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Protein

Myosin light chain 6B

Gene

Myl6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.Curated

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:Myl6bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917789 Myl6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488331 – 207Myosin light chain 6BAdd BLAST207

Proteomic databases

EPDiQ8CI43
MaxQBiQ8CI43
PaxDbiQ8CI43
PeptideAtlasiQ8CI43
PRIDEiQ8CI43

PTM databases

iPTMnetiQ8CI43
PhosphoSitePlusiQ8CI43

Expressioni

Gene expression databases

BgeeiENSMUSG00000039824 Expressed in 39 organ(s), highest expression level in brain
CleanExiMM_MYL6B

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi229752, 2 interactors
IntActiQ8CI43, 3 interactors
MINTiQ8CI43
STRINGi10090.ENSMUSP00000026428

Structurei

3D structure databases

ProteinModelPortaliQ8CI43
SMRiQ8CI43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 98EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini140 – 175EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini175 – 207EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ8CI43
KOiK12751
OMAiPREVDYK
OrthoDBiEOG091G0TQL
PhylomeDBiQ8CI43
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8CI43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKKDAPVK KPAGPSISKP AAKSTPGTPL AKAKAEPAAP QAPAKSQEPP
60 70 80 90 100
VDLSKVVIEF NKDQLEEFRE AFELFDRVGD GKILYSQCGD LMRALGQNPT
110 120 130 140 150
NAEVLKVLGN PKNEELKSRR VDFETFLPML QAVAKNRDQG TYEDYLEGLR
160 170 180 190 200
VFDKEGNGKV MGAELRHVLT TLGEKMTEEE VETVLAGHED SNGCINYEAF

LKHILSL
Length:207
Mass (Da):22,749
Last modified:March 1, 2003 - v1
Checksum:iF402A5302A44F708
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037527 mRNA Translation: AAH37527.1
CCDSiCCDS24279.1
RefSeqiNP_758463.1, NM_172259.1
XP_017169402.1, XM_017313913.1
XP_017169403.1, XM_017313914.1
XP_017169404.1, XM_017313915.1
XP_017169405.1, XM_017313916.1
XP_017169406.1, XM_017313917.1
UniGeneiMm.291688

Genome annotation databases

EnsembliENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824
GeneIDi216459
KEGGimmu:216459
UCSCiuc007hne.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037527 mRNA Translation: AAH37527.1
CCDSiCCDS24279.1
RefSeqiNP_758463.1, NM_172259.1
XP_017169402.1, XM_017313913.1
XP_017169403.1, XM_017313914.1
XP_017169404.1, XM_017313915.1
XP_017169405.1, XM_017313916.1
XP_017169406.1, XM_017313917.1
UniGeneiMm.291688

3D structure databases

ProteinModelPortaliQ8CI43
SMRiQ8CI43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229752, 2 interactors
IntActiQ8CI43, 3 interactors
MINTiQ8CI43
STRINGi10090.ENSMUSP00000026428

PTM databases

iPTMnetiQ8CI43
PhosphoSitePlusiQ8CI43

Proteomic databases

EPDiQ8CI43
MaxQBiQ8CI43
PaxDbiQ8CI43
PeptideAtlasiQ8CI43
PRIDEiQ8CI43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824
GeneIDi216459
KEGGimmu:216459
UCSCiuc007hne.1 mouse

Organism-specific databases

CTDi140465
MGIiMGI:1917789 Myl6b

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ8CI43
KOiK12751
OMAiPREVDYK
OrthoDBiEOG091G0TQL
PhylomeDBiQ8CI43
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Miscellaneous databases

PROiPR:Q8CI43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039824 Expressed in 39 organ(s), highest expression level in brain
CleanExiMM_MYL6B

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6B_MOUSE
AccessioniPrimary (citable) accession number: Q8CI43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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