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Protein

Stomatin-like protein 1

Gene

Stoml1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cholesterol transfer to late endosomes (By similarity). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (PubMed:24247984).By similarity1 Publication

GO - Molecular functioni

  • ion channel inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 1
Short name:
SLP-1
Gene namesi
Name:Stoml1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916356 Stoml1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini79 – 399CytoplasmicSequence analysisAdd BLAST321

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940301 – 399Stomatin-like protein 1Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CI66
PaxDbiQ8CI66
PRIDEiQ8CI66

PTM databases

PhosphoSitePlusiQ8CI66

Expressioni

Tissue specificityi

Expressed in dorsal root ganglion neurons.1 Publication

Gene expression databases

CleanExiMM_STOML1

Interactioni

Subunit structurei

Interacts with STOM; may redistribute STOM from the plasma membrane to late endosomes.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034883

Structurei

3D structure databases

ProteinModelPortaliQ8CI66
SMRiQ8CI66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 399SCP2Add BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi6 – 10Tyrosine-type lysosomal sorting signalSequence analysisBy similarity5

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
KOG4170 Eukaryota
COG0330 LUCA
HOGENOMiHOG000065698
HOVERGENiHBG079220
InParanoidiQ8CI66
PhylomeDBiQ8CI66

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR028517 SLP1
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF89 PTHR10264:SF89, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
SSF55718 SSF55718, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8CI66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPEPGSV GPGADAPESW
60 70 80 90 100
PSCLCHGLVS VLGFLLLLLT FPISGWFALK IVPTYERMIV FRLGRIRNPQ
110 120 130 140 150
GPGMVLLLPF IDSFQRVDLR TRAFNVPPCK LASKDGAVLS VGADVQFRIW
160 170 180 190 200
DPVLSVMAVK DLNTATRMTA HNAMTKALLR RPLQEIQMEK LKIGDQLLLE
210 220 230 240 250
INDVTRAWGL EVDRVELAVE AVLQPPQDSL TVPSLDSTLQ QLALHLLGGS
260 270 280 290 300
MNSAVGRVPS PGPDTLEMIN EVEPPASLAG AGAEPSPKQP VAEGLLTALQ
310 320 330 340 350
PFLSEALVSQ VGACYQFNVI LPSGTQSIYF LDLTTGQGRV GHGEPDGIPD
360 370 380 390
VVVEMAEADL QALLSKELRP LGAYMSGRLK VKGDLAVVMK LEAVLKALK
Length:399
Mass (Da):42,926
Last modified:March 1, 2003 - v1
Checksum:i1951248C3693B9B2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1F1A0A0B4J1F1_MOUSE
Stomatin-like protein 1
Stoml1
399Annotation score:
A0A1L1STX8A0A1L1STX8_MOUSE
Stomatin-like protein 1
Stoml1
94Annotation score:
A0A1L1STP7A0A1L1STP7_MOUSE
Stomatin-like protein 1
Stoml1
68Annotation score:
A0A1L1SV93A0A1L1SV93_MOUSE
Stomatin-like protein 1
Stoml1
44Annotation score:
A0A1L1STK3A0A1L1STK3_MOUSE
Stomatin-like protein 1
Stoml1
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135D → Y in BAC32502 (PubMed:16141072).Curated1
Sequence conflicti257R → H in BAC32502 (PubMed:16141072).Curated1
Sequence conflicti283A → P in BAC32502 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045820 mRNA Translation: BAC32502.1
BC037074 mRNA Translation: AAH37074.1
CCDSiCCDS23241.1
RefSeqiNP_081218.3, NM_026942.3
UniGeneiMm.216502

Genome annotation databases

GeneIDi69106
KEGGimmu:69106
UCSCiuc009pws.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045820 mRNA Translation: BAC32502.1
BC037074 mRNA Translation: AAH37074.1
CCDSiCCDS23241.1
RefSeqiNP_081218.3, NM_026942.3
UniGeneiMm.216502

3D structure databases

ProteinModelPortaliQ8CI66
SMRiQ8CI66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034883

PTM databases

PhosphoSitePlusiQ8CI66

Proteomic databases

EPDiQ8CI66
PaxDbiQ8CI66
PRIDEiQ8CI66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69106
KEGGimmu:69106
UCSCiuc009pws.2 mouse

Organism-specific databases

CTDi9399
MGIiMGI:1916356 Stoml1

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
KOG4170 Eukaryota
COG0330 LUCA
HOGENOMiHOG000065698
HOVERGENiHBG079220
InParanoidiQ8CI66
PhylomeDBiQ8CI66

Miscellaneous databases

PROiPR:Q8CI66
SOURCEiSearch...

Gene expression databases

CleanExiMM_STOML1

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR028517 SLP1
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF89 PTHR10264:SF89, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
SSF55718 SSF55718, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTML1_MOUSE
AccessioniPrimary (citable) accession number: Q8CI66
Secondary accession number(s): Q8BLA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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