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Entry version 127 (07 Apr 2021)
Sequence version 2 (15 May 2007)
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Protein

Neuron navigator 1

Gene

Nav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neuronal migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuron navigator 1
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nav1
Synonyms:Kiaa1151, Pomfil3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2183683, Nav1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869751 – 1875Neuron navigator 1Add BLAST1875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei162PhosphothreonineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei299PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei315PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1
Modified residuei394PhosphoserineCombined sources1
Modified residuei455PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei493PhosphoserineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei537PhosphothreonineBy similarity1
Modified residuei544PhosphoserineBy similarity1
Modified residuei547PhosphothreonineBy similarity1
Modified residuei575PhosphothreonineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei690Omega-N-methylarginineCombined sources1
Modified residuei752PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei810PhosphoserineCombined sources1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1004PhosphothreonineBy similarity1
Modified residuei1168PhosphothreonineBy similarity1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1380PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CH77

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CH77

PeptideAtlas

More...
PeptideAtlasi
Q8CH77

PRoteomics IDEntifications database

More...
PRIDEi
Q8CH77

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
287440 [Q8CH77-1]
287441 [Q8CH77-2]
287442 [Q8CH77-3]
287443 [Q8CH77-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CH77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CH77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and brain. Present in brain (at protein level). In adult brain, found almost exclusively in areas of secondary neurogenesis from the hippocampus and the subventricular zone.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in neural structures at 10 dpc. At 13 dpc and 15 dpc, highly expressed in neural tube, somites, heart and dispersed cells in tongue and face. At P5, widely expressed through the central nervous system in post-mitotic post-migratory zones. Brain expression decreases rapidly from P5 to P21 (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009418, Expressed in rostral migratory stream and 294 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CH77, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tubulin.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229647, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8CH77, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000067241

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CH77, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili258 – 283Sequence analysisAdd BLAST26
Coiled coili733 – 758Sequence analysisAdd BLAST26
Coiled coili1070 – 1161Sequence analysisAdd BLAST92
Coiled coili1301 – 1360Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1204 – 1209Poly-Lys6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSUE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001002_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CH77

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTNIQYR

Database of Orthologous Groups

More...
OrthoDBi
21830at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CH77

TreeFam database of animal gene trees

More...
TreeFami
TF329881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR12784, PTHR12784, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CH77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGSSVKSVQ PEVELSGGSG SGGDEGADES RGASRKAAAA DGRGMLPKRA
60 70 80 90 100
KAAGGSGSMA KASAAELKVF KSGSVDSRVP GGLPTSNLRK QKSLTNLSFL
110 120 130 140 150
TDSEKKLQLY EPEWSDDMAK APKGLGKLGP KGRETPLMSK TLSKSEHSLF
160 170 180 190 200
QPKGGSTGGA KTPLAPLAPS LGKPSRIPRG PYAEVKPLSK APEAAVSDDG
210 220 230 240 250
KSDDELLSSK AKAQKGSGTV PSAKGQEERA FLKVDPELVV TVLGDLEQLL
260 270 280 290 300
FSQMLDPESQ RKRTVQNVLD LRQNLEETMS SLRGSQVTHS SLEMPCYDSD
310 320 330 340 350
DANPRSVSSL SNRSSPLSWR YGQSSPRLQA GDAPSVGGSC RSEGPPAWYM
360 370 380 390 400
HGERAHYSHT MPMRSPSKLS HISRLELVES LDSDEVDLKS GYMSDSDLMG
410 420 430 440 450
KTMTEDDDIT TGWDESSSIS SGLSDASDNL SSEEFNASSS LNSLPTTPTA
460 470 480 490 500
SRRSSTIVLR TDSEKRSLAE SGLNWFSESE EKTPKKLEYD SGSLKMEPGT
510 520 530 540 550
SKWRRERPES CDDASKGGEL KKPISLGHPG SLKKGKTPPV AVTSPITHTA
560 570 580 590 600
QSALKVAGKP EGKATDKGKL AVKNTGLQRS SSDAGRDRLS DAKKPPSGIA
610 620 630 640 650
RPSTSGSFGY KKPPPATGTA TVMQTGSSAT LSKIQKSSGI PVKPVNGRKT
660 670 680 690 700
SLDVSNSVEP GFLAPGARSN IQYRSLPRPA KSSSMSVTGR GGPRPVSSSI
710 720 730 740 750
DPSLLSTKQG GLTPSRLKEP SKVASGRSTP APVNQTDREK EKAKAKAVAL
760 770 780 790 800
DSDNISLKSI GSPESTPKNQ ASHPPATKLA ELPPTPLRAT AKSFVKPPSL
810 820 830 840 850
ANLDKVNSNS LDLPSSSDTH ASKVPDLHAP SSSTGGPLPS CFTPSPAPIL
860 870 880 890 900
NINSASFSQG LELMSGFSVP KETRMYPKLS GLHRSMESLQ MPMSLPSAFP
910 920 930 940 950
SSAPIPTPPT APSEEDTEEL PWSGSPRAGQ LDSSQRDRNT LPKKGLRYQL
960 970 980 990 1000
QSQEETKERR HSHTAGGLPE SDDQAELPSP PALSMSLSAK GQLTNIVSPT
1010 1020 1030 1040 1050
AATTPRITRS NSIPTHEAAF ELYSGSQMGS TLSLAERPKG MIRSGSFRDP
1060 1070 1080 1090 1100
TDDVHGSVLS LASSASSTYS SAEERMQSEQ IRKLRRELES SQEKVATLTS
1110 1120 1130 1140 1150
QLSANANLVA AFEQSLVNMT SRLRHLAETA EEKDTELLDL RETIDFLKKK
1160 1170 1180 1190 1200
NSEAQAVIQG ALNASEATPK ELRIKRQNSS DSISSLNSIT SHSSIGSSKD
1210 1220 1230 1240 1250
ADAKKKKKKS WVYELRSSFN KAFSIKKGPK SASSYSDIEE IATPDSSAPS
1260 1270 1280 1290 1300
SPKLQHGSTE TASPSIKSST SSSVGTEVTE TPAHSVPHTR LFQANEEEEP
1310 1320 1330 1340 1350
EKKEVSELRS ELWEKEMKLT DIRLEALNSA HQLDQLRETM HNMQLEVDLL
1360 1370 1380 1390 1400
KAENDRLKVA PGPSSGCTPG QVPGSSALSS PRRSLGLALS HPFSPSLTDT
1410 1420 1430 1440 1450
DLSPMDGIST CGSKEEVTLR VVVRMPPQHI IKGDLKQQEF FLGCSKVSGK
1460 1470 1480 1490 1500
VDWKMLDEAV FQVFKDYISK MDPASTLGLS TESIHGYSLS HVKRVLDAEP
1510 1520 1530 1540 1550
PEMPPCRRGV NNISVALKGL KEKCVDSLVF ETLIPKPMMQ HYISLLLKHR
1560 1570 1580 1590 1600
RLVLSGPSGT GKTYLTNRLA EYLVERSGRE VTDGIVSTFN MHQQSCKDLQ
1610 1620 1630 1640 1650
LYLSNLANQI DRETGIGDVP LVILLDDLSE AGSISELVNG ALTCKYHKCP
1660 1670 1680 1690 1700
YIIGTTNQPV KMTPNHGLHL SFRMLTFSNN VEPANGFLVR YLRRKLVESD
1710 1720 1730 1740 1750
SDVNANKEEL LRVLDWVPKL WYHLHTFLEK HSTSDFLIGP CFFLSCPIGI
1760 1770 1780 1790 1800
EDFRTWFIDL WNNSIIPYLQ EGAKDGIKVH GQKAAWEDPV EWVRDTLPWP
1810 1820 1830 1840 1850
SAQQDQSKLY HLPPPSVGPH STASPPEDRT VKDSTPNSLD SDPLMAMLLK
1860 1870
LQEAANYIES PDRETILDPN LQATL
Length:1,875
Mass (Da):202,368
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EDEF58B6953DBB7
GO
Isoform 2 (identifier: Q8CH77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     997-1053: Missing.
     1212-1214: Missing.

Show »
Length:1,815
Mass (Da):195,896
Checksum:i2D8677445D24656F
GO
Isoform 3 (identifier: Q8CH77-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1214: Missing.
     1225-1225: I → L
     1226-1875: Missing.

Show »
Length:1,222
Mass (Da):129,744
Checksum:i85DBF0D3994D3008
GO
Isoform 4 (identifier: Q8CH77-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.
     393-412: MSDSDLMGKTMTEDDDITTG → MLHLPLPRSGRTANFPRS
     1213-1221: YELRSSFNK → CKGLGIGLC
     1222-1875: Missing.

Show »
Length:827
Mass (Da):87,805
Checksum:i485A0AA74881C107
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A589P973A0A589P973_MOUSE
Neuron navigator 1
Nav1
2,098Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSM9A0A087WSM9_MOUSE
Neuron navigator 1
Nav1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65740 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132G → D in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti310L → F in BAC65740 (PubMed:12693553).Curated1
Sequence conflicti386V → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti437A → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti899F → Y in BAC38568 (PubMed:16141072).Curated1
Sequence conflicti933Missing in AAH59840 (PubMed:15489334).Curated1
Sequence conflicti954E → D in AAH59840 (PubMed:15489334).Curated1
Sequence conflicti960R → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti975A → E in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti981P → L in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti1361P → S in AAH80292 (PubMed:15489334).Curated1
Sequence conflicti1686G → V in BAC65740 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0252601 – 392Missing in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_025261393 – 412MSDSD…DITTG → MLHLPLPRSGRTANFPRS in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_025262997 – 1053Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0252631212 – 1214Missing in isoform 2 and isoform 3. 2 Publications3
Alternative sequenceiVSP_0252641213 – 1221YELRSSFNK → CKGLGIGLC in isoform 4. 1 Publication9
Alternative sequenceiVSP_0252651222 – 1875Missing in isoform 4. 1 PublicationAdd BLAST654
Alternative sequenceiVSP_0252661225I → L in isoform 3. 1 Publication1
Alternative sequenceiVSP_0252671226 – 1875Missing in isoform 3. 1 PublicationAdd BLAST650

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF307453 mRNA Translation: AAO13290.1
AK122458 mRNA Translation: BAC65740.1 Different initiation.
AK053255 mRNA Translation: BAC35323.1
AK082667 mRNA Translation: BAC38568.1
AK153742 mRNA Translation: BAE32163.1
BC059840 mRNA Translation: AAH59840.1
BC080292 mRNA Translation: AAH80292.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35720.1 [Q8CH77-1]

NCBI Reference Sequences

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RefSeqi
NP_775613.2, NM_173437.2 [Q8CH77-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000040599; ENSMUSP00000043803; ENSMUSG00000009418 [Q8CH77-1]
ENSMUST00000067414; ENSMUSP00000067241; ENSMUSG00000009418 [Q8CH77-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
215690

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:215690

UCSC genome browser

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UCSCi
uc007ctg.2, mouse [Q8CH77-1]
uc007ctj.2, mouse [Q8CH77-2]
uc007ctl.1, mouse [Q8CH77-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307453 mRNA Translation: AAO13290.1
AK122458 mRNA Translation: BAC65740.1 Different initiation.
AK053255 mRNA Translation: BAC35323.1
AK082667 mRNA Translation: BAC38568.1
AK153742 mRNA Translation: BAE32163.1
BC059840 mRNA Translation: AAH59840.1
BC080292 mRNA Translation: AAH80292.1
CCDSiCCDS35720.1 [Q8CH77-1]
RefSeqiNP_775613.2, NM_173437.2 [Q8CH77-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi229647, 4 interactors
IntActiQ8CH77, 2 interactors
STRINGi10090.ENSMUSP00000067241

PTM databases

iPTMnetiQ8CH77
PhosphoSitePlusiQ8CH77

Proteomic databases

jPOSTiQ8CH77
PaxDbiQ8CH77
PeptideAtlasiQ8CH77
PRIDEiQ8CH77
ProteomicsDBi287440 [Q8CH77-1]
287441 [Q8CH77-2]
287442 [Q8CH77-3]
287443 [Q8CH77-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3226, 73 antibodies

Genome annotation databases

EnsembliENSMUST00000040599; ENSMUSP00000043803; ENSMUSG00000009418 [Q8CH77-1]
ENSMUST00000067414; ENSMUSP00000067241; ENSMUSG00000009418 [Q8CH77-1]
GeneIDi215690
KEGGimmu:215690
UCSCiuc007ctg.2, mouse [Q8CH77-1]
uc007ctj.2, mouse [Q8CH77-2]
uc007ctl.1, mouse [Q8CH77-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
89796
MGIiMGI:2183683, Nav1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QSUE, Eukaryota
GeneTreeiENSGT00940000156637
HOGENOMiCLU_001002_3_0_1
InParanoidiQ8CH77
OMAiRTNIQYR
OrthoDBi21830at2759
PhylomeDBiQ8CH77
TreeFamiTF329881

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
215690, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nav1, mouse

Protein Ontology

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PROi
PR:Q8CH77
RNActiQ8CH77, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009418, Expressed in rostral migratory stream and 294 other tissues
GenevisibleiQ8CH77, MM

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase
PANTHERiPTHR12784, PTHR12784, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAV1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CH77
Secondary accession number(s): Q3U5B6
, Q68EE8, Q6PB78, Q80TI7, Q8BKG2, Q8BUT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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