Transcription factor YY1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• four-way junction DNA binding Source: Ensembl
• histone deacetylase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18632988
• proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• RNA binding Source: Ensembl
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II repressing transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 10713133
• SMAD binding Source: Ensembl

GO - Biological processⁱ

• anterior/posterior pattern specification Source: Ensembl
• camera-type eye morphogenesis Source: Ensembl
• cellular response to interleukin-1 Source: RGDInferred from direct assayⁱ
  • 10860774
• cellular response to UV Source: Ensembl
• chromosome organization Source: Ensembl
• double-strand break repair via homologous recombination Source: Ensembl
• negative regulation of interferon-beta production Source: Ensembl
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 24469401
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • 16539685
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • 11487577
• response to prostaglandin F Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 11861536
• response to UV-C Source: Ensembl
• RNA localization Source: Ensembl
• spermatogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGDInferred from physical interactionⁱ
  • 18632988
• RNA polymerase II repressing transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• SMAD binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEDDDED 
        60         70         80         90        100
DEDGGGGDHG GGGGHGHAGH HHHHHHHHHP PMIALQPLVT DDPTQVHHHQ 
       110        120        130        140        150
EVILVQTREE VVGGDDSDGL RAEDGFEDQI LIPVPAPAGG DDDYIEQTLV 
       160        170        180        190        200
TVAAAGKSGG GSSSGGGRVK KGGGKKSGKK SYLGSGAGAA GGGGADPGNK 
       210        220        230        240        250
KWEQKQVQIK TLEGEFSVTM WSSDEKKDID HETVVEEQII GENSPPDYSE 
       260        270        280        290        300
YMTGKKLPPG GIPGIDLSDP KQLAEFARMK PRKIKEDDAP RTIACPHKGC 
       310        320        330        340        350
TKMFRDNSAM RKHLHTHGPR VHVCAECGKA FVESSKLKRH QLVHTGEKPF 
       360        370        380        390        400
QCTFEGCGKR FSLDFNLRTH VRIHTGDRPY VCPFDGCNKK FAQSTNLKSH 
       410 
ILTHAKAKNN Q                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ