UniProtKB - Q8CID0 (CSR2B_MOUSE)
Cysteine-rich protein 2-binding protein
Kat14
Functioni
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity).
By similarityGO - Molecular functioni
- histone acetyltransferase activity Source: MGI
GO - Biological processi
- G2/M transition of mitotic cell cycle Source: MGI
- histone acetylation Source: MGI
- histone H3 acetylation Source: MGI
- histone H3-K14 acetylation Source: MGI
- regulation of cell cycle Source: ComplexPortal
- regulation of cell division Source: ComplexPortal
- regulation of embryonic development Source: ComplexPortal
- regulation of histone deacetylation Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- regulation of tubulin deacetylation Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-rich protein 2-binding proteinShort name: CSRP2-binding protein Alternative name(s): ADA2A-containing complex subunit 2 Short name: ATAC2 CRP2-binding partner Short name: CRP2BP Lysine acetyltransferase 14By similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917264, Kat14 |
VEuPathDBi | HostDB:ENSMUSG00000027425 |
Subcellular locationi
Cytoskeleton
- mitotic spindle Source: ComplexPortal
Nucleus
- ATAC complex Source: ComplexPortal
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304937 | 1 – 779 | Cysteine-rich protein 2-binding proteinAdd BLAST | 779 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 230 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8CID0 |
MaxQBi | Q8CID0 |
PaxDbi | Q8CID0 |
PRIDEi | Q8CID0 |
ProteomicsDBi | 285211 |
PTM databases
iPTMneti | Q8CID0 |
PhosphoSitePlusi | Q8CID0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027425, Expressed in embryo and 263 other tissues |
ExpressionAtlasi | Q8CID0, baseline and differential |
Genevisiblei | Q8CID0, MM |
Interactioni
Subunit structurei
Interacts with the LIM 1 domain of CSRP2.
Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.
By similarityProtein-protein interaction databases
BioGRIDi | 230756, 10 interactors |
ComplexPortali | CPX-1025, GCN5-containing ATAC complex CPX-1029, PCAF-containing ATAC complex |
IntActi | Q8CID0, 2 interactors |
MINTi | Q8CID0 |
STRINGi | 10090.ENSMUSP00000028911 |
Miscellaneous databases
RNActi | Q8CID0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 635 – 779 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 145 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 247 – 292 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 314 – 345 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 360 – 457 | DisorderedSequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 27 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 247 – 278 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 401 – 454 | Basic and acidic residuesSequence analysisAdd BLAST | 54 |
Phylogenomic databases
eggNOGi | KOG3138, Eukaryota |
GeneTreei | ENSGT00390000001146 |
HOGENOMi | CLU_022855_0_0_1 |
InParanoidi | Q8CID0 |
OMAi | RNWPWLQ |
OrthoDBi | 1404086at2759 |
PhylomeDBi | Q8CID0 |
TreeFami | TF324809 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR037829, KAT14 |
PANTHERi | PTHR20916:SF0, PTHR20916:SF0, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDSSIHLSGL LSRHDDDATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCCDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPVYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNRPP TMRPEGEKLA ASTLKVKASK PTLDPIITVE GLRKRASRNP
260 270 280 290 300
VESAMELKEK RSRTQEAKDI RRAQKEAAGL LDRSTSSTPV KFISRGRRPD
310 320 330 340 350
LILEKGEVID FSSLSSSDRT PLTSPSPSPS LDFSAPGTPA SHSATPSLLS
360 370 380 390 400
EADLIPDVMP PQALFHDDDE LEGDGVIDPG MEYIPPPAGS ASGLLGSRKK
410 420 430 440 450
VRAPEQIKQE VDSEEEKPDR MDGDSEDTDS NISLHTRARE KRKPPLEKDM
460 470 480 490 500
KPKGPRYTPV SIYEEKLLLK RLEACPGAVA MTPEARRLKR KLIVRQAKRD
510 520 530 540 550
RGLPLFDLDE VVNAALLLVD GIYGAKDGGA SRLAAGQATY RTTCQDFRIL
560 570 580 590 600
DRYQTALPAR KGFRHQTTRF LYRLVGSEDL AVDQSIISPY TSRILKPYIR
610 620 630 640 650
RDYETKPPKL QLLSQIRSHL HRSDPHWTPG PDAPLDYCYV RPNHIPTINS
660 670 680 690 700
MCQEFFWPGI DLSECLQYPD FSVVVLYKKV IVAFGFMVPD VKYNEAYISF
710 720 730 740 750
LLVHPEWRRA GIATFMIYHL IQTCMGKDVT LHVSASNPAM LLYQKFGFKT
760 770
EEYVLDFYDK YYPLESTECK HAFFLRLRR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QA90 | E9QA90_MOUSE | Cysteine-rich protein 2-binding pro... | Kat14 Csrp2bp | 568 | Annotation score: | ||
F7C4S8 | F7C4S8_MOUSE | Cysteine-rich protein 2-binding pro... | Kat14 Csrp2bp | 92 | Annotation score: | ||
E9Q3Q5 | E9Q3Q5_MOUSE | Cysteine-rich protein 2-binding pro... | Kat14 Csrp2bp | 83 | Annotation score: | ||
F6S6Z2 | F6S6Z2_MOUSE | Cysteine-rich protein 2-binding pro... | Kat14 Csrp2bp | 97 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | G → V in AAH31563 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 497 | A → L in AAH31563 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL808123 Genomic DNA No translation available. BC031563 mRNA Translation: AAH31563.1 |
CCDSi | CCDS16819.1 |
RefSeqi | NP_852082.2, NM_181417.3 |
Genome annotation databases
Ensembli | ENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425 |
GeneIDi | 228714 |
KEGGi | mmu:228714 |
UCSCi | uc008mqy.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL808123 Genomic DNA No translation available. BC031563 mRNA Translation: AAH31563.1 |
CCDSi | CCDS16819.1 |
RefSeqi | NP_852082.2, NM_181417.3 |
3D structure databases
AlphaFoldDBi | Q8CID0 |
SMRi | Q8CID0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230756, 10 interactors |
ComplexPortali | CPX-1025, GCN5-containing ATAC complex CPX-1029, PCAF-containing ATAC complex |
IntActi | Q8CID0, 2 interactors |
MINTi | Q8CID0 |
STRINGi | 10090.ENSMUSP00000028911 |
PTM databases
iPTMneti | Q8CID0 |
PhosphoSitePlusi | Q8CID0 |
Proteomic databases
EPDi | Q8CID0 |
MaxQBi | Q8CID0 |
PaxDbi | Q8CID0 |
PRIDEi | Q8CID0 |
ProteomicsDBi | 285211 |
Protocols and materials databases
Antibodypediai | 24530, 160 antibodies from 22 providers |
DNASUi | 228714 |
Genome annotation databases
Ensembli | ENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425 |
GeneIDi | 228714 |
KEGGi | mmu:228714 |
UCSCi | uc008mqy.2, mouse |
Organism-specific databases
CTDi | 57325 |
MGIi | MGI:1917264, Kat14 |
VEuPathDBi | HostDB:ENSMUSG00000027425 |
Phylogenomic databases
eggNOGi | KOG3138, Eukaryota |
GeneTreei | ENSGT00390000001146 |
HOGENOMi | CLU_022855_0_0_1 |
InParanoidi | Q8CID0 |
OMAi | RNWPWLQ |
OrthoDBi | 1404086at2759 |
PhylomeDBi | Q8CID0 |
TreeFami | TF324809 |
Miscellaneous databases
BioGRID-ORCSi | 228714, 7 hits in 71 CRISPR screens |
ChiTaRSi | Kat14, mouse |
PROi | PR:Q8CID0 |
RNActi | Q8CID0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027425, Expressed in embryo and 263 other tissues |
ExpressionAtlasi | Q8CID0, baseline and differential |
Genevisiblei | Q8CID0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR037829, KAT14 |
PANTHERi | PTHR20916:SF0, PTHR20916:SF0, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSR2B_MOUSE | |
Accessioni | Q8CID0Primary (citable) accession number: Q8CID0 Secondary accession number(s): A2ANA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot