Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar protein sorting-associated protein 37A

Gene

Vps37a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37A
Short name:
Vps37A
Alternative name(s):
ESCRT-I complex subunit VPS37A
Gene namesi
Name:Vps37a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1261835 Vps37a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871991 – 397Vacuolar protein sorting-associated protein 37AAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CHS8
PeptideAtlasiQ8CHS8
PRIDEiQ8CHS8

PTM databases

iPTMnetiQ8CHS8
PhosphoSitePlusiQ8CHS8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031600 Expressed in 272 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_VPS37A
GenevisibleiQ8CHS8 MM

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry (By similarity).By similarity

Protein-protein interaction databases

BioGridi206532, 1 interactor
STRINGi10090.ENSMUSP00000096415

Structurei

3D structure databases

ProteinModelPortaliQ8CHS8
SMRiQ8CHS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 397VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 164Pro-richAdd BLAST38

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000008031
HOVERGENiHBG054793
InParanoidiQ8CHS8
KOiK12185
OMAiYLYSNPG
OrthoDBiEOG091G0GMF
PhylomeDBiQ8CHS8
TreeFamiTF332146

Family and domain databases

Gene3Di1.10.287.660, 1 hit
3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR016135 UBQ-conjugating_enzyme/RWD
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CHS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWLFPLAKS ASSSAAGSPA GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV
60 70 80 90 100
EYRLPFTVNN LTININILLP PQFPQEKPVI SVYPPIRHHL MDSQGLYVTS
110 120 130 140 150
PLVSNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTTFPYL YSNPGGMPPY
160 170 180 190 200
PSQGFPFLPP YPPPEANRNI TSLSVADTVS SSTTSYTAAK PVAPSFGILS
210 220 230 240 250
SLPLPVPTTE SSASVNQNGF GYKMPDIPDA FPELSELSVS QLTDMNEQEE
260 270 280 290 300
VLLEQFLMLP QLKQIITDKE DLVKNIEELA RKNLLLEHSL EGKRQTVLDK
310 320 330 340 350
YELLLQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE
360 370 380 390
DFLEGKTEID DFLNSFKEKR TICHCRRAKE EKLHQVIAMH SQFHAPL
Length:397
Mass (Da):44,419
Last modified:March 1, 2003 - v1
Checksum:i128162E458A8746A
GO
Isoform 2 (identifier: Q8CHS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-346: SCSASALQARLKVAAHEAEEESD → VGLMSSVCPQELLSHRSCPALCI
     347-397: Missing.

Show »
Length:346
Mass (Da):38,452
Checksum:i9810A3B8E8B1359E
GO
Isoform 3 (identifier: Q8CHS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-397: ICHCRRAKEEKLHQVIAMHSQFHAPL → VCNTLQLRISDNIITIFLSMFISKHR

Show »
Length:397
Mass (Da):44,399
Checksum:i223942020A140FCB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → P in BAE42131 (PubMed:16141072).Curated1
Sequence conflicti119L → P in BAE42324 (PubMed:16141072).Curated1
Sequence conflicti193A → E in BAE42324 (PubMed:16141072).Curated1
Sequence conflicti203P → L in BAE42324 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025370324 – 346SCSAS…EEESD → VGLMSSVCPQELLSHRSCPA LCI in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025371347 – 397Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_025372372 – 397ICHCR…FHAPL → VCNTLQLRISDNIITIFLSM FISKHR in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170943 mRNA Translation: BAE42131.1
AK170961 mRNA Translation: BAE42142.1
AK171055 mRNA Translation: BAE42215.1
AK171221 mRNA Translation: BAE42324.1
BC039290 mRNA Translation: AAH39290.1
BC110396 mRNA Translation: AAI10397.1
CCDSiCCDS22254.1 [Q8CHS8-1]
RefSeqiNP_291038.2, NM_033560.3 [Q8CHS8-1]
UniGeneiMm.489696

Genome annotation databases

EnsembliENSMUST00000098817; ENSMUSP00000096415; ENSMUSG00000031600 [Q8CHS8-1]
GeneIDi52348
KEGGimmu:52348
UCSCiuc009lmv.1 mouse [Q8CHS8-1]
uc009lmx.1 mouse [Q8CHS8-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170943 mRNA Translation: BAE42131.1
AK170961 mRNA Translation: BAE42142.1
AK171055 mRNA Translation: BAE42215.1
AK171221 mRNA Translation: BAE42324.1
BC039290 mRNA Translation: AAH39290.1
BC110396 mRNA Translation: AAI10397.1
CCDSiCCDS22254.1 [Q8CHS8-1]
RefSeqiNP_291038.2, NM_033560.3 [Q8CHS8-1]
UniGeneiMm.489696

3D structure databases

ProteinModelPortaliQ8CHS8
SMRiQ8CHS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206532, 1 interactor
STRINGi10090.ENSMUSP00000096415

PTM databases

iPTMnetiQ8CHS8
PhosphoSitePlusiQ8CHS8

Proteomic databases

PaxDbiQ8CHS8
PeptideAtlasiQ8CHS8
PRIDEiQ8CHS8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098817; ENSMUSP00000096415; ENSMUSG00000031600 [Q8CHS8-1]
GeneIDi52348
KEGGimmu:52348
UCSCiuc009lmv.1 mouse [Q8CHS8-1]
uc009lmx.1 mouse [Q8CHS8-3]

Organism-specific databases

CTDi137492
MGIiMGI:1261835 Vps37a

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000008031
HOVERGENiHBG054793
InParanoidiQ8CHS8
KOiK12185
OMAiYLYSNPG
OrthoDBiEOG091G0GMF
PhylomeDBiQ8CHS8
TreeFamiTF332146

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

ChiTaRSiVps37a mouse
PROiPR:Q8CHS8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031600 Expressed in 272 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_VPS37A
GenevisibleiQ8CHS8 MM

Family and domain databases

Gene3Di1.10.287.660, 1 hit
3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR016135 UBQ-conjugating_enzyme/RWD
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVP37A_MOUSE
AccessioniPrimary (citable) accession number: Q8CHS8
Secondary accession number(s): Q0VGD1
, Q3TBI5, Q3TC15, Q3TC26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again