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Protein

F-box only protein 4

Gene

Fbxo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity).By similarity3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 4
Gene namesi
Name:Fbxo4
Synonyms:Fbx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146220 Fbxo4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198801 – 385F-box only protein 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Phosphoserine1 Publication1
Modified residuei46PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-11 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase. Phosphorylation at Ser-11 is important for homodimerization and for optimal ubiquitin ligase activity towards CCND1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CHQ0
MaxQBiQ8CHQ0
PaxDbiQ8CHQ0
PeptideAtlasiQ8CHQ0
PRIDEiQ8CHQ0

PTM databases

iPTMnetiQ8CHQ0
PhosphoSitePlusiQ8CHQ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000022184 Expressed in 227 organ(s), highest expression level in membranous labyrinth
CleanExiMM_FBXO4
GenevisibleiQ8CHQ0 MM

Interactioni

Subunit structurei

Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1; this interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
YwhaeP622592EBI-3895153,EBI-356480

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222983, 3 interactors
IntActiQ8CHQ0, 2 interactors
STRINGi10090.ENSMUSP00000022791

Structurei

3D structure databases

ProteinModelPortaliQ8CHQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 100F-boxPROSITE-ProRule annotationAdd BLAST47

Phylogenomic databases

eggNOGiENOG410IE1X Eukaryota
ENOG410ZQ31 LUCA
GeneTreeiENSGT00390000014416
HOGENOMiHOG000112550
HOVERGENiHBG051585
InParanoidiQ8CHQ0
KOiK10291
OMAiRHEWQDE
OrthoDBiEOG091G0ALJ
TreeFamiTF331105

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039588 FBXO4
PANTHERiPTHR16008 PTHR16008, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CHQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSEPRGAG SPPPASDWGR LEAAILSGWR TFWYSVAKER ATPTASRKEA
60 70 80 90 100
AEETSALTRL PVDVQLYILS FLSPHDLCQL GSTDHYWNKT IRDPILWRYF
110 120 130 140 150
LLRDLPSWSS VDWKSLPDLE ILKKPISEVT DSTCLDYMEV YKMCCPYTRR
160 170 180 190 200
ALKASRPMYG VVTSFLHSLI IQNEPRFAMF GPGLEELNTS LVLSLMSSED
210 220 230 240 250
LCPTAGLPHR QIDGIGSGVN FQLNNQQKFN ILILYSTTRK ERDRAREEHT
260 270 280 290 300
STVNKMFSLQ SEGDEQQGSR YSVIPQIQKV CEVVDGFIYV ANAEAHRRHE
310 320 330 340 350
WQDEFSRIMA MTDPAFGSSG RPMLVLSCIS QADVKRMPCF YLAHELHLSL
360 370 380
LNHPWMVQDT EAETLTGFLN GIEWILEEVE SKRAK
Length:385
Mass (Da):43,777
Last modified:July 27, 2011 - v2
Checksum:i36D78194EAF9EE95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91I → V in AAH40086 (PubMed:15489334).Curated1
Sequence conflicti347H → R in AAH40086 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137902 Genomic DNA No translation available.
BC040086 mRNA Translation: AAH40086.1
AJ300659 mRNA Translation: CAC36404.1
CCDSiCCDS27359.1
RefSeqiNP_598860.2, NM_134099.2
UniGeneiMm.234191

Genome annotation databases

EnsembliENSMUST00000022791; ENSMUSP00000022791; ENSMUSG00000022184
GeneIDi106052
KEGGimmu:106052
UCSCiuc007vcf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137902 Genomic DNA No translation available.
BC040086 mRNA Translation: AAH40086.1
AJ300659 mRNA Translation: CAC36404.1
CCDSiCCDS27359.1
RefSeqiNP_598860.2, NM_134099.2
UniGeneiMm.234191

3D structure databases

ProteinModelPortaliQ8CHQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222983, 3 interactors
IntActiQ8CHQ0, 2 interactors
STRINGi10090.ENSMUSP00000022791

PTM databases

iPTMnetiQ8CHQ0
PhosphoSitePlusiQ8CHQ0

Proteomic databases

EPDiQ8CHQ0
MaxQBiQ8CHQ0
PaxDbiQ8CHQ0
PeptideAtlasiQ8CHQ0
PRIDEiQ8CHQ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022791; ENSMUSP00000022791; ENSMUSG00000022184
GeneIDi106052
KEGGimmu:106052
UCSCiuc007vcf.2 mouse

Organism-specific databases

CTDi26272
MGIiMGI:2146220 Fbxo4

Phylogenomic databases

eggNOGiENOG410IE1X Eukaryota
ENOG410ZQ31 LUCA
GeneTreeiENSGT00390000014416
HOGENOMiHOG000112550
HOVERGENiHBG051585
InParanoidiQ8CHQ0
KOiK10291
OMAiRHEWQDE
OrthoDBiEOG091G0ALJ
TreeFamiTF331105

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8CHQ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022184 Expressed in 227 organ(s), highest expression level in membranous labyrinth
CleanExiMM_FBXO4
GenevisibleiQ8CHQ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039588 FBXO4
PANTHERiPTHR16008 PTHR16008, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX4_MOUSE
AccessioniPrimary (citable) accession number: Q8CHQ0
Secondary accession number(s): E9QPM9, Q99JG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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