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UniProtKB - Q8CII2 (CD123_MOUSE)
Protein
Cell division cycle protein 123 homolog
Gene
Cdc123
Organism
Mus musculus (Mouse)
Status
Functioni
Required for S phase entry of the cell cycle.
By similarityGO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle protein 123 homolog |
Gene namesi | Name:Cdc123 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2138811, Cdc123 |
VEuPathDBi | HostDB:ENSMUSG00000039128 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000228664 | 1 – 336 | Cell division cycle protein 123 homologAdd BLAST | 336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8CII2 |
MaxQBi | Q8CII2 |
PaxDbi | Q8CII2 |
PeptideAtlasi | Q8CII2 |
PRIDEi | Q8CII2 |
ProteomicsDBi | 281131 [Q8CII2-1] 281132 [Q8CII2-2] |
PTM databases
iPTMneti | Q8CII2 |
PhosphoSitePlusi | Q8CII2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039128, Expressed in limb and 310 other tissues |
ExpressionAtlasi | Q8CII2, baseline and differential |
Genevisiblei | Q8CII2, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 221145, 1 interactor |
STRINGi | 10090.ENSMUSP00000043033 |
Miscellaneous databases
RNActi | Q8CII2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 73 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 50 – 64 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the CDC123 family.Curated
Phylogenomic databases
eggNOGi | KOG2983, Eukaryota |
GeneTreei | ENSGT00390000003057 |
HOGENOMi | CLU_034402_0_0_1 |
InParanoidi | Q8CII2 |
OMAi | RDLNHFD |
OrthoDBi | 1539674at2759 |
PhylomeDBi | Q8CII2 |
TreeFami | TF323348 |
Family and domain databases
InterProi | View protein in InterPro IPR009772, CDC123 |
PANTHERi | PTHR15323, PTHR15323, 1 hit |
Pfami | View protein in Pfam PF07065, D123, 1 hit |
PIRSFi | PIRSF007807, Cdc123, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CII2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKEHVSHCQ FSAWYPLFRS LTIKSVILPL PQNVKDYLLD DGTLVVSGRE
60 70 80 90 100
DPPTCSQSDS GNEAEETQWS DDESTATLTA PEFPEFNTQV QEAINSLGGS
110 120 130 140 150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI THDFTQPFIH
160 170 180 190 200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD
210 220 230 240 250
HISKQKEEIC RCIQDFFKEH LQYKFLDEDF VFDIYRDSRG KVWLIDFNPF
260 270 280 290 300
GEVTDSLLFT WEELTSENNL RGEVTEGDAQ EQDSPAFRCT NSEVTVQPSP
310 320 330
YLSFGLPKDF VDLSTGEDAH KLIDFLKLKR NEQEDD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YVX4 | A0A0A6YVX4_MOUSE | Cell division cycle protein 123 hom... | Cdc123 | 134 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 213 | I → T in AAH23821 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017691 | 164 – 194 | LVLRK…ISQRD → PNLVQCLYLHDLCLPARATT YLLSIAFKIAP in isoform 2. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_017692 | 195 – 336 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090122 mRNA Translation: BAC41103.1 AK141463 mRNA Translation: BAE24692.1 AK159208 mRNA Translation: BAE34899.1 AK161246 mRNA Translation: BAE36265.1 BC019753 mRNA Translation: AAH19753.1 BC022972 mRNA Translation: AAH22972.1 BC023821 mRNA Translation: AAH23821.1 BC024787 mRNA Translation: AAH24787.1 |
CCDSi | CCDS15666.1 [Q8CII2-1] |
RefSeqi | NP_598598.1, NM_133837.4 [Q8CII2-1] XP_006497629.1, XM_006497566.2 |
Genome annotation databases
Ensembli | ENSMUST00000043864; ENSMUSP00000043033; ENSMUSG00000039128 [Q8CII2-1] |
GeneIDi | 98828 |
KEGGi | mmu:98828 |
UCSCi | uc008ift.1, mouse [Q8CII2-1] uc008ifu.1, mouse [Q8CII2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090122 mRNA Translation: BAC41103.1 AK141463 mRNA Translation: BAE24692.1 AK159208 mRNA Translation: BAE34899.1 AK161246 mRNA Translation: BAE36265.1 BC019753 mRNA Translation: AAH19753.1 BC022972 mRNA Translation: AAH22972.1 BC023821 mRNA Translation: AAH23821.1 BC024787 mRNA Translation: AAH24787.1 |
CCDSi | CCDS15666.1 [Q8CII2-1] |
RefSeqi | NP_598598.1, NM_133837.4 [Q8CII2-1] XP_006497629.1, XM_006497566.2 |
3D structure databases
SMRi | Q8CII2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 221145, 1 interactor |
STRINGi | 10090.ENSMUSP00000043033 |
PTM databases
iPTMneti | Q8CII2 |
PhosphoSitePlusi | Q8CII2 |
Proteomic databases
EPDi | Q8CII2 |
MaxQBi | Q8CII2 |
PaxDbi | Q8CII2 |
PeptideAtlasi | Q8CII2 |
PRIDEi | Q8CII2 |
ProteomicsDBi | 281131 [Q8CII2-1] 281132 [Q8CII2-2] |
Protocols and materials databases
Antibodypediai | 24692, 402 antibodies from 31 providers |
Genome annotation databases
Ensembli | ENSMUST00000043864; ENSMUSP00000043033; ENSMUSG00000039128 [Q8CII2-1] |
GeneIDi | 98828 |
KEGGi | mmu:98828 |
UCSCi | uc008ift.1, mouse [Q8CII2-1] uc008ifu.1, mouse [Q8CII2-2] |
Organism-specific databases
CTDi | 8872 |
MGIi | MGI:2138811, Cdc123 |
VEuPathDBi | HostDB:ENSMUSG00000039128 |
Phylogenomic databases
eggNOGi | KOG2983, Eukaryota |
GeneTreei | ENSGT00390000003057 |
HOGENOMi | CLU_034402_0_0_1 |
InParanoidi | Q8CII2 |
OMAi | RDLNHFD |
OrthoDBi | 1539674at2759 |
PhylomeDBi | Q8CII2 |
TreeFami | TF323348 |
Miscellaneous databases
BioGRID-ORCSi | 98828, 23 hits in 65 CRISPR screens |
ChiTaRSi | Cdc123, mouse |
PROi | PR:Q8CII2 |
RNActi | Q8CII2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039128, Expressed in limb and 310 other tissues |
ExpressionAtlasi | Q8CII2, baseline and differential |
Genevisiblei | Q8CII2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009772, CDC123 |
PANTHERi | PTHR15323, PTHR15323, 1 hit |
Pfami | View protein in Pfam PF07065, D123, 1 hit |
PIRSFi | PIRSF007807, Cdc123, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD123_MOUSE | |
Accessioni | Q8CII2Primary (citable) accession number: Q8CII2 Secondary accession number(s): Q3TTR0, Q8VE51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 23, 2022 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families