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UniProtKB - Q8CI71 (VPS50_MOUSE)

Entry version 116 (29 Sep 2021)
Sequence version 2 (24 May 2005)
Previous versions | rss
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Protein

Syndetin

Gene

Vps50

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SyndetinBy similarity
Alternative name(s):
Bcl2-like protein blm1 Publication
Coiled-coil domain-containing protein 132Curated
EARP/GARPII complex subunit VPS50By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vps50By similarity
Synonyms:Ccdc132Imported, Kiaa18611 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1920538, Vps50

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000001376

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003072661 – 964SyndetinAdd BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei559PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki963Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki963Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CI71

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CI71

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CI71

PeptideAtlas

More...PeptideAtlasi		Q8CI71

PRoteomics IDEntifications database

More...PRIDEi		Q8CI71

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		297817 [Q8CI71-1]
297818 [Q8CI71-2]
297819 [Q8CI71-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CI71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CI71

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8CI71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000001376, Expressed in visual cortex and 286 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CI71, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). The EARP complex interacts with EIPR1 (By similarity).

Interacts with VPS51 and VPS53 in an EIPR1-independent manner (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		215896, 5 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000001412

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CI71, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CI71

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni532 – 563DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili81 – 107Sequence analysisAdd BLAST27
Coiled coili216 – 244Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Polar residuesSequence analysisAdd BLAST16
Compositional biasi549 – 563Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syndetin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2939, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003442

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009513_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CI71

Identification of Orthologs from Complete Genome Data

More...OMAi		MAKVKWD

Database of Orthologous Groups

More...OrthoDBi		293145at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CI71

TreeFam database of animal gene trees

More...TreeFami		TF106152

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019514, Syndetin_C
IPR040047, VPS50
IPR019515, VPS54_N

The PANTHER Classification System

More...PANTHERi		PTHR13258, PTHR13258, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10474, DUF2451, 1 hit
PF10475, Vps54_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CI71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKIKSLMTR QGLKSPPESL NDLGAFESLR VPGKEEFREL REQPSDPQAE 
        60         70         80         90        100
QELINSIEQV YFSADPFDIV KYELEKLPPV LNLQELEEYR DKLKQQQSAV 
       110        120        130        140        150
SKKVADLILE KQPAYVKELE RVTSLQTGLQ LAAVICTNGR RHLNIAKEGF 
       160        170        180        190        200
TQASLGLLAN QRKRQLLIGL LKSLRTIKTL QRTDIRLSEM LEEEDYPGAI 
       210        220        230        240        250
QLCLECQKAA STFKHYSCIS ELNSKLQDTL EQIEEQLDVA LSKICKNFDI 
       260        270        280        290        300
NHYTKVQQAY RLLGKTQTAM DQLHMHFTQA IHNTVFQVVL GYVELCAGNT 
       310        320        330        340        350
DTKFQKLQYK DLCTHVTPDS YIPCLADLCK ALWEVMLSYY RTMEWHEKHD 
       360        370        380        390        400
NEETAAAAEG SNVMSTEEAT FDRGYVKKKL EHGLTRIWQD VQLKVKTYLL 
       410        420        430        440        450
GTDLSIFKYD DFIFVLDIVS RLMQVGEEFC GSKSEVLQES IRKQSVNYFK 
       460        470        480        490        500
NHHRIRLDEL RMFLENETWE LCPVKSNFSI LQLHEFKFLE QSRSPSVSPS 
       510        520        530        540        550
KQPSATSSKP VTLFEQYCSG GNPFEIQADH KDEETEDVLA SNGYESDEQE 
       560        570        580        590        600
KSAYQDYDSD SDVPEELKRD YVDEQTGDVP VKSVSRETLK SRKKSDYSLN 
       610        620        630        640        650
KVNAPILTNT TLNVIRLVGK YMQMMNILKP IAFDVIHFMS QLFDYYLYAI 
       660        670        680        690        700
YTFFGRNDSL ESTGLGLSSS RLKTTLNRIQ ESLIDLEGSA DPTATLTAAE 
       710        720        730        740        750
ERKEKVPSPH LNQLVILTSG DTLYGLAERV VATESLVFLA EQFEFLQPHL 
       760        770        780        790        800
DAVMPAVKKP FLQQFYSQTV STASELRKPI YWIVAGKAID YEQMLLLMMN 
       810        820        830        840        850
VKWDVKEIMS QHNIYVDALL KEFEQFNKRL NEVSKRVRIP LPVSNILWEH 
       860        870        880        890        900
CIRLANRTIV EGYANVKKCS NEGRALMQLD FQQFLMKLEK LTDIRPIPDK 
       910        920        930        940        950
EFVETYIKAY YLTENDMERW IKEHREYSTK QLTNLVNVCL GSHINKKARQ 
       960 
KLLAAIDEID RPKR
Length:964
Mass (Da):111,174
Last modified:May 24, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF88C364742914D0E
GO
Isoform 2 (identifier: Q8CI71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     926-929: EYST → IFSV
     930-964: Missing.

Show »
Length:929
Mass (Da):107,173
Checksum:iC722100327790852
GO
Isoform 3 (identifier: Q8CI71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     926-938: EYSTKQLTNLVNV → VRTRVGVLILSGV
     939-964: Missing.

Show »
Length:938
Mass (Da):108,078
Checksum:iB46952067E166FF5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02304 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98268 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77 – 78LP → PS in BAC31137 (PubMed:16141072).Curated2
Sequence conflicti89 – 96YRDKLKQQ → SRYQFKQH in BAC31137 (PubMed:16141072).Curated8
Sequence conflicti160N → Y in BAC31137 (PubMed:16141072).Curated1
Sequence conflicti429F → S in BAC36038 (PubMed:16141072).Curated1
Sequence conflicti511V → M in AAH02304 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028660926 – 938EYSTK…NLVNV → VRTRVGVLILSGV in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_028661926 – 929EYST → IFSV in isoform 2. 1 Publication4
Alternative sequenceiVSP_028662930 – 964Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_028663939 – 964Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY254697 mRNA Translation: AAO84056.1
AK129458 mRNA Translation: BAC98268.1 Different initiation.
AK042031 mRNA Translation: BAC31137.1
AK075898 mRNA Translation: BAC36038.1
BC002304 mRNA Translation: AAH02304.1 Different initiation.
BC036294 mRNA Translation: AAH36294.2
BC043092 mRNA Translation: AAH43092.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39415.1 [Q8CI71-1]
CCDS51713.1 [Q8CI71-2]
CCDS51714.1 [Q8CI71-3]

NCBI Reference Sequences

More...RefSeqi		NP_001161222.1, NM_001167750.1 [Q8CI71-2]
NP_001161223.1, NM_001167751.1 [Q8CI71-3]
NP_077222.4, NM_024260.5 [Q8CI71-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000001412; ENSMUSP00000001412; ENSMUSG00000001376 [Q8CI71-1]
ENSMUST00000164052; ENSMUSP00000125872; ENSMUSG00000001376 [Q8CI71-2]
ENSMUST00000170873; ENSMUSP00000128323; ENSMUSG00000001376 [Q8CI71-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		73288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:73288

UCSC genome browser

More...UCSCi		uc009avb.2, mouse [Q8CI71-3]
uc009avc.2, mouse [Q8CI71-1]
uc012ehr.1, mouse [Q8CI71-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254697 mRNA Translation: AAO84056.1
AK129458 mRNA Translation: BAC98268.1 Different initiation.
AK042031 mRNA Translation: BAC31137.1
AK075898 mRNA Translation: BAC36038.1
BC002304 mRNA Translation: AAH02304.1 Different initiation.
BC036294 mRNA Translation: AAH36294.2
BC043092 mRNA Translation: AAH43092.1
CCDSiCCDS39415.1 [Q8CI71-1]
CCDS51713.1 [Q8CI71-2]
CCDS51714.1 [Q8CI71-3]
RefSeqiNP_001161222.1, NM_001167750.1 [Q8CI71-2]
NP_001161223.1, NM_001167751.1 [Q8CI71-3]
NP_077222.4, NM_024260.5 [Q8CI71-1]

3D structure databases

SMRiQ8CI71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215896, 5 interactors
STRINGi10090.ENSMUSP00000001412

PTM databases

iPTMnetiQ8CI71
PhosphoSitePlusiQ8CI71
SwissPalmiQ8CI71

Proteomic databases

EPDiQ8CI71
jPOSTiQ8CI71
PaxDbiQ8CI71
PeptideAtlasiQ8CI71
PRIDEiQ8CI71
ProteomicsDBi297817 [Q8CI71-1]
297818 [Q8CI71-2]
297819 [Q8CI71-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15650, 174 antibodies

Genome annotation databases

EnsembliENSMUST00000001412; ENSMUSP00000001412; ENSMUSG00000001376 [Q8CI71-1]
ENSMUST00000164052; ENSMUSP00000125872; ENSMUSG00000001376 [Q8CI71-2]
ENSMUST00000170873; ENSMUSP00000128323; ENSMUSG00000001376 [Q8CI71-3]
GeneIDi73288
KEGGimmu:73288
UCSCiuc009avb.2, mouse [Q8CI71-3]
uc009avc.2, mouse [Q8CI71-1]
uc012ehr.1, mouse [Q8CI71-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55610
MGIiMGI:1920538, Vps50
VEuPathDBiHostDB:ENSMUSG00000001376

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2939, Eukaryota
GeneTreeiENSGT00390000003442
HOGENOMiCLU_009513_1_0_1
InParanoidiQ8CI71
OMAiMAKVKWD
OrthoDBi293145at2759
PhylomeDBiQ8CI71
TreeFamiTF106152

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		73288, 4 hits in 31 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Vps50, mouse

Protein Ontology

More...PROi		PR:Q8CI71
RNActiQ8CI71, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000001376, Expressed in visual cortex and 286 other tissues
GenevisibleiQ8CI71, MM

Family and domain databases

InterProiView protein in InterPro
IPR019514, Syndetin_C
IPR040047, VPS50
IPR019515, VPS54_N
PANTHERiPTHR13258, PTHR13258, 1 hit
PfamiView protein in Pfam
PF10474, DUF2451, 1 hit
PF10475, Vps54_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS50_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CI71
Secondary accession number(s): Q6ZPG9
, Q7TSR5, Q80XR1, Q8C6D0, Q8C9I6, Q99LN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 24, 2005
Last modified: September 29, 2021
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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