UniProtKB - Q8CHK7 (NQO1_CAVPO)
Protein
NAD(P)H dehydrogenase [quinone] 1
Gene
NQO1
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.By similarity
Catalytic activityi
Cofactori
FADBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 13 | FADBy similarity | 1 | |
Binding sitei | 68 | FADBy similarity | 1 | |
Binding sitei | 157 | FADBy similarity | 1 | |
Binding sitei | 202 | FADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 19 – 20 | FADBy similarity | 2 | |
Nucleotide bindingi | 105 – 108 | FADBy similarity | 4 | |
Nucleotide bindingi | 149 – 152 | FADBy similarity | 4 |
GO - Molecular functioni
- NAD(P)H dehydrogenase (quinone) activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD, NADP |
Enzyme and pathway databases
BRENDAi | 1.6.5.2, 1225 |
Names & Taxonomyi
Protein namesi | Recommended name: NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)Alternative name(s): Azoreductase DT-diaphorase Short name: DTD Menadione reductase NAD(P)H:quinone oxidoreductase 1 Phylloquinone reductase Quinone reductase 1 Short name: QR1 |
Gene namesi | Name:NQO1 |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071621 | 1 – 275 | NAD(P)H dehydrogenase [quinone] 1Add BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Cross-linki | 252 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationExpressioni
Gene expression databases
Bgeei | ENSCPOG00000012430, Expressed in liver and 5 other tissues |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10141.ENSCPOP00000011185 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 129 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the NAD(P)H dehydrogenase (quinone) family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQMI, Eukaryota |
HOGENOMi | CLU_058643_2_0_1 |
InParanoidi | Q8CHK7 |
OMAi | WFERVLV |
OrthoDBi | 1394543at2759 |
TreeFami | TF300296 |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8CHK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP
60 70 80 90 100
IISRKDITGA LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI
110 120 130 140 150
FQFPLQWFGV PAILKGWFER VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT
160 170 180 190 200
GGSESMYSLK GIHGDMNIIL WPIQSGTLHF CGFQVLEPQL TYGIGHTPPD
210 220 230 240 250
VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL KKEIEDEQKN
260 270
NKYGLSVGHH LGKPIPTDNQ IKARK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055403 mRNA Translation: BAC53985.1 |
RefSeqi | NP_001166457.1, NM_001172986.1 |
Genome annotation databases
GeneIDi | 100135582 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055403 mRNA Translation: BAC53985.1 |
RefSeqi | NP_001166457.1, NM_001172986.1 |
3D structure databases
SMRi | Q8CHK7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000011185 |
Genome annotation databases
GeneIDi | 100135582 |
Organism-specific databases
CTDi | 1728 |
Phylogenomic databases
eggNOGi | ENOG502QQMI, Eukaryota |
HOGENOMi | CLU_058643_2_0_1 |
InParanoidi | Q8CHK7 |
OMAi | WFERVLV |
OrthoDBi | 1394543at2759 |
TreeFami | TF300296 |
Enzyme and pathway databases
BRENDAi | 1.6.5.2, 1225 |
Gene expression databases
Bgeei | ENSCPOG00000012430, Expressed in liver and 5 other tissues |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NQO1_CAVPO | |
Accessioni | Q8CHK7Primary (citable) accession number: Q8CHK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | August 12, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families