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UniProtKB - Q8CHB8 (TTLL5_MOUSE)

Entry version 136 (23 Feb 2022)
Sequence version 3 (18 Mar 2008)
Previous versions | rss
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Protein

Tubulin polyglutamylase TTLL5

Gene

Ttll5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049).

Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step (PubMed:17499049).

Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049).

Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (By similarity).

Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei180ATPBy similarity1
Binding sitei186L-glutamate residue; L-glutamate acceptor residue in protein targetBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei186Essential for specifying initiation versus elongation step of the polyglutamylase activityBy similarity1
Binding sitei247L-glutamateBy similarity1
Binding sitei293L-glutamateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi353Magnesium 1By similarity1
Metal bindingi366Magnesium 1By similarity1
Metal bindingi366Magnesium 2By similarity1
Metal bindingi368Magnesium 2By similarity1
Binding sitei384L-glutamateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi186 – 187ATPBy similarity2
Nucleotide bindingi208 – 211ATPBy similarity4
Nucleotide bindingi221 – 223ATPBy similarity3
Nucleotide bindingi268 – 269ATPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processTranscription
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.3.2.B3, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin polyglutamylase TTLL51 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttll5Imported
Synonyms:Kiaa0998
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2443657, Ttll5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000012609

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233421 – 1328Tubulin polyglutamylase TTLL5Add BLAST1328

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CHB8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8CHB8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CHB8

PRoteomics IDEntifications database

More...PRIDEi		Q8CHB8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		297753 [Q8CHB8-1]
297754 [Q8CHB8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CHB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CHB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, kidney, liver, spleen and testis (PubMed:17499049). Expressed in heart, lung, muscle and trachea (PubMed:17499049).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000012609, Expressed in spermatocyte and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8CHB8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CHB8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the transcriptional coactivators NCOA1/SRC-1 and NCOA2/TIF2.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000048809

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CHB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CHB8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 407TTLPROSITE-ProRule annotationAdd BLAST346

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni270 – 271L-glutamateBy similarity2
Regioni378 – 488c-MTBD regionBy similarityAdd BLAST111
Regioni411 – 436DisorderedSequence analysisAdd BLAST26
Regioni585 – 631DisorderedSequence analysisAdd BLAST47
Regioni834 – 853DisorderedSequence analysisAdd BLAST20
Regioni948 – 975DisorderedSequence analysisAdd BLAST28
Regioni1006 – 1032DisorderedSequence analysisAdd BLAST27
Regioni1085 – 1129DisorderedSequence analysisAdd BLAST45
Regioni1212 – 1271DisorderedSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 431Polar residuesSequence analysisAdd BLAST21
Compositional biasi595 – 617Acidic residuesSequence analysisAdd BLAST23
Compositional biasi834 – 849Polar residuesSequence analysisAdd BLAST16
Compositional biasi960 – 975Polar residuesSequence analysisAdd BLAST16
Compositional biasi1085 – 1126Polar residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity
Arg-186 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2156, Eukaryota
KOG2157, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162910

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CHB8

Identification of Orthologs from Complete Genome Data

More...OMAi		EHKTTMN

Database of Orthologous Groups

More...OrthoDBi		219807at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CHB8

TreeFam database of animal gene trees

More...TreeFami		TF313087

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004344, TTL/TTLL_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CHB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVVMARDLE ETASSSEDED LANQEDHPCI MWTGGCRRIP VLVFHAEAIL 
        60         70         80         90        100
TKDNNIRVIG ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW 
       110        120        130        140        150
TGSHLKPFLL RTLSEAQKVN HFPRSYELTR KDRLYKNIIR MQHTHGFKAF 
       160        170        180        190        200
HILPQTFLLP AEYAEFCNSY SKDRGPWIVK PVASSRGRGV YLINNPNQIS 
       210        220        230        240        250
LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL YEEGLARFAT 
       260        270        280        290        300
VRYDQGSKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML 
       310        320        330        340        350
RYLKQEGKDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY 
       360        370        380        390        400
GFDVLIDNTL KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ 
       410        420        430        440        450
DPAQRTSNRS IYPSFESSRR NPFQKPQRTR PLSASDAEMK NLVASAREKV 
       460        470        480        490        500
PGKLGGSVLG LSMEEIKVLR RVKEENDRRG GFIRIFPTSE TWEIYGSYLE 
       510        520        530        540        550
HKTSMNYMLA TRLFQDRGNP RRSLLTGRAR VSTEGAPELK VESMNSKAKL 
       560        570        580        590        600
HAALYERKLL SLEVRKRRRR SGRLRAMRPK YPVIAQPAEM NIKTETESEE 
       610        620        630        640        650
EEEVGLDNDD EEQEASQEES AGSLGENQAK YTPSLTVIVE NSPRDNAMKV 
       660        670        680        690        700
AEWTNKGEPC CKIEAQEPES KFNLMQILQD NGNLSKVQAR LAFSAYLQHV 
       710        720        730        740        750
QIRLTKDSGG QTLSPSWAAK EDEQMELVVR FLKRASSNLQ HSLRMVLPSR 
       760        770        780        790        800
RLALLERRRI LAHQLGDFIG VYNKETEQMA EKKSKKKLEE EEEDGVNAES 
       810        820        830        840        850
FQEFIRQASE AELEEVLTFY TQKNKSASVF LGTHSKSSKN SSSYSDSGAK 
       860        870        880        890        900
GDHPETIQEV KIKQPKQQQA TEIHADKLSR FTTSSGKEAK LVYTNCSSFC 
       910        920        930        940        950
SPAAVLLQRL PSSHLSSVIT TSALSAGPGH HASLSQIPPA VPSLPHQPAL 
       960        970        980        990       1000
LLSPVPDNAP PSIHSGTQNV SPAGLPRCRS GSYTIGPFSS FQSAAHIYSQ 
      1010       1020       1030       1040       1050
KLSRPSSAKA AGSCHPHKHH SGIAKTQKEG EDVSLNRRYN QSLVTAELQR 
      1060       1070       1080       1090       1100
LAEKQAARQY SPASHISLLT QQVTNLNLAS SVINRSSAST PPTLRPVISP 
      1110       1120       1130       1140       1150
SGPTWSIQPD LHASETHSSP PGSRSLQTGG FAWEGEVENN AYSKTTGVVP 
      1160       1170       1180       1190       1200
QHKYHPTAGS YQLHFALQQL EQQKLQSRQL LDQSRARHQA IFGSQTLPNS 
      1210       1220       1230       1240       1250
SLWTMNNGPG CRISSATTGG QKPNTLPQKV VAPPNSSTLV SKPASNHKQV 
      1260       1270       1280       1290       1300
LRKPASQRAS KGSSAEGQLN GLQSSLNPAA FMPITNSTGS LEAPQVIFAR 
      1310       1320 
SKPLPTQSGA LATVIGQRKS KSVKSGTI
Length:1,328
Mass (Da):147,715
Last modified:March 18, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA8D8E25F21C55C5
GO
Isoform 2 (identifier: Q8CHB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-1328: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:563
Mass (Da):64,435
Checksum:iB895E2111730E2DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q425E9Q425_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
1,295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVZ5D3YVZ5_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
1,281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJ73H3BJ73_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
795Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJC7H3BJC7_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK74H3BK74_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLA3H3BLA3_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLC0H3BLC0_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJC2H3BJC2_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BUF0Q8BUF0_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C125Q8C125_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35276 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC41462 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAE43213 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti663 – 664IE → NQ in BAE43213 (PubMed:16141072).Curated2
Sequence conflicti665A → G in BAC41462 (PubMed:12465718).Curated1
Sequence conflicti677I → M in BAE43213 (PubMed:16141072).Curated1
Sequence conflicti803E → D in BAE43213 (PubMed:16141072).Curated1
Sequence conflicti1222K → N in BAE43213 (PubMed:16141072).Curated1
Sequence conflicti1252R → K in BAB24715 (PubMed:16141072).Curated1
Sequence conflicti1266E → K in BAB24715 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041931564 – 1328Missing in isoform 2. 1 PublicationAdd BLAST765

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AM690748 mRNA Translation: CAM84325.1
AB093278 mRNA Translation: BAC41462.1 Different initiation.
BC035276 mRNA Translation: AAH35276.1 Different initiation.
AK006726 mRNA Translation: BAB24715.1
AK009255 mRNA Translation: BAE43213.1 Frameshift.
AK028083 mRNA Translation: BAC25741.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36499.2 [Q8CHB8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001074892.2, NM_001081423.2 [Q8CHB8-1]
NP_001334324.1, NM_001347395.1
XP_017170604.1, XM_017315115.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000040179; ENSMUSP00000048809; ENSMUSG00000012609 [Q8CHB8-1]
ENSMUST00000155448; ENSMUSP00000134971; ENSMUSG00000012609 [Q8CHB8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		320244

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:320244

UCSC genome browser

More...UCSCi		uc007ohj.2, mouse [Q8CHB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690748 mRNA Translation: CAM84325.1
AB093278 mRNA Translation: BAC41462.1 Different initiation.
BC035276 mRNA Translation: AAH35276.1 Different initiation.
AK006726 mRNA Translation: BAB24715.1
AK009255 mRNA Translation: BAE43213.1 Frameshift.
AK028083 mRNA Translation: BAC25741.1
CCDSiCCDS36499.2 [Q8CHB8-1]
RefSeqiNP_001074892.2, NM_001081423.2 [Q8CHB8-1]
NP_001334324.1, NM_001347395.1
XP_017170604.1, XM_017315115.1

3D structure databases

SMRiQ8CHB8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048809

PTM databases

iPTMnetiQ8CHB8
PhosphoSitePlusiQ8CHB8

Proteomic databases

EPDiQ8CHB8
MaxQBiQ8CHB8
PaxDbiQ8CHB8
PRIDEiQ8CHB8
ProteomicsDBi297753 [Q8CHB8-1]
297754 [Q8CHB8-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		320244

Genome annotation databases

EnsembliENSMUST00000040179; ENSMUSP00000048809; ENSMUSG00000012609 [Q8CHB8-1]
ENSMUST00000155448; ENSMUSP00000134971; ENSMUSG00000012609 [Q8CHB8-2]
GeneIDi320244
KEGGimmu:320244
UCSCiuc007ohj.2, mouse [Q8CHB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23093
MGIiMGI:2443657, Ttll5
VEuPathDBiHostDB:ENSMUSG00000012609

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2156, Eukaryota
KOG2157, Eukaryota
GeneTreeiENSGT00940000162910
InParanoidiQ8CHB8
OMAiEHKTTMN
OrthoDBi219807at2759
PhylomeDBiQ8CHB8
TreeFamiTF313087

Enzyme and pathway databases

BRENDAi6.3.2.B3, 3474
ReactomeiR-MMU-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		320244, 6 hits in 67 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ttll5, mouse

Protein Ontology

More...PROi		PR:Q8CHB8
RNActiQ8CHB8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000012609, Expressed in spermatocyte and 251 other tissues
ExpressionAtlasiQ8CHB8, baseline and differential
GenevisibleiQ8CHB8, MM

Family and domain databases

InterProiView protein in InterPro
IPR004344, TTL/TTLL_fam
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CHB8
Secondary accession number(s): A4Q9E7
, Q3V468, Q8C1F0, Q8CFV5, Q9CVS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 18, 2008
Last modified: February 23, 2022
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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