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Protein

BAG family molecular chaperone regulator 4

Gene

Bag4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-75893 TNF signaling

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 4
Short name:
BAG-4
Alternative name(s):
Bcl-2-associated athanogene 4
Silencer of death domains
Gene namesi
Name:Bag4
Synonyms:Sodd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914634 Bag4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi387L → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication1
Mutagenesisi416L → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication1
Mutagenesisi441A → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888711 – 457BAG family molecular chaperone regulator 4Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei41Omega-N-methylarginineBy similarity1
Modified residuei54Omega-N-methylarginineCombined sources1
Modified residuei108Omega-N-methylarginineBy similarity1
Modified residuei185Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8CI61
MaxQBiQ8CI61
PaxDbiQ8CI61
PRIDEiQ8CI61

PTM databases

iPTMnetiQ8CI61
PhosphoSitePlusiQ8CI61

Expressioni

Gene expression databases

BgeeiENSMUSG00000037316 Expressed in 264 organ(s), highest expression level in primary oocyte
CleanExiMM_BAG4
ExpressionAtlasiQ8CI61 baseline and differential
GenevisibleiQ8CI61 MM

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF12 (By similarity). Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Interacts with PRKN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212150, 2 interactors
STRINGi10090.ENSMUSP00000044725

Structurei

3D structure databases

ProteinModelPortaliQ8CI61
SMRiQ8CI61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 456BAGPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 298Pro-richAdd BLAST270

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000290673
HOVERGENiHBG004809
InParanoidiQ8CI61
KOiK09558
OMAiPAETTWP
OrthoDBiEOG091G08LY
PhylomeDBiQ8CI61
TreeFamiTF102013

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PANTHERiPTHR12329 PTHR12329, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CI61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HVPPPLYPPL RPEPPQPPVS
60 70 80 90 100
WRGRGGAPAE TTWPGEGAGG DGYYPSGGAW AEASRAGGGH QEQPPYPGYN
110 120 130 140 150
SNYWNSVRPR APYPGSYSVR PELQGQSLNS YANGAYGPPY PPGPGASTAS
160 170 180 190 200
YSGAYYVPGY TQSNYSTEVP NTYRSPGNSP TPMSRWMYSQ QDCPTEAPPL
210 220 230 240 250
RGQVPGYPAS QNPGMTLPHY PYGDGNRAVP QSGGTGRPQD DAWASSAYGM
260 270 280 290 300
GARYPWPSAA PSAPSAGSLY MTESASPWPG NSSPQPPPSP PPQQPKDPSY
310 320 330 340 350
SYNPSGQGLS RHSFPCSVHQ YESPGAVNND NSDLLDSQVQ YSAEPQLYGN
360 370 380 390 400
ASSEHPSNQV PSNNLPEECF SSDEGTPPSI KKIIHVLEKV QFLEQEVEEF
410 420 430 440 450
VGKKTDKAYW LLEEMLTKEL LELDSVETGG QDSVRQARKE AVCKIQAILE

KLEKKGL
Length:457
Mass (Da):49,095
Last modified:May 9, 2003 - v2
Checksum:i5A70275BD42A6E20
GO

Sequence cautioni

The sequence AAH37239 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332863 mRNA Translation: AAL99586.1
AK010765 mRNA Translation: BAB27167.1
AK136899 mRNA Translation: BAE23161.1
AK162658 mRNA Translation: BAE37009.1
BC009102 mRNA Translation: AAH09102.1
BC037239 mRNA Translation: AAH37239.1 Different initiation.
BC058518 mRNA Translation: AAH58518.1
CCDSiCCDS22201.1
RefSeqiNP_080397.1, NM_026121.3
UniGeneiMm.118400

Genome annotation databases

EnsembliENSMUST00000038498; ENSMUSP00000044725; ENSMUSG00000037316
GeneIDi67384
KEGGimmu:67384
UCSCiuc009lgy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332863 mRNA Translation: AAL99586.1
AK010765 mRNA Translation: BAB27167.1
AK136899 mRNA Translation: BAE23161.1
AK162658 mRNA Translation: BAE37009.1
BC009102 mRNA Translation: AAH09102.1
BC037239 mRNA Translation: AAH37239.1 Different initiation.
BC058518 mRNA Translation: AAH58518.1
CCDSiCCDS22201.1
RefSeqiNP_080397.1, NM_026121.3
UniGeneiMm.118400

3D structure databases

ProteinModelPortaliQ8CI61
SMRiQ8CI61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212150, 2 interactors
STRINGi10090.ENSMUSP00000044725

PTM databases

iPTMnetiQ8CI61
PhosphoSitePlusiQ8CI61

Proteomic databases

EPDiQ8CI61
MaxQBiQ8CI61
PaxDbiQ8CI61
PRIDEiQ8CI61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038498; ENSMUSP00000044725; ENSMUSG00000037316
GeneIDi67384
KEGGimmu:67384
UCSCiuc009lgy.1 mouse

Organism-specific databases

CTDi9530
MGIiMGI:1914634 Bag4

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000290673
HOVERGENiHBG004809
InParanoidiQ8CI61
KOiK09558
OMAiPAETTWP
OrthoDBiEOG091G08LY
PhylomeDBiQ8CI61
TreeFamiTF102013

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-75893 TNF signaling

Miscellaneous databases

PROiPR:Q8CI61
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037316 Expressed in 264 organ(s), highest expression level in primary oocyte
CleanExiMM_BAG4
ExpressionAtlasiQ8CI61 baseline and differential
GenevisibleiQ8CI61 MM

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PANTHERiPTHR12329 PTHR12329, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAG4_MOUSE
AccessioniPrimary (citable) accession number: Q8CI61
Secondary accession number(s): Q3TRL9, Q91VT5, Q9CWG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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