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Entry version 84 (03 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

MKIAA0320 protein

Gene

Tln2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA0320 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tln2Imported
Synonyms:mKIAA0320Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917799 Tln2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q8CHG4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CHG4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1208 – 1462I/LWEQInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili151 – 171Sequence analysisAdd BLAST21
Coiled coili1430 – 1457Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261 Eukaryota
ENOG410XQ0V LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006734

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12150 talin-RS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR037438 Talin1/2-RS
IPR015009 Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01608 I_LWEQ, 2 hits
PF08913 VBS, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00307 ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109885 SSF109885, 2 hits
SSF47220 SSF47220, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50945 I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q8CHG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EKCAQDLGST SKGVGSSMAQ LLTCAAQGNE HYTGVAARET AQALKTLAQA
60 70 80 90 100
ARGVAASTND PEAAHAMLDS ARDVMEGSAM LIQEAKQALI APGDTESQQR
110 120 130 140 150
LAQVAKAVSH SLNNCVNCLP GQKDVDVALK SIGEASKKLL VDSLPPSTKP
160 170 180 190 200
FQEAQSELNQ AAADLNQSAG EVVHATRGQS GELAAASGKF SDDFDEFLDA
210 220 230 240 250
GIEMAGQAQT KEDQMQVIGN LKNISMASSK LLLAAKSLSV DPGAPNAKNL
260 270 280 290 300
LAAAARAVTE SINQLIMLCT QQAPGQKECD NALRELETVK GMLENPNEPV
310 320 330 340 350
SDLSYFDCIE SVMENSKVLG ESMAGISQNA KTGDLPAFGE CVGIASKALC
360 370 380 390 400
GLTEAAAQAA YLVGISDPNS QAGHQGLVDP IQFARANQAI QMACQNLVDP
410 420 430 440 450
GSSPSQVLSA ATIVAKHTSA LCNACRIASS KTANPVAKRH FVQSAKEVAN
460 470 480 490 500
STANLVKTIK ALDGDFSEDN RNKCRIATTP LIEAVENLTA FASNPEFASI
510 520 530 540 550
PAQISSEGSQ AQEPILVSAK TMLESSSYLI RTARSLAINP KDPPTWSVLA
560 570 580 590 600
GHSHTVSDSI KSLITSIRDK APGQRECDYS IDGINRCIRD IEQASLAAVS
610 620 630 640 650
QNLATRDDIS VEALQEQLTS VVQEIGHLID PIATAARGEA AQLGHKVTQL
660 670 680 690 700
ASYFEPLILA AVGVASKMLD HQQQMTVLDQ TKTLAESALQ MLYAAKEGGG
710 720 730 740 750
NPKAQHTHDA ITEAAQLMKE AVDDIMVTLN EAASEVGLVG GMVDAIAEAM
760 770 780 790 800
SKLDEGTPPE PKGTFVDYQT TVVKYSKAIA VTAQEMMTKS VTNPEELGGL
810 820 830 840 850
ASQMTTDYGH LALQGQMAAA TAEPEEIGFQ IRTRVQDLGH GCIFLVQKAG
860 870 880 890 900
ALQVCPTDSY TKRELIECAR SVTEKVSLVL SALQAGNKGT QACITAATAV
910 920 930 940 950
SGIIADLDTT IMFATAGTLN AENGETFADH RENILKTAKA LVEDTKLLVS
960 970 980 990 1000
GAASTPDKLA QAAQSSAATI TQLAEVVKLG AASLGSNDPE TQVVLINAIK
1010 1020 1030 1040 1050
DVAKALSDLI GATKGAASKP ADDPSMYQLK GAAKVMVTNV TSLLKTVKAV
1060 1070 1080 1090 1100
EDEATRGTRA LEATIEYIKQ ELTVFQSKDI PEKTSSPEES IRMTKGITMA
1110 1120 1130 1140 1150
TAKAVAAGNS CRQEDVIATA NLSRKAVSDM LIACKQASFY PDVSEEVRTR
1160 1170 1180 1190 1200
ALRYGTECTL GYLDLLEHVL VILQKPTPEL KHQLAAFSKR VAGAVTELIQ
1210 1220 1230 1240 1250
AAEAMKGTEW VDPEDPTVIA ETELLGAAAS IEAAAKKLEQ LKPRAKPKQA
1260 1270 1280 1290 1300
DETLDFEEQI LEAAKSIAAA TSALVKSASA AQRELVAQGK VGSIPANAAD
1310 1320 1330 1340 1350
DGQWSQGLIS AARMVAAATS SLCEAANASV QGHASEEKLI SSAKQVAAST
1360 1370 1380 1390 1400
AQLLVACKVK ADQDSEAMKR LQVMVTDAGG KILLLERAAG NAVKRASDNL
1410 1420 1430 1440 1450
VRAAQKAAFG KADDDDVVVK TKFVGGIAQI IAAQEEMLKK ERELEEARKK
1460 1470
LAQIRQQQYK FLPTELREDE G
Length:1,471
Mass (Da):154,835
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD05048FC9E5E6E86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB093231 mRNA Translation: BAC41415.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc009qfw.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093231 mRNA Translation: BAC41415.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ8CHG4
PRIDEiQ8CHG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009qfw.2 mouse

Organism-specific databases

MGIiMGI:1917799 Tln2

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
HOGENOMiHOG000006734

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tln2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd12150 talin-RS, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR037438 Talin1/2-RS
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF01608 I_LWEQ, 2 hits
PF08913 VBS, 2 hits
SMARTiView protein in SMART
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109885 SSF109885, 2 hits
SSF47220 SSF47220, 5 hits
PROSITEiView protein in PROSITE
PS50945 I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8CHG4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CHG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 3, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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