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Protein

Conserved oligomeric Golgi complex subunit 3

Gene

Cog3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ER-Golgi transport.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 3
Short name:
COG complex subunit 3
Alternative name(s):
Component of oligomeric Golgi complex 3
Gene namesi
Name:Cog3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2450151 Cog3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135011 – 820Conserved oligomeric Golgi complex subunit 3Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei655PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CI04
MaxQBiQ8CI04
PaxDbiQ8CI04
PeptideAtlasiQ8CI04
PRIDEiQ8CI04

PTM databases

iPTMnetiQ8CI04
PhosphoSitePlusiQ8CI04

Expressioni

Gene expression databases

CleanExiMM_COG3

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045016

Family & Domainsi

Sequence similaritiesi

Belongs to the COG3 family.Curated

Phylogenomic databases

eggNOGiKOG2604 Eukaryota
ENOG410XNXH LUCA
HOGENOMiHOG000264596
HOVERGENiHBG051062
InParanoidiQ8CI04
PhylomeDBiQ8CI04

Family and domain databases

InterProiView protein in InterPro
IPR007265 COG_su3
PANTHERiPTHR13302 PTHR13302, 1 hit
PfamiView protein in Pfam
PF04136 Sec34, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CI04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAAAERDA REKLSLWDGR PDSMAPLTDR QTDSVLELKA AVENLPVPAE
60 70 80 90 100
LPIEDVCSLA SQSLPIELTA VVPDSTEDIL LKGFTSLGME EERIETAQQF
110 120 130 140 150
FSWFAKLQTQ MDQDEGTKYR QMRDYLSGFQ EQCDAILNDV NSALQHLESL
160 170 180 190 200
QKQYLFVSNK TGTLHEACEQ LLKEQSELAD LAEHIQQKLS YFNELETINT
210 220 230 240 250
KLNSPTLSVN SEGFIPMLAK LDDCITYISS HPNFKDYPVY LLKFKQCLSK
260 270 280 290 300
ALHLMKTYTV NTLQTLTNQL LKRDPSSVPN ADNAFTLFYV KFRAAAPKVR
310 320 330 340 350
TLIEQIEQRS EKIPEYQHLL NDIHQCYLDQ RELLLGPSIA YTVTELTSQN
360 370 380 390 400
NRDHCALVRS GCAFMVHVCQ DEHQLYNEFF TKPTSKLDEL LEKLCVSLYD
410 420 430 440 450
VFRPLIIHVI HLETLSELCG ILKNEVLEDH VQHNAEQLGA FAAGVKQMLE
460 470 480 490 500
DVQERLVYRT HIYIQTDITG YKPAPGDLAY PDKLVMMEQI AQSLKDEQKK
510 520 530 540 550
APSEASFSDV RLEEGEASGL RKSGSTDSLN PRPQTTISPA DLHGMWYPTV
560 570 580 590 600
RRTLVCLSKL YRCIDRAVFQ GLSQEALSAC IQSLLGASES ISKNKTQIDG
610 620 630 640 650
QLFLIKHLLI LREQIAPFHT EFTIKEISLD LKKTRDAAFK ILNPMTVPRF
660 670 680 690 700
FRLNSNNALI EFLLEGTPEI REHYLDSKKD VDRHLKSACE QFIQQQTRLF
710 720 730 740 750
GEQLEEFMTK VSALKTMASQ GGPKYTLSQQ PWAQPAKVND LVATAYKTIK
760 770 780 790 800
TKLPLTLRSM ALYLSNKDTE FILFKPVRNN IQQVFQKFHA LLKEEFSSED
810 820
IQIIACPSME QLNLLLSVSK
Length:820
Mass (Da):93,283
Last modified:January 23, 2007 - v3
Checksum:iFBB2D019E6DA6AA6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QL65E9QL65_MOUSE
Conserved oligomeric Golgi complex ...
Cog3
828Annotation score:
A0A2I3BQD7A0A2I3BQD7_MOUSE
Conserved oligomeric Golgi complex ...
Cog3
818Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038030 mRNA Translation: AAH38030.1
UniGeneiMm.86507

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038030 mRNA Translation: AAH38030.1
UniGeneiMm.86507

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045016

PTM databases

iPTMnetiQ8CI04
PhosphoSitePlusiQ8CI04

Proteomic databases

EPDiQ8CI04
MaxQBiQ8CI04
PaxDbiQ8CI04
PeptideAtlasiQ8CI04
PRIDEiQ8CI04

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2450151 Cog3

Phylogenomic databases

eggNOGiKOG2604 Eukaryota
ENOG410XNXH LUCA
HOGENOMiHOG000264596
HOVERGENiHBG051062
InParanoidiQ8CI04
PhylomeDBiQ8CI04

Miscellaneous databases

PROiPR:Q8CI04
SOURCEiSearch...

Gene expression databases

CleanExiMM_COG3

Family and domain databases

InterProiView protein in InterPro
IPR007265 COG_su3
PANTHERiPTHR13302 PTHR13302, 1 hit
PfamiView protein in Pfam
PF04136 Sec34, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOG3_MOUSE
AccessioniPrimary (citable) accession number: Q8CI04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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