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UniProtKB - Q8CHJ0 (PIGU_CRIGR)
Protein
Phosphatidylinositol glycan anchor biosynthesis class U protein
Gene
PIGU
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Functioni
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
1 Publication: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Molecular functioni
- GPI anchor binding Source: Ensembl
GO - Biological processi
- attachment of GPI anchor to protein Source: Ensembl
- regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Keywordsi
Biological process | GPI-anchor biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol glycan anchor biosynthesis class U proteinAlternative name(s): Cell division cycle protein 91-like 1 Short name: Protein CDC91-like 1 GPI transamidase component PIG-U |
Gene namesi | Name:PIGU Synonyms:CDC91L1 |
Organismi | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
Taxonomic identifieri | 10029 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Cricetidae › Cricetinae › Cricetulus |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- GPI-anchor transamidase complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 286 – 306 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 313 – 333 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 355 – 375 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 274 – 275 | FW → LL: Loss of function. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121393 | 1 – 435 | Phosphatidylinositol glycan anchor biosynthesis class U proteinAdd BLAST | 435 |
Interactioni
Subunit structurei
Forms a complex with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1.
1 PublicationProtein-protein interaction databases
STRINGi | 10029.NP_001233736.1 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 269 – 289 | May be involved in recognition of long-chain fatty acids in GPIAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the PIGU family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2552, Eukaryota |
GeneTreei | ENSGT00390000014941 |
OMAi | LMRYTFF |
OrthoDBi | 1339553at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009600, PIG-U |
PANTHERi | PTHR13121, PTHR13121, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8CHJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPLALVLV VAVTVRAALF RSSLAEFISE RVEVVSPLSS WKRVVEGLSL
60 70 80 90 100
LDLGVSPYSG AVFHETPLII YLFHFLIDYA ELVFMITDAL TAIALYFAIQ
110 120 130 140 150
DFNKVVFKKQ KLLLELDQYA PDVAELIRTP MEMRYIPLKV ALFYLLNPYT
160 170 180 190 200
ILSCVAKSTC AINNTLIAFF ILTTIKGSVF LSAIFLALAT YQTLYPVTLF
210 220 230 240 250
APGLLYLLQR QYIPVKVKSK AFWIFSWEYA MMYIGSLVVI VCLSFFLLSS
260 270 280 290 300
WDFIPAVYGF ILSVPDLTPN IGLFWYFFAE MFEHFSLFFV CVFQINVFFY
310 320 330 340 350
TVPLAIKLKE HPIFFMFIQI AIISIFKSYP TVGDVALYMA FFPVWNHLYR
360 370 380 390 400
FLRNVFVLTC IIVVCSLLFP VLWHLWIYAG SANSNFFYAI TLTFNVGQIL
410 420 430
LISDYFYAFL RREYYLTHGL YLTAKDGTEA MLVLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB086843 mRNA Translation: BAC53627.1 |
RefSeqi | NP_001233736.1, NM_001246807.1 |
Genome annotation databases
Ensembli | ENSCGRT00001016898; ENSCGRP00001012663; ENSCGRG00001013977 |
GeneIDi | 100689380 |
KEGGi | cge:100689380 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB086843 mRNA Translation: BAC53627.1 |
RefSeqi | NP_001233736.1, NM_001246807.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10029.NP_001233736.1 |
Genome annotation databases
Ensembli | ENSCGRT00001016898; ENSCGRP00001012663; ENSCGRG00001013977 |
GeneIDi | 100689380 |
KEGGi | cge:100689380 |
Organism-specific databases
CTDi | 128869 |
Phylogenomic databases
eggNOGi | KOG2552, Eukaryota |
GeneTreei | ENSGT00390000014941 |
OMAi | LMRYTFF |
OrthoDBi | 1339553at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Family and domain databases
InterProi | View protein in InterPro IPR009600, PIG-U |
PANTHERi | PTHR13121, PTHR13121, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PIGU_CRIGR | |
Accessioni | Q8CHJ0Primary (citable) accession number: Q8CHJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 67 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families