linked (GalNAc...) threonineBy similarityCurated1
Glycosylationi1477O-linked (GalNAc...) threonineBy similarityCurated1
Glycosylationi1486O-linked (GalNAc...) serineBy similarityCurated1
Glycosylationi1515N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi1574N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi1669 ↔ 1670By similarity
Glycosylationi1679O-linked (GalNAc...) threonineBy similarityCurated1
Disulfide bondi1686 ↔ 1872By similarity
Disulfide bondi1879 ↔ 1904By similarity
Disulfide bondi1899 ↔ 1940Or C-1899 with C-1942PROSITE-ProRule annotationBy similarity
Disulfide bondi1927 ↔ 2088By similarity
Disulfide bondi1950 ↔ 2085By similarity
Disulfide bondi1972 ↔ 2123By similarity
Disulfide bondi1993 ↔ 2001By similarity
Glycosylationi2223N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi2290N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi2298O-linked (GalNAc...) threonineBy similarityCurated1
Glycosylationi2400N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi2546N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi2585N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi2724 ↔ 2774By similarity
Disulfide bondi2739 ↔ 2788By similarity
Disulfide bondi2750 ↔ 2804By similarity
Disulfide bondi2754 ↔ 2806By similarity
Glycosylationi2790N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi2810N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds.By similarity
N- and O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CIZ8

PRoteomics IDEntifications database

More...
PRIDEi
Q8CIZ8

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CIZ8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CIZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma. Expressed in liver.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8CIZ8, 1 interactor

Molecular INTeraction database

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MINTi
Q8CIZ8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001995

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12813
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U0OX-ray2.70C1261-1468[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8CIZ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CIZ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8CIZ8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 240VWFD 1PROSITE-ProRule annotationAdd BLAST207
Domaini295 – 348TIL 1Add BLAST54
Domaini387 – 598VWFD 2PROSITE-ProRule annotationAdd BLAST212
Domaini652 – 707TIL 2Add BLAST56
Domaini804 – 827TIL 3Add BLAST24
Domaini866 – 1074VWFD 3PROSITE-ProRule annotationAdd BLAST209
Domaini1146 – 1196TIL 4Add BLAST51
Domaini1277 – 1453VWFA 1; binding site for platelet glycoprotein IbPROSITE-ProRule annotationAdd BLAST177
Domaini1498 – 1665VWFA 2PROSITE-ProRule annotationAdd BLAST168
Domaini1691 – 1871VWFA 3; principal binding site for collagens type I and IIIPROSITE-ProRule annotationAdd BLAST181
Domaini1949 – 2153VWFD 4PROSITE-ProRule annotationAdd BLAST205
Domaini2255 – 2328VWFC 1PROSITE-ProRule annotationAdd BLAST74
Domaini2429 – 2495VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini2580 – 2645VWFC 3PROSITE-ProRule annotationAdd BLAST66
Domaini2724 – 2812CTCKPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni764 – 787Amino-terminalAdd BLAST24
Regioni788 – 833E1Add BLAST46
Regioni826 – 853CXAdd BLAST28
Regioni2216 – 2261E2Add BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2507 – 2509Cell attachment siteBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR8A Eukaryota
ENOG41100RZ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169747

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004380

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CIZ8

KEGG Orthology (KO)

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KOi
K03900

Database of Orthologous Groups

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OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CIZ8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11339:SF361 PTHR11339:SF361, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 4 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8CIZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPFRYEICL LVLALTWPGT LCTEKPRDRP STARCSLFGD DFINTFDETM
60 70 80 90 100
YSFAGGCSYL LAGDCQKRSF SILGNFQDGK RMSLSVYLGE FFDIHLFANG
110 120 130 140 150
TVMQGDQSIS MPYASQGLYL ELEAGYYKLS SETFGFAARI DGNGNFQVLM
160 170 180 190 200
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC
210 220 230 240 250
KRASPPSRNC ESSSGDMHQA MWEQCQLLKT ASVFARCHPL VDPESFVALC
260 270 280 290 300
EKILCTCATG PECACPVLLE YARTCAQEGM VLYGWTDHSA CRPACPAGME
310 320 330 340 350
YKECVSPCPR TCQSLSINEV CQQQCVDGCS CPEGELLDED RCVQSSDCPC
360 370 380 390 400
VHAGKRYPPG TSLSQDCNTC ICRNSLWICS NEECPGECLV TGQSHFKSFD
410 420 430 440 450
NRYFTFSGIC QYLLARDCED HTFSIVIETM QCADDPDAVC TRSVSVRLSA
460 470 480 490 500
LHNSLVKLKH GGAVGIDGQD VQLPFLQGDL RIQHTVMASV RLSYAEDLQM
510 520 530 540 550
DWDGRGRLLV KLSPVYSGKT CGLCGNYNGN KGDDFLTPAG LVEPLVVDFG
560 570 580 590 600
NAWKLQGDCS DLRRQHSDPC SLNPRLTRFA EEACALLTSS KFEACHHAVS
610 620 630 640 650
PLPYLQNCRY DVCSCSDSRD CLCNAVANYA AECARKGVHI GWREPGFCAL
660 670 680 690 700
GCPQGQVYLQ CGNSCNLTCR SLSLPDEECS EVCLEGCYCP PGLYQDERGD
710 720 730 740 750
CVPKAQCPCY YDGELFQPAD IFSDHHTMCY CEDGFMHCTT SGTLGSLLPD
760 770 780 790 800
TVLSSPLSHR SKRSLSCRPP MVKLVCPADN PRAQGLECAK TCQNYDLERM
810 820 830 840 850
SLGCVSGCLC PPGMVRHENK CVALERCPCF HQGAEYAPGD TVKIGCNTCV
860 870 880 890 900
CRERKWNCTN HVCDATRSAI GMAHYLTFDG LKYLFPGECQ YVLVYDYCGS
910 920 930 940 950
NPGTFQILVG NEGCSYPSVK CRKRVTILVD GGELELFDGE VNVKRPLRDE
960 970 980 990 1000
SHFEVVESGR YVILLLGQAL SVVWDHHLSI SVVLKHTYQE QVCGLCGNFD
1010 1020 1030 1040 1050
GIQNNDSTTS SLQVEEDPVN FGNSWKVSSQ CADTRKLSLD VSPATCHNNI
1060 1070 1080 1090 1100
MKQTMVDSAC RILTSDVFQG CNRLVDPEPY LDICIYDTCS CESIGDCACF
1110 1120 1130 1140 1150
CDTIAAYAHV CAQHGQVVAW RTPTLCPQSC EEKNVRENGY ECEWRYNSCA
1160 1170 1180 1190 1200
PACPVTCQHP EPLACPVQCV EGCHAHCPPG RILDELLQTC VDPQDCPVCE
1210 1220 1230 1240 1250
VAGRRLAPGK KITLSPDDPA HCQNCHCDGV NLTCEACQEP GGLVAPPTDA
1260 1270 1280 1290 1300
PVSSTTPYVE DTPEPPLHNF YCSKLLDLVF LLDGSSMLSE AEFEVLKAFV
1310 1320 1330 1340 1350
VGMMERLHIS QKRIRVAVVE YHDGSRAYLE LKARKRPSEL RRITSQIKYT
1360 1370 1380 1390 1400
GSQVASTSEV LKYTLFQIFG KIDRPEASHI TLLLTASQEP PRMARNLVRY
1410 1420 1430 1440 1450
VQGLKKKKVI VIPVGIGPHA SLKQIRLIEK QAPENKAFLL SGVDELEQRR
1460 1470 1480 1490 1500
DEIVSYLCDL APEAPAPTQP PQVAHVTVSP GIAGISSPGP KRKSMVLDVV
1510 1520 1530 1540 1550
FVLEGSDEVG EANFNKSKEF VEEVIQRMDV SPDATRISVL QYSYTVTMEY
1560 1570 1580 1590 1600
AFNGAQSKEE VLRHVREIRY QGGNRTNTGQ ALQYLSEHSF SPSQGDRVEA
1610 1620 1630 1640 1650
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPHANMQELE RISRPIAPIF
1660 1670 1680 1690 1700
IRDFETLPRE APDLVLQTCC SKEGLQLPTL PPLPDCSQPL DVVLLLDGSS
1710 1720 1730 1740 1750
SLPESSFDKM KSFAKAFISK ANIGPHLTQV SVIQYGSINT IDVPWNVVQE
1760 1770 1780 1790 1800
KAHLQSLVDL MQQEGGPSQI GDALAFAVRY VTSQIHGARP GASKAVVIII
1810 1820 1830 1840 1850
MDTSLDPVDT AADAARSNRV AVFPVGVGDR YDEAQLRILA GPGASSNVVK
1860 1870 1880 1890 1900
LQQVEDLSTM ATLGNSFFHK LCSGFSGVCV DEDGNEKRPG DVWTLPDQCH
1910 1920 1930 1940 1950
TVTCLANGQT LLQSHRVNCD HGPRPSCANS QSPVRVEETC GCRWTCPCVC
1960 1970 1980 1990 2000
TGSSTRHIVT FDGQNFKLTG SCSYVIFQNK EQDLEVLLHN GACSPGAKQA
2010 2020 2030 2040 2050
CMKSIEIKHA GVSAELHSNM EMAVDGRLVL APYVGENMEV SIYGAIMYEV
2060 2070 2080 2090 2100
RFTHLGHILT YTPQNNEFQL QLSPKTFASK MHGLCGICDE NGANDFTLRD
2110 2120 2130 2140 2150
GTVTTDWKRL VQEWTVQQPG YTCQAVPEEQ CPVSDSSHCQ VLLSASFAEC
2160 2170 2180 2190 2200
HKVIAPATFH TICQQDSCHQ ERVCEVIASY AHLCRTSGVC VDWRTTDFCA
2210 2220 2230 2240 2250
MSCPPSLVYN HCERGCPRHC DGNTSFCGDH PSEGCFCPQH QVFLEGSCVP
2260 2270 2280 2290 2300
EEACTQCVGE DGVRHQFLET WVPDHQPCQI CMCLSGRKIN CTAQPCPTAR
2310 2320 2330 2340 2350
APTCGPCEVA RLKQSTNLCC PEYECVCDLF NCNLPPVPPC EGGLQPTLTN
2360 2370 2380 2390 2400
PGECRPTFTC DCRKEECKRV SPPSCPPHRT PTLRKTQCCD EYECACSCVN
2410 2420 2430 2440 2450
STLSCPLGYL ASATTNDCGC TTTTCLPDKV CVHRGTVYPV GQFWEEGCDT
2460 2470 2480 2490 2500
CTCTDMEDTV VGLRVVQCSQ RPCEDSCQPG FSYVLHEGEC CGRCLPSACK
2510 2520 2530 2540 2550
VVAGSLRGDS HSSWKSVGSR WAVPENPCLV NECVRVEDAV FVQQRNISCP
2560 2570 2580 2590 2600
QLAVPTCPTG FQLNCETSEC CPSCHCEPVE ACLLNGTIIG PGKSVMVDLC
2610 2620 2630 2640 2650
TTCRCIVQTD AISRFKLECR KTTCEACPMG YREEKSQGEC CGRCLPTACT
2660 2670 2680 2690 2700
IQLRGGRIMT LKQDETFQDG CDSHLCRVNE RGEYIWEKRV TGCPPFDEHK
2710 2720 2730 2740 2750
CLAEGGKIVK IPGTCCDTCE EPDCKDITAK VQYIKVGDCK SQEEVDIHYC
2760 2770 2780 2790 2800
QGKCASKAVY SIDIEDVQEQ CSCCLPSRTE PMRVPLHCTN GSVVYHEVIN
2810
AMQCRCSPRN CSK
Length:2,813
Mass (Da):309,269
Last modified:October 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EE2C7D8FF21FFA6
GO
Isoform 2Curated (identifier: Q8CIZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-402: ECLVTGQSHFKSFDNR → RLGTFSPFLPVLCGEV
     403-2813: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:402
Mass (Da):44,467
Checksum:i36201FC93F1EE915
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPU1E9QPU1_MOUSE
von Willebrand factor
Vwf
2,813Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TPE1Q3TPE1_MOUSE
von Willebrand factor
Vwf
405Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TD35Q3TD35_MOUSE
von Willebrand factor
Vwf
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R195S4R195_MOUSE
von Willebrand factor
Vwf
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC38822 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103M → T in AAP41950 (Ref. 1) Curated1
Sequence conflicti122L → R in AAP41950 (Ref. 1) Curated1
Sequence conflicti799R → C in AAP41950 (Ref. 1) Curated1
Sequence conflicti867R → C in AAP41950 (Ref. 1) Curated1
Sequence conflicti895Y → Q in AAP41950 (Ref. 1) Curated1
Sequence conflicti1007S → F in AAP41950 (Ref. 1) Curated1
Sequence conflicti1245A → V in CAB86200 (PubMed:10722222).Curated1
Sequence conflicti1421S → D in AAA82929 (PubMed:8193357).Curated1
Sequence conflicti1485 – 1486IS → TL in AAA82929 (PubMed:8193357).Curated2
Sequence conflicti2361D → A in AAP41950 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051618387 – 402ECLVT…SFDNR → RLGTFSPFLPVLCGEV in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_051619403 – 2813Missing in isoform 2. 1 PublicationAdd BLAST2411

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY208897 mRNA Translation: AAP41950.1
AY162409 mRNA Translation: AAN73055.1
AF539800 mRNA Translation: AAN07781.2
AK083237 mRNA Translation: BAC38822.1 Different initiation.
AJ238390 Genomic DNA Translation: CAB86200.1
U27810 Genomic DNA Translation: AAA82929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20552.1 [Q8CIZ8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_035838.3, NM_011708.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22339

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22371

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208897 mRNA Translation: AAP41950.1
AY162409 mRNA Translation: AAN73055.1
AF539800 mRNA Translation: AAN07781.2
AK083237 mRNA Translation: BAC38822.1 Different initiation.
AJ238390 Genomic DNA Translation: CAB86200.1
U27810 Genomic DNA Translation: AAA82929.1
CCDSiCCDS20552.1 [Q8CIZ8-1]
RefSeqiNP_035838.3, NM_011708.4
UniGeneiMm.22339

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U0OX-ray2.70C1261-1468[»]
ProteinModelPortaliQ8CIZ8
SMRiQ8CIZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CIZ8, 1 interactor
MINTiQ8CIZ8
STRINGi10090.ENSMUSP00000001995

Protein family/group databases

MEROPSiI08.950

PTM databases

PhosphoSitePlusiQ8CIZ8
SwissPalmiQ8CIZ8

Proteomic databases

PaxDbiQ8CIZ8
PRIDEiQ8CIZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22371
KEGGimmu:22371

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7450
MGIiMGI:98941 Vwf

Phylogenomic databases

eggNOGiENOG410IR8A Eukaryota
ENOG41100RZ LUCA
HOGENOMiHOG000169747
HOVERGENiHBG004380
InParanoidiQ8CIZ8
KOiK03900
OrthoDBi12226at2759
PhylomeDBiQ8CIZ8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Vwf mouse
EvolutionaryTraceiQ8CIZ8

Protein Ontology

More...
PROi
PR:Q8CIZ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 2 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 4 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 7 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVWF_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CIZ8
Secondary accession number(s): Q60863
, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2003
Last modified: February 13, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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