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Entry version 142 (29 Sep 2021)
Sequence version 2 (26 Feb 2008)
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Protein

Caspase recruitment domain-containing protein 11

Gene

Card11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:12356734, PubMed:12154356, PubMed:16356855).

Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:12356734, PubMed:12154356, PubMed:16356855).

Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (By similarity).

Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).

Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (By similarity).

Stimulates the phosphorylation of BCL10 (By similarity).

Also activates the TORC1 signaling pathway (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Maintained in an autoinhibited state via homodimerization in which the CARD domain forms an extensive interaction with the adjacent linker and coiled-coil regions (By similarity). Activation downstream of T-cell receptor (TCR) by phosphorylation by PRKCB and PRKCQ triggers CARD11 homooligomerization and BCL10 recruitment, followed by activation of NF-kappa-B (PubMed:16356855).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-202424, Downstream TCR signaling
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-5607764, CLEC7A (Dectin-1) signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 111 Publication
Alternative name(s):
CARD-containing MAGUK protein 11 Publication
Short name:
Carma 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Card111 PublicationImported
Synonyms:Carma11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916978, Card11

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000036526

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired activation of NF-kappa-B downstream of T-cell receptor (TCR), leading to defects in interleukin-2 (IL2) production.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35R → A: Strongly decreased interaction with BCL10. 1 Publication1
Mutagenesisi41K → A: Slightly decreased interaction with BCL10. 1 Publication1
Mutagenesisi69K → A: Decreased interaction with BCL10. 1 Publication1
Mutagenesisi72R → A: Decreased interaction with BCL10. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003201021 – 1159Caspase recruitment domain-containing protein 11Add BLAST1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28InterchainBy similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei540PhosphoserineBy similarity1
Modified residuei564Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication1
Modified residuei598PhosphoserineBy similarity1
Modified residuei649Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication1
Modified residuei657Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication1
Modified residuei891PhosphoserineCombined sources1
Modified residuei930PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-564, Ser-649 and Ser-657 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CIS0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CIS0

PeptideAtlas

More...
PeptideAtlasi
Q8CIS0

PRoteomics IDEntifications database

More...
PRIDEi
Q8CIS0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
265276 [Q8CIS0-1]
265277 [Q8CIS0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CIS0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CIS0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CIS0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036526, Expressed in spleen and 99 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CIS0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (By similarity). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (By similarity).

Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:22880103).

Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (By similarity).

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (By similarity).

Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
224389, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-49692N

Protein interaction database and analysis system

More...
IntActi
Q8CIS0, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000082941

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CIS0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CIS0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 110CARDPROSITE-ProRule annotationAdd BLAST93
Domaini672 – 760PDZAdd BLAST89
Domaini978 – 1145Guanylate kinase-likeAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 128LinkerBy similarityAdd BLAST18
Regioni441 – 496DisorderedSequence analysisAdd BLAST56
Regioni450 – 671Inhibitory domain (ID)By similarityAdd BLAST222
Regioni532 – 578DisorderedSequence analysisAdd BLAST47
Regioni610 – 631DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili176 – 449Sequence analysisAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi453 – 477Polar residuesSequence analysisAdd BLAST25
Compositional biasi540 – 571Polar residuesSequence analysisAdd BLAST32
Compositional biasi617 – 631Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The linker region, also named autoinhibitory interface, is less inhibitory on its own than that of CARD9. The linker region together with the inhibitory domain (ID) are required to prevent constitutive activation and maintain CARD11 in an autoinhibitory state. Disruption of the inhibitory domain (ID) region triggers polymerization and activation, leading to formation of BCL10-nucleating filaments.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0708, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158573

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009760_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CIS0

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTSGGHV

Database of Orthologous Groups

More...
OrthoDBi
115953at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CIS0

TreeFam database of animal gene trees

More...
TreeFami
TF351139

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08808, CARD_CARD11_CARMA1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
2.30.42.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR033538, CARD11
IPR042141, CARD_CARD11
IPR011029, DEATH-like_dom_sf
IPR027417, P-loop_NTPase
IPR036034, PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14559:SF4, PTHR14559:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CIS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK
60 70 80 90 100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP
110 120 130 140 150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC
160 170 180 190 200
ELLAKSRQLE DEKKQLSLIR VELLTFQERY YKMKEERDSY NDELVKVKDD
210 220 230 240 250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS
260 270 280 290 300
LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA
310 320 330 340 350
ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK
360 370 380 390 400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK
410 420 430 440 450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DNGSLDQSLP
460 470 480 490 500
RHLPATIISQ NLGDTSPRTN GQEADDSSTS EESPEDSKYF LPYHPPRRRM
510 520 530 540 550
NLKGIQLQRA KSPISMKQAS EFQALMRTVK GHEEDFTDGS PSSSRSLPVT
560 570 580 590 600
SSFSKMQPHR SRSSIMSITA EPPGNDSIVR RCKEDAPHRS TVEEDNDSCG
610 620 630 640 650
FDALDLDDEN HERYSFGPPS IHSSSSSHQS EGLDAYDLEQ VNLMLRKFSL
660 670 680 690 700
ERPFRPSVTS GGHVRGTGPL VQHTTLNGDG LITQLTLLGG NARGSFIHSV
710 720 730 740 750
KPGSLAERAG LREGHQLLLL EGCIRGERQS VPLDACTKEE ARWTIQRCSG
760 770 780 790 800
LITLHYKVNH EGYRKLLKEM EDGLITSGDS FYIRLNLNIS SQLDACSMSL
810 820 830 840 850
KCDDVVHVLD TMYQDRHEWL CARVDPFTDQ DLDTGTIPSY SRAQQLLLVK
860 870 880 890 900
LQRLVHRGNR EEADSAHHTL RSLRNTLQPE EMLSTSDPRV SPRLSRASFF
910 920 930 940 950
FGQLLQFVSR SENKYKRMNS NERVRIISGS PLGSLSRSSL DATKLLTEKH
960 970 980 990 1000
EELDPENELS RNLTLIPYSL VRAFHCERRR PVLFTPTMLA KTLVQKLLNS
1010 1020 1030 1040 1050
GGAMEFTICK SDIVTRDEFL RKQKTETIIY SREKNPNTFE CIVPANIEAV
1060 1070 1080 1090 1100
AAKNKHCLLE AGIGCVRDLI KCKVYPIVLL IRVSEKNIKR FRKLLPRPET
1110 1120 1130 1140 1150
EEEFLRVCRL KEKELEALPC LYATVEAEMW SSVEELLRVL KDKIVEEQRK

TIWVDEDQL
Length:1,159
Mass (Da):134,040
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ED53905B99DD94E
GO
Isoform 2 (identifier: Q8CIS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-528: Missing.

Show »
Length:1,154
Mass (Da):133,468
Checksum:iCE5FA71361B2EB19
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD21384 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti258E → Q in AAN10150 (PubMed:12356734).Curated1
Sequence conflicti860R → L in BAC29910 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031595524 – 528Missing in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY135367 mRNA Translation: AAN10150.1
AK131134 mRNA Translation: BAD21384.1 Different initiation.
BC096592 mRNA Translation: AAH96592.1
AK037968 mRNA Translation: BAC29910.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS51686.1 [Q8CIS0-2]

NCBI Reference Sequences

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RefSeqi
NP_780571.2, NM_175362.2 [Q8CIS0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000085786; ENSMUSP00000082941; ENSMUSG00000036526 [Q8CIS0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
108723

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:108723

UCSC genome browser

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UCSCi
uc009aik.2, mouse [Q8CIS0-2]
uc012egd.1, mouse [Q8CIS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135367 mRNA Translation: AAN10150.1
AK131134 mRNA Translation: BAD21384.1 Different initiation.
BC096592 mRNA Translation: AAH96592.1
AK037968 mRNA Translation: BAC29910.1
CCDSiCCDS51686.1 [Q8CIS0-2]
RefSeqiNP_780571.2, NM_175362.2 [Q8CIS0-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I16X-ray1.75A18-110[»]
SMRiQ8CIS0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi224389, 7 interactors
DIPiDIP-49692N
IntActiQ8CIS0, 7 interactors
STRINGi10090.ENSMUSP00000082941

PTM databases

iPTMnetiQ8CIS0
PhosphoSitePlusiQ8CIS0
SwissPalmiQ8CIS0

Proteomic databases

jPOSTiQ8CIS0
PaxDbiQ8CIS0
PeptideAtlasiQ8CIS0
PRIDEiQ8CIS0
ProteomicsDBi265276 [Q8CIS0-1]
265277 [Q8CIS0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
11155, 322 antibodies

Genome annotation databases

EnsembliENSMUST00000085786; ENSMUSP00000082941; ENSMUSG00000036526 [Q8CIS0-2]
GeneIDi108723
KEGGimmu:108723
UCSCiuc009aik.2, mouse [Q8CIS0-2]
uc012egd.1, mouse [Q8CIS0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84433
MGIiMGI:1916978, Card11
VEuPathDBiHostDB:ENSMUSG00000036526

Phylogenomic databases

eggNOGiKOG0708, Eukaryota
GeneTreeiENSGT00940000158573
HOGENOMiCLU_009760_1_0_1
InParanoidiQ8CIS0
OMAiVTSGGHV
OrthoDBi115953at2759
PhylomeDBiQ8CIS0
TreeFamiTF351139

Enzyme and pathway databases

ReactomeiR-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-202424, Downstream TCR signaling
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-5607764, CLEC7A (Dectin-1) signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
108723, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Card11, mouse

Protein Ontology

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PROi
PR:Q8CIS0
RNActiQ8CIS0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036526, Expressed in spleen and 99 other tissues
GenevisibleiQ8CIS0, MM

Family and domain databases

CDDicd08808, CARD_CARD11_CARMA1, 1 hit
Gene3Di1.10.533.10, 1 hit
2.30.42.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR033538, CARD11
IPR042141, CARD_CARD11
IPR011029, DEATH-like_dom_sf
IPR027417, P-loop_NTPase
IPR036034, PDZ_sf
PANTHERiPTHR14559:SF4, PTHR14559:SF4, 1 hit
PfamiView protein in Pfam
PF00619, CARD, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAR11_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CIS0
Secondary accession number(s): Q4VA14, Q6KAS3, Q8BYV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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