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Entry version 154 (13 Nov 2019)
Sequence version 3 (27 Jul 2011)
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Protein

E1A-binding protein p400

Gene

Ep400

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1115 – 1122ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E1A-binding protein p400 (EC:3.6.4.-)
Alternative name(s):
Domino homolog
Short name:
mDomino
p400 kDa SWI2/SNF2-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ep400
Synonyms:Kiaa1498
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1276124 Ep400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743131 – 3072E1A-binding protein p400Add BLAST3072

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei735PhosphoserineBy similarity1
Modified residuei741PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei922PhosphothreonineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei927PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei944PhosphothreonineCombined sources1
Modified residuei1009PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1471N6-acetyllysineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1650PhosphoserineBy similarity1
Modified residuei2265N6-acetyllysineBy similarity1
Modified residuei2272N6-acetyllysineBy similarity1
Modified residuei2614PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3461

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8CHI8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8CHI8

PeptideAtlas

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PeptideAtlasi
Q8CHI8

PRoteomics IDEntifications database

More...
PRIDEi
Q8CHI8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8CHI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8CHI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, thymus, lung, liver, spleen, kidney, colon and bone marrow.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029505 Expressed in 273 organ(s), highest expression level in vestibular organ

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8CHI8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8CHI8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC. EP400 interacts with TRRAP, RUVBL1 and RUVBL2.

Component of a SWR1-like complex (By similarity).

Interacts with ZNF42.

Interacts with PHF5A.

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
217577, 16 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-990 NuA4 histone acetyltransferase complex

Database of interacting proteins

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DIPi
DIP-61766N

Protein interaction database and analysis system

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IntActi
Q8CHI8, 11 interactors

Molecular INTeraction database

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MINTi
Q8CHI8

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000049038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CHI8

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini798 – 870HSAPROSITE-ProRule annotationAdd BLAST73
Domaini1102 – 1267Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1815 – 1972Helicase C-terminalPROSITE-ProRule annotationAdd BLAST158
Domaini2276 – 2345Myb-likePROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni950 – 1364Interactions with RUVBL1 and RUVBL2By similarityAdd BLAST415
Regioni2440 – 2699Interaction with ZNF421 PublicationAdd BLAST260

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1218 – 1221DEAD box-like4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi277 – 281Poly-Gln5
Compositional biasi316 – 319Poly-Pro4
Compositional biasi426 – 436Poly-GluAdd BLAST11
Compositional biasi699 – 704Poly-Ser6
Compositional biasi956 – 959Poly-Glu4
Compositional biasi2462 – 2479Poly-GlnAdd BLAST18
Compositional biasi2480 – 2484Poly-Pro5
Compositional biasi2487 – 2494Poly-Pro8
Compositional biasi2685 – 2698Poly-GlnAdd BLAST14
Compositional biasi2739 – 2745Poly-Pro7
Compositional biasi2767 – 2770Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0391 Eukaryota
COG0553 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154764

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CHI8

KEGG Orthology (KO)

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KOi
K11320

Identification of Orthologs from Complete Genome Data

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OMAi
GQEGIWG

Database of Orthologous Groups

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OrthoDBi
188211at2759

TreeFam database of animal gene trees

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TreeFami
TF106424

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031575 EP400_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15790 EP400_N, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CHI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHHGSGPQNV QHQLQRSRSF TGSEEEQPAH PNLPPSPAAP FAPSASPSAP
60 70 80 90 100
QSPGYQIQQL MSRSPVAGQN VNITLQNVGP VVGGNQQITL APLPLPNPTS
110 120 130 140 150
PGFQFGAQQR RFEHGSPSYI QVTSPMSQQV QTQSPTQPSP GPGQTLQNVR
160 170 180 190 200
AGAPGPGLGI CSNSPTGGFV DASVLVRQIS LSPSSGGHFV FQEAPGLTQM
210 220 230 240 250
AQGAQVQLQH SGAPITVRER RLSQPHAQSG GTIHHLGPQS PAAAGGTGLQ
260 270 280 290 300
PLASPNHITT ASLPPQISSI IQGQLIQQQQ QVLQGQPMNR SLGFERTPGV
310 320 330 340 350
LLPGVGGPSA FGMTSPPPPT SPSRTTMPPG LSSVPLTSMG SSGMKKVPKK
360 370 380 390 400
LEEIPPASQE MAQMRKQCLD YHYKEMEALK EVFKEYLIEL FFLQHLQGNM
410 420 430 440 450
MDFLAFKKKH YAPLQAYLRQ NDLDIEEEEE EEEEEEGKSE VINDEVKVVT
460 470 480 490 500
GKDGQTGTPV AIATQLPPNV SAAFSSQQQP FQHQSLTGSL VVGPGSATEA
510 520 530 540 550
DPFKRQQVMP PTEQSKRPRL EVGHPGVVFQ HPGVNAGVPL QQLMPTVQGG
560 570 580 590 600
MPPTPQATQL TGQKQSQQQY DPSTGPPVQN AASLHTPPPQ LPARLPPASV
610 620 630 640 650
PATALPSTLQ FSQQSQMVEA STQLQIPVKT QQLNAPIPAP LPSQLPAPSS
660 670 680 690 700
QPAQPALHVP MPGKAQMQTS QLSSQTQTVA STRPPLDSAQ PCQRSLPTSS
710 720 730 740 750
SSSSLVPVSG SGPGPSPARS SPVNRPSSAT NKALSPITSR SPGVAVSAPP
760 770 780 790 800
KPQSPAQNAA SSQDGSQDKL AEQITLENQI HQRIADLRKE GLWSLRRLPK
810 820 830 840 850
LQEAPRPKSH WDYLLEEMQW MATDFAQERR WKLAAAKKLV RTVARHHEEK
860 870 880 890 900
KLREERGKKE EQSRLRRIAA TTAREIEYFW SNIEQVVEIK LQVELEEKRK
910 920 930 940 950
KALNLQKVSR RGKESRLKGF DTSPEHSLDL GISGRKRKAS TSLTDDEVED
960 970 980 990 1000
EEETIEEEEA HEGLVDHHTE LTNLAKEAEL PLIDLMKLYE GAFLPNFQWP
1010 1020 1030 1040 1050
QPEPDHEESS GEEDVEDCPS DRESRRDSVL IDSLFIMDQF KAAERMSIGK
1060 1070 1080 1090 1100
SNTKDITEVT AVAEAILPKG SARVTTAVKF SAPSLLYGAL RDYQKIGLDW
1110 1120 1130 1140 1150
LAKLYRKNLN GILADEAGLG KTVQIIAFFA HLACNEGNWG PHLVVMRSCN
1160 1170 1180 1190 1200
ILKWELELKR WCPGLKTLSY VGSHRELKAK RQEWTEPNNF HICITSYKQF
1210 1220 1230 1240 1250
FRGYTAFSRV HWKCLVVDEM QRVKGMTERH WEAIFKLQSQ QRLLLIDVPL
1260 1270 1280 1290 1300
HNTFLELWTM VHFLIPGISR PYLSFPLKAP NEENQDYYHK MVIRLHRVTQ
1310 1320 1330 1340 1350
PFILRRTKRD VEKQLTRKYE HVLKCRLSSR QKALYEDVIL QPRTQEALKS
1360 1370 1380 1390 1400
GHFVSVLSVL TRLQRICNHP GLVEPRVPGS SFAAGSLQYK SASLILRVLE
1410 1420 1430 1440 1450
REFWKETDLS IFDLIGLENK ITRHEAELLC KKKVTRKLME EVFASPPPSA
1460 1470 1480 1490 1500
RPAAVKLKAS RLFQPVQYGQ KPEGRTVAFP STHPPRMANT NTSTATPQGQ
1510 1520 1530 1540 1550
VRGRPPIATF SANPDTKGGE VVKIAQLASI AGPQSRVAQP ETPVTLQFQG
1560 1570 1580 1590 1600
NKFTLSHSQL RQLTAGQPLQ LQGSVLQIVS APGQPYLRAP GPVVMQTVSQ
1610 1620 1630 1640 1650
AGAVHSTLGS KPPTSGPSPA PLTPQVGVPG RVAVSAMAVG EPGLASKPAS
1660 1670 1680 1690 1700
PAAGPTQEEK SRLLKERLDQ IHFINERRCS QAPVYGRDLL RICSLPGRRK
1710 1720 1730 1740 1750
RPLCWSLDSN FGKGPKGVNY DMSLSKSEGD LILTLSQESL QDVLGRVACV
1760 1770 1780 1790 1800
IPPVVATPPS LWVARPPSLY SSRLRALRQC LREHTGPYHR QLQQLTALRS
1810 1820 1830 1840 1850
LQFPELRLVQ FDSGKLEALA ILLQKLKSEG RRVLILSQMV LMLDILEMFL
1860 1870 1880 1890 1900
NFHYLTYVRI DENANSEQRQ ELMRSFNRDR RIFCALLSTH SRATGINLVE
1910 1920 1930 1940 1950
ADTVVFYDND LNPVMDAKAQ EWCDRIGRCK DIHIYRLVSG NSIEEKLLKN
1960 1970 1980 1990 2000
GTKDLIREVA AQGNDYSMAF LTQRTIQELF EVYSPMDDTG FPVKAEEFVV
2010 2020 2030 2040 2050
LSQEPSVSET IAPKIARPFI EALKSIECLE EDAQRSTEEA VPGSSSVAVS
2060 2070 2080 2090 2100
SDSDGSRYDE EPSQLEELAD FMEQLTPIEK YALNYLELFH TTTEQEKERI
2110 2120 2130 2140 2150
SEDLVMASMK DWETRNARAL QEREARLQLE QEEAELLTYT REDAYTMEYV
2160 2170 2180 2190 2200
YEDADGQTEV MPLWTPPTPP QDDNDIYIDS VMCLMYETTP IPEAKLPPVY
2210 2220 2230 2240 2250
VRKERKRHKT DPSAAGRKKK QRHGEAVVPP RSLFDRATPG MLKIRREGKE
2260 2270 2280 2290 2300
QKKNLLLKQQ TPFAKPLPTY VKSSGEPAQD SPDWLIGEDW ALLQAVKQLL
2310 2320 2330 2340 2350
ELPLNLTIVS PAHTPNWDLV SDVVNSCSRI YRSSKQCRNR YENVIIPREE
2360 2370 2380 2390 2400
GKSKNNRPLR TSQIYAQDEN ATHTQLYTSH FELMKMTAGK RSPPIKPLLG
2410 2420 2430 2440 2450
MNPFQKNPKH ASVLAESGIN YDKPLPPIQV ASLRAERIAK EKKALADQQK
2460 2470 2480 2490 2500
AQQPPVTQPP PQQQQQQQQQ QQQQQQQQQP PPPPQQPPPP VPQPQAASSQ
2510 2520 2530 2540 2550
TPAGQPAVQP QPQPQVQTQP QPVQPQSKGQ PTMTTVGSAA VLAGTIKTSV
2560 2570 2580 2590 2600
TGTSIPTGTV SGNVIVNTIA GVPAATFQSI NKRLASPVAP GTLTTSGGSA
2610 2620 2630 2640 2650
PAQVVHTQQR AVGSPATATT DLVSMTTTQG VRAVTSVTAS AVVTTNLTPV
2660 2670 2680 2690 2700
QTPTRSLVTQ VSQATGVQLP GKTITPAAHF QLLRQQQQQQ QQQQQQQQTS
2710 2720 2730 2740 2750
QVQVPQLQSQ AQSPAQIKAV SKLGPEHIIK MQKQKMQLPP QPPPPQAQPG
2760 2770 2780 2790 2800
PPQQPAQVQV QTPQPPQQQQ SPQLTTVTAP RPGALLTGTT VTNLQVARLT
2810 2820 2830 2840 2850
RVPTSQLQAQ GQMQTQTPQP AQVALAKPPV VSVPAAVVSS PGVTTLPMNV
2860 2870 2880 2890 2900
AGISVAIGQP QKTAGQTVVA QPVNVQQLLK YKQQTAVQQQ KAIQPQVAQG
2910 2920 2930 2940 2950
QAAVQQKLTT QQITTQGPQQ KVAYAAQPAL KTQFLTTPIS QAQKLAGTQQ
2960 2970 2980 2990 3000
VQTQIQVAKL PQVVQQQTPV ASIQQVASAS QQASPQTVTL TQATAAGQQV
3010 3020 3030 3040 3050
QMIPTVTATA QLVQQKLIQQ QVVTTASASL QTPGGPSPAQ LPASSDSPSQ
3060 3070
QPKLQMRVPA VRLKTPTKPP CQ
Length:3,072
Mass (Da):337,180
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02990AAF5FAB7CEF
GO
Isoform 2 (identifier: Q8CHI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-482: Missing.

Show »
Length:3,035
Mass (Da):333,399
Checksum:i523E218E21EF0D63
GO
Isoform 3 (identifier: Q8CHI8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-482: Missing.
     513-548: Missing.

Show »
Length:2,999
Mass (Da):329,486
Checksum:i8FA686677DA6A7F4
GO
Isoform 4 (identifier: Q8CHI8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2800-2806: Missing.

Note: No experimental confirmation available.
Show »
Length:3,065
Mass (Da):336,410
Checksum:iD27440C486EA5F2E
GO
Isoform 5 (identifier: Q8CHI8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1764-1919: Missing.
     2800-2806: Missing.

Note: No experimental confirmation available.
Show »
Length:2,909
Mass (Da):318,235
Checksum:i2783A7314508CE76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6R8D3Z6R8_MOUSE
E1A-binding protein p400
Ep400
686Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R9G0F6R9G0_MOUSE
E1A-binding protein p400
Ep400
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q641K9Q641K9_MOUSE
E1A-binding protein p400
Ep400
649Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB24439 differs from that shown. Intron retention.Curated
The sequence BAC26781 differs from that shown. Intron retention.Curated
The sequence BAC32913 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102G → S in BAC26781 (PubMed:16141072).Curated1
Sequence conflicti107A → D in BAC29849 (PubMed:16141072).Curated1
Sequence conflicti163N → S in BAC45253 (PubMed:12653961).Curated1
Sequence conflicti163N → S in BAC45254 (PubMed:12653961).Curated1
Sequence conflicti678 – 686TVASTRPPL → VLCGHWLFY in BAB24439 (PubMed:16141072).Curated9
Sequence conflicti678 – 686TVASTRPPL → VLCGHWLFY in BAC26781 (PubMed:16141072).Curated9
Sequence conflicti896E → G in BAC29849 (PubMed:16141072).Curated1
Sequence conflicti2249K → N in BAC32913 (PubMed:16141072).Curated1
Sequence conflicti2353 – 2359SKNNRPL → LICEANP in BAC32913 (PubMed:16141072).Curated7
Sequence conflicti2518T → A in BAC45253 (PubMed:12653961).Curated1
Sequence conflicti2518T → A in BAC45254 (PubMed:12653961).Curated1
Sequence conflicti2518T → A in AAH22153 (PubMed:15489334).Curated1
Sequence conflicti2539A → V in BAC45253 (PubMed:12653961).Curated1
Sequence conflicti2539A → V in BAC45254 (PubMed:12653961).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011996446 – 482Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_011997513 – 548Missing in isoform 3. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_0171271764 – 1919Missing in isoform 5. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_0119982800 – 2806Missing in isoform 4 and isoform 5. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB092694 mRNA Translation: BAC45253.1
AB092695 mRNA Translation: BAC45254.1
AC161348 Genomic DNA No translation available.
AK006168 mRNA Translation: BAB24439.1 Sequence problems.
AK030095 mRNA Translation: BAC26781.1 Sequence problems.
AK037693 mRNA Translation: BAC29849.2
AK046892 mRNA Translation: BAC32913.2 Different initiation.
AK163566 mRNA Translation: BAE37399.1
AK164049 mRNA Translation: BAE37604.1
AK122517 Transcribed RNA Translation: BAC65799.2
BC022153 mRNA Translation: AAH22153.1
BC085511 mRNA Translation: AAH85511.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19529.1 [Q8CHI8-2]
CCDS51612.1 [Q8CHI8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_083613.2, NM_029337.2 [Q8CHI8-2]
NP_775089.1, NM_173066.1 [Q8CHI8-3]
XP_006535339.1, XM_006535276.3 [Q8CHI8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041558; ENSMUSP00000049038; ENSMUSG00000029505 [Q8CHI8-2]
ENSMUST00000112435; ENSMUSP00000108054; ENSMUSG00000029505 [Q8CHI8-5]
ENSMUST00000112436; ENSMUSP00000108055; ENSMUSG00000029505 [Q8CHI8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
75560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:75560

UCSC genome browser

More...
UCSCi
uc008yrf.1 mouse [Q8CHI8-4]
uc008yrg.1 mouse [Q8CHI8-2]
uc008yrh.1 mouse [Q8CHI8-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092694 mRNA Translation: BAC45253.1
AB092695 mRNA Translation: BAC45254.1
AC161348 Genomic DNA No translation available.
AK006168 mRNA Translation: BAB24439.1 Sequence problems.
AK030095 mRNA Translation: BAC26781.1 Sequence problems.
AK037693 mRNA Translation: BAC29849.2
AK046892 mRNA Translation: BAC32913.2 Different initiation.
AK163566 mRNA Translation: BAE37399.1
AK164049 mRNA Translation: BAE37604.1
AK122517 Transcribed RNA Translation: BAC65799.2
BC022153 mRNA Translation: AAH22153.1
BC085511 mRNA Translation: AAH85511.1
CCDSiCCDS19529.1 [Q8CHI8-2]
CCDS51612.1 [Q8CHI8-3]
RefSeqiNP_083613.2, NM_029337.2 [Q8CHI8-2]
NP_775089.1, NM_173066.1 [Q8CHI8-3]
XP_006535339.1, XM_006535276.3 [Q8CHI8-4]

3D structure databases

SMRiQ8CHI8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi217577, 16 interactors
ComplexPortaliCPX-990 NuA4 histone acetyltransferase complex
DIPiDIP-61766N
IntActiQ8CHI8, 11 interactors
MINTiQ8CHI8
STRINGi10090.ENSMUSP00000049038

PTM databases

iPTMnetiQ8CHI8
PhosphoSitePlusiQ8CHI8

Proteomic databases

CPTACinon-CPTAC-3461
jPOSTiQ8CHI8
PaxDbiQ8CHI8
PeptideAtlasiQ8CHI8
PRIDEiQ8CHI8

Genome annotation databases

EnsembliENSMUST00000041558; ENSMUSP00000049038; ENSMUSG00000029505 [Q8CHI8-2]
ENSMUST00000112435; ENSMUSP00000108054; ENSMUSG00000029505 [Q8CHI8-5]
ENSMUST00000112436; ENSMUSP00000108055; ENSMUSG00000029505 [Q8CHI8-3]
GeneIDi75560
KEGGimmu:75560
UCSCiuc008yrf.1 mouse [Q8CHI8-4]
uc008yrg.1 mouse [Q8CHI8-2]
uc008yrh.1 mouse [Q8CHI8-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57634
MGIiMGI:1276124 Ep400

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0391 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000154764
InParanoidiQ8CHI8
KOiK11320
OMAiGQEGIWG
OrthoDBi188211at2759
TreeFamiTF106424

Enzyme and pathway databases

ReactomeiR-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ep400 mouse

Protein Ontology

More...
PROi
PR:Q8CHI8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029505 Expressed in 273 organ(s), highest expression level in vestibular organ
ExpressionAtlasiQ8CHI8 baseline and differential
GenevisibleiQ8CHI8 MM

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR031575 EP400_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF15790 EP400_N, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEP400_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CHI8
Secondary accession number(s): E9QKV1
, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 27, 2011
Last modified: November 13, 2019
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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