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Entry version 99 (18 Sep 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Required for meiotic nuclear division protein 1 homolog

Gene

Rmnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Required for meiotic nuclear division protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rmnd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913334 Rmnd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 5MitochondrionSequence analysis5
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297346 – 450Required for meiotic nuclear division protein 1 homologAdd BLAST445

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CI78

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CI78

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CI78

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CI78

PeptideAtlas

More...
PeptideAtlasi
Q8CI78

PRoteomics IDEntifications database

More...
PRIDEi
Q8CI78

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CI78

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CI78

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019763 Expressed in 237 organ(s), highest expression level in brown adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CI78 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CI78 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000043355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CI78

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RMD1/sif2 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2861 Eukaryota
COG1723 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013337

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CI78

KEGG Orthology (KO)

More...
KOi
K23499

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLMQCTA

Database of Orthologous Groups

More...
OrthoDBi
954411at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CI78

TreeFam database of animal gene trees

More...
TreeFami
TF105813

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003734 DUF155

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02582 DUF155, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CI78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRLLHTLA SLHSISAKAH QCQRLTWLTL RPLRKSESTT CHNGLTIQQH
60 70 80 90 100
LHSFFPSITA DSLNKPEILE MSRITSDTSR LFPLNAVHWL DGKEHWPSMH
110 120 130 140 150
PFGTHRSMTH KPNLLCSKWF IKAVKRHHSS VSNEALVPKQ DLPQIKRPLK
160 170 180 190 200
ASRTRQPSRT NLPDLSVNED LMQCTAFATA DEYHLGSLSQ ELVSCGYVEV
210 220 230 240 250
TSLPRDAANI LVMGVESSAK EGDPGTIFLF REGAAVFWNV KEKTMKHVMQ
260 270 280 290 300
VLERHETQPY EVALVHWENE ELNYIKTEGQ SKLHRGEIKL NSELDLDDAI
310 320 330 340 350
LEKFAFSNAL CLSVKLAIWE ATLDKFIESI QSIPEALKAG KKVKLSHKEV
360 370 380 390 400
MQKMGELFAL RHRINLSSDF LITPDFYWDR ANLEELYDKT CQFLSITRRV
410 420 430 440 450
KVMNEKLQHC MELTDLMRNH LNEKRALRLE WMIVILITIE VMFELGRVFF
Length:450
Mass (Da):51,843
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE085AE029FFA3822
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QWS3F6QWS3_MOUSE
Required for meiotic nuclear divisi...
Rmnd1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z331D3Z331_MOUSE
Required for meiotic nuclear divisi...
Rmnd1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVL9D3YVL9_MOUSE
Required for meiotic nuclear divisi...
Rmnd1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZC3D3YZC3_MOUSE
Required for meiotic nuclear divisi...
Rmnd1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41C → S in BAC35851 (PubMed:16141072).Curated1
Sequence conflicti68I → R in AAH27299 (PubMed:15489334).Curated1
Sequence conflicti74 – 76ITS → VTW in AAH27299 (PubMed:15489334).Curated3
Sequence conflicti130S → T in AAH27299 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK007323 mRNA Translation: BAB24958.1
AK009625 mRNA Translation: BAB26398.1
AK075603 mRNA Translation: BAC35851.1
AK163523 mRNA Translation: BAE37381.1
BC019572 mRNA Translation: AAH19572.1
BC027299 mRNA Translation: AAH27299.1
BC036150 mRNA Translation: AAH36150.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56675.1

NCBI Reference Sequences

More...
RefSeqi
NP_079619.4, NM_025343.5
XP_006512540.1, XM_006512477.3
XP_006512541.1, XM_006512478.3
XP_017169542.1, XM_017314053.1
XP_017169543.1, XM_017314054.1
XP_017169544.1, XM_017314055.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000042251; ENSMUSP00000043355; ENSMUSG00000019763

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66084

UCSC genome browser

More...
UCSCi
uc007ehd.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007323 mRNA Translation: BAB24958.1
AK009625 mRNA Translation: BAB26398.1
AK075603 mRNA Translation: BAC35851.1
AK163523 mRNA Translation: BAE37381.1
BC019572 mRNA Translation: AAH19572.1
BC027299 mRNA Translation: AAH27299.1
BC036150 mRNA Translation: AAH36150.1
CCDSiCCDS56675.1
RefSeqiNP_079619.4, NM_025343.5
XP_006512540.1, XM_006512477.3
XP_006512541.1, XM_006512478.3
XP_017169542.1, XM_017314053.1
XP_017169543.1, XM_017314054.1
XP_017169544.1, XM_017314055.1

3D structure databases

SMRiQ8CI78
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043355

PTM databases

PhosphoSitePlusiQ8CI78
SwissPalmiQ8CI78

Proteomic databases

EPDiQ8CI78
jPOSTiQ8CI78
MaxQBiQ8CI78
PaxDbiQ8CI78
PeptideAtlasiQ8CI78
PRIDEiQ8CI78

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042251; ENSMUSP00000043355; ENSMUSG00000019763
GeneIDi66084
KEGGimmu:66084
UCSCiuc007ehd.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55005
MGIiMGI:1913334 Rmnd1

Phylogenomic databases

eggNOGiKOG2861 Eukaryota
COG1723 LUCA
GeneTreeiENSGT00390000013337
InParanoidiQ8CI78
KOiK23499
OMAiDLMQCTA
OrthoDBi954411at2759
PhylomeDBiQ8CI78
TreeFamiTF105813

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8CI78

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019763 Expressed in 237 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ8CI78 baseline and differential
GenevisibleiQ8CI78 MM

Family and domain databases

InterProiView protein in InterPro
IPR003734 DUF155
PfamiView protein in Pfam
PF02582 DUF155, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRMND1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CI78
Secondary accession number(s): Q3TQK1
, Q8BW19, Q8R2S0, Q8VCK4, Q9CV49, Q9CVN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: September 18, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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