Transcription factor Ovo-like 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.10

    "Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells."
    Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.
    Dev. Cell 29:47-58(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.3

    "Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as a transcription factors."
    Unezaki S., Nishizawa M., Okuda-Ashitaka E., Masu Y., Mukai M., Kobayashi S., Sawamoto K., Okano H., Ito S.
    Gene 336:47-58(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • Ref.10

    "Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells."
    Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.
    Dev. Cell 29:47-58(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• DNA-binding transcription factor activity Source: MGI <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.1

    "Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis."
    Masu Y., Ikeda S., Okuda-Ashitaka E., Sato E., Ito S.
    FEBS Lett. 421:224-228(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: MGI

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice."
    Unezaki S., Horai R., Sudo K., Iwakura Y., Ito S.
    Genes Cells 12:773-785(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral pattern formation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• embryonic digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• endocardium formation Source: MGIInferred from mutant phenotypeⁱ
  • "Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice."
    Unezaki S., Horai R., Sudo K., Iwakura Y., Ito S.
    Genes Cells 12:773-785(2007) [PubMed] [Europe PMC] [Abstract]
• epidermal cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.11

    "Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor."
    Watanabe K., Villarreal-Ponce A., Sun P., Salmans M.L., Fallahi M., Andersen B., Dai X.
    Dev. Cell 29:59-74(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• epidermis development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.10

    "Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells."
    Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.
    Dev. Cell 29:47-58(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • "Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice."
    Unezaki S., Horai R., Sudo K., Iwakura Y., Ito S.
    Genes Cells 12:773-785(2007) [PubMed] [Europe PMC] [Abstract]
• heart trabecula formation Source: MGIInferred from mutant phenotypeⁱ
  • "Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice."
    Unezaki S., Horai R., Sudo K., Iwakura Y., Ito S.
    Genes Cells 12:773-785(2007) [PubMed] [Europe PMC] [Abstract]
• labyrinthine layer blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • "Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice."
    Unezaki S., Horai R., Sudo K., Iwakura Y., Ito S.
    Genes Cells 12:773-785(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• negative regulation of epithelial to mesenchymal transition Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of keratinocyte differentiation Source: UniProtKB
• negative regulation of Notch signaling pathway Source: UniProtKB
• negative regulation of stem cell proliferation Source: MGIInferred from genetic interactionⁱ
  • Ref.10

    "Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells."
    Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.
    Dev. Cell 29:47-58(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of transcription by competitive promoter binding Source: MGI
• neural crest cell migration Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• neural fold formation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "The mouse Ovol2 gene is required for cranial neural tube development."
    Mackay D.R., Hu M., Li B., Rheaume C., Dai X.
    Dev. Biol. 291:38-52(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, FUNCTION.
• positive regulation of gene expression Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of keratinocyte differentiation Source: MGIInferred from direct assayⁱ
  • Ref.10

    "Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells."
    Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.
    Dev. Cell 29:47-58(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of cell cycle Source: UniProtKB
• regulation of keratinocyte proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1."
    Wells J., Lee B., Cai A.Q., Karapetyan A., Lee W.J., Rugg E., Sinha S., Nie Q., Dai X.
    J. Biol. Chem. 284:29125-29135(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of SMAD protein signal transduction Source: ARUK-UCLInferred from direct assayⁱ
  • "OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis."
    Wu R.S., Hong J.J., Wu J.F., Yan S., Wu D., Liu N., Liu Q.F., Wu Q.W., Xie Y.Y., Liu Y.J., Zheng Z.Z., Chan E.C., Zhang Z.M., Li B.A.
    Oncotarget 8:39401-39416(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPKVFLVKRR SPGVSVRSWD ELPDDKRADT YIPVSLGCLL RDPPEDCRSD 
        60         70         80         90        100
GGSSSGCSSS AGEPGGAESS SSPRAPEPET PELHDAQGTD GHLAAMQRPV 
       110        120        130        140        150
ARSKIKFTTG TCDNSVIHNC DLCGKSFRLQ RMLNRHLKCH NQVKRHLCTF 
       160        170        180        190        200
CGKGFNDTFD LKRHVRTHTG IRPYKCEVCN KAFTQRCSLE SHLKKIHGVQ 
       210        220        230        240        250
QQYAYKQRRD KLYVCEDCGY TGPTQEDLYL HVNSDHPGST FLKKTSKKLA 
       260        270 
ALMQNKLTSP LQENSTLSEE EEKK                             

        10         20         30         40         50
MSLGCLLRDP PEDCRSDGGS SSGCSSSAGE PGGAESSSSP RAPEPETPEL 
        60         70         80         90        100
HDAQGTDGHL AAMQRPVARS KIKFTTGTCD NSVIHNCDLC GKSFRLQRML 
       110        120        130        140        150
NRHLKCHNQV KRHLCTFCGK GFNDTFDLKR HVRTHTGIRP YKCEVCNKAF 
       160        170        180        190        200
TQRCSLESHL KKIHGVQQQY AYKQRRDKLY VCEDCGYTGP TQEDLYLHVN 
       210        220        230        240 
SDHPGSTFLK KTSKKLAALM QNKLTSPLQE NSTLSEEEEK K          

        10         20         30         40         50
MQRPVARSKI KFTTGTCDNS VIHNCDLCGK SFRLQRMLNR HLKCHNQVKR 
        60         70         80         90        100
HLCTFCGKGF NDTFDLKRHV RTHTGIRPYK CEVCNKAFTQ RCSLESHLKK 
       110        120        130        140        150
IHGVQQQYAY KQRRDKLYVC EDCGYTGPTQ EDLYLHVNSD HPGSTFLKKT 
       160        170 
SKKLAALMQN KLTSPLQENS TLSEEEEKK                        

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families