The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q8CIA5 (S35B4_MOUSE)
Protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Gene
Slc35b4
Organism
Mus musculus (Mouse)
Status
Functioni
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: GO_Central
- UDP-N-acetylglucosamine transmembrane transporter activity Source: MGI
- UDP-xylose transmembrane transporter activity Source: MGI
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- regulation of gluconeogenesis Source: MGI
- UDP-N-acetylglucosamine transmembrane transport Source: MGI
- UDP-xylose transmembrane transport Source: MGI
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-727802, Transport of nucleotide sugars |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-xylose and UDP-N-acetylglucosamine transporterAlternative name(s): Solute carrier family 35 member B4 |
Gene namesi | Name:Slc35b4 ORF Names:MNCb-4414 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1931249, Slc35b4 |
VEuPathDBi | HostDB:ENSMUSG00000018999 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- integral component of endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: MGI
- integral component of Golgi membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 251 – 267 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213387 | 1 – 331 | UDP-xylose and UDP-N-acetylglucosamine transporterAdd BLAST | 331 |
Proteomic databases
PaxDbi | Q8CIA5 |
PeptideAtlasi | Q8CIA5 |
PRIDEi | Q8CIA5 |
ProteomicsDBi | 256883 [Q8CIA5-1] 256884 [Q8CIA5-2] |
PTM databases
PhosphoSitePlusi | Q8CIA5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018999, Expressed in cardiac ventricle and 302 other tissues |
ExpressionAtlasi | Q8CIA5, baseline and differential |
Genevisiblei | Q8CIA5, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019143 |
Miscellaneous databases
RNActi | Q8CIA5, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q8CIA5 |
OMAi | NYAFDFN |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q8CIA5 |
TreeFami | TF312926 |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CIA5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPAFAVGLV FAGCCSNVIF LELLARTHPG CGNIVTFAQF LFIAVEGFLF
60 70 80 90 100
EANLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS
110 120 130 140 150
LIANMILGII ILKKRYSMFK YTSIALVSAG IFICTFMSAK QVTVQTGLSD
160 170 180 190 200
KDGFQAFAWW LLGIAALTFA LLMSARMGIF QETLYRQFGK HSKEALFYNH
210 220 230 240 250
ALPLPGFIFL ASDIYDHVVL FNKSELYQVP VIGVTMPVMW FYLLMNVVTQ
260 270 280 290 300
YVCIRGVFIL TTECTSLTVT LVVTLRKFVS LIFSILYFQN QFTMWHWLGT
310 320 330
SFVFIGTLMY TEVWKNLGTT KSELQKDDKK D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R2P0 | S4R2P0_MOUSE | UDP-xylose and UDP-N-acetylglucosam... | Slc35b4 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 238 | V → I in AAH33512 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016203 | 1 – 172 | Missing in isoform 2. 1 PublicationAdd BLAST | 172 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041549 mRNA Translation: BAA95034.1 AK029969 mRNA Translation: BAC26707.1 AK033913 mRNA Translation: BAC28512.1 AK042150 mRNA Translation: BAC31186.1 AK138591 mRNA Translation: BAE23707.1 AK163299 mRNA Translation: BAE37285.1 BC033512 mRNA Translation: AAH33512.1 |
CCDSi | CCDS19989.1 [Q8CIA5-1] |
RefSeqi | NP_067410.1, NM_021435.3 [Q8CIA5-1] |
Genome annotation databases
Ensembli | ENSMUST00000019143; ENSMUSP00000019143; ENSMUSG00000018999 [Q8CIA5-1] |
GeneIDi | 58246 |
KEGGi | mmu:58246 |
UCSCi | uc009bgw.1, mouse [Q8CIA5-2] uc009bgx.1, mouse [Q8CIA5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041549 mRNA Translation: BAA95034.1 AK029969 mRNA Translation: BAC26707.1 AK033913 mRNA Translation: BAC28512.1 AK042150 mRNA Translation: BAC31186.1 AK138591 mRNA Translation: BAE23707.1 AK163299 mRNA Translation: BAE37285.1 BC033512 mRNA Translation: AAH33512.1 |
CCDSi | CCDS19989.1 [Q8CIA5-1] |
RefSeqi | NP_067410.1, NM_021435.3 [Q8CIA5-1] |
3D structure databases
AlphaFoldDBi | Q8CIA5 |
SMRi | Q8CIA5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019143 |
PTM databases
PhosphoSitePlusi | Q8CIA5 |
Proteomic databases
PaxDbi | Q8CIA5 |
PeptideAtlasi | Q8CIA5 |
PRIDEi | Q8CIA5 |
ProteomicsDBi | 256883 [Q8CIA5-1] 256884 [Q8CIA5-2] |
Protocols and materials databases
Antibodypediai | 53731, 39 antibodies from 12 providers |
DNASUi | 58246 |
Genome annotation databases
Ensembli | ENSMUST00000019143; ENSMUSP00000019143; ENSMUSG00000018999 [Q8CIA5-1] |
GeneIDi | 58246 |
KEGGi | mmu:58246 |
UCSCi | uc009bgw.1, mouse [Q8CIA5-2] uc009bgx.1, mouse [Q8CIA5-1] |
Organism-specific databases
CTDi | 84912 |
MGIi | MGI:1931249, Slc35b4 |
VEuPathDBi | HostDB:ENSMUSG00000018999 |
Phylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q8CIA5 |
OMAi | NYAFDFN |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q8CIA5 |
TreeFami | TF312926 |
Enzyme and pathway databases
Reactomei | R-MMU-727802, Transport of nucleotide sugars |
Miscellaneous databases
BioGRID-ORCSi | 58246, 4 hits in 71 CRISPR screens |
PROi | PR:Q8CIA5 |
RNActi | Q8CIA5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018999, Expressed in cardiac ventricle and 302 other tissues |
ExpressionAtlasi | Q8CIA5, baseline and differential |
Genevisiblei | Q8CIA5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35B4_MOUSE | |
Accessioni | Q8CIA5Primary (citable) accession number: Q8CIA5 Secondary accession number(s): Q3TQU7, Q5U681, Q9JJF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families