Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger MIZ domain-containing protein 2

Gene

Zmiz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 2
Alternative name(s):
PIAS-like protein Zimp7
Gene namesi
Name:Zmiz2
Synonyms:D11Bwg0280e, Zimp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106374 Zmiz2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189901 – 920Zinc finger MIZ domain-containing protein 2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111Omega-N-methylarginineCombined sources1
Modified residuei245Asymmetric dimethylarginineCombined sources1
Modified residuei262Asymmetric dimethylarginineCombined sources1
Cross-linki402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDbiQ8CIE2
PeptideAtlasiQ8CIE2
PRIDEiQ8CIE2

PTM databases

iPTMnetiQ8CIE2
PhosphoSitePlusiQ8CIE2

Expressioni

Gene expression databases

BgeeiENSMUSG00000041164
CleanExiMM_ZMIZ2
GenevisibleiQ8CIE2 MM

Interactioni

Subunit structurei

Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8CIE2, 1 interactor
STRINGi10090.ENSMUSP00000012612

Structurei

3D structure databases

ProteinModelPortaliQ8CIE2
SMRiQ8CIE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 506Interaction with ARBy similarityAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
HOVERGENiHBG056252
InParanoidiQ8CIE2
KOiK22403
OMAiSMNPMKP
OrthoDBiEOG091G01NY
PhylomeDBiQ8CIE2
TreeFamiTF316952

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CIE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN
60 70 80 90 100
ATQSQVLGNP MGPAGSPPGG SMMPGVAGGS SALTSPQCLG QQAFAEGGAS
110 120 130 140 150
KSYVQQGVYG RGSYPGGSSF TTGYAGGPAG LGLPTHAARP STDFTQAAAA
160 170 180 190 200
AAMAAAAATA TATATATVAA LQEKQSQELS QYGAMGTGQS FNSQFLQHGG
210 220 230 240 250
PRGPSVPPGM NPSGMGGMMG PSGLSSMAMT PTRAAGMTPL YAGQRLPQHG
260 270 280 290 300
YPGPPQGQPL PRQGIKRAYS EVYPGQQYLQ GGQYAANTAQ YAPGPGQPPG
310 320 330 340 350
PASSYAGHRL PLQQGMAQSL SAPGPTGLHY KPTEQFNGQG ASFNGGSISY
360 370 380 390 400
SQPGLSGPSR SIPGYPSSPL PGNPTPPMTP SSNVPYMSPS QEVKSPFLPD
410 420 430 440 450
LKPGLSSLHP SPSASVHCDE LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ
460 470 480 490 500
LRDSVYKTLM LRPDLELQFK CYHHEDRQMN TNWPASVQVS VNATPLSIER
510 520 530 540 550
GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL VHRPSVRSVL
560 570 580 590 600
QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
610 620 630 640 650
PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG
660 670 680 690 700
LEVDQYMLGI LIYIQNSDYE EITIDPTCSW KPVPVKPDLH IKEEPDGPVL
710 720 730 740 750
KRCRTVSPAH VLMPSVMEMI AALGPGAAPF APLQPPSAPT PSDYPSQGSN
760 770 780 790 800
FMGPGTFPES FPSATPTTPN LAEFTQGPPP ISYQSDIPSS LLTPDKSTPC
810 820 830 840 850
LPGQMAPAGH LDPAHNPGPP GLHTPNLGPT PGTQLHHPNP SPASRQPLGQ
860 870 880 890 900
PNTGPISELA FNPASGMMGP PSMTGAGEAS EPALDLLPEL TNPDELLSYL
910 920
GPPDLPTNSS DDLLSLFENN
Length:920
Mass (Da):96,719
Last modified:December 7, 2004 - v2
Checksum:i0F9C6A6D53146279
GO
Isoform 2 (identifier: Q8CIE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-87: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:888
Mass (Da):93,870
Checksum:i642A11E0236828B2
GO
Isoform 3 (identifier: Q8CIE2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-358: Missing.

Note: Gene prediction based on EST data.
Show »
Length:894
Mass (Da):94,150
Checksum:iA011E787B0CD5C59
GO

Sequence cautioni

The sequence BAC33364 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01219156 – 87Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_024919333 – 358Missing in isoform 3. CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607152 Genomic DNA No translation available.
BC024081 mRNA Translation: AAH24081.1
BC060652 mRNA Translation: AAH60652.1
BC063069 mRNA Translation: AAH63069.1
AK048533 mRNA Translation: BAC33364.1 Different initiation.
CCDSiCCDS24417.1 [Q8CIE2-2]
CCDS24418.1 [Q8CIE2-1]
RefSeqiNP_001005867.1, NM_001005867.1 [Q8CIE2-2]
NP_082877.2, NM_028601.3 [Q8CIE2-1]
XP_006514811.1, XM_006514748.2 [Q8CIE2-1]
XP_006514813.1, XM_006514750.3 [Q8CIE2-1]
XP_011242034.1, XM_011243732.1 [Q8CIE2-1]
XP_011242035.1, XM_011243733.2 [Q8CIE2-3]
UniGeneiMm.1144

Genome annotation databases

EnsembliENSMUST00000012612; ENSMUSP00000012612; ENSMUSG00000041164 [Q8CIE2-1]
ENSMUST00000102914; ENSMUSP00000099978; ENSMUSG00000041164 [Q8CIE2-2]
ENSMUST00000109785; ENSMUSP00000105408; ENSMUSG00000041164 [Q8CIE2-3]
ENSMUST00000109786; ENSMUSP00000105409; ENSMUSG00000041164 [Q8CIE2-1]
ENSMUST00000109787; ENSMUSP00000105410; ENSMUSG00000041164 [Q8CIE2-1]
GeneIDi52915
KEGGimmu:52915
UCSCiuc007hym.1 mouse [Q8CIE2-2]
uc056yjq.1 mouse [Q8CIE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZMIZ2_MOUSE
AccessioniPrimary (citable) accession number: Q8CIE2
Secondary accession number(s): Q5SVX4
, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health