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Entry version 142 (17 Jun 2020)
Sequence version 2 (19 Jul 2004)
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Protein

Transcriptional repressor p66 alpha

Gene

Gatad2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor (By similarity). Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri410 – 462GATA-typeAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6804758 Regulation of TP53 Activity through Acetylation
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-8943724 Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional repressor p66 alpha
Alternative name(s):
GATA zinc finger domain-containing protein 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gatad2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2384585 Gatad2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835011 – 629Transcriptional repressor p66 alphaAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei96PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei133PhosphoserineBy similarity1
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei185PhosphothreonineBy similarity1
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei221Omega-N-methylarginineCombined sources1
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei245Omega-N-methylarginineCombined sources1
Modified residuei253Omega-N-methylarginineBy similarity1
Modified residuei268Omega-N-methylarginineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei280Omega-N-methylarginineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei509PhosphoserineBy similarity1
Modified residuei536Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei536Omega-N-methylarginine; alternateBy similarity1
Modified residuei543PhosphoserineBy similarity1
Modified residuei545PhosphoserineBy similarity1
Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei553PhosphoserineBy similarity1
Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei594PhosphoserineBy similarity1
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CHY6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CHY6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CHY6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CHY6

PeptideAtlas

More...
PeptideAtlasi
Q8CHY6

PRoteomics IDEntifications database

More...
PRIDEi
Q8CHY6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CHY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CHY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036180 Expressed in heart and 301 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CHY6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CHY6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MBD2 and MBD3 (By similarity). Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (By similarity).

Component of the MeCP1 histone deacetylase complex (By similarity).

Interacts with histone tails, including that of histones H2A, H2B, H3 and H4 (By similarity). This interaction is reduced by histone acetylation (By similarity).

Interacts with ERCC6 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231518, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-953 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-954 MBD3/NuRD nucleosome remodeling and deacetylase complex

Protein interaction database and analysis system

More...
IntActi
Q8CHY6, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8CHY6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000070229

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CHY6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CHY6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni140 – 174CR1; interaction with MBD2By similarityAdd BLAST35
Regioni335 – 478CR2; histone tail-bindingBy similarityAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili135 – 170Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi402 – 407Poly-Ala6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both CR1 and CR2 regions are required for speckled nuclear localization.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri410 – 462GATA-typeAdd BLAST53

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3740 Eukaryota
ENOG410XRVM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004097

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CHY6

KEGG Orthology (KO)

More...
KOi
K23194

Database of Orthologous Groups

More...
OrthoDBi
885815at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CHY6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040386 P66
IPR032346 P66_CC

The PANTHER Classification System

More...
PANTHERi
PTHR13455 PTHR13455, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16563 P66_CC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CHY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEACRTRS QKRTLEPDLT EDDVENKKMK MEKGSSELTV DGDSRVMPEP
60 70 80 90 100
SAGSAQGLLR TTEAMGTGSG EGLLGDGPVD MRTSHSDMKS EKRPPSPDVI
110 120 130 140 150
VLSDSEQPSS PRVNGLTTVA LKDTSTEALL KSSPEERERM IKQLKEELRL
160 170 180 190 200
EEAKLVLLKK LRQSQIQKEA TAQKPTASSG STVTTPPPLV RGTQNIPAGK
210 220 230 240 250
TSLQTSSTRI PGSIIPPPLV RGGQQVSAKL GPQASSQVVM PPLVRGAQIH
260 270 280 290 300
NIRQHSSTGP PPLLLAPRAS VPSMQIQGQR IIQQGLIRVA NVPNTSLLVN
310 320 330 340 350
IPQPTAASMK GTAVASAQAN STPTSVASVV ASAESPASRQ AAAKLALRKQ
360 370 380 390 400
LEKTLLEIPP PKPPAPEMNF LPSAANNEFI YLVGLEEVVQ NLLETQAGRI
410 420 430 440 450
SATAAAAVLS REPYMCVQCK TDFTCRWREK GGAVMCENCM TSNQKKALKV
460 470 480 490 500
EHTSRLKAAF VKALQQEQEM EQRLLQQGVG TASIKAEPAA PHPTLKQVIK
510 520 530 540 550
PRRKLAFRSG EARVWNNGSS LQASSQLSRG SATAPRGVLH TFSQSPKLQN
560 570 580 590 600
AASATALVSR TGRHSERVVG TGKGTASNWK KTPLSTGGTL AFVSPSLAVH
610 620
KTSSAVDRQR EYLLDMIPPR SIPQSATWK
Length:629
Mass (Da):67,334
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EA79CC71C9E29A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QMN5E9QMN5_MOUSE
Transcriptional repressor p66 alpha
Gatad2a
630Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM58A0A1D5RM58_MOUSE
Transcriptional repressor p66 alpha
Gatad2a
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1I7Q4G8A0A1I7Q4G8_MOUSE
Transcriptional repressor p66 alpha
Gatad2a
614Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM07A0A1D5RM07_MOUSE
Transcriptional repressor p66 alpha
Gatad2a
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19178 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH31407 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC40736 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248Q → QQ in BAC40736 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK089074 mRNA Translation: BAC40736.1 Different initiation.
BC019178 mRNA Translation: AAH19178.1 Different initiation.
BC031407 mRNA Translation: AAH31407.1 Different initiation.
BC038221 mRNA Translation: AAH38221.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52567.1

NCBI Reference Sequences

More...
RefSeqi
NP_001106817.1, NM_001113346.1
XP_011240597.1, XM_011242295.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000116463; ENSMUSP00000112164; ENSMUSG00000036180
ENSMUST00000212478; ENSMUSP00000148474; ENSMUSG00000036180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
234366

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:234366

UCSC genome browser

More...
UCSCi
uc009lyf.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089074 mRNA Translation: BAC40736.1 Different initiation.
BC019178 mRNA Translation: AAH19178.1 Different initiation.
BC031407 mRNA Translation: AAH31407.1 Different initiation.
BC038221 mRNA Translation: AAH38221.2
CCDSiCCDS52567.1
RefSeqiNP_001106817.1, NM_001113346.1
XP_011240597.1, XM_011242295.2

3D structure databases

SMRiQ8CHY6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231518, 12 interactors
ComplexPortaliCPX-953 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-954 MBD3/NuRD nucleosome remodeling and deacetylase complex
IntActiQ8CHY6, 8 interactors
MINTiQ8CHY6
STRINGi10090.ENSMUSP00000070229

PTM databases

iPTMnetiQ8CHY6
PhosphoSitePlusiQ8CHY6

Proteomic databases

EPDiQ8CHY6
jPOSTiQ8CHY6
MaxQBiQ8CHY6
PaxDbiQ8CHY6
PeptideAtlasiQ8CHY6
PRIDEiQ8CHY6

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8CHY6 40 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1819 220 antibodies

Genome annotation databases

EnsembliENSMUST00000116463; ENSMUSP00000112164; ENSMUSG00000036180
ENSMUST00000212478; ENSMUSP00000148474; ENSMUSG00000036180
GeneIDi234366
KEGGimmu:234366
UCSCiuc009lyf.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54815
MGIiMGI:2384585 Gatad2a

Phylogenomic databases

eggNOGiKOG3740 Eukaryota
ENOG410XRVM LUCA
GeneTreeiENSGT00390000004097
InParanoidiQ8CHY6
KOiK23194
OrthoDBi885815at2759
PhylomeDBiQ8CHY6

Enzyme and pathway databases

ReactomeiR-MMU-6804758 Regulation of TP53 Activity through Acetylation
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
234366 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Gatad2a mouse

Protein Ontology

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PROi
PR:Q8CHY6
RNActiQ8CHY6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000036180 Expressed in heart and 301 other tissues
ExpressionAtlasiQ8CHY6 baseline and differential
GenevisibleiQ8CHY6 MM

Family and domain databases

InterProiView protein in InterPro
IPR040386 P66
IPR032346 P66_CC
PANTHERiPTHR13455 PTHR13455, 1 hit
PfamiView protein in Pfam
PF16563 P66_CC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP66A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CHY6
Secondary accession number(s): Q8BTQ2, Q8VEC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 17, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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