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Protein

Oxysterol-binding protein-related protein 11

Gene

Osbpl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol.By similarity

GO - Molecular functioni

  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 11
Short name:
ORP-11
Short name:
OSBP-related protein 11
Gene namesi
Name:Osbpl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2146553 Osbpl11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003821 – 751Oxysterol-binding protein-related protein 11Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei27PhosphothreonineBy similarity1
Modified residuei177PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei189PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CI95
MaxQBiQ8CI95
PaxDbiQ8CI95
PeptideAtlasiQ8CI95
PRIDEiQ8CI95

PTM databases

iPTMnetiQ8CI95
PhosphoSitePlusiQ8CI95

Expressioni

Gene expression databases

CleanExiMM_OSBPL11

Interactioni

Subunit structurei

Heterodimer with OSBPL9.By similarity

Protein-protein interaction databases

IntActiQ8CI95, 2 interactors
MINTiQ8CI95
STRINGi10090.ENSMUSP00000039632

Structurei

3D structure databases

ProteinModelPortaliQ8CI95
SMRiQ8CI95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 160PHPROSITE-ProRule annotationAdd BLAST98

Domaini

The PH domain binds phosphoinositides.By similarity

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
HOGENOMiHOG000233871
HOVERGENiHBG053376
InParanoidiQ8CI95
PhylomeDBiQ8CI95

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CI95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGGEPASVM KVSESEGKLE GLATAVTPNK NSGNSSCGGA ISSSSSNSSR
60 70 80 90 100
GGSAKGWQYS DHMESVNGYL MKYTNLVTGW QYRFFVLNNE AGLLEYFVNE
110 120 130 140 150
QSRNQKPRGT LQLAGAVISP SDEDSHTFTV NAASGEQYKL RATDAKERQH
160 170 180 190 200
WVSRLQICTQ HHTEAIGKNN PPLKSRSFSL ASSGNSPISQ RRPSQNAMSF
210 220 230 240 250
FNVGHSKLQS VNKRAHLHPD HLVEVREMMS HAEGQQRDLI RRIECLPASG
260 270 280 290 300
LLSSLDQDLL MLKATSMATM NCLNDCFHIL QLQHASHQKG ALPSGTTIEW
310 320 330 340 350
LEPKIPLSNH YKNGAEQPFA TEPNKPMGAP EAQCVAESGV LAREPEDISA
360 370 380 390 400
DDEVEDTCDN KEDDLGAVEE QRSVILHLLS QLKLGMDLTR VVLPTFILEK
410 420 430 440 450
RSLLEMYADF MSHPDLFIGI TNGATPEDRM IRFVEYYLTS FHEGRKGAIA
460 470 480 490 500
KKPYNPIIGE TFHCSWRMPK SEVASGVSSS SSTPAITDHA PLPEEAPTQS
510 520 530 540 550
VSDCYTVRFV AEQVSHHPPV SGFYAECAER KMCVNAHVWT KSKFLGMSIG
560 570 580 590 600
VTMVGEGVLC LLEHGEEYTF SLPCAYARSI LTVPWVELGG KVSVNCAKTG
610 620 630 640 650
YSASITFHTK PFYGGKLHRV TAEVKYNLTN TVVCRVQGEW NSVLEFTYSN
660 670 680 690 700
GETKFVDLAK LAVTKKRVRP LEKQDPFESR RLWKNVTDSL RESEIDKATE
710 720 730 740 750
HKRSLEERQR TEERLRTETG TPWKTKYFIK EGDGWVYHKP LWKGIPSQPA

E
Length:751
Mass (Da):83,629
Last modified:April 13, 2004 - v2
Checksum:i70E5817835DC5B87
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8A0G5E8A0_MOUSE
Oxysterol-binding protein
Osbpl11 mCG_130137
757Annotation score:
A0A338P6F2A0A338P6F2_MOUSE
Oxysterol-binding protein
Osbpl11
751Annotation score:

Sequence cautioni

The sequence AAH35278 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035278 mRNA Translation: AAH35278.1 Different initiation.
UniGeneiMm.486405

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035278 mRNA Translation: AAH35278.1 Different initiation.
UniGeneiMm.486405

3D structure databases

ProteinModelPortaliQ8CI95
SMRiQ8CI95
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CI95, 2 interactors
MINTiQ8CI95
STRINGi10090.ENSMUSP00000039632

PTM databases

iPTMnetiQ8CI95
PhosphoSitePlusiQ8CI95

Proteomic databases

EPDiQ8CI95
MaxQBiQ8CI95
PaxDbiQ8CI95
PeptideAtlasiQ8CI95
PRIDEiQ8CI95

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2146553 Osbpl11

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
HOGENOMiHOG000233871
HOVERGENiHBG053376
InParanoidiQ8CI95
PhylomeDBiQ8CI95

Miscellaneous databases

PROiPR:Q8CI95
SOURCEiSearch...

Gene expression databases

CleanExiMM_OSBPL11

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSB11_MOUSE
AccessioniPrimary (citable) accession number: Q8CI95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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