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Entry version 110 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

SID1 transmembrane family member 2

Gene

Sidt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365, PubMed:28724756). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA (PubMed:27846365). Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (PubMed:26067272).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SID1 transmembrane family member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sidt2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2446134 Sidt2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 293ExtracellularSequence analysisAdd BLAST275
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 447CytoplasmicSequence analysisAdd BLAST133
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 499ExtracellularSequence analysisAdd BLAST31
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 546CytoplasmicSequence analysisAdd BLAST26
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 605ExtracellularSequence analysisAdd BLAST38
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Topological domaini627 – 631CytoplasmicSequence analysis5
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 688ExtracellularSequence analysisAdd BLAST36
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Topological domaini710 – 715CytoplasmicSequence analysis6
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Topological domaini737 – 746ExtracellularSequence analysis10
Transmembranei747 – 767HelicalSequence analysisAdd BLAST21
Topological domaini768 – 796CytoplasmicSequence analysisAdd BLAST29
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 832ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice demonstrate a statistically significant departure from Mendel's law, but there is no significant differences in their weights or appearance as compared to wild-type controls as newborns. At 5 weeks of age, male mice show reduced weight and size as compared to control animals. This phenotype is not observed in females. Mutant animals exhibit increased fasting glucose levels and impaired glucose tolerance, probably due to impaired insulin granule exocytosis by pancreatic islet cells (PubMed:23776622). At 3 months of age, serum triglyceride and free fatty acid levels increase in knockout mice fed on normal chow. Mice gradually develop hepatic steatosis, with varying degrees of inflammatory changes (PubMed:27233614).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi154F → T: Decreased gymnosis and decreased affinity for 700-bp RNA. No effect on subcellular location. 2 Publications1
Mutagenesisi359Y → S: Decreased lysosomal localization. Decreased interaction with AP-1 and AP-2 complexes; when associated with S-410. Almost complete loss of lysosomal localization and decreased interaction with AP-1 and AP-2 complexes; when associated with S-428. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-410 and S-428. 1 Publication1
Mutagenesisi410Y → S: Drastically decreased lysosomal localization. Decreased interaction with AP-1 and AP-2 complexes; when associated with S-359. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-359 and S-428. No effect on interaction with AP-1 and AP-2 complexes, nor on RNA uptake by lysosomes; when associated with S-428. 1 Publication1
Mutagenesisi428Y → S: Drastically decreased lysosomal localization. Almost complete loss of lysosomal localization and decreased interaction with AP-1 and AP-2 complexes; when associated with S-359. No effect on interaction with AP-1 and AP-2 complexes, nor on RNA uptake by lysosomes; when associated with S-410. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-359 and S-410. 1 Publication1
Mutagenesisi564S → A: Decreased gymnosis and RNA and DNA uptake by lysosomes and degradation. Decreased affinity for 700-bp RNA. No effect on lysosomal subcellular location, nor on LAMP2-binding. 3 Publications1
Mutagenesisi830Y → S: No effect on lysosomal localization, nor on RNA uptake by lysosomes. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18By similarityAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003257919 – 832SID1 transmembrane family member 2Add BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei401PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8CIF6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8CIF6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CIF6

PRoteomics IDEntifications database

More...
PRIDEi
Q8CIF6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CIF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CIF6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CIF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in the liver, brain and kidney (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034908 Expressed in 298 organ(s), highest expression level in morula

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CIF6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CIF6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with adapter protein complex 1 (AP-1) and AP-2, but not AP-3 and AP-4 (PubMed:28724756).

Interacts with LAMP2 (PubMed:27046251).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
229546, 34 interactors

Protein interaction database and analysis system

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IntActi
Q8CIF6, 34 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044290

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CIF6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi764 – 767Poly-Phe4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF6Z Eukaryota
ENOG410XPBN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020635

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CIF6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPVFDLE

Database of Orthologous Groups

More...
OrthoDBi
139174at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CIF6

TreeFam database of animal gene trees

More...
TreeFami
TF313076

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025958 SID1_TM_fam

The PANTHER Classification System

More...
PANTHERi
PTHR12185 PTHR12185, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13965 SID-1_RNA_chan, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CIF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIAWRLPLCV LLVASVESHL GALGPKNVSQ KDAEFERTYA DDVNSELVNI
60 70 80 90 100
YTFNHTVTRN RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR
110 120 130 140 150
GLYQRKYLYQ KVERTLCQPP TKNESEIQFF YVDVSTLSPV NTTYQLRVNR
160 170 180 190 200
VDNFVLRTGE LFTFNTTAAQ PQYFKYEFPD GVDSVIVKVT SKKAFPCSVI
210 220 230 240 250
SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS NSFYVVVVVK
260 270 280 290 300
TEDQACGGSL PFYPFVEDEP VDQGHRQKTL SVLVSQAVTS EAYVGGMLFC
310 320 330 340 350
LGIFLSFYLL TVLLACWENW RQRKKTLLLA IDRACPESGH ARVLADSFPG
360 370 380 390 400
SAPYEGYNYG SFENGSGSTD GLVESAGSGD LSYSYQDRSF DAVGPRPRLD
410 420 430 440 450
SMSSVEEDDY DTLTDIDSDK NVIRTKQYLC VADLARKDKR VLRKKYQIYF
460 470 480 490 500
WNIATIAVFY ALPVVQLVIT YQTVVNVTGN QDICYYNFLC AHPLGNLSAF
510 520 530 540 550
NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLYALE CGIPKHFGLF
560 570 580 590 600
YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP
610 620 630 640 650
DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSVI HIISTLLLST
660 670 680 690 700
QLYYMGRWKL DSGIFRRILH VLYTDCIRQC SGPLYTDRMV LLVMGNIINW
710 720 730 740 750
SLAAYGLIMR PNDFASYLLA IGICNLLLYF AFYIIMKLRS GERIKLIPLL
760 770 780 790 800
CIVCTSVVWG FALFFFFQGL STWQKTPAES REHNRDCILL DFFDDHDIWH
810 820 830
FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF
Length:832
Mass (Da):94,501
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99C5C8C25E4464A5
GO
Isoform 2 (identifier: Q8CIF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-386: Q → QGHDQFKRRLPSGQMRQLCIAM

Note: No experimental confirmation available.
Show »
Length:853
Mass (Da):96,956
Checksum:i55F16A325F4D3919
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SS13F6SS13_MOUSE
SID1 transmembrane family member 2
Sidt2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXC7E0CXC7_MOUSE
SID1 transmembrane family member 2
Sidt2
493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7DF36F7DF36_MOUSE
SID1 transmembrane family member 2
Sidt2
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B6N2F7B6N2_MOUSE
SID1 transmembrane family member 2
Sidt2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SV01F6SV01_MOUSE
SID1 transmembrane family member 2
Sidt2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CNB6F7CNB6_MOUSE
SID1 transmembrane family member 2
Sidt2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7DFH5F7DFH5_MOUSE
SID1 transmembrane family member 2
Sidt2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TVH9F6TVH9_MOUSE
SID1 transmembrane family member 2
Sidt2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013525386Q → QGHDQFKRRLPSGQMRQLCI AM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC006873 mRNA Translation: AAH06873.1
BC023957 mRNA Translation: AAH23957.1
BC051101 mRNA Translation: AAH51101.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23138.1 [Q8CIF6-1]
CCDS72225.1 [Q8CIF6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001276597.1, NM_001289668.1 [Q8CIF6-2]
NP_758461.1, NM_172257.4 [Q8CIF6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038488; ENSMUSP00000044290; ENSMUSG00000034908 [Q8CIF6-1]
ENSMUST00000114573; ENSMUSP00000110220; ENSMUSG00000034908 [Q8CIF6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
214597

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:214597

UCSC genome browser

More...
UCSCi
uc009pgt.2 mouse [Q8CIF6-1]
uc009pgu.2 mouse [Q8CIF6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006873 mRNA Translation: AAH06873.1
BC023957 mRNA Translation: AAH23957.1
BC051101 mRNA Translation: AAH51101.1
CCDSiCCDS23138.1 [Q8CIF6-1]
CCDS72225.1 [Q8CIF6-2]
RefSeqiNP_001276597.1, NM_001289668.1 [Q8CIF6-2]
NP_758461.1, NM_172257.4 [Q8CIF6-1]

3D structure databases

SMRiQ8CIF6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229546, 34 interactors
IntActiQ8CIF6, 34 interactors
STRINGi10090.ENSMUSP00000044290

PTM databases

iPTMnetiQ8CIF6
PhosphoSitePlusiQ8CIF6
SwissPalmiQ8CIF6

Proteomic databases

EPDiQ8CIF6
jPOSTiQ8CIF6
PaxDbiQ8CIF6
PRIDEiQ8CIF6

Genome annotation databases

EnsembliENSMUST00000038488; ENSMUSP00000044290; ENSMUSG00000034908 [Q8CIF6-1]
ENSMUST00000114573; ENSMUSP00000110220; ENSMUSG00000034908 [Q8CIF6-2]
GeneIDi214597
KEGGimmu:214597
UCSCiuc009pgt.2 mouse [Q8CIF6-1]
uc009pgu.2 mouse [Q8CIF6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51092
MGIiMGI:2446134 Sidt2

Phylogenomic databases

eggNOGiENOG410IF6Z Eukaryota
ENOG410XPBN LUCA
GeneTreeiENSGT00390000010091
HOGENOMiHOG000020635
InParanoidiQ8CIF6
OMAiCPVFDLE
OrthoDBi139174at2759
PhylomeDBiQ8CIF6
TreeFamiTF313076

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sidt2 mouse

Protein Ontology

More...
PROi
PR:Q8CIF6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034908 Expressed in 298 organ(s), highest expression level in morula
ExpressionAtlasiQ8CIF6 baseline and differential
GenevisibleiQ8CIF6 MM

Family and domain databases

InterProiView protein in InterPro
IPR025958 SID1_TM_fam
PANTHERiPTHR12185 PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965 SID-1_RNA_chan, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDT2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CIF6
Secondary accession number(s): Q80XD7, Q922R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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