Transcription factor YY1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2."
    Klar M., Bode J.
    Mol. Cell. Biol. 25:10159-10170(2005) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene."
    Shou Z., Yamada K., Inazu T., Kawata H., Hirano S., Mizutani T., Yazawa T., Sekiguchi T., Yoshino M., Kajitani T., Okada K., Miyamoto K.
    Gene 302:83-94(2003) [PubMed] [Europe PMC] [Abstract]
  • "Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse."
    Bravo-Nuevo A., Walsh N., Stone J.
    Invest. Ophthalmol. Vis. Sci. 45:2005-2012(2004) [PubMed] [Europe PMC] [Abstract]
  • "A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription."
    Giangrande P.H., Zhu W., Schlisio S., Sun X., Mori S., Gaubatz S., Nevins J.R.
    Genes Dev. 18:2941-2951(2004) [PubMed] [Europe PMC] [Abstract]
  • "YY1 tethers Xist RNA to the inactive X nucleation center."
    Jeon Y., Lee J.T.
    Cell 146:119-133(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "YY1 activates Msx2 gene independent of bone morphogenetic protein signaling."
    Tan D.P., Nonaka K., Nuckolls G.H., Liu Y.H., Maxson R.E., Slavkin H.C., Shum L.
    Nucleic Acids Res. 30:1213-1223(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2."
    Cho Y.D., Yoon W.J., Woo K.M., Baek J.H., Park J.C., Ryoo H.M.
    J. Biol. Chem. 285:36369-36376(2010) [PubMed] [Europe PMC] [Abstract]
  • "Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis."
    Tian F.J., An L.N., Wang G.K., Zhu J.Q., Li Q., Zhang Y.Y., Zeng A., Zou J., Zhu R.F., Han X.S., Shen N., Yang H.T., Zhao X.X., Huang S., Qin Y.W., Jing Q.
    Cardiovasc. Res. 103:100-110(2014) [PubMed] [Europe PMC] [Abstract]
• four-way junction DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• promoter-specific chromatin binding Source: Ensembl
• RNA binding Source: RGDInferred from sequence orthologyⁱ
  • "YY1 tethers Xist RNA to the inactive X nucleation center."
    Jeon Y., Lee J.T.
    Cell 146:119-133(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Juxtaposed Polycomb complexes co-regulate vertebral identity."
    Kim S.Y., Paylor S.W., Magnuson T., Schumacher A.
    Development 133:4957-4968(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene."
    Bergad P.L., Towle H.C., Berry S.A.
    J. Biol. Chem. 275:8114-8120(2000) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
    Lee K.H., Evans S., Ruan T.Y., Lassar A.B.
    Development 131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals."
    Du K., Leu J.I., Peng Y., Taub R.
    J. Biol. Chem. 273:35208-35215(1998) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: RGDInferred from sequence orthologyⁱ
  • "Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A."
    Lorente M., Perez C., Sanchez C., Donohoe M., Shi Y., Vidal M.
    Mech. Dev. 123:312-320(2006) [PubMed] [Europe PMC] [Abstract]
• camera-type eye morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A."
    Lorente M., Perez C., Sanchez C., Donohoe M., Shi Y., Vidal M.
    Mech. Dev. 123:312-320(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to DNA damage stimulus Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: RGDInferred from direct assayⁱ
  • "IL-1 beta increases abundance and activity of the negative transcriptional regulator yin yang-1 (YY1) in neonatal rat cardiac myocytes."
    Patten M., Wang W., Aminololama-Shakeri S., Burson M., Long C.S.
    J. Mol. Cell. Cardiol. 32:1341-1352(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• chromosome organization Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• double-strand break repair via homologous recombination Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• gene expression Source: Ensembl
• negative regulation of cell growth involved in cardiac muscle cell development Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5."
    Sucharov C.C., Dockstader K., McKinsey T.A.
    Mol. Biol. Cell 19:4141-4153(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1."
    Siednienko J., Maratha A., Yang S., Mitkiewicz M., Miggin S.M., Moynagh P.N.
    J. Biol. Chem. 286:44750-44763(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interferon-beta production Source: RGDInferred from sequence orthologyⁱ
  • "Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2."
    Klar M., Bode J.
    Mol. Cell. Biol. 25:10159-10170(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis."
    Tian F.J., An L.N., Wang G.K., Zhu J.Q., Li Q., Zhang Y.Y., Zeng A., Zou J., Zhu R.F., Han X.S., Shen N., Yang H.T., Zhao X.X., Huang S., Qin Y.W., Jing Q.
    Cardiovasc. Res. 103:100-110(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes."
    Karki P., Webb A., Smith K., Johnson J. Jr., Lee K., Son D.S., Aschner M., Lee E.
    Mol. Cell. Biol. 34:1280-1289(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-23a promotes myelination in the central nervous system."
    Lin S.T., Huang Y., Zhang L., Heng M.Y., Ptacek L.J., Fu Y.H.
    Proc. Natl. Acad. Sci. U.S.A. 110:17468-17473(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "The transcription factor Yin Yang 1 is an activator of BACE1 expression."
    Nowak K., Lange-Dohna C., Zeitschel U., Gunther A., Luscher B., Robitzki A., Perez-Polo R., Rossner S.
    J. Neurochem. 96:1696-1707(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2."
    Santiago F.S., Lowe H.C., Bobryshev Y.V., Khachigian L.M.
    J. Biol. Chem. 276:41143-41149(2001) [PubMed] [Europe PMC] [Abstract]
• response to prostaglandin F Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1."
    Nackley A.C., Shea-Eaton W., Lopez D., McLean M.P.
    Endocrinology 143:1085-1096(2002) [PubMed] [Europe PMC] [Abstract]
• response to UV-C Source: RGDInferred from sequence orthologyⁱ
  • "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
    Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
    Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
• RNA localization Source: RGDInferred from sequence orthologyⁱ
  • "YY1 tethers Xist RNA to the inactive X nucleation center."
    Jeon Y., Lee J.T.
    Cell 146:119-133(2011) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis."
    Wu S., Hu Y.C., Liu H., Shi Y.
    Mol. Cell. Biol. 29:6245-6256(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
    Lee K.H., Evans S., Ruan T.Y., Lassar A.B.
    Development 131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEDDDED 
        60         70         80         90        100
DEDGGGGDHG GGGGHGHAGH HHHHHHHHHP PMIALQPLVT DDPTQVHHHQ 
       110        120        130        140        150
EVILVQTREE VVGGDDSDGL RAEDGFEDQI LIPVPAPAGG DDDYIEQTLV 
       160        170        180        190        200
TVAAAGKSGG GSSSGGGRVK KGGGKKSGKK SYLGSGAGAA GGGGADPGNK 
       210        220        230        240        250
KWEQKQVQIK TLEGEFSVTM WSSDEKKDID HETVVEEQII GENSPPDYSE 
       260        270        280        290        300
YMTGKKLPPG GIPGIDLSDP KQLAEFARMK PRKIKEDDAP RTIACPHKGC 
       310        320        330        340        350
TKMFRDNSAM RKHLHTHGPR VHVCAECGKA FVESSKLKRH QLVHTGEKPF 
       360        370        380        390        400
QCTFEGCGKR FSLDFNLRTH VRIHTGDRPY VCPFDGCNKK FAQSTNLKSH 
       410 
ILTHAKAKNN Q                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ