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UniProtKB - Q8CHJ4 (Q8CHJ4_RAT)
Protein
Submitted name:
Transcription factor YY1
Gene
Yy1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: Ensembl
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- four-way junction DNA binding Source: RGD
- RNA binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- SMAD binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: RGD
- B cell differentiation Source: RGD
- camera-type eye morphogenesis Source: RGD
- cell development Source: RGD
- cellular response to DNA damage stimulus Source: RGD
- cellular response to interleukin-1 Source: RGD
- cellular response to UV Source: RGD
- chromosome organization Source: RGD
- double-strand break repair via homologous recombination Source: RGD
- gene expression Source: RGD
- immunoglobulin heavy chain V-D-J recombination Source: RGD
- negative regulation of cell growth involved in cardiac muscle cell development Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of interferon-beta production Source: RGD
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- nucleosome mobilization Source: Ensembl
- positive regulation of DNA repair Source: Ensembl
- positive regulation of gene expression Source: RGD
- positive regulation of telomere maintenance in response to DNA damage Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of cell cycle Source: Ensembl
- regulation of DNA replication Source: Ensembl
- regulation of DNA strand elongation Source: Ensembl
- regulation of embryonic development Source: Ensembl
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to prostaglandin F Source: RGD
- response to UV-C Source: RGD
- RNA localization Source: RGD
- spermatogenesis Source: RGD
- telomere maintenance Source: Ensembl
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-5689603, UCH proteinases R-RNO-5696394, DNA Damage Recognition in GG-NER R-RNO-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor YY1ImportedSubmitted name: YY1 transcription factorImported |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3982, Yy1 |
Subcellular locationi
Nucleus
- chromatin silencing complex Source: RGD
- Ino80 complex Source: RGD
- nuclear matrix Source: RGD
- nucleus Source: RGD
- PcG protein complex Source: RGD
Other locations
- chromatin Source: RGD
- cytoplasm Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000004339, Expressed in thymus and 20 other tissues |
Interactioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: Ensembl
- SMAD binding Source: RGD
Protein-protein interaction databases
IntActi | Q8CHJ4, 2 interactors |
STRINGi | 10116.ENSRNOP00000005743 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 293 – 317 | C2H2-typeInterPro annotationAdd BLAST | 25 | |
Domaini | 322 – 349 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 350 – 379 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 380 – 409 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 80 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 155 – 200 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 55 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 66 – 80 | Basic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the YY transcription factor family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154763 |
HOGENOMi | CLU_002678_42_2_1 |
OMAi | DAGGRKW |
OrthoDBi | 1318335at2759 |
TreeFami | TF106493 |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q8CHJ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEDDDED
60 70 80 90 100
DEDGGGGDHG GGGGHGHAGH HHHHHHHHHP PMIALQPLVT DDPTQVHHHQ
110 120 130 140 150
EVILVQTREE VVGGDDSDGL RAEDGFEDQI LIPVPAPAGG DDDYIEQTLV
160 170 180 190 200
TVAAAGKSGG GSSSGGGRVK KGGGKKSGKK SYLGSGAGAA GGGGADPGNK
210 220 230 240 250
KWEQKQVQIK TLEGEFSVTM WSSDEKKDID HETVVEEQII GENSPPDYSE
260 270 280 290 300
YMTGKKLPPG GIPGIDLSDP KQLAEFARMK PRKIKEDDAP RTIACPHKGC
310 320 330 340 350
TKMFRDNSAM RKHLHTHGPR VHVCAECGKA FVESSKLKRH QLVHTGEKPF
360 370 380 390 400
QCTFEGCGKR FSLDFNLRTH VRIHTGDRPY VCPFDGCNKK FAQSTNLKSH
410
ILTHAKAKNN Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07065506 Genomic DNA No translation available. AY442180 Genomic DNA Translation: AAR14688.1 AB080317 mRNA Translation: BAC53761.1 |
RefSeqi | NP_775412.1, NM_173290.1 |
Genome annotation databases
Ensembli | ENSRNOT00000005743; ENSRNOP00000005743; ENSRNOG00000004339 |
GeneIDi | 24919 |
KEGGi | rno:24919 |
UCSCi | RGD:3982, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07065506 Genomic DNA No translation available. AY442180 Genomic DNA Translation: AAR14688.1 AB080317 mRNA Translation: BAC53761.1 |
RefSeqi | NP_775412.1, NM_173290.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8CHJ4, 2 interactors |
STRINGi | 10116.ENSRNOP00000005743 |
Genome annotation databases
Ensembli | ENSRNOT00000005743; ENSRNOP00000005743; ENSRNOG00000004339 |
GeneIDi | 24919 |
KEGGi | rno:24919 |
UCSCi | RGD:3982, rat |
Organism-specific databases
CTDi | 7528 |
RGDi | 3982, Yy1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154763 |
HOGENOMi | CLU_002678_42_2_1 |
OMAi | DAGGRKW |
OrthoDBi | 1318335at2759 |
TreeFami | TF106493 |
Enzyme and pathway databases
Reactomei | R-RNO-5689603, UCH proteinases R-RNO-5696394, DNA Damage Recognition in GG-NER R-RNO-9018519, Estrogen-dependent gene expression |
Gene expression databases
Bgeei | ENSRNOG00000004339, Expressed in thymus and 20 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8CHJ4_RAT | |
Accessioni | Q8CHJ4Primary (citable) accession number: Q8CHJ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |