UniProtKB - Q8CID0 (CSR2B_MOUSE)

BLAST

>sp|Q8CID0|CSR2B_MOUSE Cysteine-rich protein 2-binding protein OS=Mus musculus OX=10090 GN=Kat14 PE=1 SV=2
MDSSIHLSGLLSRHDDDATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLN
SDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCCDCSADGKEQYERL
KLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGC
LSVGSPVYFRSGAQEFGEPGWWKLVHNRPPTMRPEGEKLAASTLKVKASKPTLDPIITVE
GLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGLLDRSTSSTPVKFISRGRRPD
LILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMP
PQALFHDDDELEGDGVIDPGMEYIPPPAGSASGLLGSRKKVRAPEQIKQEVDSEEEKPDR
MDGDSEDTDSNISLHTRAREKRKPPLEKDMKPKGPRYTPVSIYEEKLLLKRLEACPGAVA
MTPEARRLKRKLIVRQAKRDRGLPLFDLDEVVNAALLLVDGIYGAKDGGASRLAAGQATY
RTTCQDFRILDRYQTALPARKGFRHQTTRFLYRLVGSEDLAVDQSIISPYTSRILKPYIR
RDYETKPPKLQLLSQIRSHLHRSDPHWTPGPDAPLDYCYVRPNHIPTINSMCQEFFWPGI
DLSECLQYPDFSVVVLYKKVIVAFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMIYHL
IQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR

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History
Entry version 111 (07 Nov 2018)
Sequence version 2 (02 Oct 2007)
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Protein

Cysteine-rich protein 2-binding protein

Gene

Kat14

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity).By similarity

GO - Molecular functionⁱ

histone acetyltransferase activity
Source: MGI
Inferred from sequence orthologyⁱ
- 19103755

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G2/M transition of mitotic cell cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 19103755
histone acetylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 19103755
histone H3 acetylation Source: MGI

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cysteine-rich protein 2-binding protein Short name: CSRP2-binding protein Alternative name(s): ADA2A-containing complex subunit 2 Short name: ATAC2 CRP2-binding partner Short name: CRP2BP Lysine acetyltransferase 14By similarity
Gene namesⁱ	Name:Kat14By similarity Synonyms:Csrp2bp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1917264 Kat14

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Early embryonic lethality. Severe growth retardation, increased apoptosis, and alterations in the cell cycle.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000304937	1 – 779	Cysteine-rich protein 2-binding proteinAdd BLAST		779

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	4	PhosphoserineBy similarity	1
Modified residueⁱ	230	N6-acetyllysineCombined sources	1
Modified residueⁱ	284	PhosphoserineBy similarity	1
Modified residueⁱ	291	N6-acetyllysineCombined sources	1
Modified residueⁱ	413	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CID0
PaxDbⁱ	Q8CID0
PRIDEⁱ	Q8CID0

PTM databases

iPTMnetⁱ	Q8CID0
PhosphoSitePlusⁱ	Q8CID0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027425 Expressed in 238 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q8CID0 baseline and differential
Genevisibleⁱ	Q8CID0 MM

Interactionⁱ

Subunit structureⁱ

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.By similarity

Protein-protein interaction databases

BioGridⁱ	230756, 9 interactors
ComplexPortalⁱ	CPX-1025 GCN5-containing ATAC complex CPX-1029 PCAF-containing ATAC complex
IntActⁱ	Q8CID0, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q8CID0
STRINGⁱ	10090.ENSMUSP00000028911

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CID0
SMRⁱ	Q8CID0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	635 – 779	N-acetyltransferasePROSITE-ProRule annotationAdd BLAST		145

Phylogenomic databases

eggNOGⁱ	ENOG410IQJZ Eukaryota ENOG410Y6C7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001146
HOGENOMⁱ	HOG000230880
HOVERGENⁱ	HBG051142
InParanoidⁱ	Q8CID0
OMAⁱ	DCSEDGK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CJX
PhylomeDBⁱ	Q8CID0
TreeFamⁱ	TF324809

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom IPR037829 KAT14
PANTHERⁱ	PTHR20916:SF0 PTHR20916:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8CID0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSSIHLSGL LSRHDDDATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL 
        60         70         80         90        100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN 
       110        120        130        140        150
FFRFTCCDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE 
       160        170        180        190        200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPVYFR SGAQEFGEPG 
       210        220        230        240        250
WWKLVHNRPP TMRPEGEKLA ASTLKVKASK PTLDPIITVE GLRKRASRNP 
       260        270        280        290        300
VESAMELKEK RSRTQEAKDI RRAQKEAAGL LDRSTSSTPV KFISRGRRPD 
       310        320        330        340        350
LILEKGEVID FSSLSSSDRT PLTSPSPSPS LDFSAPGTPA SHSATPSLLS 
       360        370        380        390        400
EADLIPDVMP PQALFHDDDE LEGDGVIDPG MEYIPPPAGS ASGLLGSRKK 
       410        420        430        440        450
VRAPEQIKQE VDSEEEKPDR MDGDSEDTDS NISLHTRARE KRKPPLEKDM 
       460        470        480        490        500
KPKGPRYTPV SIYEEKLLLK RLEACPGAVA MTPEARRLKR KLIVRQAKRD 
       510        520        530        540        550
RGLPLFDLDE VVNAALLLVD GIYGAKDGGA SRLAAGQATY RTTCQDFRIL 
       560        570        580        590        600
DRYQTALPAR KGFRHQTTRF LYRLVGSEDL AVDQSIISPY TSRILKPYIR 
       610        620        630        640        650
RDYETKPPKL QLLSQIRSHL HRSDPHWTPG PDAPLDYCYV RPNHIPTINS 
       660        670        680        690        700
MCQEFFWPGI DLSECLQYPD FSVVVLYKKV IVAFGFMVPD VKYNEAYISF 
       710        720        730        740        750
LLVHPEWRRA GIATFMIYHL IQTCMGKDVT LHVSASNPAM LLYQKFGFKT 
       760        770 
EEYVLDFYDK YYPLESTECK HAFFLRLRR

Length:779

Mass (Da):88,217

Last modified:October 2, 2007 - v2

Checksum:ⁱ6750A26E6DF1B749

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9QA90	E9QA90_MOUSE	Cysteine-rich protein 2-binding pro... Cysteine-rich protein 2-binding protein	Kat14 Csrp2bp	568	Annotation score:
E9Q3Q5	E9Q3Q5_MOUSE	Cysteine-rich protein 2-binding pro... Cysteine-rich protein 2-binding protein	Kat14 Csrp2bp	83	Annotation score:
F7C4S8	F7C4S8_MOUSE	Cysteine-rich protein 2-binding pro... Cysteine-rich protein 2-binding protein	Kat14 Csrp2bp	92	Annotation score:
F6S6Z2	F6S6Z2_MOUSE	Cysteine-rich protein 2-binding pro... Cysteine-rich protein 2-binding protein	Kat14 Csrp2bp	97	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	144	G → V in AAH31563 (PubMed:15489334).Curated		1
Sequence conflictⁱ	497	A → L in AAH31563 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL808123 Genomic DNA No translation available. BC031563 mRNA Translation: AAH31563.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16819.1
NCBI Reference Sequences More...RefSeqⁱ	NP_852082.2, NM_181417.3
UniGeneⁱ	Mm.227925 Mm.490976

Genome annotation databases

Ensemblⁱ	ENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425
GeneIDⁱ	228714
KEGGⁱ	mmu:228714
UCSC genome browser More...UCSCⁱ	uc008mqy.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CID0	Cysteine and glycine-rich protein 2 binding protein		MUSSP		779	UniRef100_Q8CID0
Cysteine-rich protein 2-binding protein		MOUSE		568
UPI0001BB0BF8		MOUSE		651

Protein	Similar proteins		Species	Score	Length	Source
Q8CID0	Cysteine-rich protein 2-binding protein		HUMAN		782	UniRef90_Q9H8E8
Uncharacterized protein		ICTTR		794
Cysteine-rich protein 2-binding protein		HETGA		789
Uncharacterized protein (Fragment)		AILME		786
Lysine acetyltransferase 14		OTOGA		783
+143

Protein	Similar proteins		Species	Score	Length	Source
Q8CID0	Cysteine-rich protein 2-binding protein		HUMAN		782	UniRef50_Q9H8E8
Uncharacterized protein		ICTTR		794
Cysteine-rich protein 2-binding protein		HETGA		789
Uncharacterized protein (Fragment)		AILME		786
Lysine acetyltransferase 14		OTOGA		783
+462

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL808123 Genomic DNA No translation available. BC031563 mRNA Translation: AAH31563.1
CCDSⁱ	CCDS16819.1
RefSeqⁱ	NP_852082.2, NM_181417.3
UniGeneⁱ	Mm.227925 Mm.490976

3D structure databases

ProteinModelPortalⁱ	Q8CID0
SMRⁱ	Q8CID0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230756, 9 interactors
ComplexPortalⁱ	CPX-1025 GCN5-containing ATAC complex CPX-1029 PCAF-containing ATAC complex
IntActⁱ	Q8CID0, 2 interactors
MINTⁱ	Q8CID0
STRINGⁱ	10090.ENSMUSP00000028911

PTM databases

iPTMnetⁱ	Q8CID0
PhosphoSitePlusⁱ	Q8CID0

Proteomic databases

MaxQBⁱ	Q8CID0
PaxDbⁱ	Q8CID0
PRIDEⁱ	Q8CID0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425
GeneIDⁱ	228714
KEGGⁱ	mmu:228714
UCSCⁱ	uc008mqy.2 mouse

Organism-specific databases

CTDⁱ	57325
MGIⁱ	MGI:1917264 Kat14

Phylogenomic databases

eggNOGⁱ	ENOG410IQJZ Eukaryota ENOG410Y6C7 LUCA
GeneTreeⁱ	ENSGT00390000001146
HOGENOMⁱ	HOG000230880
HOVERGENⁱ	HBG051142
InParanoidⁱ	Q8CID0
OMAⁱ	DCSEDGK
OrthoDBⁱ	EOG091G0CJX
PhylomeDBⁱ	Q8CID0
TreeFamⁱ	TF324809

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CID0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027425 Expressed in 238 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q8CID0 baseline and differential
Genevisibleⁱ	Q8CID0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom IPR037829 KAT14
PANTHERⁱ	PTHR20916:SF0 PTHR20916:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSR2B_MOUSE
Accessionⁱ	Q8CID0Primary (citable) accession number: Q8CID0 Secondary accession number(s): A2ANA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CID0 (CSR2B_MOUSE)

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Cysteine-rich protein 2-binding protein

Kat14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ