UniProtKB - Q8CII2 (CD123_MOUSE)

BLAST

>sp|Q8CII2|CD123_MOUSE Cell division cycle protein 123 homolog OS=Mus musculus OX=10090 GN=Cdc123 PE=1 SV=2
MKKEHVSHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPTCSQSDS
GNEAEETQWSDDESTATLTAPEFPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNS
SLKCKTLSDIFLLFKSSDFITHDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRC
FVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKEHLQYKFLDEDFVFDIYRDSRG
KVWLIDFNPFGEVTDSLLFTWEELTSENNLRGEVTEGDAQEQDSPAFRCTNSEVTVQPSP
YLSFGLPKDFVDLSTGEDAHKLIDFLKLKRNEQEDD

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History
Entry version 106 (07 Nov 2018)
Sequence version 2 (21 Mar 2006)
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Protein

Cell division cycle protein 123 homolog

Gene

Cdc123

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for S phase entry of the cell cycle.By similarity

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division

Biological process

Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division cycle protein 123 homolog
Gene namesⁱ	Name:Cdc123
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2138811 Cdc123

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000228664	1 – 336	Cell division cycle protein 123 homologAdd BLAST		336

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	60	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Phosphorylated.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8CII2
PaxDbⁱ	Q8CII2
PeptideAtlas More...PeptideAtlasⁱ	Q8CII2
PRIDEⁱ	Q8CII2

PTM databases

iPTMnetⁱ	Q8CII2
PhosphoSitePlusⁱ	Q8CII2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039128 Expressed in 288 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CDC123
ExpressionAtlasⁱ	Q8CII2 baseline and differential
Genevisibleⁱ	Q8CII2 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000043033

STRINGⁱ

10090.ENSMUSP00000043033

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CII2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CDC123 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2983 Eukaryota ENOG410XSVC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003057
HOGENOMⁱ	HOG000231938
HOVERGENⁱ	HBG080491
InParanoidⁱ	Q8CII2
OMAⁱ	CQFSVWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9C
PhylomeDBⁱ	Q8CII2
TreeFamⁱ	TF323348

Family and domain databases

InterProⁱ	View protein in InterPro IPR009772 CDC123
PANTHERⁱ	PTHR15323 PTHR15323, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07065 D123, 1 hit
PIRSFⁱ	PIRSF007807 Cdc123, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8CII2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKEHVSHCQ FSAWYPLFRS LTIKSVILPL PQNVKDYLLD DGTLVVSGRE 
        60         70         80         90        100
DPPTCSQSDS GNEAEETQWS DDESTATLTA PEFPEFNTQV QEAINSLGGS 
       110        120        130        140        150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI THDFTQPFIH 
       160        170        180        190        200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD 
       210        220        230        240        250
HISKQKEEIC RCIQDFFKEH LQYKFLDEDF VFDIYRDSRG KVWLIDFNPF 
       260        270        280        290        300
GEVTDSLLFT WEELTSENNL RGEVTEGDAQ EQDSPAFRCT NSEVTVQPSP 
       310        320        330 
YLSFGLPKDF VDLSTGEDAH KLIDFLKLKR NEQEDD

Length:336

Mass (Da):38,816

Last modified:March 21, 2006 - v2

Checksum:ⁱ1E59461A424B7A76

Isoform 2 (identifier: Q8CII2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
164-194: LVLRKWCELIPGAEFRCFVKENKLIGISQRD → PNLVQCLYLHDLCLPARATTYLLSIAFKIAP
195-336: Missing.

« Hide

        10         20         30         40         50
MKKEHVSHCQ FSAWYPLFRS LTIKSVILPL PQNVKDYLLD DGTLVVSGRE 
        60         70         80         90        100
DPPTCSQSDS GNEAEETQWS DDESTATLTA PEFPEFNTQV QEAINSLGGS 
       110        120        130        140        150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI THDFTQPFIH 
       160        170        180        190 
CTDDSPDPCI EYEPNLVQCL YLHDLCLPAR ATTYLLSIAF KIAP

Note: No experimental confirmation available.

Show »

Length:194

Mass (Da):21,833

Checksum:ⁱ5C3BBC8106FA9830

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A6YVX4	A0A0A6YVX4_MOUSE		Cell division cycle protein 123 hom... Cell division cycle protein 123 homolog	Cdc123	134	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	213	I → T in AAH23821 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017691	164 – 194	LVLRK…ISQRD → PNLVQCLYLHDLCLPARATT YLLSIAFKIAP in isoform 2. 1 PublicationAdd BLAST		31
Alternative sequenceⁱVSP_017692	195 – 336	Missing in isoform 2. 1 PublicationAdd BLAST		142

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090122 mRNA Translation: BAC41103.1 AK141463 mRNA Translation: BAE24692.1 AK159208 mRNA Translation: BAE34899.1 AK161246 mRNA Translation: BAE36265.1 BC019753 mRNA Translation: AAH19753.1 BC022972 mRNA Translation: AAH22972.1 BC023821 mRNA Translation: AAH23821.1 BC024787 mRNA Translation: AAH24787.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15666.1 [Q8CII2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_598598.1, NM_133837.4 [Q8CII2-1] XP_006497629.1, XM_006497566.2
UniGeneⁱ	Mm.181490

Genome annotation databases

Ensemblⁱ	ENSMUST00000043864; ENSMUSP00000043033; ENSMUSG00000039128 [Q8CII2-1]
GeneIDⁱ	98828
KEGGⁱ	mmu:98828
UCSC genome browser More...UCSCⁱ	uc008ift.1 mouse [Q8CII2-1] uc008ifu.1 mouse [Q8CII2-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CII2	Cell division cycle protein 123 (Fragment)		MUSSP		229	UniRef100_Q8CII2

Protein	Similar proteins		Species	Score	Length	Source
Q8CII2	Cell division cycle protein 123 homolog		HUMAN		336	UniRef90_O75794
Cell division cycle protein 123 homolog		MACFA		336
Cell division cycle protein 123 homolog		RAT		336
Cell division cycle protein 123 homolog		BOVIN		335
CDC123 isoform 8 (Fragment)		PANTR		157
+103

Protein	Similar proteins		Species	Score	Length	Source
Q8CII2	Cell division cycle protein 123 homolog		HUMAN		336	UniRef50_O75794
Cell division cycle protein 123 homolog		RAT		336
Cell division cycle protein 123 homolog		MACFA		336
Cell division cycle protein 123 homolog		BOVIN		335
CDC123 isoform 8 (Fragment)		PANTR		157
+151
Q8CII2-2	Uncharacterized protein		COLVI		194	UniRef50_Q8CII2-2
Uncharacterized protein		NEOLE		233
UPI0003D768D7		MOUSE		183
UPI0005214D8F		APAVI		162

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090122 mRNA Translation: BAC41103.1 AK141463 mRNA Translation: BAE24692.1 AK159208 mRNA Translation: BAE34899.1 AK161246 mRNA Translation: BAE36265.1 BC019753 mRNA Translation: AAH19753.1 BC022972 mRNA Translation: AAH22972.1 BC023821 mRNA Translation: AAH23821.1 BC024787 mRNA Translation: AAH24787.1
CCDSⁱ	CCDS15666.1 [Q8CII2-1]
RefSeqⁱ	NP_598598.1, NM_133837.4 [Q8CII2-1] XP_006497629.1, XM_006497566.2
UniGeneⁱ	Mm.181490

3D structure databases

ProteinModelPortalⁱ	Q8CII2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000043033

STRINGⁱ

10090.ENSMUSP00000043033

PTM databases

iPTMnetⁱ	Q8CII2
PhosphoSitePlusⁱ	Q8CII2

Proteomic databases

EPDⁱ	Q8CII2
PaxDbⁱ	Q8CII2
PeptideAtlasⁱ	Q8CII2
PRIDEⁱ	Q8CII2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043864; ENSMUSP00000043033; ENSMUSG00000039128 [Q8CII2-1]
GeneIDⁱ	98828
KEGGⁱ	mmu:98828
UCSCⁱ	uc008ift.1 mouse [Q8CII2-1] uc008ifu.1 mouse [Q8CII2-2]

Organism-specific databases

CTDⁱ	8872
MGIⁱ	MGI:2138811 Cdc123

Phylogenomic databases

eggNOGⁱ	KOG2983 Eukaryota ENOG410XSVC LUCA
GeneTreeⁱ	ENSGT00390000003057
HOGENOMⁱ	HOG000231938
HOVERGENⁱ	HBG080491
InParanoidⁱ	Q8CII2
OMAⁱ	CQFSVWY
OrthoDBⁱ	EOG091G0A9C
PhylomeDBⁱ	Q8CII2
TreeFamⁱ	TF323348

Miscellaneous databases

ChiTaRSⁱ	Cdc123 mouse
Protein Ontology More...PROⁱ	PR:Q8CII2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039128 Expressed in 288 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CDC123
ExpressionAtlasⁱ	Q8CII2 baseline and differential
Genevisibleⁱ	Q8CII2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR009772 CDC123
PANTHERⁱ	PTHR15323 PTHR15323, 1 hit
Pfamⁱ	View protein in Pfam PF07065 D123, 1 hit
PIRSFⁱ	PIRSF007807 Cdc123, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD123_MOUSE
Accessionⁱ	Q8CII2Primary (citable) accession number: Q8CII2 Secondary accession number(s): Q3TTR0, Q8VE51
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	March 21, 2006
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CII2 (CD123_MOUSE)

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Cell division cycle protein 123 homolog

Cdc123

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ