UniProtKB - Q8CIV7 (OVOL2_MOUSE)
Transcription factor Ovo-like 2
Ovol2
Functioni
Zinc-finger transcription repressor factor (PubMed:15225875, PubMed:23319585).
Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (PubMed:24735878, PubMed:24735879).
Positively regulates neuronal differentiation (PubMed:16423343, PubMed:23319585).
Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity).
Important for the correct development of primordial germ cells in embryos (PubMed:28059165).
By similarity6 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- cellular response to transforming growth factor beta stimulus Source: ARUK-UCL
- dorsal/ventral pattern formation Source: MGI
- embryonic digestive tract morphogenesis Source: MGI
- endocardium formation Source: MGI
- epidermal cell differentiation Source: UniProtKB
- epidermis development Source: MGI
- heart development Source: MGI
- heart looping Source: MGI
- heart trabecula formation Source: MGI
- labyrinthine layer blood vessel development Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of epithelial to mesenchymal transition Source: ARUK-UCL
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of keratinocyte differentiation Source: UniProtKB
- negative regulation of Notch signaling pathway Source: UniProtKB
- negative regulation of stem cell proliferation Source: MGI
- negative regulation of transcription by competitive promoter binding Source: MGI
- neural crest cell migration Source: MGI
- neural fold formation Source: MGI
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of keratinocyte differentiation Source: MGI
- regulation of cell cycle Source: UniProtKB
- regulation of keratinocyte proliferation Source: BHF-UCL
- regulation of SMAD protein signal transduction Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Ovo-like 2Short name: mOvo2 Alternative name(s): Zinc finger OVO2 Zinc finger protein 339 Zinc finger protein mOVO |
Gene namesi | Name:Ovol2 Synonyms:Ovo2, Zfp339, Znf339 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338039, Ovol2 |
VEuPathDBi | HostDB:ENSMUSG00000037279 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047014 | 1 – 274 | Transcription factor Ovo-like 2Add BLAST | 274 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 268 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8CIV7 |
PRIDEi | Q8CIV7 |
ProteomicsDBi | 294138 [Q8CIV7-1] 294139 [Q8CIV7-2] 294140 [Q8CIV7-3] |
PTM databases
iPTMneti | Q8CIV7 |
PhosphoSitePlusi | Q8CIV7 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000037279, Expressed in testis and 117 other tissues |
Genevisiblei | Q8CIV7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000044026 |
Miscellaneous databases
RNActi | Q8CIV7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 88 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 67 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000159359 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | Q8CIV7 |
OMAi | IPVSLDC |
OrthoDBi | 1419156at2759 |
PhylomeDBi | Q8CIV7 |
TreeFami | TF337552 |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKVFLVKRR SPGVSVRSWD ELPDDKRADT YIPVSLGCLL RDPPEDCRSD
60 70 80 90 100
GGSSSGCSSS AGEPGGAESS SSPRAPEPET PELHDAQGTD GHLAAMQRPV
110 120 130 140 150
ARSKIKFTTG TCDNSVIHNC DLCGKSFRLQ RMLNRHLKCH NQVKRHLCTF
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG IRPYKCEVCN KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QQYAYKQRRD KLYVCEDCGY TGPTQEDLYL HVNSDHPGST FLKKTSKKLA
260 270
ALMQNKLTSP LQENSTLSEE EEKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | A → S in AAM11991 (PubMed:12213202).Curated | 1 | |
Sequence conflicti | 67 | A → S in AAM11992 (PubMed:12213202).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013576 | 1 – 95 | Missing in isoform 3. 3 PublicationsAdd BLAST | 95 | |
Alternative sequenceiVSP_013577 | 1 – 33 | Missing in isoform 2. 2 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_013578 | 34 | V → M in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY090537 mRNA Translation: AAM11991.1 AY090538 mRNA Translation: AAM11992.1 AB101294 mRNA Translation: BAD29939.1 AB101295 mRNA Translation: BAD29940.1 AB101296 mRNA Translation: BAD29941.1 AB101299 Genomic DNA Translation: BAD29942.1 AB101299 Genomic DNA Translation: BAD29943.1 AB101299 Genomic DNA Translation: BAD29944.1 AK007360 mRNA Translation: BAB24985.1 AL808123 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28455.1 BC031771 mRNA Translation: AAH31771.1 BC057210 mRNA Translation: AAH57210.1 BC094445 mRNA Translation: AAH94445.1 |
CCDSi | CCDS16817.1 [Q8CIV7-1] CCDS16818.1 [Q8CIV7-2] |
RefSeqi | NP_081200.2, NM_026924.3 [Q8CIV7-1] NP_694455.2, NM_152947.2 [Q8CIV7-2] |
Genome annotation databases
Ensembli | ENSMUST00000037423; ENSMUSP00000044026; ENSMUSG00000037279 [Q8CIV7-1] ENSMUST00000103171; ENSMUSP00000099460; ENSMUSG00000037279 [Q8CIV7-2] |
GeneIDi | 107586 |
KEGGi | mmu:107586 |
UCSCi | uc008mqv.1, mouse [Q8CIV7-2] uc008mqw.1, mouse [Q8CIV7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY090537 mRNA Translation: AAM11991.1 AY090538 mRNA Translation: AAM11992.1 AB101294 mRNA Translation: BAD29939.1 AB101295 mRNA Translation: BAD29940.1 AB101296 mRNA Translation: BAD29941.1 AB101299 Genomic DNA Translation: BAD29942.1 AB101299 Genomic DNA Translation: BAD29943.1 AB101299 Genomic DNA Translation: BAD29944.1 AK007360 mRNA Translation: BAB24985.1 AL808123 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28455.1 BC031771 mRNA Translation: AAH31771.1 BC057210 mRNA Translation: AAH57210.1 BC094445 mRNA Translation: AAH94445.1 |
CCDSi | CCDS16817.1 [Q8CIV7-1] CCDS16818.1 [Q8CIV7-2] |
RefSeqi | NP_081200.2, NM_026924.3 [Q8CIV7-1] NP_694455.2, NM_152947.2 [Q8CIV7-2] |
3D structure databases
AlphaFoldDBi | Q8CIV7 |
SMRi | Q8CIV7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000044026 |
PTM databases
iPTMneti | Q8CIV7 |
PhosphoSitePlusi | Q8CIV7 |
Proteomic databases
PaxDbi | Q8CIV7 |
PRIDEi | Q8CIV7 |
ProteomicsDBi | 294138 [Q8CIV7-1] 294139 [Q8CIV7-2] 294140 [Q8CIV7-3] |
Protocols and materials databases
Antibodypediai | 24517, 166 antibodies from 25 providers |
DNASUi | 107586 |
Genome annotation databases
Ensembli | ENSMUST00000037423; ENSMUSP00000044026; ENSMUSG00000037279 [Q8CIV7-1] ENSMUST00000103171; ENSMUSP00000099460; ENSMUSG00000037279 [Q8CIV7-2] |
GeneIDi | 107586 |
KEGGi | mmu:107586 |
UCSCi | uc008mqv.1, mouse [Q8CIV7-2] uc008mqw.1, mouse [Q8CIV7-1] |
Organism-specific databases
CTDi | 58495 |
MGIi | MGI:1338039, Ovol2 |
VEuPathDBi | HostDB:ENSMUSG00000037279 |
Phylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000159359 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | Q8CIV7 |
OMAi | IPVSLDC |
OrthoDBi | 1419156at2759 |
PhylomeDBi | Q8CIV7 |
TreeFami | TF337552 |
Miscellaneous databases
BioGRID-ORCSi | 107586, 1 hit in 73 CRISPR screens |
ChiTaRSi | Ovol2, mouse |
PROi | PR:Q8CIV7 |
RNActi | Q8CIV7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037279, Expressed in testis and 117 other tissues |
Genevisiblei | Q8CIV7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OVOL2_MOUSE | |
Accessioni | Q8CIV7Primary (citable) accession number: Q8CIV7 Secondary accession number(s): Q505Q7 Q9D949 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families