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Protein

Zinc finger and BTB domain-containing protein 8B

Gene

Zbtb8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri331 – 353C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri359 – 382C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8B
Gene namesi
Name:Zbtb8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387181 Zbtb8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477221 – 484Zinc finger and BTB domain-containing protein 8BAdd BLAST484

Proteomic databases

PaxDbiQ8CII0
PRIDEiQ8CII0

PTM databases

PhosphoSitePlusiQ8CII0

Interactioni

Protein-protein interaction databases

BioGridi229641, 1 interactor
STRINGi10090.ENSMUSP00000058157

Structurei

3D structure databases

ProteinModelPortaliQ8CII0
SMRiQ8CII0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 149Ala-richAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri331 – 353C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri359 – 382C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000124661
InParanoidiQ8CII0
KOiK10495
PhylomeDBiQ8CII0

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CII0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQSYCAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR
60 70 80 90 100
ALLLHYIQDS GRHSTASLDI VTSDAFSTIL DFLYSGKLDL CGENVIEVMS
110 120 130 140 150
AASYLQMNEV VNFCKTYIRS SLDICRKMEK EAAVAAAMAA AAAAAAAAAH
160 170 180 190 200
QIDSESPSSG LEGTSCGTKS FVSSPVDGEG SLDCTISSCD DCHPLELVAK
210 220 230 240 250
DSQGSGVSDN DLCVVPRRVE PKVEFDVARV EVEADEQLQQ YAAPLAHMEE
260 270 280 290 300
GLPSNQALDL TYSSYHVKQF LEALLRNGAV QSKDDLDCHS SRGLEGRLEG
310 320 330 340 350
PGVAMSSVMD VQNDWYREDA GDVLVVPIKL HRCPFCPYTA KQKGILKRHI
360 370 380 390 400
RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSSRPIIC KGCRRTFTSH
410 420 430 440 450
LSQGLRRFGL CDSCTCVTDP QEEEDDLMPV NLSLVEASSE SHEKSDTDDW
460 470 480
PIYIESGEEN DPTAEDSDDK PHIRPNLPAP ETLT
Length:484
Mass (Da):53,387
Last modified:March 1, 2003 - v1
Checksum:iB4FF082555B0CA1A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HLR7I7HLR7_MOUSE
Zinc finger and BTB domain-containi...
Zbtb8b
517Annotation score:
A0A0R4J0Q8A0A0R4J0Q8_MOUSE
Zinc finger and BTB domain-containi...
Zbtb8b
484Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263S → N in BAE37541 (PubMed:16141072).Curated1
Sequence conflicti263S → N in BAE24519 (PubMed:16141072).Curated1
Sequence conflicti263S → N in BAE20999 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132152 mRNA Translation: BAE20999.1
AK140914 mRNA Translation: BAE24519.1
AK163930 mRNA Translation: BAE37541.1
BC023839 mRNA Translation: AAH23839.1
CCDSiCCDS18691.1
RefSeqiNP_705769.2, NM_153541.3
UniGeneiMm.428660
Mm.458339

Genome annotation databases

GeneIDi215627
KEGGimmu:215627

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132152 mRNA Translation: BAE20999.1
AK140914 mRNA Translation: BAE24519.1
AK163930 mRNA Translation: BAE37541.1
BC023839 mRNA Translation: AAH23839.1
CCDSiCCDS18691.1
RefSeqiNP_705769.2, NM_153541.3
UniGeneiMm.428660
Mm.458339

3D structure databases

ProteinModelPortaliQ8CII0
SMRiQ8CII0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229641, 1 interactor
STRINGi10090.ENSMUSP00000058157

PTM databases

PhosphoSitePlusiQ8CII0

Proteomic databases

PaxDbiQ8CII0
PRIDEiQ8CII0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi215627
KEGGimmu:215627

Organism-specific databases

CTDi728116
MGIiMGI:2387181 Zbtb8b

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000124661
InParanoidiQ8CII0
KOiK10495
PhylomeDBiQ8CII0

Miscellaneous databases

PROiPR:Q8CII0
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT8B_MOUSE
AccessioniPrimary (citable) accession number: Q8CII0
Secondary accession number(s): Q3US18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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