UniProtKB - Q8CI33 (C19L1_MOUSE)
Protein
CWF19-like protein 1
Gene
Cwf19l1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- RNA lariat debranching enzyme activator activity Source: GO_Central
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: CWF19-like protein 1 |
Gene namesi | Name:Cwf19l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919752, Cwf19l1 |
Subcellular locationi
Nucleus
- post-mRNA release spliceosomal complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315642 | 1 – 537 | CWF19-like protein 1Add BLAST | 537 |
Proteomic databases
EPDi | Q8CI33 |
PaxDbi | Q8CI33 |
PeptideAtlasi | Q8CI33 |
PRIDEi | Q8CI33 |
PTM databases
iPTMneti | Q8CI33 |
PhosphoSitePlusi | Q8CI33 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025200, Expressed in substantia nigra and 283 other tissues |
ExpressionAtlasi | Q8CI33, baseline and differential |
Genevisiblei | Q8CI33, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 215403, 1 interactor |
STRINGi | 10090.ENSMUSP00000026218 |
Miscellaneous databases
RNActi | Q8CI33, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CWF19 family.Curated
Phylogenomic databases
eggNOGi | KOG2476, Eukaryota |
GeneTreei | ENSGT00940000156000 |
HOGENOMi | CLU_019955_2_0_1 |
InParanoidi | Q8CI33 |
OMAi | LKPRYHL |
OrthoDBi | 414028at2759 |
TreeFami | TF105790 |
Family and domain databases
Gene3Di | 3.30.428.10, 1 hit |
InterProi | View protein in InterPro IPR040194, Cwf19-like IPR006768, Cwf19-like_C_dom-1 IPR006767, Cwf19-like_C_dom-2 IPR036265, HIT-like_sf |
PANTHERi | PTHR12072, PTHR12072, 1 hit |
Pfami | View protein in Pfam PF04677, CwfJ_C_1, 1 hit PF04676, CwfJ_C_2, 1 hit |
SUPFAMi | SSF54197, SSF54197, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CI33-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQKPLRLLA CGDVEGKFDV LFNRVRTIQK KSGNFDLLLC VGNFFGSAQD
60 70 80 90 100
AEWEEYKTGN KKAPIQTYVL GANNEETANY FQGADGCELA ENITYLGRKG
110 120 130 140 150
VFTGSSGLQI VYLSGTESLD EPVPAHSFSP KDVSSLRTML CSASQFKGVD
160 170 180 190 200
ILLTSPWPKY VGSFGNSSGE VDTKNCGSAL ISSLAVSLKP RYHFAALEKS
210 220 230 240 250
YYERLPYRNH VVLQESAQHA TRFIALANVG NPEKKKYLYA FSIVPMKLMA
260 270 280 290 300
VAELVKQPPD VTENPYRDSG KQAAGGKHIP APQEESACQF FFDLSEKQGR
310 320 330 340 350
KRPSTGRDTR PPHAKQPRKP PQPPGPCWFC LASPEVEKHL VVNIGTHCYL
360 370 380 390 400
ALAKGGLSDD HVLILPIGHY QSVVELSAEV VEEVEKYKAT LQRFFKSRGK
410 420 430 440 450
RCVLFERNYR SHHLQLQVIP VPLSCCATDD IKDAFITQAQ EQQIELLEIP
460 470 480 490 500
EHSDIKQIAQ PGAAYFYVEL DTGEKLFHRI KKNFPLQFGR EVLASEAILN
510 520 530
IPEKADWRQC QTSKDEEEAL ARRFRKDFEP FDFTLDD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494B9Q5 | A0A494B9Q5_MOUSE | CWF19-like protein 1 | Cwf19l1 | 296 | Annotation score: | ||
A0A494BBD4 | A0A494BBD4_MOUSE | CWF19-like protein 1 | Cwf19l1 | 113 | Annotation score: |
Sequence cautioni
The sequence AAH27553 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | G → D in AAH37640 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 480 | I → S in BAE24095 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030589 | 1 – 138 | Missing in isoform 2. 1 PublicationAdd BLAST | 138 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK088543 mRNA Translation: BAC40413.1 AK139654 mRNA Translation: BAE24095.1 AC125101 Genomic DNA No translation available. BC027553 mRNA Translation: AAH27553.1 Sequence problems. BC037640 mRNA Translation: AAH37640.1 |
CCDSi | CCDS37995.1 [Q8CI33-1] |
RefSeqi | NP_001074546.1, NM_001081077.1 [Q8CI33-1] XP_006527427.1, XM_006527364.2 [Q8CI33-2] XP_006527428.1, XM_006527365.2 XP_011245659.1, XM_011247357.2 [Q8CI33-2] XP_011245660.1, XM_011247358.2 [Q8CI33-2] XP_017173785.1, XM_017318296.1 [Q8CI33-2] XP_017173786.1, XM_017318297.1 [Q8CI33-2] |
Genome annotation databases
Ensembli | ENSMUST00000026218; ENSMUSP00000026218; ENSMUSG00000025200 [Q8CI33-1] |
GeneIDi | 72502 |
KEGGi | mmu:72502 |
UCSCi | uc008hpj.1, mouse [Q8CI33-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK088543 mRNA Translation: BAC40413.1 AK139654 mRNA Translation: BAE24095.1 AC125101 Genomic DNA No translation available. BC027553 mRNA Translation: AAH27553.1 Sequence problems. BC037640 mRNA Translation: AAH37640.1 |
CCDSi | CCDS37995.1 [Q8CI33-1] |
RefSeqi | NP_001074546.1, NM_001081077.1 [Q8CI33-1] XP_006527427.1, XM_006527364.2 [Q8CI33-2] XP_006527428.1, XM_006527365.2 XP_011245659.1, XM_011247357.2 [Q8CI33-2] XP_011245660.1, XM_011247358.2 [Q8CI33-2] XP_017173785.1, XM_017318296.1 [Q8CI33-2] XP_017173786.1, XM_017318297.1 [Q8CI33-2] |
3D structure databases
SMRi | Q8CI33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215403, 1 interactor |
STRINGi | 10090.ENSMUSP00000026218 |
PTM databases
iPTMneti | Q8CI33 |
PhosphoSitePlusi | Q8CI33 |
Proteomic databases
EPDi | Q8CI33 |
PaxDbi | Q8CI33 |
PeptideAtlasi | Q8CI33 |
PRIDEi | Q8CI33 |
Protocols and materials databases
Antibodypediai | 49159, 100 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026218; ENSMUSP00000026218; ENSMUSG00000025200 [Q8CI33-1] |
GeneIDi | 72502 |
KEGGi | mmu:72502 |
UCSCi | uc008hpj.1, mouse [Q8CI33-1] |
Organism-specific databases
CTDi | 55280 |
MGIi | MGI:1919752, Cwf19l1 |
Phylogenomic databases
eggNOGi | KOG2476, Eukaryota |
GeneTreei | ENSGT00940000156000 |
HOGENOMi | CLU_019955_2_0_1 |
InParanoidi | Q8CI33 |
OMAi | LKPRYHL |
OrthoDBi | 414028at2759 |
TreeFami | TF105790 |
Miscellaneous databases
BioGRID-ORCSi | 72502, 5 hits in 18 CRISPR screens |
ChiTaRSi | Cwf19l1, mouse |
PROi | PR:Q8CI33 |
RNActi | Q8CI33, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025200, Expressed in substantia nigra and 283 other tissues |
ExpressionAtlasi | Q8CI33, baseline and differential |
Genevisiblei | Q8CI33, MM |
Family and domain databases
Gene3Di | 3.30.428.10, 1 hit |
InterProi | View protein in InterPro IPR040194, Cwf19-like IPR006768, Cwf19-like_C_dom-1 IPR006767, Cwf19-like_C_dom-2 IPR036265, HIT-like_sf |
PANTHERi | PTHR12072, PTHR12072, 1 hit |
Pfami | View protein in Pfam PF04677, CwfJ_C_1, 1 hit PF04676, CwfJ_C_2, 1 hit |
SUPFAMi | SSF54197, SSF54197, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C19L1_MOUSE | |
Accessioni | Q8CI33Primary (citable) accession number: Q8CI33 Secondary accession number(s): E9QNL3 Q8C2J2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families