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Entry version 153 (02 Jun 2021)
Sequence version 2 (07 Jun 2005)
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Protein

PH domain leucine-rich repeat-containing protein phosphatase 1

Gene

Phlpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (By similarity).

Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity).

Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity).

Involved in the hippocampus-dependent long-term memory formation (PubMed:17382888).

Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (PubMed:20080691).

Involved in development and function of regulatory T-cells (PubMed:21498666).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Insensitive to okadaic acid. Deubiquitination by WDR48-USP12 complex positively regulates PHLPP1 stability.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1166Manganese 1By similarity1
Metal bindingi1166Manganese 2By similarity1
Metal bindingi1167Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi1330Manganese 2By similarity1
Metal bindingi1369Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processApoptosis
LigandManganese, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-199418, Negative regulation of the PI3K/AKT network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Pleckstrin homology domain-containing family E member 1
Short name:
PH domain-containing family E member 1
Suprachiasmatic nucleus circadian oscillatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phlpp1
Synonyms:Kiaa0606, Phlpp, Plekhe1, Scop
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2138327, Phlpp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577821 – 1687PH domain leucine-rich repeat-containing protein phosphatase 1Add BLAST1687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CHE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CHE4

PeptideAtlas

More...
PeptideAtlasi
Q8CHE4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CHE4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
288142 [Q8CHE4-1]
288143 [Q8CHE4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CHE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CHE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms 1 and 2 are expressed in the retina (PubMed:20089132).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in the hippocampus upon chronic methamphetamine treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044340, Expressed in cerebellar nuclear complex and 303 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CHE4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity).

Interacts with AKT2, AKT3 and PRKCB.

Interacts with WDR48 and USP12 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
221058, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8CHE4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000056530

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CHE4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini492 – 592PHPROSITE-ProRule annotationAdd BLAST101
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati594 – 615LRR 1Add BLAST22
Repeati617 – 638LRR 2Add BLAST22
Repeati648 – 669LRR 3Add BLAST22
Repeati671 – 692LRR 4Add BLAST22
Repeati694 – 715LRR 5Add BLAST22
Repeati717 – 739LRR 6Add BLAST23
Repeati740 – 760LRR 7Add BLAST21
Repeati764 – 785LRR 8Add BLAST22
Repeati788 – 809LRR 9Add BLAST22
Repeati829 – 850LRR 10Add BLAST22
Repeati851 – 872LRR 11Add BLAST22
Repeati874 – 895LRR 12Add BLAST22
Repeati897 – 918LRR 13Add BLAST22
Repeati919 – 940LRR 14Add BLAST22
Repeati943 – 964LRR 15Add BLAST22
Repeati969 – 989LRR 16Add BLAST21
Repeati993 – 1014LRR 17Add BLAST22
Repeati1017 – 1038LRR 18Add BLAST22
Repeati1040 – 1061LRR 19Add BLAST22
Repeati1062 – 1083LRR 20Add BLAST22
Repeati1085 – 1106LRR 21Add BLAST22
Domaini1131 – 1378PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96DisorderedSequence analysisAdd BLAST96
Regioni230 – 406DisorderedSequence analysisAdd BLAST177
Regioni1414 – 1465DisorderedSequence analysisAdd BLAST52
Regioni1604 – 1687DisorderedSequence analysisAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1685 – 1687PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 348Polar residuesSequence analysisAdd BLAST35
Compositional biasi357 – 373Pro residuesSequence analysisAdd BLAST17
Compositional biasi1420 – 1465Polar residuesSequence analysisAdd BLAST46
Compositional biasi1624 – 1638Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1648 – 1669Pro residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain is required for interaction with PRKCB and its dephosphorylation.By similarity

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0618, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003020_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CHE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDICGYF

Database of Orthologous Groups

More...
OrthoDBi
172467at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CHE4

TreeFam database of animal gene trees

More...
TreeFami
TF315993

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 1 hit
PF13855, LRR_8, 2 hits
PF00169, PH, 1 hit
PF00481, PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 9 hits
SM00332, PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 17 hits
PS50003, PH_DOMAIN, 1 hit
PS51746, PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CHE4-1) [UniParc]FASTAAdd to basket
Also known as: beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAAAAPAQ RLADPTGEDQ ALAAAAAEGG RCPDPALSAA APSGGNGGAA
60 70 80 90 100
REEAPCEAPP GPLPGRAGGT GRRRRRGAPQ PAAGGAAPVP AAGGGANSLL
110 120 130 140 150
LKRGRLKRNL SAAAAASSSS SPSSASSAAG GLPASCSASA SLCTRSLDRK
160 170 180 190 200
TLLLKHRQLL QLQPSDRDWV RHQLQRGCVH VFDRHMASSY LRPVLCTLDT
210 220 230 240 250
TAAEVAARLL QLGHKGGGVV KVLGYGPPPA AAPAASDQTL DGEHGRDVEP
260 270 280 290 300
PPSSGTVGAV RGPARAPPAD LPLPGGAWTR CAPRISPAPS DSSPGELFAG
310 320 330 340 350
GPGSPPRAPR PASDTESFSL SPSAESVSDR LDPYSSGGGG SSSSSEELEA
360 370 380 390 400
DPAMPHRPGR PAQPRPPSPK TSALLQPKAP TGVDSTGVIA GEGPGDDKAM
410 420 430 440 450
AAAAPDVPLS TSGRIRETVQ KTSPPSLYVQ LHGETTRRLE ADEKPLQIQN
460 470 480 490 500
DYLFQLGFGE LWRVQEEGMD SEIGCLIRFY AGKPHSTGSS ERIQLSGMYN
510 520 530 540 550
VRKGKMQLPV NRWTRRQVIL CGTCLIVSSV KDSVSGKMHV LPLIGGKVEE
560 570 580 590 600
VKKHQHCLAF SSSGPQSQTY YICFDTFTEY LRWLRQVSKV ASQRISSVDL
610 620 630 640 650
SCCSLEHLPA NLFYSQDLTH LNLKQNFLRQ TPTLPAARGL GELQRFTKLK
660 670 680 690 700
SLNLSNNHLG AFPSAVCSIP TLAELNVSCN ALREVPAAVG DMQNLQTFLL
710 720 730 740 750
DGNFLQSLPA ELESMHQLSY LGLSFNEFTD IPEVLEKLTA VDKLCMAGNC
760 770 780 790 800
VETLRLQALR RMPHIKHVDL RLNILRKLMA DEVDFVQHVT QLDLRDNKLG
810 820 830 840 850
DLDAMIFNNI EVLHCERNQL VTLNVCGYFL KALYASSNEL AQLDVYPVPN
860 870 880 890 900
YLSYMDVSRN CLESVPEWVC ESRKLEVLDI GHNQICELPA RLFCNSSLRK
910 920 930 940 950
LLAGHNRLAR LPERLERTSV EVLDVQHNQI TELPPNLLMK ADSLRFLNAS
960 970 980 990 1000
ANKLETLPPA TLSEETSSIL QELYLTNNCL TDKCVPLLTG HPRLKILHMA
1010 1020 1030 1040 1050
YNRLQSFPAS KMAKLEELEE IDISGNKLKA IPTTIMNCRR MHTVIAHSNC
1060 1070 1080 1090 1100
IEVFPEVMQL PEVKCVDLSC NELSEITLPE NLPPKLQELD LTGNPRLALD
1110 1120 1130 1140 1150
HKSLELLNNI RCFKIDQPSA GDASGAPAVW SHGYTEASGV KNKLCVAALS
1160 1170 1180 1190 1200
VNNFRDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ KTKNEEEYMV
1210 1220 1230 1240 1250
NTFIVMQRKL GTAGQKLGGA AVLCHIKPDP VDLGGSFTLT SANVGKCQTV
1260 1270 1280 1290 1300
LCRNGKPLSL SRSYIMSCEE ERKRIKQHKA IITEDGKVNG VTESTRILGY
1310 1320 1330 1340 1350
TFLHPSVVPR PHVQSVLLTP QDEFFILGSK GLWDSLSIDE AVEAVRNVPD
1360 1370 1380 1390 1400
ALAAAKKLCT LAQSYGCHDS ISAVVVQLSV TEDSFCCCEL SAGGSMPPPS
1410 1420 1430 1440 1450
PGIFPPSVNM VIKDRPSDGL GVPSSSSGMA SEISSELSTS EMSSEVGSTA
1460 1470 1480 1490 1500
SDEPPSGVLN ESSPAYPNEQ RCMLHPVCLS NSFQRQLSSA TFSSAFSDNG
1510 1520 1530 1540 1550
LDSDDEEPIE GVFSNGSRVE VEVDIHCSRA KEKERQQHLL QVPAEASDEG
1560 1570 1580 1590 1600
IVISANEDES GLSKKADFSA VGTIGRRRAN GSVAPQERSH NVIEVAADAP
1610 1620 1630 1640 1650
LRKPGGYFAA PAQPDPDDQF IIPPELEEEV KEIMKHHQEQ QQQQQQQQLP
1660 1670 1680
PPPQPPQPQP QPQPQPQPQP QRHFQMDHLP DCYDTPL
Length:1,687
Mass (Da):182,367
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32B0809AAB3D2412
GO
Isoform 2 (identifier: Q8CHE4-2) [UniParc]FASTAAdd to basket
Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-468: Missing.

Show »
Length:1,219
Mass (Da):134,965
Checksum:iEB222C83571C9050
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH59254 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti724S → F in AAH59254 (PubMed:15489334).Curated1
Sequence conflicti1506E → K in AAH22703 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0578101 – 468Missing in isoform 2. Add BLAST468

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC101663 Genomic DNA No translation available.
AC124710 Genomic DNA No translation available.
AC144773 Genomic DNA No translation available.
AB093251 mRNA Translation: BAC41435.1
BC004581 mRNA Translation: AAH04581.1
BC022703 mRNA Translation: AAH22703.1
BC024670 mRNA Translation: AAH24670.1
BC059254 mRNA Translation: AAH59254.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS48337.1 [Q8CHE4-1]

NCBI Reference Sequences

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RefSeqi
NP_598582.3, NM_133821.3 [Q8CHE4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000061047; ENSMUSP00000056530; ENSMUSG00000044340 [Q8CHE4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
98432

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:98432

UCSC genome browser

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UCSCi
uc007cgv.2, mouse [Q8CHE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101663 Genomic DNA No translation available.
AC124710 Genomic DNA No translation available.
AC144773 Genomic DNA No translation available.
AB093251 mRNA Translation: BAC41435.1
BC004581 mRNA Translation: AAH04581.1
BC022703 mRNA Translation: AAH22703.1
BC024670 mRNA Translation: AAH24670.1
BC059254 mRNA Translation: AAH59254.1 Frameshift.
CCDSiCCDS48337.1 [Q8CHE4-1]
RefSeqiNP_598582.3, NM_133821.3 [Q8CHE4-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi221058, 5 interactors
IntActiQ8CHE4, 1 interactor
STRINGi10090.ENSMUSP00000056530

PTM databases

iPTMnetiQ8CHE4
PhosphoSitePlusiQ8CHE4

Proteomic databases

EPDiQ8CHE4
PaxDbiQ8CHE4
PeptideAtlasiQ8CHE4
PRIDEiQ8CHE4
ProteomicsDBi288142 [Q8CHE4-1]
288143 [Q8CHE4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23071, 171 antibodies

The DNASU plasmid repository

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DNASUi
98432

Genome annotation databases

EnsembliENSMUST00000061047; ENSMUSP00000056530; ENSMUSG00000044340 [Q8CHE4-1]
GeneIDi98432
KEGGimmu:98432
UCSCiuc007cgv.2, mouse [Q8CHE4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23239
MGIiMGI:2138327, Phlpp1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0618, Eukaryota
GeneTreeiENSGT00940000158137
HOGENOMiCLU_003020_0_0_1
InParanoidiQ8CHE4
OMAiLDICGYF
OrthoDBi172467at2759
PhylomeDBiQ8CHE4
TreeFamiTF315993

Enzyme and pathway databases

ReactomeiR-MMU-199418, Negative regulation of the PI3K/AKT network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
98432, 5 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Phlpp1, mouse

Protein Ontology

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PROi
PR:Q8CHE4
RNActiQ8CHE4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044340, Expressed in cerebellar nuclear complex and 303 other tissues
GenevisibleiQ8CHE4, MM

Family and domain databases

CDDicd00143, PP2Cc, 1 hit
Gene3Di2.30.29.30, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF13516, LRR_6, 1 hit
PF13855, LRR_8, 2 hits
PF00169, PH, 1 hit
PF00481, PP2C, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 9 hits
SM00332, PP2Cc, 1 hit
SUPFAMiSSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 17 hits
PS50003, PH_DOMAIN, 1 hit
PS51746, PPM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CHE4
Secondary accession number(s): Q6PCN0
, Q8QZU8, Q8R5E5, Q99KL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: June 2, 2021
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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