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Protein

BAG family molecular chaperone regulator 5

Gene

Bag5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • protein kinase binding Source: MGI
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 5
Short name:
BAG-5
Alternative name(s):
Bcl-2-associated athanogene 5
Gene namesi
Name:Bag5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1917619 Bag5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888731 – 447BAG family molecular chaperone regulator 5Add BLAST447

Proteomic databases

EPDiQ8CI32
MaxQBiQ8CI32
PaxDbiQ8CI32
PeptideAtlasiQ8CI32
PRIDEiQ8CI32

PTM databases

iPTMnetiQ8CI32
PhosphoSitePlusiQ8CI32

Expressioni

Gene expression databases

BgeeiENSMUSG00000049792 Expressed in 262 organ(s), highest expression level in testis
CleanExiMM_BAG5
ExpressionAtlasiQ8CI32 baseline and differential
GenevisibleiQ8CI32 MM

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PRKN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214005, 1 interactor
IntActiQ8CI32, 4 interactors
STRINGi10090.ENSMUSP00000051049

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8CI32
SMRiQ8CI32
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CI32

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 86BAG 1PROSITE-ProRule annotationAdd BLAST78
Domaini95 – 167BAG 2PROSITE-ProRule annotationAdd BLAST73
Domaini182 – 260BAG 3PROSITE-ProRule annotationAdd BLAST79
Domaini275 – 350BAG 4PROSITE-ProRule annotationAdd BLAST76
Domaini365 – 442BAG 5PROSITE-ProRule annotationAdd BLAST78

Domaini

The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000070447
HOVERGENiHBG004810
InParanoidiQ8CI32
KOiK09559
OMAiRTEIRNY
OrthoDBiEOG091G08LY
PhylomeDBiQ8CI32
TreeFamiTF102014

Family and domain databases

Gene3Di1.20.58.120, 5 hits
InterProiView protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PANTHERiPTHR12329 PTHR12329, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 4 hits
SMARTiView protein in SMART
SM00264 BAG, 4 hits
SUPFAMiSSF63491 SSF63491, 4 hits
PROSITEiView protein in PROSITE
PS51035 BAG, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CI32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMGNQHPSI SRLQEIQREV KAIEPQVVGF SGLSDDKNYK RLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFKE
110 120 130 140 150
AQALVKDKIV PFYSGGNCVT DEFEEGIQDI ILRLTHVKTG GKVSLRKARY
160 170 180 190 200
RTLTKICAVQ EVIEDCMKKQ PSLPLSEDVH PSVAKINSVM CEVNKARGTL
210 220 230 240 250
IALLMGVDSS ETCRHLSCVL SGLIADLDAL DVCGRTEIRN YRREVVEDIN
260 270 280 290 300
KLLKYLDLEE EADSTHAFDL GQNHSIIKIE NVLKRMREIK NELLQAQSPP
310 320 330 340 350
ELYLRAKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ ILITYLDLKE
360 370 380 390 400
ALEKRKLFPC EEHPPHKAVW EILGNLSEIL GEVLSFGGNR TDKNYIRLEE
410 420 430 440
LLTKQLLALD AVDPQGEEKC KAARKQAVKL AQNILSYLDM KSDEWEY
Length:447
Mass (Da):50,943
Last modified:March 1, 2003 - v1
Checksum:i72E2C5472DA95416
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYW3E0CYW3_MOUSE
BAG family molecular chaperone regu...
Bag5
59Annotation score:
E0CX76E0CX76_MOUSE
BAG family molecular chaperone regu...
Bag5
37Annotation score:

Sequence cautioni

The sequence AAH27827 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB24105 differs from that shown. Reason: Frameshift at positions 5, 8, 16, 34, 40, 42, 44, 54, 56 and 64.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6Q → H in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti23I → K in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti36D → E in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti52E → G in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti142K → E in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti148A → S in BAB24105 (PubMed:16141072).Curated1
Sequence conflicti341I → T in AAH27827 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005534 mRNA Translation: BAB24105.1 Frameshift.
AK160246 mRNA Translation: BAE35711.1
BC027827 mRNA Translation: AAH27827.1 Different initiation.
BC037642 mRNA Translation: AAH37642.1
CCDSiCCDS26185.1
RefSeqiNP_001311409.1, NM_001324480.1
NP_001311410.1, NM_001324481.1
NP_001311411.1, NM_001324482.1
NP_081680.1, NM_027404.2
XP_006516280.1, XM_006516217.3
UniGeneiMm.44239

Genome annotation databases

EnsembliENSMUST00000054636; ENSMUSP00000051049; ENSMUSG00000049792
ENSMUST00000160576; ENSMUSP00000125183; ENSMUSG00000049792
GeneIDi70369
KEGGimmu:70369
UCSCiuc007pdr.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005534 mRNA Translation: BAB24105.1 Frameshift.
AK160246 mRNA Translation: BAE35711.1
BC027827 mRNA Translation: AAH27827.1 Different initiation.
BC037642 mRNA Translation: AAH37642.1
CCDSiCCDS26185.1
RefSeqiNP_001311409.1, NM_001324480.1
NP_001311410.1, NM_001324481.1
NP_001311411.1, NM_001324482.1
NP_081680.1, NM_027404.2
XP_006516280.1, XM_006516217.3
UniGeneiMm.44239

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UGONMR-A1-86[»]
ProteinModelPortaliQ8CI32
SMRiQ8CI32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214005, 1 interactor
IntActiQ8CI32, 4 interactors
STRINGi10090.ENSMUSP00000051049

PTM databases

iPTMnetiQ8CI32
PhosphoSitePlusiQ8CI32

Proteomic databases

EPDiQ8CI32
MaxQBiQ8CI32
PaxDbiQ8CI32
PeptideAtlasiQ8CI32
PRIDEiQ8CI32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054636; ENSMUSP00000051049; ENSMUSG00000049792
ENSMUST00000160576; ENSMUSP00000125183; ENSMUSG00000049792
GeneIDi70369
KEGGimmu:70369
UCSCiuc007pdr.3 mouse

Organism-specific databases

CTDi9529
MGIiMGI:1917619 Bag5

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000070447
HOVERGENiHBG004810
InParanoidiQ8CI32
KOiK09559
OMAiRTEIRNY
OrthoDBiEOG091G08LY
PhylomeDBiQ8CI32
TreeFamiTF102014

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

EvolutionaryTraceiQ8CI32
PROiPR:Q8CI32
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049792 Expressed in 262 organ(s), highest expression level in testis
CleanExiMM_BAG5
ExpressionAtlasiQ8CI32 baseline and differential
GenevisibleiQ8CI32 MM

Family and domain databases

Gene3Di1.20.58.120, 5 hits
InterProiView protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PANTHERiPTHR12329 PTHR12329, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 4 hits
SMARTiView protein in SMART
SM00264 BAG, 4 hits
SUPFAMiSSF63491 SSF63491, 4 hits
PROSITEiView protein in PROSITE
PS51035 BAG, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBAG5_MOUSE
AccessioniPrimary (citable) accession number: Q8CI32
Secondary accession number(s): Q3TVA8, Q8K175, Q9DAU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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