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Protein

Transcription termination factor 1a, mitochondrial

Gene

Mterf1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

ReactomeiR-MMU-163316 Mitochondrial transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 1a, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 1a
Short name:
mTERF1a
Gene namesi
Name:Mterf1a
Synonyms:Mterf, Mterf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918240 Mterf1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Double knockout of Mterf1a and Mterf1b results in viable animals with no gross phenotype, and normal oxidative phosphorylation capacity. Steady-state mitochondrial DNA levels are normal. There are subtle effects on levels of mitochondrial transcripts: transcripts initiated at the light strand promoter and also downstream of the MTERF binding site are increased, levels of 7S RNA are reduced, while levels of other mitochondrial transcripts are normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionSequence analysisAdd BLAST37
ChainiPRO_000002178038 – 379Transcription termination factor 1a, mitochondrialAdd BLAST342

Post-translational modificationi

Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CHZ9
PaxDbiQ8CHZ9
PeptideAtlasiQ8CHZ9
PRIDEiQ8CHZ9

PTM databases

iPTMnetiQ8CHZ9
PhosphoSitePlusiQ8CHZ9

Expressioni

Tissue specificityi

Predominantly expressed in heart and liver, with extremely low levels in other tissues (PubMed:15582606). Expressed strongly in the heart and at lower levels in brain, liver and kidney (PubMed:23562081).2 Publications

Gene expression databases

BgeeiENSMUSG00000040429
CleanExiMM_MTERF
GenevisibleiQ8CHZ9 MM

Interactioni

Subunit structurei

Monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei144Interaction with DNABy similarity1
Sitei184Interaction with DNABy similarity1
Sitei332Interaction with DNABy similarity1

Protein-protein interaction databases

IntActiQ8CHZ9, 1 interactor
STRINGi10090.ENSMUSP00000046017

Structurei

3D structure databases

ProteinModelPortaliQ8CHZ9
SMRiQ8CHZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 152Interaction with DNABy similarity2
Regioni229 – 233Interaction with DNABy similarity5
Regioni306 – 313Interaction with DNABy similarity8
Regioni337 – 340Interaction with DNABy similarity4
Regioni366 – 373Interaction with DNABy similarity8

Domaini

Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA (By similarity).By similarity

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00530000063817
HOGENOMiHOG000252957
HOVERGENiHBG052524
InParanoidiQ8CHZ9
KOiK15031
OMAiXNLENNI
OrthoDBiEOG091G0AQ5
PhylomeDBiQ8CHZ9
TreeFamiTF330821

Family and domain databases

Gene3Di1.25.70.10, 1 hit
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRNIWCVR RNFLFDLRDW MLQYSAEVFL KSISFRPFSA ECDSKDKESL
60 70 80 90 100
EEEREDLLSN LVTMGVDIDM ARRRQPGVFN KAVTNEQELK LFLLSKGASD
110 120 130 140 150
KVIGSIISRY PRAITRTPES LSKRWDLWRK IMASDLEIVN ILERSPESFF
160 170 180 190 200
RSNNNLNLEN NIKFLCSVGL THKCLCRLLT NAPRTFSNSL NLNKQMVEFL
210 220 230 240 250
QETGMSLGHN DPRDFVRKII SKNPSILIQS TKRVKTNIEF LQSTFNLNKR
260 270 280 290 300
DLLLLICGPG ARILDLSNDC TKKNYTNIRE RLLSLGCSEE EVQRFVLSYL
310 320 330 340 350
NMVFLSEKKF NDKIDCLIEE KISASQIIEN PRILDSSINT LKTRIRELSH
360 370
AGYDLSTSSI ALLSWSQRRY EAKLKRLCG
Length:379
Mass (Da):43,815
Last modified:March 1, 2003 - v1
Checksum:i735133D605A04054
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19D → G in AAH82778 (PubMed:15489334).Curated1
Sequence conflicti19D → G in AAH94442 (PubMed:15489334).Curated1
Sequence conflicti40A → V in AAH82778 (PubMed:15489334).Curated1
Sequence conflicti40A → V in AAH94442 (PubMed:15489334).Curated1
Sequence conflicti91L → I in AAH82778 (PubMed:15489334).Curated1
Sequence conflicti91L → I in AAH94442 (PubMed:15489334).Curated1
Sequence conflicti126D → H in AAH82778 (PubMed:15489334).Curated1
Sequence conflicti126D → H in AAH94442 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY726770 mRNA Translation: AAU26065.1
AC027653 Genomic DNA No translation available.
BC038058 mRNA Translation: AAH38058.1
BC051251 mRNA Translation: AAH51251.1
BC082778 mRNA Translation: AAH82778.1
BC094442 mRNA Translation: AAH94442.1
AK049308 mRNA Translation: BAC33673.1
CCDSiCCDS39003.1
RefSeqiNP_001013041.2, NM_001013023.2
NP_742147.1, NM_172135.2
UniGeneiMm.489094
Mm.99593

Genome annotation databases

EnsembliENSMUST00000044746; ENSMUSP00000046017; ENSMUSG00000040429
ENSMUST00000117463; ENSMUSP00000113306; ENSMUSG00000040429
GeneIDi545725
KEGGimmu:545725
UCSCiuc008why.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTF1A_MOUSE
AccessioniPrimary (citable) accession number: Q8CHZ9
Secondary accession number(s): Q63ZX5, Q8C7T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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