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Protein

Corticoliberin

Gene

Crh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (PubMed:23470617).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
Synonyms:Gm1347
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88496 Crh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000621420 – 144By similarityAdd BLAST125
PeptideiPRO_0000006215145 – 185CorticoliberinAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185Isoleucine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8CIT0
PRIDEiQ8CIT0

PTM databases

PhosphoSitePlusiQ8CIT0

Expressioni

Tissue specificityi

Expressed in parvocellular paraventricular nucleus of the hypothalamus and in medial accessory olivary nucleus.1 Publication

Inductioni

Up-regulated during water-avoidance stress.1 Publication

Gene expression databases

BgeeiENSMUSG00000049796 Expressed in 91 organ(s), highest expression level in medial vestibular nucleus
CleanExiMM_CRH
GenevisibleiQ8CIT0 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061185

Structurei

3D structure databases

ProteinModelPortaliQ8CIT0
SMRiQ8CIT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK Eukaryota
ENOG4111ZIN LUCA
GeneTreeiENSGT00510000048573
HOGENOMiHOG000004762
HOVERGENiHBG001951
InParanoidiQ8CIT0
KOiK05256
OMAiREMMEMS
OrthoDBiEOG091G0QDI
PhylomeDBiQ8CIT0
TreeFamiTF332956

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ
60 70 80 90 100
QPQPVLIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA
110 120 130 140 150
NFFRVLLQQL QMPQRSLDSR AEPAERGAED ALGGHQGALE RERRSEEPPI
160 170 180
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK
Length:187
Mass (Da):20,778
Last modified:March 1, 2003 - v1
Checksum:i5E51665291FAA998
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128673 Genomic DNA Translation: AAN07905.1
BC116921 mRNA Translation: AAI16922.1
BC119036 mRNA Translation: AAI19037.1
CCDSiCCDS17258.1
RefSeqiNP_991338.1, NM_205769.3
UniGeneiMm.290689

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796
GeneIDi12918
KEGGimmu:12918
UCSCiuc008orx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128673 Genomic DNA Translation: AAN07905.1
BC116921 mRNA Translation: AAI16922.1
BC119036 mRNA Translation: AAI19037.1
CCDSiCCDS17258.1
RefSeqiNP_991338.1, NM_205769.3
UniGeneiMm.290689

3D structure databases

ProteinModelPortaliQ8CIT0
SMRiQ8CIT0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061185

PTM databases

PhosphoSitePlusiQ8CIT0

Proteomic databases

PaxDbiQ8CIT0
PRIDEiQ8CIT0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796
GeneIDi12918
KEGGimmu:12918
UCSCiuc008orx.2 mouse

Organism-specific databases

CTDi1392
MGIiMGI:88496 Crh

Phylogenomic databases

eggNOGiENOG410IWZK Eukaryota
ENOG4111ZIN LUCA
GeneTreeiENSGT00510000048573
HOGENOMiHOG000004762
HOVERGENiHBG001951
InParanoidiQ8CIT0
KOiK05256
OMAiREMMEMS
OrthoDBiEOG091G0QDI
PhylomeDBiQ8CIT0
TreeFamiTF332956

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q8CIT0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049796 Expressed in 91 organ(s), highest expression level in medial vestibular nucleus
CleanExiMM_CRH
GenevisibleiQ8CIT0 MM

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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