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Entry version 127 (11 Dec 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Lysine-specific histone demethylase 1B

Gene

Kdm1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.2 Publications

Miscellaneous

Acetylation of 'Lys-9' decreases the binding of the substrate, while hyperacetylation of 'Lys-9', 'Lys-14' and 'Lys-18', phosphorylation of 'Thr3' or 'Ser-10', and methylation of 'Arg-2' or 'Arg-8' abolishes its binding. Methylation of 'Lys-9' and 'Arg-17' are the only two epigenetic modifications that have no significant effect on catalysis.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by tranylcypromine, but not by pargyline, deprenyl or rasagiline (PubMed:19407342). Histone H3K4me1 and H3K4me2 demethylase activity is enhanced by GLYR1 (By similarity).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=9.2 µM for mono-methylated 'Lys-4' histone H3 N-terminal peptide1 Publication
  2. KM=11.3 µM for di-methylated 'Lys-4' histone H3 N-terminal peptide1 Publication
  3. KM=9.0 µM for mono-methylated 'Lys-4', mono-methylated 'Lys-9' histone H3 N-terminal peptide1 Publication
  4. KM=6.6 µM for di-methylated 'Lys-4', di-methylated 'Lys-9' histone H3 N-terminal peptide1 Publication
  5. KM=70.5 µM for mono-methylated 'Lys-4', acetylated 'Lys-9' histone H3 N-terminal peptide1 Publication
  6. KM=8.1 µM for mono-methylated 'Lys-4', mono-methylated 'Arg-17' histone H3 N-terminal peptide1 Publication

    pH dependencei

    Optimum pH is 8.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53Zinc 1By similarity1
    Metal bindingi58Zinc 1By similarity1
    Metal bindingi65Zinc 2By similarity1
    Metal bindingi73Zinc 2By similarity1
    Metal bindingi84Zinc 1; via pros nitrogenBy similarity1
    Metal bindingi90Zinc 1; via tele nitrogenBy similarity1
    Metal bindingi92Zinc 2By similarity1
    Metal bindingi95Zinc 2By similarity1
    Metal bindingi142Zinc 3By similarity1
    Metal bindingi147Zinc 3By similarity1
    Metal bindingi169Zinc 3By similarity1
    Metal bindingi185Zinc 3By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei604FAD; via amide nitrogen and carbonyl oxygenBy similarity1
    Binding sitei799FAD; via amide nitrogenBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri133 – 193CW-typePROSITE-ProRule annotationAdd BLAST61
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi389 – 445FADSequence analysisBy similarityAdd BLAST57
    Nucleotide bindingi807 – 809FADBy similarity3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionChromatin regulator, Developmental protein, Oxidoreductase, Repressor
    Biological processTranscription, Transcription regulation
    LigandFAD, Flavoprotein, Metal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-3214842 HDMs demethylate histones
    R-MMU-5689603 UCH proteinases

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lysine-specific histone demethylase 1B (EC:1.-.-.-)
    Alternative name(s):
    Flavin-containing amine oxidase domain-containing protein 1
    Lysine-specific histone demethylase 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Kdm1b
    Synonyms:Aof1, Lsd2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2145261 Kdm1b

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    No effect on mouse development and oogenesis, but embryos derived from oocytes from Kdm1b-deficient females die before mid-gestation.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi667K → A: Loss of activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002473371 – 826Lysine-specific histone demethylase 1BAdd BLAST826

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
    Modified residuei26PhosphoserineBy similarity1
    Modified residuei253PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8CIG3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8CIG3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8CIG3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8CIG3

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8CIG3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8CIG3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in growing oocytes and in intestinal gland.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000038080 Expressed in 254 organ(s), highest expression level in gonadal ridge

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8CIG3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8CIG3 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with its cofactor GLYR1 at nucleosomes; this interaction stimulates H3K4me1 and H3K4me2 demethylation (By similarity). Does not form a complex with RCOR1/CoREST.

    By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    230002, 1 interactor

    Database of interacting proteins

    More...
    DIPi
    DIP-59111N

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000038373

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8CIG3 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8CIG3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 379SWIRMPROSITE-ProRule annotationAdd BLAST99

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni279 – 298GLYR1-bindingBy similarityAdd BLAST20
    Regioni444 – 473Histone H3-bindingBy similarityAdd BLAST30
    Regioni493 – 504Histone H3-bindingBy similarityAdd BLAST12
    Regioni544 – 578Histone H3-bindingBy similarityAdd BLAST35
    Regioni570 – 572GLYR1-bindingBy similarity3
    Regioni802 – 818GLYR1-bindingBy similarityAdd BLAST17

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The SWIRM domain may act as an anchor site for a histone tail.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri133 – 193CW-typePROSITE-ProRule annotationAdd BLAST61

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0029 Eukaryota
    ENOG410XSNC LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157751

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000230870

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8CIG3

    KEGG Orthology (KO)

    More...
    KOi
    K19413

    Database of Orthologous Groups

    More...
    OrthoDBi
    1034142at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8CIG3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF352593

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.10.10, 1 hit
    3.50.50.60, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002937 Amino_oxidase
    IPR036188 FAD/NAD-bd_sf
    IPR009057 Homeobox-like_sf
    IPR007526 SWIRM
    IPR036388 WH-like_DNA-bd_sf
    IPR011124 Znf_CW

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01593 Amino_oxidase, 1 hit
    PF04433 SWIRM, 1 hit
    PF07496 zf-CW, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46689 SSF46689, 1 hit
    SSF51905 SSF51905, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50934 SWIRM, 1 hit
    PS51050 ZF_CW, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8CIG3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAASRGRSKK RSNLELSPDN LPLRSSGRQA KKKAVEIPDE DEDGSSEKKY
    60 70 80 90 100
    RKCEKAGCTA AYPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY
    110 120 130 140 150
    RSHKDGYDKY SAWKRVWTSN GKTEPSPKAF MADQQLPYWV QCTKPECGKW
    160 170 180 190 200
    RQLTKEIQLT PHMARTYRCG MKPNTITKPD TPDHCSFPED LRVLEVSNHW
    210 220 230 240 250
    WYPMLIQPPL LKDSVAAPLL SAYYPDCVGM SPSCTSTHRA TVTAATTTTG
    260 270 280 290 300
    SASPGEMEPS KAAPSSLVLG MNRYFQPFYQ PNECGKALCV RPDVMELDEL
    310 320 330 340 350
    YEFPEYSRDP TMYLALRNLI LALWYTNCKE ALTPQKCIPH IIVRGLVRIR
    360 370 380 390 400
    CVQEVERILY FMTRKGLINT GVLTVAAGQH LLPKHYHNKS VLVVGAGPAG
    410 420 430 440 450
    LAAARQLHNF GMKVTVLEAK DRIGGRVWDD KSFKGVVVGR GPQIVNGCIN
    460 470 480 490 500
    NPVALMCEQL GISMRKLGER CDLIQEGGRI TDPTVDKRMD FHFNALLDVV
    510 520 530 540 550
    SEWRKDKTLL QDVPLGEKIE EIYRAFVKES GIQFSELEGQ VLQFHLSNLE
    560 570 580 590 600
    YACGSSLHQV SARSWDHNEF FAQFAGDHTL LTPGYSTIIE KLAEGLDIRL
    610 620 630 640 650
    KSPVQSIDYT GDEVQVTTTD GMGHSAQKVL VTVPLAILQR GAIQFNPPLS
    660 670 680 690 700
    EKKMKAINSL GAGIIEKIAL QFPYRFWDSK VQGADFFGHV PPSASQRGLF
    710 720 730 740 750
    AVFYDMDSQQ SVLMSVITGE AVASLRTMDD KQVLQQCMGI LRELFKEQEI
    760 770 780 790 800
    PEPTKYFVTR WSTEPWIQMA YSFVKTFGSG EAYDIIAEEI QGTVFFAGEA
    810 820
    TNRHFPQTVT GAYLSGVREA SKIAAF
    Length:826
    Mass (Da):92,633
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02FD6FE991B1C030
    GO
    Isoform 2 (identifier: Q8CIG3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         459-558: Missing.

    Show »
    Length:726
    Mass (Da):81,183
    Checksum:iA1DDEA3678E43BE8
    GO
    Isoform 3 (identifier: Q8CIG3-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-621: Missing.

    Show »
    Length:205
    Mass (Da):22,813
    Checksum:i1277A6D29E57E50C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D3Z353D3Z353_MOUSE
    Lysine-specific histone demethylase...
    Kdm1b
    176Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6V3V2F6V3V2_MOUSE
    Lysine-specific histone demethylase...
    Kdm1b
    443Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAC26005 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence BAC37460 differs from that shown. Reason: Frameshift.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0199681 – 621Missing in isoform 3. 1 PublicationAdd BLAST621
    Alternative sequenceiVSP_019969459 – 558Missing in isoform 2. 1 PublicationAdd BLAST100

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK028553 mRNA Translation: BAC26005.1 Different initiation.
    AK078920 mRNA Translation: BAC37460.1 Frameshift.
    BC023917 mRNA Translation: AAH23917.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS26489.1 [Q8CIG3-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_758466.1, NM_172262.3 [Q8CIG3-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000037025; ENSMUSP00000038373; ENSMUSG00000038080 [Q8CIG3-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    218214

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:218214

    UCSC genome browser

    More...
    UCSCi
    uc007qht.3 mouse [Q8CIG3-1]
    uc007qhu.3 mouse [Q8CIG3-2]
    uc011yyy.2 mouse [Q8CIG3-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK028553 mRNA Translation: BAC26005.1 Different initiation.
    AK078920 mRNA Translation: BAC37460.1 Frameshift.
    BC023917 mRNA Translation: AAH23917.1
    CCDSiCCDS26489.1 [Q8CIG3-1]
    RefSeqiNP_758466.1, NM_172262.3 [Q8CIG3-1]

    3D structure databases

    SMRiQ8CIG3
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi230002, 1 interactor
    DIPiDIP-59111N
    STRINGi10090.ENSMUSP00000038373

    PTM databases

    iPTMnetiQ8CIG3
    PhosphoSitePlusiQ8CIG3

    Proteomic databases

    EPDiQ8CIG3
    PaxDbiQ8CIG3
    PeptideAtlasiQ8CIG3
    PRIDEiQ8CIG3

    Genome annotation databases

    EnsembliENSMUST00000037025; ENSMUSP00000038373; ENSMUSG00000038080 [Q8CIG3-1]
    GeneIDi218214
    KEGGimmu:218214
    UCSCiuc007qht.3 mouse [Q8CIG3-1]
    uc007qhu.3 mouse [Q8CIG3-2]
    uc011yyy.2 mouse [Q8CIG3-3]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    221656
    MGIiMGI:2145261 Kdm1b

    Phylogenomic databases

    eggNOGiKOG0029 Eukaryota
    ENOG410XSNC LUCA
    GeneTreeiENSGT00940000157751
    HOGENOMiHOG000230870
    InParanoidiQ8CIG3
    KOiK19413
    OrthoDBi1034142at2759
    PhylomeDBiQ8CIG3
    TreeFamiTF352593

    Enzyme and pathway databases

    ReactomeiR-MMU-3214842 HDMs demethylate histones
    R-MMU-5689603 UCH proteinases

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Kdm1b mouse

    Protein Ontology

    More...
    PROi
    PR:Q8CIG3
    RNActiQ8CIG3 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000038080 Expressed in 254 organ(s), highest expression level in gonadal ridge
    ExpressionAtlasiQ8CIG3 baseline and differential
    GenevisibleiQ8CIG3 MM

    Family and domain databases

    Gene3Di1.10.10.10, 1 hit
    3.50.50.60, 1 hit
    InterProiView protein in InterPro
    IPR002937 Amino_oxidase
    IPR036188 FAD/NAD-bd_sf
    IPR009057 Homeobox-like_sf
    IPR007526 SWIRM
    IPR036388 WH-like_DNA-bd_sf
    IPR011124 Znf_CW
    PfamiView protein in Pfam
    PF01593 Amino_oxidase, 1 hit
    PF04433 SWIRM, 1 hit
    PF07496 zf-CW, 1 hit
    SUPFAMiSSF46689 SSF46689, 1 hit
    SSF51905 SSF51905, 1 hit
    PROSITEiView protein in PROSITE
    PS50934 SWIRM, 1 hit
    PS51050 ZF_CW, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM1B_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CIG3
    Secondary accession number(s): Q8C5C4, Q8CEC1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2003
    Last modified: December 11, 2019
    This is version 127 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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