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Protein

DEP domain-containing protein 1A

Gene

Depdc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 1A
Gene namesi
Name:Depdc1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1923381 Depdc1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847871 – 804DEP domain-containing protein 1AAdd BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CIG0
PRIDEiQ8CIG0

PTM databases

iPTMnetiQ8CIG0
PhosphoSitePlusiQ8CIG0

Expressioni

Gene expression databases

BgeeiENSMUSG00000028175 Expressed in 24 organ(s), highest expression level in liver
CleanExiMM_DEPDC1A
ExpressionAtlasiQ8CIG0 baseline and differential
GenevisibleiQ8CIG0 MM

Interactioni

Subunit structurei

Can form dimers. Interacts with ZNF224 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113216

Structurei

3D structure databases

ProteinModelPortaliQ8CIG0
SMRiQ8CIG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 108DEPPROSITE-ProRule annotationAdd BLAST85
Domaini282 – 322Rho-GAPAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni592 – 647Interaction with ZNF224By similarityAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili726 – 760Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOGENOMiHOG000013064
HOVERGENiHBG059792
InParanoidiQ8CIG0
OMAiNIKSRCY
PhylomeDBiQ8CIG0

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CIG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERQGAPLGP YRATKLWNEV TTSFRVGMPL RKHRQHLKKY SNCFTAVEAI
60 70 80 90 100
DWLYDLLRSN SNFGPEVTRQ QTIQLLRKFL KNHVIEDIKG RWGSESLDDN
110 120 130 140 150
NQLFRFPATS PLKTFPQRHT EIKKTNTEYF SKDKDGIFKL RNLSQKTSKK
160 170 180 190 200
RGLHFSQENT EKINHERITN EDLEIAPDNQ EISQEDVEEV WRYVIMIYLQ
210 220 230 240 250
TILSLPSIEE LLNPNQVIPQ YIMYNMANTS KHGVVILQDK SDDLPHWVLS
260 270 280 290 300
AMKCLANWPR SNDTNNLTYV GFERDVFKTI ADYFLNLPEP LLTFEYYELF
310 320 330 340 350
VNILVVCGYI TVSDRTSGIH KIQDDPRSSK IHDLSNLNSF KSTECLLLSL
360 370 380 390 400
LYKDKSNEEL DSTKRLQRND QGFQERCAKK MQLDNLRNRR ASANDIMGGS
410 420 430 440 450
CHNLIGLSNT NALSSNIKPR CSSLEGIVDR PVNSSEKKSS IFYQSVLNIE
460 470 480 490 500
EQNSKQSLVS APKQTPLFNL HSDENAQQPH CVGFNRTSAL TVQDQEELCN
510 520 530 540 550
EKYKSKQLCR SQSLLLRSST RQNSCINKPV AEIIMKPNVG QGSTSELGES
560 570 580 590 600
STTINKRLCK STIELSEKSL PPAASVLTGT QSLLQPHLER VAINALQLCC
610 620 630 640 650
LLLPPPNRRK LQLLMRMISR MSQNVDMPKL HEQIGTRSLM INTFSRCVLC
660 670 680 690 700
CAEEVDLDEL LASRLVSFLM DHHQEILQVP TYLQAAVEKH LDYIKKGNVK
710 720 730 740 750
NHGDGLVVPL PTYSYCKQIS AKEFDEQKIS TSQAAIAELL ENIVRSKSLS
760 770 780 790 800
LKEKRRKLKQ KEYPLIYQKR FPTTESEAAL FDDKPTIKQP MLNLRNPKLH

SLRY
Length:804
Mass (Da):92,201
Last modified:March 1, 2003 - v1
Checksum:iC811F34A87EE33D9
GO
Isoform 2 (identifier: Q8CIG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: V → G
     306-582: Missing.
     760-760: Q → QFQ

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):61,785
Checksum:i257B6657E242D591
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6J1D3Z6J1_MOUSE
DEP domain containing 1a, isoform C...
Depdc1a mCG_2598
806Annotation score:

Sequence cautioni

The sequence AAH05799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024656305V → G in isoform 2. 2 Publications1
Alternative sequenceiVSP_024657306 – 582Missing in isoform 2. 2 PublicationsAdd BLAST277
Alternative sequenceiVSP_024658760Q → QFQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050456 mRNA Translation: BAC34267.1
AK088719 mRNA Translation: BAC40526.1
BC005799 mRNA Translation: AAH05799.1 Different initiation.
BC023934 mRNA Translation: AAH23934.1
CCDSiCCDS17936.1 [Q8CIG0-1]
CCDS51106.1 [Q8CIG0-2]
RefSeqiNP_001165563.1, NM_001172092.1
NP_001165564.1, NM_001172093.1 [Q8CIG0-2]
NP_083799.2, NM_029523.3 [Q8CIG0-1]
UniGeneiMm.371655

Genome annotation databases

EnsembliENSMUST00000029825; ENSMUSP00000029825; ENSMUSG00000028175 [Q8CIG0-1]
ENSMUST00000106041; ENSMUSP00000101656; ENSMUSG00000028175 [Q8CIG0-2]
GeneIDi76131
KEGGimmu:76131
UCSCiuc008rvy.2 mouse [Q8CIG0-1]
uc008rwa.2 mouse [Q8CIG0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050456 mRNA Translation: BAC34267.1
AK088719 mRNA Translation: BAC40526.1
BC005799 mRNA Translation: AAH05799.1 Different initiation.
BC023934 mRNA Translation: AAH23934.1
CCDSiCCDS17936.1 [Q8CIG0-1]
CCDS51106.1 [Q8CIG0-2]
RefSeqiNP_001165563.1, NM_001172092.1
NP_001165564.1, NM_001172093.1 [Q8CIG0-2]
NP_083799.2, NM_029523.3 [Q8CIG0-1]
UniGeneiMm.371655

3D structure databases

ProteinModelPortaliQ8CIG0
SMRiQ8CIG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113216

PTM databases

iPTMnetiQ8CIG0
PhosphoSitePlusiQ8CIG0

Proteomic databases

PaxDbiQ8CIG0
PRIDEiQ8CIG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029825; ENSMUSP00000029825; ENSMUSG00000028175 [Q8CIG0-1]
ENSMUST00000106041; ENSMUSP00000101656; ENSMUSG00000028175 [Q8CIG0-2]
GeneIDi76131
KEGGimmu:76131
UCSCiuc008rvy.2 mouse [Q8CIG0-1]
uc008rwa.2 mouse [Q8CIG0-2]

Organism-specific databases

CTDi76131
MGIiMGI:1923381 Depdc1a

Phylogenomic databases

eggNOGiENOG410IEI5 Eukaryota
ENOG410YMM7 LUCA
GeneTreeiENSGT00530000063030
HOGENOMiHOG000013064
HOVERGENiHBG059792
InParanoidiQ8CIG0
OMAiNIKSRCY
PhylomeDBiQ8CIG0

Miscellaneous databases

PROiPR:Q8CIG0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028175 Expressed in 24 organ(s), highest expression level in liver
CleanExiMM_DEPDC1A
ExpressionAtlasiQ8CIG0 baseline and differential
GenevisibleiQ8CIG0 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008936 Rho_GTPase_activation_prot
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEP1A_MOUSE
AccessioniPrimary (citable) accession number: Q8CIG0
Secondary accession number(s): Q8BHF1, Q99JN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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