Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GRIP and coiled-coil domain-containing protein 2

Gene

Gcc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 2
Alternative name(s):
185 kDa Golgi coiled-coil protein
Short name:
GCC185
Gene namesi
Name:Gcc2
Synonyms:Kiaa0336
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917547 Gcc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900751 – 1679GRIP and coiled-coil domain-containing protein 2Add BLAST1679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei1474PhosphoserineBy similarity1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CHG3
MaxQBiQ8CHG3
PaxDbiQ8CHG3
PRIDEiQ8CHG3

PTM databases

iPTMnetiQ8CHG3
PhosphoSitePlusiQ8CHG3

Expressioni

Gene expression databases

CleanExiMM_GCC2

Interactioni

Subunit structurei

Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; might be involved in GCC2 Golgi localization. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Wasf2Q8BH436EBI-643470,EBI-643162

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CHG3, 2 interactors
STRINGi10090.ENSMUSP00000054033

Structurei

3D structure databases

ProteinModelPortaliQ8CHG3
SMRiQ8CHG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1604 – 1654GRIPPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1569 – 1679Mediates interaction with RAB9ABy similarityAdd BLAST111
Regioni1569 – 1608Mediates interaction with RAB6ABy similarityAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 1613Sequence analysisAdd BLAST1583

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IUCE Eukaryota
ENOG410Y42S LUCA
HOVERGENiHBG045522
InParanoidiQ8CHG3

Family and domain databases

InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q8CHG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSAPDAVA AAPSGTPKSK LETLPREDLI KFAKKQMMLL QKAKARCTEL
60 70 80 90 100
DKEVEELKSK PVDGGTDDII KVLTERLDAL LLEKAETEQQ CLCLKKENVK
110 120 130 140 150
MKQEVEDSVT KLEETHKEFE QSHRNYVKEI ESCKNELMAV HSEHSKETAI
160 170 180 190 200
LQKELEEAVH KQVELREQLK SQSDSEDNVR KLQEEIQNIT AAFEEQISCL
210 220 230 240 250
EKKLEATSDE KQQEIIHLQK VIEDKAQHYQ KDINTFQAEI LQLRATHKEE
260 270 280 290 300
VTELMSQIET SAKEHEAEIN KLKENRVTQC EASENIPEKY QCESENLNEV
310 320 330 340 350
ASDASPESQN CSVALQEDPS AEQTVCDKVR QLEDSLKELE SQHSILKDEV
360 370 380 390 400
TYMNNLKLKL EMDAQHIKDE FFHEREDLEF KINELLLAKE EQGYVVEKLK
410 420 430 440 450
YEREDLNRQL CCAVEQHNKE IQRLQEHHQK EVSELSETFI SGSEKEKLAL
460 470 480 490 500
MFEIQGLKEQ CENLQHEKQE VVLNYESLRE MMEILQTELG ESAGKISQEF
510 520 530 540 550
ETMKQQQASD VHELQQKLRS AFNEKDALLE TVNRLQGENE KLLSQQELVP
560 570 580 590 600
ELESTIKNLQ ADNSMYLASL GQKDTMLQEL EAKISSLAKE KDDFISKIKT
610 620 630 640 650
SHEEMDDLHQ KWEREQRLSV ELREAAGQAA QHNSELRQRV SELTGKLDEL
660 670 680 690 700
VREKSQNDQS ITVQMKTMTE DQEALSSKIK SLYEENNRLH SEKAQLSRDL
710 720 730 740 750
EALQAQQDFA HKEHVAEFEK KLQLMVEERD DLNKLLENEQ VQKSFVKTQL
760 770 780 790 800
YEYLKQLRAS ILEENEEEDV VKLIQAVGES LVKVKEEEHN LVFEYDARVL
810 820 830 840 850
ELENKIKCLQ EDSAVQCEEL RTLVRDSEQE KILLRKELDA VTSAKEALQL
860 870 880 890 900
DLLEMKNTNE KASLENQTLS TQVEELSQTL HSRNEVHDEK VLVIEHENLR
910 920 930 940 950
LLLKQRESEL QDVRAELILL KDSLEKSPSV KDQLSLVKEL EEKIESLEKE
960 970 980 990 1000
SKDKDEKISK IKLVAVKAKK ELDSNRKEAQ TLREELESVR SEKDRLSASM
1010 1020 1030 1040 1050
KEFLQGAESY KSLLLEYDKQ SEQLDVEKER AHNFERHIED LTKQLRNSTC
1060 1070 1080 1090 1100
QYERLTSDNE DLLARIETLQ ANAKLLEAQI LEVQKAKGVV EKELDAEELQ
1110 1120 1130 1140 1150
KEQKIKEHVS TVNELEELQL QFQKEKKQLQ KTMQELELVK KDAQQTTLMN
1160 1170 1180 1190 1200
MEIADYERLM KELNQKLTNK NSTIEDLEQE MKIQKEKQET LQEEITSLQS
1210 1220 1230 1240 1250
SVQHYEEKNT KIKQLLVKTK KELADAKQAE TDHLLLQASL KGELEASQQQ
1260 1270 1280 1290 1300
VEVYKIQLAE MTSEKHKIHE HLKTSAEQHQ RTLSAYQQRV VALQEESRAA
1310 1320 1330 1340 1350
KAEQAAVTSE FESYKVRVHN VLKQQKNKSV SQVETEGAKQ EREHLEMLID
1360 1370 1380 1390 1400
QLKIKLQDSQ NSLQISVSEY QTLQAEHDTL LERHNRMLQE TVTKEAELRE
1410 1420 1430 1440 1450
KLCSVQSENT MMKSEHSQTM CQLTSQNEAL RTSFRDQVRH LQDEHRKTVE
1460 1470 1480 1490 1500
TLQHQLSKLE AQLFQLKSEP STRSPASSHQ PSKSLRERRT TDLPLLDMHT
1510 1520 1530 1540 1550
VAREEGEGME TTDSESVSSA GTHIQSLEQL LSSPDTKLER LAETSLWHNE
1560 1570 1580 1590 1600
FTKEELAEKL SSTTKSADHL NGLLRETEAT NAILMEQIKL LKSEIRRLER
1610 1620 1630 1640 1650
NQEREKSVAN LEYLKNVLLR FIFLKPGSER ERLLPVIDTM LQLSPEEKGK
1660 1670
LATVAQGEEE SASRSSGWAS YLHSWSGLR
Length:1,679
Mass (Da):194,445
Last modified:July 3, 2003 - v2
Checksum:i6E2F84263E5E0103
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RSU7B2RSU7_MOUSE
GRIP and coiled-coil domain contain...
Gcc2 mCG_19017
1,680Annotation score:
E9PWI6E9PWI6_MOUSE
GRIP and coiled-coil domain-contain...
Gcc2
1,644Annotation score:
E0CYI9E0CYI9_MOUSE
GRIP and coiled-coil domain-contain...
Gcc2
1,576Annotation score:
E0CX24E0CX24_MOUSE
GRIP and coiled-coil domain-contain...
Gcc2
51Annotation score:
E0CY89E0CY89_MOUSE
GRIP and coiled-coil domain-contain...
Gcc2
94Annotation score:
F6UT01F6UT01_MOUSE
GRIP and coiled-coil domain-contain...
Gcc2
181Annotation score:

Sequence cautioni

The sequence AAH27339 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440I → M in AAH27339 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027339 mRNA Translation: AAH27339.1 Different initiation.
AK011206 mRNA Translation: BAB27466.3
AK045701 mRNA Translation: BAC32463.2
AB093232 Transcribed RNA Translation: BAC41416.1
UniGeneiMm.25531

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027339 mRNA Translation: AAH27339.1 Different initiation.
AK011206 mRNA Translation: BAB27466.3
AK045701 mRNA Translation: BAC32463.2
AB093232 Transcribed RNA Translation: BAC41416.1
UniGeneiMm.25531

3D structure databases

ProteinModelPortaliQ8CHG3
SMRiQ8CHG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CHG3, 2 interactors
STRINGi10090.ENSMUSP00000054033

PTM databases

iPTMnetiQ8CHG3
PhosphoSitePlusiQ8CHG3

Proteomic databases

EPDiQ8CHG3
MaxQBiQ8CHG3
PaxDbiQ8CHG3
PRIDEiQ8CHG3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917547 Gcc2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IUCE Eukaryota
ENOG410Y42S LUCA
HOVERGENiHBG045522
InParanoidiQ8CHG3

Miscellaneous databases

PROiPR:Q8CHG3
SOURCEiSearch...

Gene expression databases

CleanExiMM_GCC2

Family and domain databases

InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCC2_MOUSE
AccessioniPrimary (citable) accession number: Q8CHG3
Secondary accession number(s): Q8BR44, Q8R2Q5, Q9CT45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: July 18, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again