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Protein

Transient receptor potential cation channel subfamily M member 6

Gene

Trpm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1786ATPBy similarity1
Binding sitei1810ATPBy similarity1
Binding sitei1882ATPBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1915ZincBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1929Proton acceptorBy similarity1
Binding sitei1931ATPBy similarity1
Binding sitei1939ATPBy similarity1
Metal bindingi1972ZincBy similarity1
Metal bindingi1974ZincBy similarity1
Metal bindingi1978ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1956 – 1962ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3295583 TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2675603 Trpm6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 747CytoplasmicSequence analysisAdd BLAST747
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 847ExtracellularSequence analysisAdd BLAST79
Transmembranei848 – 868HelicalSequence analysisAdd BLAST21
Topological domaini869 – 910CytoplasmicSequence analysisAdd BLAST42
Transmembranei911 – 931HelicalSequence analysisAdd BLAST21
Topological domaini932 – 945ExtracellularSequence analysisAdd BLAST14
Transmembranei946 – 966HelicalSequence analysisAdd BLAST21
Topological domaini967 – 978CytoplasmicSequence analysisAdd BLAST12
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Topological domaini1000 – 1018ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei1019 – 1039Pore-formingSequence analysisAdd BLAST21
Topological domaini1040 – 1053ExtracellularSequence analysisAdd BLAST14
Transmembranei1054 – 1074HelicalSequence analysisAdd BLAST21
Topological domaini1075 – 2028CytoplasmicSequence analysisAdd BLAST954

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153301 – 2028Transient receptor potential cation channel subfamily M member 6Add BLAST2028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1857Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CIR4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CIR4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CIR4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CIR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024727 Expressed in 84 organ(s), highest expression level in conjunctival fornix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CIR4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CIR4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with TRPM7. Interacts (via kinase domain) with RACK1 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037443

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8CIR4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CIR4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1756 – 1986Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST231

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230920

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055663

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CIR4

KEGG Orthology (KO)

More...
KOi
K04981

Identification of Orthologs from Complete Genome Data

More...
OMAi
NERMAMK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DHL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CIR4

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029597 TRPM6
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF15 PTHR13800:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811 Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8CIR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVKKSWIEG VFYKRECNKF IPSSKDPHRC TPGCQICHNL VRCYCGRLIE
60 70 80 90 100
EHHGLDRAWN LSVTEGHGDE QWSVEKHTVK SPTDTFGTIN FQDGEHIHHS
110 120 130 140 150
KYIRTSWDTK SDHLLHLMLK EWNMELPKLV ISVHGGLQNF KISSKLKETF
160 170 180 190 200
SQGLVKAAET TGAWIITEGI NSGVSKHVGD ALKAHSSKSL RKIWTVGIPP
210 220 230 240 250
WGVIENQREL VGKDVVCMYQ TLGNPLSKLT TLNCMHSHFI LCDDGTVGMY
260 270 280 290 300
GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVMEGGPNV ILWVWETVKN
310 320 330 340 350
KEPVVVCEGT GRAADLLAFT YKHLEDGGIL RPQVKEELFC LIQNMFNFSL
360 370 380 390 400
RQSKHLFQIL MECMVHKDSI TIFDADSEEH QDLDLAILTA LLKGTSLSIS
410 420 430 440 450
EQLNLAMAWD RMDIAKKHIL TYGQHWKPGA LEQAMLDALV MDRVDFVKLL
460 470 480 490 500
IENGVNLHRF LTIPRLEELY NTKQGPTNKF LRHLVQDVKQ HTLLSSYRIT
510 520 530 540 550
LIDIGLVIEY LIGGAYRSSY TRKSFRILYN NLYRKHKSVS SFAQGLSQHS
560 570 580 590 600
LHQRHSLRNR KESSESTLHS QFFRTAQPYK SKEKPEDSQK SKKKSKERQS
610 620 630 640 650
LSEEPEAAGF IYPYNDLLVW AVLMKRQNMA MFFWQHGEEA TVKAVIASIL
660 670 680 690 700
YRAMAREAKE SNMVDDTSEE LKNYSEQFGQ LALDVLEKAF KQNEPMAMKL
710 720 730 740 750
LTYELKNWSN STCLKLAVSG GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW
760 770 780 790 800
LKIIISILLP PMILTLEFKS KAEMSHVPQS QDFQFTWNYS DQGLSNTKES
810 820 830 840 850
ACVKDYDLER GPDEKPDEPL HLDLRNVPQS LPWTRRVYEF YSAPFVKFWF
860 870 880 890 900
YTMAYLAFLM LFTYTVLVEM QPQPSVHEWL VIIYIFTNAI EKVREICISE
910 920 930 940 950
PSKFKQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL QTAGRLIYCI
960 970 980 990 1000
DIIFWFSRLM DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA
1010 1020 1030 1040 1050
RKAILSPKEP PSWRLARDIV FEPYWMMYGE VYASDIDVCS NETSCPPGSF
1060 1070 1080 1090 1100
LTPFLQAVYL FVQYIIMVNL LIACFNNIYL DIKSISNKLW KYNRYRYIMT
1110 1120 1130 1140 1150
YHQKPWLPPP FILLNHLCLL LRGLCCRPAP QDQEEGDGGL KLYLTKDDLK
1160 1170 1180 1190 1200
KLHDFEEQCV EKYFHEKTEG LNCSFEEQIR MTSERVSEMF FQLKEMNEKV
1210 1220 1230 1240 1250
SFIKDSLLSL DSQVGHLQDL SAITVDTLKV LSAVDTLQED EILLANRKHS
1260 1270 1280 1290 1300
TCRKRPHSWT NVICAKVLSD MESCGKKKLQ YYSMPPSLLR SLARSQLPPS
1310 1320 1330 1340 1350
VQRGALVEVT HSKREASHVR EEQEEREMEQ RTTASGISHV RQAHSKYGQF
1360 1370 1380 1390 1400
LLVPSSGKQV PLSLETPPHL FRSSEEAGID GLVLEHIHQS DLTTHLPQQT
1410 1420 1430 1440 1450
PAASHQALVA EHKDQHEAVT QMSDKPAKAE QDLLAFSGTP APMTVTSLPS
1460 1470 1480 1490 1500
RAISMQDEGG YVNWAFSEND ETGVFSFKKK WKTCLASTCN SDSNPGGDYF
1510 1520 1530 1540 1550
LHTGGRSGLD NSRRLAQSCE CPAGPWTQAR RSFWINPLCR DKALIKSHSF
1560 1570 1580 1590 1600
RFHKEEKLRK TWKNNSHSKS LETRSTWLKA KLLTKTRSLS KKKRKTQGLQ
1610 1620 1630 1640 1650
VPVITVNACY QSDQLNAEPG ETNTTEEFSK KWLSVSNFSQ IGLEPYIYQK
1660 1670 1680 1690 1700
MKMKEIKRHT TQASDHLRQP QENRDKTPTW NSGSTSLSRS FLTRSPNEVH
1710 1720 1730 1740 1750
KISTSLKSPQ EPHHHYSAIE RNNLMRLSQT IPFTPIQLFT GEEVTIYKLE
1760 1770 1780 1790 1800
ESSPLTLDKS MSSWSQHGRA AMIQVLSQEE MDGGLRKAMR VISTWSEDDV
1810 1820 1830 1840 1850
LKPGQVFIVK SFLPEVVQTW YKIFQESTVL HLCLREIQQQ RAAQKLIYTF
1860 1870 1880 1890 1900
NQVKPQTIPY TPRFLEVSLV YCHSANQWLT IEKYMTGEFR KYNNNNGDEI
1910 1920 1930 1940 1950
APTNTLEELM LAFSHWTYEY TRGELLVLDL QGVGENLTDP SVIKPEDKQS
1960 1970 1980 1990 2000
RGMVFGPANL GEDAIRSFIA KHRCNSCCGK LRLPDLKRND YSLSRTHCNL
2010 2020
GFGQTIEPTE ELPERDKNRS SLEDHTRL
Length:2,028
Mass (Da):232,888
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3060C1D70DC9A20E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY135644 mRNA Translation: AAN15217.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29691.1

NCBI Reference Sequences

More...
RefSeqi
NP_700466.1, NM_153417.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.215171

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040489; ENSMUSP00000037443; ENSMUSG00000024727

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
225997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:225997

UCSC genome browser

More...
UCSCi
uc008gya.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135644 mRNA Translation: AAN15217.1
CCDSiCCDS29691.1
RefSeqiNP_700466.1, NM_153417.1
UniGeneiMm.215171

3D structure databases

ProteinModelPortaliQ8CIR4
SMRiQ8CIR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037443

PTM databases

iPTMnetiQ8CIR4
PhosphoSitePlusiQ8CIR4

Proteomic databases

PaxDbiQ8CIR4
PRIDEiQ8CIR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040489; ENSMUSP00000037443; ENSMUSG00000024727
GeneIDi225997
KEGGimmu:225997
UCSCiuc008gya.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140803
MGIiMGI:2675603 Trpm6

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000158164
HOGENOMiHOG000230920
HOVERGENiHBG055663
InParanoidiQ8CIR4
KOiK04981
OMAiNERMAMK
OrthoDBiEOG091G0DHL
PhylomeDBiQ8CIR4
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8CIR4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024727 Expressed in 84 organ(s), highest expression level in conjunctival fornix
ExpressionAtlasiQ8CIR4 baseline and differential
GenevisibleiQ8CIR4 MM

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029597 TRPM6
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF15 PTHR13800:SF15, 1 hit
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CIR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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