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Protein

Tubulin-specific chaperone E

Gene

Tbce

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation (PubMed:12389029, PubMed:17184771). Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network (By similarity).By similarity2 Publications

GO - Molecular functioni

  • unfolded protein binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone E
Alternative name(s):
Tubulin-folding cofactor E
Gene namesi
Name:Tbce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1917680 Tbce

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000835392 – 524Tubulin-specific chaperone EAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei492PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CIV8
MaxQBiQ8CIV8
PaxDbiQ8CIV8
PeptideAtlasiQ8CIV8
PRIDEiQ8CIV8

PTM databases

PhosphoSitePlusiQ8CIV8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000039233 Expressed in 289 organ(s), highest expression level in female gonad
CleanExiMM_TBCE
ExpressionAtlasiQ8CIV8 baseline and differential
GenevisibleiQ8CIV8 MM

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Interacts with TBCD (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214045, 1 interactor
STRINGi10090.ENSMUSP00000047880

Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8CIV8
SMRiQ8CIV8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CIV8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 71CAP-GlyPROSITE-ProRule annotationAdd BLAST45
Repeati154 – 175LRR 1Add BLAST22
Repeati180 – 201LRR 2Add BLAST22
Repeati206 – 227LRR 3Add BLAST22
Repeati231 – 253LRR 4Add BLAST23
Repeati254 – 275LRR 5Add BLAST22
Repeati279 – 300LRR 6Add BLAST22
Repeati309 – 330LRR 7Add BLAST22
Domaini343 – 381LRRCTAdd BLAST39

Sequence similaritiesi

Belongs to the TBCE family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3207 Eukaryota
ENOG410YS3M LUCA
GeneTreeiENSGT00530000063405
HOGENOMiHOG000154513
HOVERGENiHBG084170
InParanoidiQ8CIV8
KOiK21768
OMAiRMITVQT
OrthoDBiEOG091G07V5
PhylomeDBiQ8CIV8
TreeFamiTF313455

Family and domain databases

Gene3Di2.30.30.190, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032675 LRR_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CIV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDILPLDVI GRRVEVNGEY ATVRFCGAVP PVAGLWLGVE WDNPERGKHD
60 70 80 90 100
GSHEGTMYFK CRHPTGGSFV RPSKVNFGDD FLTALKKRYV LEDGPDDDEN
110 120 130 140 150
SCSLKVGSKQ VQTIGFEHIT KKQSQLRALQ DISLWNCAVS HAGEQGRIAE
160 170 180 190 200
ACPNIRVVNL SKNLLSTWDE VVLIAEQLKD LEALDLSENK LQFPSDSPTL
210 220 230 240 250
TRTFSTLKTL VLNKTGITWT EVLHCAPSWP VLEELYLKSN NISISERPVN
260 270 280 290 300
VLQKMRLLDL SSNPSIDESQ LSLIADLPRL EHLVLSDIGL SSIHFPDAEI
310 320 330 340 350
GCKTSMFPAL KYLIVNDNQI SEWSFINELD KLQSLQALSC TRNPLSKADK
360 370 380 390 400
AEEIIIAKIA QLRTLNRCQI LPEERRGAEL DYRKAFGNEW RKAGGHPDPD
410 420 430 440 450
KNRPNAAFLS AHPRYQLLCC KYGAPEDEEL KTQQPFMLKK QLLTLKIKCS
460 470 480 490 500
NQPERQILEK QLPDSMTVQK VKGLLSRLLK VPVSELLLSY ESSKMPGREI
510 520
ELENDLQPLQ FYSVENGDCL LVRW
Length:524
Mass (Da):59,086
Last modified:March 1, 2003 - v1
Checksum:iE95280086D80FEF8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ81E0CZ81_MOUSE
Tubulin-specific chaperone E
Tbce
428Annotation score:
E0CXJ6E0CXJ6_MOUSE
Tubulin-specific chaperone E
Tbce
75Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti348A → V1 Publication1
Natural varianti524W → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082332 mRNA Translation: AAL92570.1
AK167383 mRNA Translation: BAE39475.1
BC050206 mRNA Translation: AAH50206.1
CCDSiCCDS26247.1
RefSeqiNP_848027.1, NM_178337.3
UniGeneiMm.260209

Genome annotation databases

EnsembliENSMUST00000039894; ENSMUSP00000047880; ENSMUSG00000039233
GeneIDi70430
KEGGimmu:70430
UCSCiuc007pmq.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082332 mRNA Translation: AAL92570.1
AK167383 mRNA Translation: BAE39475.1
BC050206 mRNA Translation: AAH50206.1
CCDSiCCDS26247.1
RefSeqiNP_848027.1, NM_178337.3
UniGeneiMm.260209

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJNNMR-A441-524[»]
ProteinModelPortaliQ8CIV8
SMRiQ8CIV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214045, 1 interactor
STRINGi10090.ENSMUSP00000047880

PTM databases

PhosphoSitePlusiQ8CIV8

Proteomic databases

EPDiQ8CIV8
MaxQBiQ8CIV8
PaxDbiQ8CIV8
PeptideAtlasiQ8CIV8
PRIDEiQ8CIV8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039894; ENSMUSP00000047880; ENSMUSG00000039233
GeneIDi70430
KEGGimmu:70430
UCSCiuc007pmq.2 mouse

Organism-specific databases

CTDi6905
MGIiMGI:1917680 Tbce

Phylogenomic databases

eggNOGiKOG3207 Eukaryota
ENOG410YS3M LUCA
GeneTreeiENSGT00530000063405
HOGENOMiHOG000154513
HOVERGENiHBG084170
InParanoidiQ8CIV8
KOiK21768
OMAiRMITVQT
OrthoDBiEOG091G07V5
PhylomeDBiQ8CIV8
TreeFamiTF313455

Miscellaneous databases

EvolutionaryTraceiQ8CIV8
PROiPR:Q8CIV8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039233 Expressed in 289 organ(s), highest expression level in female gonad
CleanExiMM_TBCE
ExpressionAtlasiQ8CIV8 baseline and differential
GenevisibleiQ8CIV8 MM

Family and domain databases

Gene3Di2.30.30.190, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032675 LRR_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBCE_MOUSE
AccessioniPrimary (citable) accession number: Q8CIV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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