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Protein

ELAV-like protein 2

Gene

Elavl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
Hu-antigen B
Short name:
HuB
Gene namesi
Name:Elavl2
Synonyms:Hub
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628611 Elavl2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327681 – 359ELAV-like protein 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CH84
PRIDEiQ8CH84

PTM databases

iPTMnetiQ8CH84
PhosphoSitePlusiQ8CH84

Interactioni

Subunit structurei

Interacts with IGF2BP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009034

Structurei

3D structure databases

ProteinModelPortaliQ8CH84
SMRiQ8CH84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini276 – 354RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ8CH84
PhylomeDBiQ8CH84

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CH84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQLSNGPT CNNTANGPTT VNNNCSSPVD SGNTEDSKTN LIDNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
310 320 330 340 350
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS

FKTNKTHKA
Length:359
Mass (Da):39,506
Last modified:March 1, 2003 - v1
Checksum:i1F07FBCA37DEFE72
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6U4G3V6U4_RAT
ELAV-like protein
Elavl2 rCG_53485
388Annotation score:
A0A1B0GWU2A0A1B0GWU2_RAT
ELAV-like protein
Elavl2
373Annotation score:
A0A1B0GWQ5A0A1B0GWQ5_RAT
ELAV-like protein
Elavl2
347Annotation score:
A0A1B0GWY9A0A1B0GWY9_RAT
ELAV-like protein 2
Elavl2
109Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098713 mRNA Translation: BAC53775.1
UniGeneiRn.12662

Genome annotation databases

UCSCiRGD:628611 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098713 mRNA Translation: BAC53775.1
UniGeneiRn.12662

3D structure databases

ProteinModelPortaliQ8CH84
SMRiQ8CH84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009034

PTM databases

iPTMnetiQ8CH84
PhosphoSitePlusiQ8CH84

Proteomic databases

PaxDbiQ8CH84
PRIDEiQ8CH84

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:628611 rat

Organism-specific databases

RGDi628611 Elavl2

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ8CH84
PhylomeDBiQ8CH84

Miscellaneous databases

PROiPR:Q8CH84

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiELAV2_RAT
AccessioniPrimary (citable) accession number: Q8CH84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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