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Protein

Nucleoporin-like protein 2

Gene

Nupl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin-like protein 2
Alternative name(s):
NLP-1
Gene namesi
Name:Nupl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387631 Nupl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048961 – 420Nucleoporin-like protein 2Add BLAST420

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8CIC2
PaxDbiQ8CIC2
PeptideAtlasiQ8CIC2
PRIDEiQ8CIC2

PTM databases

iPTMnetiQ8CIC2
PhosphoSitePlusiQ8CIC2

Expressioni

Gene expression databases

CleanExiMM_NUPL2

Interactioni

Subunit structurei

Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062766

Structurei

3D structure databases

ProteinModelPortaliQ8CIC2
SMRiQ8CIC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 15FG 12
Repeati82 – 83FG 22
Repeati95 – 96FG 32
Repeati218 – 219FG 42
Repeati220 – 221FG 52
Repeati228 – 229FG 62
Repeati265 – 266FG 72
Repeati271 – 272FG 82
Repeati288 – 289FG 92
Repeati345 – 346FG 102
Repeati364 – 365FG 112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 420Interaction with GLE1By similarityAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 376Ser-richAdd BLAST139

Domaini

The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIH3 Eukaryota
ENOG4111HKJ LUCA
HOGENOMiHOG000113895
HOVERGENiHBG082070
InParanoidiQ8CIC2
KOiK14321
PhylomeDBiQ8CIC2

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CIC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTICQFFLQG RCRFGDRCWN EHPGARGAGG ARQPPPQQQP PSGNNRRGWN
60 70 80 90 100
ASSQRYSNVI QPSSFPKSTP WGGSRDQDKP PFGSFDSGAS TSRGFGSSQN
110 120 130 140 150
PFASPLSDEQ KDEKKLLEGI VKDVEVWESS GQWMFSVYSP VRKKPNISGF
160 170 180 190 200
TDISPEELRL EYHNFLTSNN LQSYLNSVQQ LVSQWRNRIN ELKNLTMSTK
210 220 230 240 250
GALLSDVKDG VSQAVPAFGF GSKQAGSFGS PGFPVNNSSS STVQNFSFKT
260 270 280 290 300
SPGLATPPSG STSVFGSHPA FGAGPSAGSS ISSSTPAFGL GKPEATSAAS
310 320 330 340 350
FSFKSPEASS FASPGFSGFP ASMAASPSGS TTAPPLRSGS SVVGFGSPSP
360 370 380 390 400
HSQAVFAKPS TDVFGGSGIS TSVLASGAAD NALFTPRDQL MKEELEQFQS
410 420
QRFTLGKIPL KPPPVELLTV
Length:420
Mass (Da):44,337
Last modified:March 1, 2003 - v1
Checksum:iFE2CDDBD6F17492A
GO
Isoform 2 (identifier: Q8CIC2-2) [UniParc]FASTAAdd to basket
Also known as: T

The sequence of this isoform differs from the canonical sequence as follows:
     149-160: GFTDISPEELRL → AKLCSTACKSVE
     161-420: Missing.

Show »
Length:160
Mass (Da):17,619
Checksum:i5B12FDA0D213D7B3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QL43E9QL43_MOUSE
Nucleoporin-like protein 2
Nupl2
420Annotation score:
A0A0R4J1K6A0A0R4J1K6_MOUSE
Nucleoporin-like protein 2
Nupl2
161Annotation score:

Sequence cautioni

The sequence BAC36589 differs from that shown. Reason: Frameshift at position 227.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137V → A in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti142R → G in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti308A → G in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti308A → G in BAC37297 (PubMed:16141072).Curated1
Sequence conflicti343V → A in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti343V → A in BAC37297 (PubMed:16141072).Curated1
Sequence conflicti375A → T in BAC37297 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016483149 – 160GFTDI…EELRL → AKLCSTACKSVE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_016484161 – 420Missing in isoform 2. 1 PublicationAdd BLAST260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067574 mRNA Translation: BAB62307.1
AK077066 mRNA Translation: BAC36589.1 Frameshift.
AK078478 mRNA Translation: BAC37297.1
BC033270 mRNA Translation: AAH33270.1
CCDSiCCDS19115.1 [Q8CIC2-1]
RefSeqiNP_001333511.1, NM_001346582.1
NP_694732.3, NM_153092.4
UniGeneiMm.45513

Genome annotation databases

GeneIDi231042
KEGGimmu:231042

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067574 mRNA Translation: BAB62307.1
AK077066 mRNA Translation: BAC36589.1 Frameshift.
AK078478 mRNA Translation: BAC37297.1
BC033270 mRNA Translation: AAH33270.1
CCDSiCCDS19115.1 [Q8CIC2-1]
RefSeqiNP_001333511.1, NM_001346582.1
NP_694732.3, NM_153092.4
UniGeneiMm.45513

3D structure databases

ProteinModelPortaliQ8CIC2
SMRiQ8CIC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062766

PTM databases

iPTMnetiQ8CIC2
PhosphoSitePlusiQ8CIC2

Proteomic databases

EPDiQ8CIC2
PaxDbiQ8CIC2
PeptideAtlasiQ8CIC2
PRIDEiQ8CIC2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231042
KEGGimmu:231042

Organism-specific databases

CTDi11097
MGIiMGI:2387631 Nupl2

Phylogenomic databases

eggNOGiENOG410IIH3 Eukaryota
ENOG4111HKJ LUCA
HOGENOMiHOG000113895
HOVERGENiHBG082070
InParanoidiQ8CIC2
KOiK14321
PhylomeDBiQ8CIC2

Miscellaneous databases

ChiTaRSiNupl2 mouse
PROiPR:Q8CIC2
SOURCEiSearch...

Gene expression databases

CleanExiMM_NUPL2

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUPL2_MOUSE
AccessioniPrimary (citable) accession number: Q8CIC2
Secondary accession number(s): Q8BJX3, Q8BVP7, Q924S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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