Transcription factor YY1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGD
• cis-regulatory region sequence-specific DNA binding Source: RGD
• DNA binding Source: RGD
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor binding Source: Ensembl
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
• four-way junction DNA binding Source: RGD
• RNA binding Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene."
    Bergad P.L., Towle H.C., Berry S.A.
    J Biol Chem 275:8114-8120(2000) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: RGD
• SMAD binding Source: RGD
• transcription cis-regulatory region binding Source: RGD

GO - Biological processⁱ

• anterior/posterior pattern specification Source: RGD
• B cell differentiation Source: RGD
• camera-type eye morphogenesis Source: RGD
• cell development Source: RGD
• cellular response to DNA damage stimulus Source: RGD
• cellular response to interleukin-1 Source: RGDInferred from direct assayⁱ
  • "IL-1 beta increases abundance and activity of the negative transcriptional regulator yin yang-1 (YY1) in neonatal rat cardiac myocytes."
    Patten M., Wang W., Aminololama-Shakeri S., Burson M., Long C.S.
    J Mol Cell Cardiol 32:1341-1352(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV Source: RGD
• chromosome organization Source: RGD
• double-strand break repair via homologous recombination Source: RGD
• gene expression Source: RGD
• immunoglobulin heavy chain V-D-J recombination Source: RGD
• negative regulation of cell growth involved in cardiac muscle cell development Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5."
    Sucharov C.C., Dockstader K., McKinsey T.A.
    Mol Biol Cell 19:4141-4153(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGD
• negative regulation of interferon-beta production Source: RGD
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes."
    Karki P., Webb A., Smith K., Johnson J. Jr., Lee K., Son D.S., Aschner M., Lee E.
    Mol Cell Biol 34:1280-1289(2014) [PubMed] [Europe PMC] [Abstract]
• nucleosome mobilization Source: Ensembl
• positive regulation of DNA repair Source: Ensembl
• positive regulation of gene expression Source: RGD
• positive regulation of telomere maintenance in response to DNA damage Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "The transcription factor Yin Yang 1 is an activator of BACE1 expression."
    Nowak K., Lange-Dohna C., Zeitschel U., Gunther A., Luscher B., Robitzki A., Perez-Polo R., Rossner S.
    J Neurochem 96:1696-1707(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: Ensembl
• regulation of DNA replication Source: Ensembl
• regulation of DNA strand elongation Source: Ensembl
• regulation of embryonic development Source: Ensembl
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2."
    Santiago F.S., Lowe H.C., Bobryshev Y.V., Khachigian L.M.
    J Biol Chem 276:41143-41149(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to prostaglandin F Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1."
    Nackley A.C., Shea-Eaton W., Lopez D., McLean M.P.
    Endocrinology 143:1085-1096(2002) [PubMed] [Europe PMC] [Abstract]
• response to UV-C Source: RGD
• RNA localization Source: RGD
• spermatogenesis Source: RGD
• telomere maintenance Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• DNA-binding transcription factor binding Source: Ensembl
• SMAD binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEDDDED 
        60         70         80         90        100
DEDGGGGDHG GGGGHGHAGH HHHHHHHHHP PMIALQPLVT DDPTQVHHHQ 
       110        120        130        140        150
EVILVQTREE VVGGDDSDGL RAEDGFEDQI LIPVPAPAGG DDDYIEQTLV 
       160        170        180        190        200
TVAAAGKSGG GSSSGGGRVK KGGGKKSGKK SYLGSGAGAA GGGGADPGNK 
       210        220        230        240        250
KWEQKQVQIK TLEGEFSVTM WSSDEKKDID HETVVEEQII GENSPPDYSE 
       260        270        280        290        300
YMTGKKLPPG GIPGIDLSDP KQLAEFARMK PRKIKEDDAP RTIACPHKGC 
       310        320        330        340        350
TKMFRDNSAM RKHLHTHGPR VHVCAECGKA FVESSKLKRH QLVHTGEKPF 
       360        370        380        390        400
QCTFEGCGKR FSLDFNLRTH VRIHTGDRPY VCPFDGCNKK FAQSTNLKSH 
       410 
ILTHAKAKNN Q                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ